node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acnA | gapA | Dda3937_04039 | Dda3937_03335 | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | Protein involved in glyceraldehyde-3-phosphate dehydrogenase activity, NAD binding, glycolysis, pyridoxine biosynthetic process, gluconeogenesis and glucose metabolic process. | 0.651 |
acnA | mtlD | Dda3937_04039 | Dda3937_00994 | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | Mannitol-1-phosphate dehydrogenase, NAD(P)-binding protein; Protein involved in oxidoreductase activity, coenzyme binding, catalytic activity, carbohydrate catabolic process and metabolic process. | 0.666 |
dnaK | gapA | Dda3937_00385 | Dda3937_03335 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Protein involved in glyceraldehyde-3-phosphate dehydrogenase activity, NAD binding, glycolysis, pyridoxine biosynthetic process, gluconeogenesis and glucose metabolic process. | 0.514 |
dnaK | gyrA | Dda3937_00385 | Dda3937_01774 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.668 |
dnaK | gyrB | Dda3937_00385 | Dda3937_01057 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.678 |
dnaX | gapA | Dda3937_03291 | Dda3937_03335 | DNA polymerase III/DNA elongation factor III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | Protein involved in glyceraldehyde-3-phosphate dehydrogenase activity, NAD binding, glycolysis, pyridoxine biosynthetic process, gluconeogenesis and glucose metabolic process. | 0.674 |
dnaX | gyrA | Dda3937_03291 | Dda3937_01774 | DNA polymerase III/DNA elongation factor III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.757 |
dnaX | gyrB | Dda3937_03291 | Dda3937_01057 | DNA polymerase III/DNA elongation factor III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.826 |
gapA | acnA | Dda3937_03335 | Dda3937_04039 | Protein involved in glyceraldehyde-3-phosphate dehydrogenase activity, NAD binding, glycolysis, pyridoxine biosynthetic process, gluconeogenesis and glucose metabolic process. | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 0.651 |
gapA | dnaK | Dda3937_03335 | Dda3937_00385 | Protein involved in glyceraldehyde-3-phosphate dehydrogenase activity, NAD binding, glycolysis, pyridoxine biosynthetic process, gluconeogenesis and glucose metabolic process. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.514 |
gapA | dnaX | Dda3937_03335 | Dda3937_03291 | Protein involved in glyceraldehyde-3-phosphate dehydrogenase activity, NAD binding, glycolysis, pyridoxine biosynthetic process, gluconeogenesis and glucose metabolic process. | DNA polymerase III/DNA elongation factor III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.674 |
gapA | gyrA | Dda3937_03335 | Dda3937_01774 | Protein involved in glyceraldehyde-3-phosphate dehydrogenase activity, NAD binding, glycolysis, pyridoxine biosynthetic process, gluconeogenesis and glucose metabolic process. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.626 |
gapA | gyrB | Dda3937_03335 | Dda3937_01057 | Protein involved in glyceraldehyde-3-phosphate dehydrogenase activity, NAD binding, glycolysis, pyridoxine biosynthetic process, gluconeogenesis and glucose metabolic process. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.584 |
gapA | mtlD | Dda3937_03335 | Dda3937_00994 | Protein involved in glyceraldehyde-3-phosphate dehydrogenase activity, NAD binding, glycolysis, pyridoxine biosynthetic process, gluconeogenesis and glucose metabolic process. | Mannitol-1-phosphate dehydrogenase, NAD(P)-binding protein; Protein involved in oxidoreductase activity, coenzyme binding, catalytic activity, carbohydrate catabolic process and metabolic process. | 0.589 |
gyrA | dnaK | Dda3937_01774 | Dda3937_00385 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.668 |
gyrA | dnaX | Dda3937_01774 | Dda3937_03291 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA polymerase III/DNA elongation factor III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.757 |
gyrA | gapA | Dda3937_01774 | Dda3937_03335 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Protein involved in glyceraldehyde-3-phosphate dehydrogenase activity, NAD binding, glycolysis, pyridoxine biosynthetic process, gluconeogenesis and glucose metabolic process. | 0.626 |
gyrA | gyrB | Dda3937_01774 | Dda3937_01057 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.993 |
gyrB | dnaK | Dda3937_01057 | Dda3937_00385 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.678 |
gyrB | dnaX | Dda3937_01057 | Dda3937_03291 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA polymerase III/DNA elongation factor III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.826 |