STRINGSTRING
polB polB pelX pelX atpD atpD pehK pehK pehX pehX trxA trxA pecT pecT slyA slyA hrp hrp hrpL hrpL hrpJ hrpJ hrcR hrcR yfiN yfiN pecS pecS prtD prtD prtE prtE prtF prtF celY celY infB infB celH celH cel5Z cel5Z pelL pelL hrpK hrpK hrpW hrpW dspE dspE dspF dspF yddV yddV xynA xynA avrL avrL yaiC yaiC hrpA hrpA hrpS hrpS hrpY hrpY hrpX hrpX pelD pelD pemA pemA lfaA lfaA kdgR kdgR prtC prtC hrpN hrpN hecB hecB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
polBDNA polymerase II; Protein involved in nucleotide binding, nucleic acid binding, DNA-directed DNA polymerase activity, DNA binding, response to radiation, DNA-dependent DNA replication, DNA repair, SOS response, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process and DNA replication. (790 aa)
pelXExopolygalacturonate lyase PelX; Protein involved in pectate lyase activity, polysaccharide catabolic process, interaction with host via protein secreted by type II secretion system, metabolism by symbiont of substance in host and pectin catabolic process. (734 aa)
atpDF1 sector of membrane-bound ATP synthase, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (460 aa)
pehKPolygalacturonase; Protein involved in polygalacturonase activity, catalytic activity, carbohydrate catabolic process, polysaccharide catabolic process, metabolism by symbiont of host cell wall pectin, interaction with host via protein secreted by type II secretion system and carbohydrate metabolic process; Belongs to the glycosyl hydrolase 28 family. (459 aa)
pehXExo-poly-alpha-D-galacturonosidase precursor; Protein involved in polygalacturonase activity, pectate lyase activity, polysaccharide catabolic process, carbohydrate catabolic process, interaction with host via protein secreted by type II secretion system, metabolism by symbiont of substance in host, carbohydrate metabolic process, pectin catabolic process and metabolism by symbiont of host cell wall pectin; Belongs to the glycosyl hydrolase 28 family. (602 aa)
trxAThioredoxin 1; Protein involved in electron carrier activity, protein disulfide oxidoreductase activity, cell redox homeostasis and glycerol ether metabolic process; Belongs to the thioredoxin family. (108 aa)
pecTProbable HTH-type transcriptional regulator lrhA; Regulates pectinase gene expression. (316 aa)
slyADNA-binding transcriptional activator; Transcription regulator that can specifically activate or repress expression of target genes; Belongs to the SlyA family. (145 aa)
hrpPredicted ATP-dependent helicase; Protein involved in nucleic acid binding, helicase activity, ATP binding, ATP-dependent helicase activity and DNA-dependent DNA replication. (835 aa)
hrpLRNA polymerase sigma-54 factor rpoN; E. coli containing D. dadantii hrp cluster is capable of secreting an exogenous effector into tobacco, eliciting a hypersensitive response; Protein involved in DNA binding, transcription factor activity, sigma factor activity, transcription activator activity, pellicle formation, transcription initiation, regulation of transcription, DNA-dependent, pathogenesis, positive regulation of transcription and interaction with host via protein secreted by type III secretion system; Belongs to the sigma-70 factor family. ECF subfamily. (184 aa)
hrpJType III secretion protein; E. coli containing D. dadantii hrp cluster is capable of secreting an exogenous effector into tobacco, eliciting a hypersensitive response; Protein involved in protein secretion by the type III secretion system, interaction with host via protein secreted by type III secretion system, pathogenesis, secretion and negative regulation of protein secretion. (389 aa)
hrcRType III secretion inner membrane protein; E. coli containing D. dadantii hrp cluster is capable of secreting an exogenous effector into tobacco, eliciting a hypersensitive response; Protein involved in protein secretion by the type III secretion system, interaction with host via protein secreted by type III secretion system, protein secretion, protein transport and pathogenesis. (217 aa)
yfiNProtein involved in (DEPRECATED) molecular function unknown, signal transducer activity, (DEPRECATED) biological process unknown and signal transduction. (422 aa)
