STRINGSTRING
coaD coaD pelX pelX atpD atpD asnC asnC rhiT rhiT rhiN rhiN rfe rfe wzzE wzzE rffM rffM purA purA kdgN kdgN ADM97677.1 ADM97677.1 gyrB gyrB dnaA dnaA togT togT mltB mltB arsC arsC bglA bglA rhiE rhiE gltA gltA prtD prtD celY celY kdgK kdgK rfaQ rfaQ rfaD rfaD hecA2 hecA2 flgA flgA nagZ nagZ ganA ganA ganB ganB ganL ganL outC outC celH celH yggR yggR wcaB wcaB exuT exuT virB5 virB5 virB2 virB2 virB1 virB1 cheZ cheZ cheB cheB cheW cheW cel5Z cel5Z cas2 cas2 xynA xynA kdgT kdgT expI expI galF galF gapA gapA pelW pelW kdgM kdgM paeX paeX paeY paeY fliA fliA fliC fliC ADM96804.1 ADM96804.1 lfaA lfaA ogl ogl bgxA bgxA arbB arbB rfbC rfbC wzc wzc wzb wzb wza wza flhA flhA pnlH pnlH hrpN hrpN hecB hecB plcA plcA gnd gnd acpP acpP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
pelXExopolygalacturonate lyase PelX; Protein involved in pectate lyase activity, polysaccharide catabolic process, interaction with host via protein secreted by type II secretion system, metabolism by symbiont of substance in host and pectin catabolic process. (734 aa)
atpDF1 sector of membrane-bound ATP synthase, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (460 aa)
asnCDNA-binding transcriptional dual regulator; Asparagine is a repressor of the activator AsnC; AsnC belongs to the AsnC family of transcriptional regulators; Protein involved in transcription activator activity, transcription repressor activity, transcription factor activity, sequence-specific DNA binding, asparagine biosynthetic process, transcription and regulation of transcription, DNA-dependent. (154 aa)
rhiTOligogalacturonide transporter; Protein involved in carbohydrate catabolic process, interaction with host via protein secreted by type II secretion system, metabolism by symbiont of substance in host and pathogenesis. (526 aa)
rhiNRhamnogalacturonides degradation protein RhiN; Protein involved in (DEPRECATED) molecular function unknown, catalytic activity, (DEPRECATED) biological process unknown and pathogenesis. (379 aa)
rfeUndecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (358 aa)
wzzEEnterobacterial Common Antigen (ECA) polysaccharide chain length modulator; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. (344 aa)
rffMUDP-N-acetyl-D-mannosaminuronic acid (ManNAcA) transferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis. (245 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
kdgNOligogalacturonate specific porin; Protein involved in channel activity, voltage-gated ion channel activity, metabolism by symbiont of host cell wall pectin, interaction with host via protein secreted by type II secretion system and pectin metabolic process. (243 aa)
ADM97677.1ImpB; Protein involved in (DEPRECATED) molecular function unknown and (DEPRECATED) biological process unknown. (167 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (803 aa)
dnaAChromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (462 aa)
togTOligogalacturonide transporter; Protein involved in carbohydrate catabolic process and pathogenesis. (508 aa)
mltBMembrane-bound lytic murein transglycosylase B; Protein involved in peptidoglycan biosynthetic process. (367 aa)
arsCArsenate reductase; Remnant of arsB lacking N-terminus and containing internal frameshift, resulting in two open reading frames, arsB_1 and arsB_2; Protein involved in (OBSOLETE) ATP-binding cassette (ABC) transporter activity. (143 aa)
bglA6-phospho-beta-glucosidase; Protein involved in hydrolase activity, hydrolyzing O-glycosyl compounds, catalytic activity, cation binding, carbohydrate catabolic process and carbohydrate metabolic process; Belongs to the glycosyl hydrolase 1 family. (483 aa)
rhiERhamnogalacturonate lyase precursor; Degrades the rhamnogalacturonan I (RG-I) backbone of pectin. Is required for the full virulence of E.chrysanthemi strain 3937 as it is involved in rotting of plant tissue; Belongs to the polysaccharide lyase 4 family. (578 aa)
gltACitrate synthase; Protein involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer, tricarboxylic acid cycle, aerobic respiration and anaerobic respiration; Belongs to the citrate synthase family. (428 aa)
prtDAlkaline protease secretion ATP-binding protein aprD; Protein involved in (OBSOLETE) ATP-binding cassette (ABC) transporter activity, ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleotide binding, nucleoside-triphosphatase activity, modulation by symbiont of host protease activity, interaction with host via secreted substance, transport, protein transport and protein secretion. (575 aa)
celYEndoglucanase Y; Represents only 3% of the global cellulase activity; Belongs to the glycosyl hydrolase 8 (cellulase D) family. (332 aa)
kdgK2-dehydro-3-deoxygluconate kinase; Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). Belongs to the carbohydrate kinase PfkB family. (310 aa)
