STRINGSTRING
paeY paeY pemA pemA kdgR kdgR rnc rnc oxyR oxyR pelZ pelZ pelC pelC pelB pelB lpp lpp fabI fabI ompR ompR greB greB rhlB rhlB iscR iscR gppA gppA budB budB gcvT gcvT gcvH gcvH gcvP gcvP ADM96880.1 ADM96880.1 polB polB pecS pecS indC indC vfmD vfmD vfmE vfmE hrpL hrpL araC araC crp crp pcnB pcnB pecT pecT mrcA mrcA smtA smtA pelA pelA pelE pelE pelD pelD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
paeYPectin acetylesterase; PaeY is secreted by the Out secretion system; Protein involved in hydrolase activity, acetylesterase activity, polysaccharide catabolic process, carbohydrate catabolic process, metabolism by symbiont of host cell wall pectin, interaction with host via protein secreted by type II secretion system, pathogenesis and entry into host. (551 aa)
pemAPectinesterase; Involved in maceration and soft-rotting of plant tissue. (366 aa)
kdgRDNA-binding transcriptional regulatory protein KdgR; KdgR interacts with 2-keto-3-deoxygluconate which is an inducer; The consensus KdgR-binding site is ATRAAAYRNYRTTTYAT; KdgR belongs to the IclR family of transcriptional regulator; Protein involved in DNA binding, transcription repressor activity, metabolism by symbiont of host cell wall pectin, regulation of transcription, DNA-dependent, negative regulation of transcription and pathogenesis. (263 aa)
rncRNase III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (226 aa)
oxyROxyR belongs to the LysR family of transcriptional regulators; OxyR is inactivated by reduction of its essential disulfide bond (Cys 199-Cys 208); while other genes regulated by OxyR are present in ECH3937, the gene for the regulatory RNA OxyS is not detected; Protein involved in transcription activator activity, transcription repressor activity, transcription factor activity, transcription and regulation of transcription, DNA-dependent. (305 aa)
pelZPectate lyase; PelZ is secreted by the Out secretion system; Protein involved in pectate lyase activity, interaction with host via protein secreted by type II secretion system, metabolism by symbiont of substance in host, pectin catabolic process and pathogenesis. (425 aa)
pelCPectate lyase C; PelC is secretd by the Out secretion system; Protein involved in polysaccharide catabolic process, carbohydrate catabolic process and pathogenesis. (374 aa)
pelBPectate lyase B; PelB is secreted by the Out secretion system; Protein involved in pectate lyase activity, polysaccharide catabolic process, interaction with host via protein secreted by type II secretion system, metabolism by symbiont of substance in host and pathogenesis. (375 aa)
lppMurein lipoprotein. (78 aa)
fabIEnoyl-[acyl-carrier-protein] reductase [NADH]; Protein involved in oxidoreductase activity and metabolic process. (263 aa)
ompRDNA-binding response regulator in two-component regulatory system with EnvZ; OmpR is phosphorylated by the sensor-histidine kinase EnvZ in response to variations of the osmolarity of the growth medium; Protein involved in transcription activator activity, transcription repressor activity, two-component response regulator activity, transcription, positive regulation of transcription and negative regulation of transcription. (239 aa)
greBTranscription elongation factor GreB; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length. (166 aa)
rhlBATP-dependent RNA helicase; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (428 aa)
iscRFe-S cluster-containing transcription factor; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. (164 aa)
gppAGuanosine-5'-triphosphate,3'-diphosphate pyrophosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (498 aa)
budBAcetolactate synthase, catabolic; Protein involved in magnesium ion binding, transferase activity, thiamin pyrophosphate binding, acetolactate synthase activity, FAD binding, catalytic activity and branched chain family amino acid biosynthetic process; Belongs to the TPP enzyme family. (565 aa)
gcvTAminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. (366 aa)
gcvHGlycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (135 aa)
gcvPGlycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa)
ADM96880.1Threonine efflux protein; Protein involved in (DEPRECATED) lysine permease activity and amino acid transport. (216 aa)