pecSDNA-binding transcriptional regulatory protein PecS; Negative regulator of pectinase, cellulase, blue pigment production and virulence genes. Also binds to promoter sites in the pecS-pecM intergenic region and negatively autoregulate its expression as well as that of pecM. (166 aa)
prtDAlkaline protease secretion ATP-binding protein aprD; Protein involved in (OBSOLETE) ATP-binding cassette (ABC) transporter activity, ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleotide binding, nucleoside-triphosphatase activity, modulation by symbiont of host protease activity, interaction with host via secreted substance, transport, protein transport and protein secretion. (575 aa)
prtEProteases secretion protein prtE; HylD domain; Protein involved in (OBSOLETE) type I protein secretor activity, protein transporter activity, protein secretion, protein transport and pathogenesis. (448 aa)
prtFOuter membrane exporter of proteases; Protein involved in transporter activity, modulation by symbiont of host protease activity, interaction with host via protein secreted by type II secretion system, protein transport, transport and protein secretion. (467 aa)
celYEndoglucanase Y; Represents only 3% of the global cellulase activity; Belongs to the glycosyl hydrolase 8 (cellulase D) family. (332 aa)
infBTranslation initiation factor IF2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (905 aa)
celHBeta-glucosidase; Protein involved in hydrolase activity, hydrolyzing O-glycosyl compounds, catalytic activity, cation binding, carbohydrate catabolic process and carbohydrate metabolic process; Belongs to the glycosyl hydrolase 1 family. (478 aa)
cel5ZEndo-1,4-beta-glucanase precursor; Represents 97% of the global cellulase activity. (426 aa)
pelLPectate lyase pelL; Presents an endo-cleaving activity on polygalacturonate or partially methylated pectin. Is effective in the maceration of plant tissue, and has an important role in soft-rot disease. Is 280-fold less active against polygalacturonate than the major pectate lyase PelB. When assayed on polygalacturonate, PelL releases oligogalacturonates of different sizes; upon prolonged incubation, PelL degrades the primary products to unsaturated tetramer and pentamer in addition to unsaturated dimer and trimer. When assayed on oligogalacturonates (degrees of polymerization of 2 to [...] (425 aa)
hrpKPathogenicity locus protein hrpK; May be an TTSS helper; Protein involved in interaction with host via protein secreted by type III secretion system and pathogenesis. (571 aa)
hrpWType III secreted protein; HR-eliciting activity; Protein involved in pectate lyase activity, interaction with host via protein secreted by type III secretion system and pathogenesis. (569 aa)
dspEdspE of Erwinia amylovora is required for pathogenicity; Protein involved in modification by symbiont of host morphology or physiology via secreted substance, interaction with host via protein secreted by type III secretion system and pathogenesis. (1625 aa)
dspFDspF; Protein involved in protein folding, modification by symbiont of host morphology or physiology via secreted substance and pathogenesis. (155 aa)
yddVPutative Heme-regulated two-component response regulator; Protein involved in (DEPRECATED) molecular function unknown, iron ion binding, oxygen binding, heme binding and (DEPRECATED) biological process unknown. (460 aa)
xynAXylanase; Protein involved in catalytic activity, cation binding, glucosylceramidase activity, endo-1,4-beta-xylanase activity, carbohydrate catabolic process, glucose metabolic process, polysaccharide catabolic process, metabolism by symbiont of substance in host, carbohydrate metabolic process, sphingolipid metabolic process and lysosome organization; Belongs to the glycosyl hydrolase 30 family. (413 aa)
avrLAvirulence protein; AvrL is secreted by the Out system; promoter is bound by pecS; Protein involved in metallopeptidase activity, zinc ion binding, interaction with host via protein secreted by type II secretion system and proteolysis. (618 aa)
yaiCThis protein contains a GGDEF motif; Protein involved in (DEPRECATED) molecular function unknown and (DEPRECATED) biological process unknown. (365 aa)