rfaQLipopolysaccharide core biosynthesis protein; Protein involved in (OBSOLETE) cell surface antigen activity, host-interacting, transferase activity, lipopolysaccharide core region biosynthetic process and metabolic process. (361 aa)
rfaDADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding protein; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (310 aa)
hecA2Putative member of ShlA/HecA/FhaA exoprotein family; Toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. CDI is neutralized by its cognate immunity protein CdiI, but not by non-cognate CdiI from other bacteria. The C-terminal domain (CT) has strong DNase activity; this activity is inhibited by cognate CdiI. In the N-terminal section; belongs to the CdiA family. (3326 aa)
flgAFlagellar basal-body P-ring formation protein flgA; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P- ring assembly; Belongs to the FlgA family. (228 aa)
nagZbeta-N-acetylglucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (341 aa)
ganAPeriplasmic 1,4-beta-endogalactanase; Protein involved in (DEPRECATED) molecular function unknown, glucosidase activity, catalytic activity, cation binding, (DEPRECATED) biological process unknown and carbohydrate metabolic process. (399 aa)
ganB1,4-beta-exogalactanase; Protein involved in catalytic activity, cation binding, carbohydrate catabolic process and carbohydrate metabolic process. (685 aa)
ganLGalactan outer membrane porin; Involved in the transport of maltose and maltodextrins. Belongs to the porin LamB (TC 1.B.3) family. (423 aa)
outCGeneral secretion pathway protein C; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for the translocation of the multiple pectic enzymes. (272 aa)
celHBeta-glucosidase; Protein involved in hydrolase activity, hydrolyzing O-glycosyl compounds, catalytic activity, cation binding, carbohydrate catabolic process and carbohydrate metabolic process; Belongs to the glycosyl hydrolase 1 family. (478 aa)
yggRPredicted transporter; Protein involved in ATP binding, nucleotide binding, nucleoside-triphosphatase activity and transport. (337 aa)
wcaBColanic acid biosynthesis acetyltransferase wcaB; Protein involved in acyltransferase activity, colanic acid biosynthetic process and amino acid catabolic process. (166 aa)
exuTHexuronate transport system; Protein involved in transporter activity, carbohydrate catabolic process and transport. (432 aa)
virB5Minor pilin of type IV secretion complex (VirB5). (238 aa)
virB2Major pilus subunit of type IV secretion complex (VirB2). (93 aa)
virB1VirB1; Bores hole in peptidoglycan layer allowing type IV secretion complex assembly to occur; Protein involved in (DEPRECATED) molecular function unknown and (DEPRECATED) biological process unknown. (228 aa)
cheZChemotaxis response - phosphatase CheZ; Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P). (214 aa)
cheBChemotaxis response regulator protein-glutamate methylesterase CheB; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (350 aa)
cheWPositive regulator of CheA protein activity (CheW); Protein involved in signal transducer activity, taxis, chemotaxis and signal transduction. (165 aa)
cel5ZEndo-1,4-beta-glucanase precursor; Represents 97% of the global cellulase activity. (426 aa)
cas2CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (97 aa)
xynAXylanase; Protein involved in catalytic activity, cation binding, glucosylceramidase activity, endo-1,4-beta-xylanase activity, carbohydrate catabolic process, glucose metabolic process, polysaccharide catabolic process, metabolism by symbiont of substance in host, carbohydrate metabolic process, sphingolipid metabolic process and lysosome organization; Belongs to the glycosyl hydrolase 30 family. (413 aa)
kdgT2-keto-3-deoxygluconate permease; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system. Belongs to the KdgT transporter family. (355 aa)
expIHomoserine lactone synthase YpeI; Required for the synthesis of OHHL (N-(3-oxohexanoyl)-L- homoserine lactone), an autoinducer molecule which binds to ExpR and thus acts in virulence (soft rot disease) through the activation of genes for plant tissue macerating enzymes. (212 aa)
galFPredicted regulatory subunit of UTP--glucose-1-phosphate uridylyltransferase, with GalU; Protein involved in nucleotidyltransferase activity, nucleotide-sugar biosynthetic process and biosynthetic process. (298 aa)
gapAProtein involved in glyceraldehyde-3-phosphate dehydrogenase activity, NAD binding, glycolysis, pyridoxine biosynthetic process, gluconeogenesis and glucose metabolic process. (331 aa)
pelWExopolygalacturonate lyase; Catalyzes the formation of unsaturated digalacturonates from polygalacturonate or short oligogalacturonates. Belongs to the polysaccharide lyase 2 family. (543 aa)