polBDNA polymerase II; Protein involved in nucleotide binding, nucleic acid binding, DNA-directed DNA polymerase activity, DNA binding, response to radiation, DNA-dependent DNA replication, DNA repair, SOS response, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process and DNA replication. (790 aa)
pecSDNA-binding transcriptional regulatory protein PecS; Negative regulator of pectinase, cellulase, blue pigment production and virulence genes. Also binds to promoter sites in the pecS-pecM intergenic region and negatively autoregulate its expression as well as that of pecM. (166 aa)
indCIndigoidine synthase; Protein involved in catalytic activity, cofactor binding, hydrolase activity, acting on ester bonds, ligase activity, antibiotic biosynthetic process, response to defenses of other organism during symbiotic interaction, nonribosomal peptide biosynthetic process, metabolic process, biosynthetic process and pathogenesis. (1488 aa)
vfmDProbable hydrolase; Protein involved in (DEPRECATED) molecular function unknown and (DEPRECATED) biological process unknown. (362 aa)
vfmEVfmE belongs to the AraC family of transcriptional regulators; Protein involved in transcription factor activity, sequence-specific DNA binding, DNA binding, transcription, regulation of transcription, DNA-dependent, metabolism by symbiont of substance in host, regulation of transcription and pathogenesis. (187 aa)
hrpLRNA polymerase sigma-54 factor rpoN; E. coli containing D. dadantii hrp cluster is capable of secreting an exogenous effector into tobacco, eliciting a hypersensitive response; Protein involved in DNA binding, transcription factor activity, sigma factor activity, transcription activator activity, pellicle formation, transcription initiation, regulation of transcription, DNA-dependent, pathogenesis, positive regulation of transcription and interaction with host via protein secreted by type III secretion system; Belongs to the sigma-70 factor family. ECF subfamily. (184 aa)
araCDNA-binding transcriptional dual regulator; Interacts with L-arabinose which is an inducer; interacts with D-fucose which is an anti-inducer; Protein involved in transcription activator activity, transcription repressor activity, transcription factor activity, sequence-specific DNA binding, DNA binding, carbohydrate catabolic process, transcription, regulation of transcription, DNA-dependent and regulation of transcription. (316 aa)
crpCyclic AMP receptor protein; Protein involved in transcription activator activity, transcription repressor activity, transcription factor activity, DNA binding, transcription, regulation of transcription, DNA-dependent and regulation of transcription. (210 aa)
pcnBpoly(A) polymerase I; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (467 aa)
pecTProbable HTH-type transcriptional regulator lrhA; Regulates pectinase gene expression. (316 aa)
mrcAPenicillin-binding protein 1A (PBP1A); End of contig6; Protein involved in peptidase activity, transferase activity, transferring pentosyl groups, catalytic activity, penicillin binding, peptidoglycan biosynthetic process, response to drug, response to antibiotic and peptidoglycan-based cell wall biogenesis. (852 aa)
smtAPredicted S-adenosyl-L-methionine-dependent methyltransferase; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family. (267 aa)
pelAPectate lyase, Pla; Involved in maceration and soft-rotting of plant tissue. (392 aa)
pelEPectate lyase pelE; Involved in maceration and soft-rotting of plant tissue. Pectate lyases have been implicated as pathogenicity factors which induce maceration or rotting of plant tissue. PelE is sufficient to induce these effects under laboratory conditions. (404 aa)
pelDPectate lyase D; PelE is secreted by the Out secretion system; Protein involved in pectate lyase activity, polysaccharide catabolic process, carbohydrate catabolic process, interaction with host via protein secreted by type II secretion system, metabolism by symbiont of substance in host and pathogenesis. (392 aa)
Your Current Organism:
Dickeya dadantii
NCBI taxonomy Id: 198628
Other names: D. dadantii 3937, Dickeya dadantii 3937, Dickeya dadantii str. 3937, Dickeya dadantii strain 3937, Erwinia chrysanthemi str. 3937, Pectobacterium chrysanthemi str. 3937
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.