hrpAHrp pili protein hrpA; E. coli containing D. dadantii hrp cluster is capable of secreting an exogenous effector into tobacco, eliciting a hypersensitive response; Protein involved in pellicle formation, interaction with host via protein secreted by type III secretion system and pathogenesis. (67 aa)
hrpSHrpS type III protein secretion system regulatory protein; HrpS possesses a sigma 54 interaction domain; belongs to the Fis family; E. coli containing D. dadantii hrp cluster is capable of secreting an exogenous effector into tobacco, eliciting a hypersensitive response; Protein involved in transcription activator activity, nucleotide binding, nucleoside-triphosphatase activity, ATP binding, transcription factor binding, transcription factor activity, pellicle formation, interaction with host via protein secreted by type III secretion system, regulation of transcription, DNA-dependent, [...] (327 aa)
hrpYDNA-binding response regulator, LuxR family, near polyamine transporter; HrpY is a response regulator of a putative two component transcriptional regulatory system; E. coli containing D. dadantii hrp cluster is capable of secreting an exogenous effector into tobacco, eliciting a hypersensitive response; Protein involved in transcription activator activity, two-component response regulator activity, transcription factor activity, sequence-specific DNA binding, pellicle formation, regulation of transcription, DNA-dependent, interaction with host via protein secreted by type III secretion [...] (213 aa)
hrpXType III protein secretion system sensor kinase; End of contig, partial hrpX sequence; Required for wild-type pellicle formation; E. coli containing D. dadantii hrp cluster is capable of secreting an exogenous effector into tobacco, eliciting a hypersensitive response; Protein involved in signal transducer activity, ATP binding, two-component sensor activity, protein histidine kinase activity, protein modification process, pellicle formation, interaction with host via protein secreted by type III secretion system, signal transduction, regulation of transcription, DNA-dependent, peptidy [...] (490 aa)
pelDPectate lyase D; PelE is secreted by the Out secretion system; Protein involved in pectate lyase activity, polysaccharide catabolic process, carbohydrate catabolic process, interaction with host via protein secreted by type II secretion system, metabolism by symbiont of substance in host and pathogenesis. (392 aa)
pemAPectinesterase; Involved in maceration and soft-rotting of plant tissue. (366 aa)
lfaAAlpha-glucosidase; Protein involved in hydrolase activity, hydrolyzing O-glycosyl compounds, polysaccharide catabolic process and carbohydrate metabolic process; Belongs to the glycosyl hydrolase 31 family. (791 aa)
kdgRDNA-binding transcriptional regulatory protein KdgR; KdgR interacts with 2-keto-3-deoxygluconate which is an inducer; The consensus KdgR-binding site is ATRAAAYRNYRTTTYAT; KdgR belongs to the IclR family of transcriptional regulator; Protein involved in DNA binding, transcription repressor activity, metabolism by symbiont of host cell wall pectin, regulation of transcription, DNA-dependent, negative regulation of transcription and pathogenesis. (263 aa)
prtCSecreted protease C precursor; Protein involved in calcium ion binding, metallopeptidase activity, zinc ion binding, metalloendopeptidase activity, peptidase activity, modulation by symbiont of host protease activity, interaction with host via protein secreted by type II secretion system, proteolysis and protein catabolic process. (479 aa)
hrpNHarpin hrpN; E. coli containing D. dadantii hrp cluster is capable of secreting an exogenous effector into tobacco, eliciting a hypersensitive response; Protein involved in pellicle formation, pathogenesis and interaction with host via protein secreted by type III secretion system. (342 aa)
hecBHemolysin activator protein precursor; Probable outer membrane protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. This protein may be required for secretion and assembly of the CdiA toxin; Belongs to the TPS (TC 1.B.20) family. (558 aa)
Your Current Organism:
Dickeya dadantii
NCBI taxonomy Id: 198628
Other names: D. dadantii 3937, Dickeya dadantii 3937, Dickeya dadantii str. 3937, Dickeya dadantii strain 3937, Erwinia chrysanthemi str. 3937, Pectobacterium chrysanthemi str. 3937
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