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ppiD ppiD rnb rnb cpxP cpxP hisB hisB hisD hisD dsbB dsbB dps dps pelL pelL cel5Z cel5Z cheA cheA groL groL dipZ dipZ prfC prfC cspE cspE gltI gltI murC murC suhB suhB dsbC dsbC fliD fliD fliE fliE flgL flgL flgK flgK flgI flgI flgG flgG flgF flgF flgE flgE flgB flgB fre fre dcrB dcrB yaeT yaeT rcsB rcsB clpB clpB yfiO yfiO raiA raiA pgm pgm def def surA surA bipA bipA dsbA dsbA yfbG yfbG speE speE uspE uspE tufB tufB trxA trxA dnaJ dnaJ dnaK dnaK speA speA metK metK gshB gshB ohr ohr degP degP fkpA fkpA trpD trpD degQ degQ katG katG rplL rplL flgC flgC leuA leuA pelC pelC trpS trpS rpe rpe oppA oppA speD speD yiiU yiiU rpoE rpoE sfcA sfcA prt1 prt1 leuA-2 leuA-2 fliC fliC pemA pemA pelE pelE pelA pelA osmE osmE clpP clpP recA recA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ppiDProtein involved in isomerase activity and protein folding. (626 aa)
rnbRibonuclease II; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction. (643 aa)
cpxPPutative exported protein precursor; Protein involved in transcription and xenobiotic metabolic process. (186 aa)
hisBBifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase; Protein involved in imidazoleglycerol-phosphate dehydratase activity, histidinol-phosphatase activity and histidine biosynthetic process. (355 aa)
hisDBifunctional histidinal dehydrogenase/histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (436 aa)
dsbBOxidoreductase that catalyzes reoxidation of DsbA protein disulfide isomerase I; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family. (176 aa)
dpsFe-binding and storage protein; During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction; Belongs to the Dps family. (167 aa)
pelLPectate lyase pelL; Presents an endo-cleaving activity on polygalacturonate or partially methylated pectin. Is effective in the maceration of plant tissue, and has an important role in soft-rot disease. Is 280-fold less active against polygalacturonate than the major pectate lyase PelB. When assayed on polygalacturonate, PelL releases oligogalacturonates of different sizes; upon prolonged incubation, PelL degrades the primary products to unsaturated tetramer and pentamer in addition to unsaturated dimer and trimer. When assayed on oligogalacturonates (degrees of polymerization of 2 to [...] (425 aa)
cel5ZEndo-1,4-beta-glucanase precursor; Represents 97% of the global cellulase activity. (426 aa)
cheAChemotaxis protein CheA; Protein involved in ATP binding, signal transducer activity, protein histidine kinase activity, nucleic acid binding, ATP-dependent helicase activity, transferase activity, transferring phosphorus-containing groups, two-component sensor activity, taxis, protein modification process, chemotaxis, signal transduction, peptidyl-histidine phosphorylation and phosphorylation. (675 aa)
groLCpn60 chaperonin GroEL, large subunit of GroESL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (548 aa)
dipZCytochrome c-type biogenesis protein DsbD, protein-disulfide reductase; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. (572 aa)
prfCPeptide chain release factor RF-3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (529 aa)
cspEDNA-binding transcriptional repressor; Protein involved in transcription activator activity, nucleic acid binding, DNA binding, transcription, response to temperature stimulus and regulation of transcription, DNA-dependent. (69 aa)
gltIPeriplasmic-binding component of an ABC superfamily glutamate/aspartate transporter; Protein involved in ATPase activity, coupled to transmembrane movement of substances, transporter activity, glutamate biosynthetic process and transport. (307 aa)
murCUDP-N-acetylmuramate:L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (486 aa)
suhBMyo-inositol-1(or 4)-monophosphatase; Protein involved in inositol or phosphatidylinositol phosphatase activity and transcription; Belongs to the inositol monophosphatase superfamily. (267 aa)
dsbCProtein disulfide isomerase II; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase. (238 aa)
fliDFlagellar hook-associated protein fliD; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. (484 aa)
fliEFlagellar hook-basal body complex protein fliE; Protein involved in motor activity, structural molecule activity, flagellum assembly, taxis and ciliary or flagellar motility. (104 aa)
flgLFlagellar hook-associated protein flgL; Protein involved in structural molecule activity, flagellum assembly, protein folding, taxis and ciliary or flagellar motility. (309 aa)
flgKFlagellar hook-associated protein flgK; Protein involved in structural molecule activity, motor activity, flagellum assembly, protein folding, taxis and ciliary or flagellar motility; Belongs to the flagella basal body rod proteins family. (640 aa)
flgIFlagellar P-ring protein flgI; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (369 aa)
flgGFlagellar basal-body rod protein flgG; Protein involved in motor activity, structural molecule activity, flagellum assembly, taxis, cell motion, flagellum organization and ciliary or flagellar motility; Belongs to the flagella basal body rod proteins family. (260 aa)
flgFFlagellar basal-body rod protein flgF; Protein involved in motor activity, structural molecule activity, flagellum assembly, taxis, cell motion, flagellum organization and ciliary or flagellar motility. (251 aa)
flgEFlagellar hook protein flgE; Protein involved in motor activity, structural molecule activity, flagellum assembly, taxis and ciliary or flagellar motility. (399 aa)
flgBFlagellar basal-body rod protein flgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body. (139 aa)
freFlavin reductase; Protein involved in electron carrier activity, oxidoreductase activity and (OBSOLETE) electron transport. (233 aa)
dcrBDcrB protein precursor; Putative lipoproteine; Protein involved in (DEPRECATED) molecular function unknown and (DEPRECATED) biological process unknown. (221 aa)
yaeTConserved protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (805 aa)
rcsBDNA-binding response regulator in two-component regulatory system with RcsC and YojN; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. (216 aa)
clpBClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (857 aa)