kdgMOligogalacturonate specific porin; Porin specific for oligogalacturonides. Also required for full virulence; Belongs to the oligogalacturonate-specific porin KdgM (TC 1.B.35) family. (236 aa)
paeXProtein involved in acetylesterase activity, metabolism by symbiont of host cell wall pectin, interaction with host via protein secreted by type II secretion system, pathogenesis and pectin catabolic process. (322 aa)
paeYPectin acetylesterase; PaeY is secreted by the Out secretion system; Protein involved in hydrolase activity, acetylesterase activity, polysaccharide catabolic process, carbohydrate catabolic process, metabolism by symbiont of host cell wall pectin, interaction with host via protein secreted by type II secretion system, pathogenesis and entry into host. (551 aa)
fliARNA polymerase, sigma 28 (sigma F) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (240 aa)
fliCFlagellar filament structural protein (flagellin); Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (280 aa)
ADM96804.1Pectate lyase; Homologous to type III helper protein HopPmaH. However, this protein has cysteines, while HopPmaH lacks cysteines - a characteristic of type III helper proteins. Therefore, this is not likely to be a type III helper; Protein involved in polysaccharide catabolic process, protein secretion by the type II secretion system, interaction with host via protein secreted by type II secretion system and metabolism by symbiont of host cell wall pectin. (315 aa)
lfaAAlpha-glucosidase; Protein involved in hydrolase activity, hydrolyzing O-glycosyl compounds, polysaccharide catabolic process and carbohydrate metabolic process; Belongs to the glycosyl hydrolase 31 family. (791 aa)
oglOligogalacturonate lyase; Involved in degradation of pectin, which causes soft-rod disease in plants. (388 aa)
bgxABeta-glucosidase (Gentiobiase) (Cellobiase) / Beta- xylosidase; Protein involved in hydrolase activity, hydrolyzing O-glycosyl compounds, polysaccharide catabolic process and carbohydrate metabolic process. (671 aa)
arbBPhospho-beta-glucosidase; Protein involved in hydrolase activity, hydrolyzing O-glycosyl compounds, catalytic activity, cation binding, carbohydrate catabolic process and carbohydrate metabolic process; Belongs to the glycosyl hydrolase 1 family. (466 aa)
rfbCdTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (178 aa)
wzcTyrosine-protein kinase wzc; Protein involved in colanic acid biosynthetic process, protein modification process and lipopolysaccharide biosynthetic process. (726 aa)
wzbLow molecular weight protein-tyrosine-phosphatase wzb; Protein involved in protein tyrosine phosphatase activity, colanic acid biosynthetic process and protein amino acid dephosphorylation; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (144 aa)
wzaCapsule polysaccharide export protein; Protein involved in (OBSOLETE) cell surface antigen activity, host-interacting, polysaccharide transmembrane transporter activity and polysaccharide transport. (378 aa)
flhAPredicted flagellar export pore protein; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (695 aa)
pnlHPectate lyase; Protein involved in carbohydrate catabolic process, polysaccharide catabolic process, protein secretion by the type II secretion system, interaction with host via protein secreted by type II secretion system and metabolism by symbiont of substance in host. (310 aa)
hrpNHarpin hrpN; E. coli containing D. dadantii hrp cluster is capable of secreting an exogenous effector into tobacco, eliciting a hypersensitive response; Protein involved in pellicle formation, pathogenesis and interaction with host via protein secreted by type III secretion system. (342 aa)
hecBHemolysin activator protein precursor; Probable outer membrane protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. This protein may be required for secretion and assembly of the CdiA toxin; Belongs to the TPS (TC 1.B.20) family. (558 aa)
plcAExtracellular phospholipase C; E. coli containing D. dadantii hrp cluster is capable of secreting an exogenous effector into tobacco, eliciting a hypersensitive response; Protein involved in phospholipase A1 activity, phosphorus metabolic process, modulation of signal transduction pathway in other organism during symbiotic interaction, interaction with host via protein secreted by type III secretion system and pathogenesis. (349 aa)
gndGluconate-6-phosphate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
acpPAcyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa)
Your Current Organism:
Dickeya dadantii
NCBI taxonomy Id: 198628
Other names: D. dadantii 3937, Dickeya dadantii 3937, Dickeya dadantii str. 3937, Dickeya dadantii strain 3937, Erwinia chrysanthemi str. 3937, Pectobacterium chrysanthemi str. 3937
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.