yfiOPredicted lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (244 aa)
raiACold shock protein associated with 30S ribosomal subunit; Protein involved in translation. (111 aa)
pgmPhosphoglucomutase; Protein involved in intramolecular transferase activity, phosphotransferases, phosphoglucomutase activity, carbohydrate catabolic process, glucose metabolic process and carbohydrate metabolic process. (547 aa)
defPeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (169 aa)
surAPeptidyl-prolyl cis-trans isomerase (PPIase); Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (430 aa)
bipAProtein involved in GTPase activity, GTP binding and taxis. (607 aa)
dsbAPeriplasmic protein disulfide isomerase I; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis; Belongs to the thioredoxin family. DsbA subfamily. (207 aa)
yfbGBifunctional UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'-decarboxylase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the N-terminal section; belongs to the Fmt family. UDP- L-Ara4N formyltransferase subfamily. (663 aa)
speESpermidine synthase (putrescine aminopropyltransferase); Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (287 aa)
uspEProtein involved in response to radiation and response to stress. (321 aa)
tufBTranslation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (394 aa)
trxAThioredoxin 1; Protein involved in electron carrier activity, protein disulfide oxidoreductase activity, cell redox homeostasis and glycerol ether metabolic process; Belongs to the thioredoxin family. (108 aa)
dnaJChaperone Hsp40, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] (377 aa)
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (636 aa)
speABiosynthetic arginine decarboxylase, PLP-binding protein; Catalyzes the biosynthesis of agmatine from arginine. (658 aa)
metKMethionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa)
gshBGlutathione synthetase; Protein involved in catalytic activity, ATP binding, glutathione synthase activity and glutathione biosynthetic process; Belongs to the prokaryotic GSH synthase family. (317 aa)
ohrOrganic hydroperoxide resistance protein; Protein involved in xenobiotic metabolic process, protein modification process and response to stress. (142 aa)
degPSerine endoprotease (protease Do), membrane-associated; Protein involved in serine-type endopeptidase activity, protein binding, response to temperature stimulus and proteolysis; Belongs to the peptidase S1C family. (486 aa)
fkpAFKBP-type peptidyl-prolyl cis-trans isomerase (rotamase); Protein involved in protein folding. (283 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa)
degQProtease; Protein involved in protein binding, serine-type endopeptidase activity and proteolysis; Belongs to the peptidase S1C family. (456 aa)
katGCatalase / Peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (660 aa)
rplL50S ribosomal subunit protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa)
flgCFlagellar basal-body rod protein flgC; Protein involved in motor activity, structural molecule activity, flagellum assembly, taxis and ciliary or flagellar motility; Belongs to the flagella basal body rod proteins family. (134 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (524 aa)
pelCPectate lyase C; PelC is secretd by the Out secretion system; Protein involved in polysaccharide catabolic process, carbohydrate catabolic process and pathogenesis. (374 aa)
trpStryptophan-tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (334 aa)
rpeD-ribulose-5-phosphate 3-epimerase; Protein involved in catalytic activity, ribulose-phosphate 3-epimerase activity, pentose-phosphate shunt, oxidative branch, carbohydrate catabolic process, pentose-phosphate shunt, non-oxidative branch, metabolic process and carbohydrate metabolic process. (225 aa)
oppAOligopeptide transport; Protein involved in (OBSOLETE) ATP-binding cassette (ABC) transporter activity, transporter activity, peptidoglycan metabolic process and transport. (547 aa)
speDS-adenosylmethionine decarboxylase; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. (264 aa)
yiiUConserved protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. (80 aa)
rpoERNA polymerase, sigma 24 (sigma E) factor; Protein involved in DNA binding, transcription factor activity, sigma factor activity, transcription, response to temperature stimulus, transcription initiation and regulation of transcription, DNA-dependent; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa)
sfcAMalate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme); Protein involved in malic enzyme activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, NAD binding, gluconeogenesis and malate metabolic process. (565 aa)
prt1Extracellular metalloprotease precursor; Extracellular zinc metalloprotease. (349 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (567 aa)
fliCFlagellar filament structural protein (flagellin); Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (280 aa)
pemAPectinesterase; Involved in maceration and soft-rotting of plant tissue. (366 aa)
pelEPectate lyase pelE; Involved in maceration and soft-rotting of plant tissue. Pectate lyases have been implicated as pathogenicity factors which induce maceration or rotting of plant tissue. PelE is sufficient to induce these effects under laboratory conditions. (404 aa)
pelAPectate lyase, Pla; Involved in maceration and soft-rotting of plant tissue. (392 aa)
osmEOsmotically inducible lipoprotein E precursor; OsmE belongs to the SmpA-OmlA family of bacterial lipoprotein; Protein involved in transcription activator activity, transcription and response to osmotic stress. (109 aa)
clpPProteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP-dependent serine proteases; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (207 aa)
recADNA strand exchange and recombination protein with protease and nuclease activity; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (358 aa)
Your Current Organism:
Dickeya dadantii
NCBI taxonomy Id: 198628
Other names: D. dadantii 3937, Dickeya dadantii 3937, Dickeya dadantii str. 3937, Dickeya dadantii strain 3937, Erwinia chrysanthemi str. 3937, Pectobacterium chrysanthemi str. 3937
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