(5 nodes) Membrane-bound tetrahaem cytochrome TorC/YecK, and trimethylamine-N-oxide reductase (cytochrome c) activity network (Escherichia coli CFT073)

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	torC	Cytochrome c-type protein torC; Escherichia coli K-12 ortholog: b0996; Escherichia coli O157:H7 ortholog: z1414; Belongs to the TorC/TorY family. (406 aa)
	torA	Trimethylamine-N-oxide reductase 1 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. (848 aa)
	torD	Chaperone protein torD; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily. (210 aa)
	bisZ	Trimethylamine-N-oxide reductase 2 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N- oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency (By similarity); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (815 aa)
	yecK	Cytochrome c-type protein torY; Escherichia coli K-12 ortholog: b1873; Escherichia coli O157:H7 ortholog: z2926; Belongs to the TorC/TorY family. (366 aa)

Your Current Organism:

Escherichia coli CFT073

NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
bisZ	torA	c2286	c1133	Trimethylamine-N-oxide reductase 2 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N- oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency (By similarity); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Trimethylamine-N-oxide reductase 1 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.	0.907
bisZ	torC	c2286	c1132	Trimethylamine-N-oxide reductase 2 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N- oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency (By similarity); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Cytochrome c-type protein torC; Escherichia coli K-12 ortholog: b0996; Escherichia coli O157:H7 ortholog: z1414; Belongs to the TorC/TorY family.	0.974
bisZ	torD	c2286	c1134	Trimethylamine-N-oxide reductase 2 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N- oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency (By similarity); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Chaperone protein torD; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily.	0.954
bisZ	yecK	c2286	c2287	Trimethylamine-N-oxide reductase 2 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N- oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency (By similarity); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	Cytochrome c-type protein torY; Escherichia coli K-12 ortholog: b1873; Escherichia coli O157:H7 ortholog: z2926; Belongs to the TorC/TorY family.	0.999
torA	bisZ	c1133	c2286	Trimethylamine-N-oxide reductase 1 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.	Trimethylamine-N-oxide reductase 2 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N- oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency (By similarity); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.907
torA	torC	c1133	c1132	Trimethylamine-N-oxide reductase 1 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.	Cytochrome c-type protein torC; Escherichia coli K-12 ortholog: b0996; Escherichia coli O157:H7 ortholog: z1414; Belongs to the TorC/TorY family.	0.999
torA	torD	c1133	c1134	Trimethylamine-N-oxide reductase 1 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.	Chaperone protein torD; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily.	0.999
torA	yecK	c1133	c2287	Trimethylamine-N-oxide reductase 1 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.	Cytochrome c-type protein torY; Escherichia coli K-12 ortholog: b1873; Escherichia coli O157:H7 ortholog: z2926; Belongs to the TorC/TorY family.	0.987
torC	bisZ	c1132	c2286	Cytochrome c-type protein torC; Escherichia coli K-12 ortholog: b0996; Escherichia coli O157:H7 ortholog: z1414; Belongs to the TorC/TorY family.	Trimethylamine-N-oxide reductase 2 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N- oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency (By similarity); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.974
torC	torA	c1132	c1133	Cytochrome c-type protein torC; Escherichia coli K-12 ortholog: b0996; Escherichia coli O157:H7 ortholog: z1414; Belongs to the TorC/TorY family.	Trimethylamine-N-oxide reductase 1 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.	0.999
torC	torD	c1132	c1134	Cytochrome c-type protein torC; Escherichia coli K-12 ortholog: b0996; Escherichia coli O157:H7 ortholog: z1414; Belongs to the TorC/TorY family.	Chaperone protein torD; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily.	0.998
torC	yecK	c1132	c2287	Cytochrome c-type protein torC; Escherichia coli K-12 ortholog: b0996; Escherichia coli O157:H7 ortholog: z1414; Belongs to the TorC/TorY family.	Cytochrome c-type protein torY; Escherichia coli K-12 ortholog: b1873; Escherichia coli O157:H7 ortholog: z2926; Belongs to the TorC/TorY family.	0.916
torD	bisZ	c1134	c2286	Chaperone protein torD; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily.	Trimethylamine-N-oxide reductase 2 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N- oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency (By similarity); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.954
torD	torA	c1134	c1133	Chaperone protein torD; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily.	Trimethylamine-N-oxide reductase 1 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.	0.999
torD	torC	c1134	c1132	Chaperone protein torD; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily.	Cytochrome c-type protein torC; Escherichia coli K-12 ortholog: b0996; Escherichia coli O157:H7 ortholog: z1414; Belongs to the TorC/TorY family.	0.998
torD	yecK	c1134	c2287	Chaperone protein torD; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily.	Cytochrome c-type protein torY; Escherichia coli K-12 ortholog: b1873; Escherichia coli O157:H7 ortholog: z2926; Belongs to the TorC/TorY family.	0.968
yecK	bisZ	c2287	c2286	Cytochrome c-type protein torY; Escherichia coli K-12 ortholog: b1873; Escherichia coli O157:H7 ortholog: z2926; Belongs to the TorC/TorY family.	Trimethylamine-N-oxide reductase 2 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N- oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency (By similarity); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.999
yecK	torA	c2287	c1133	Cytochrome c-type protein torY; Escherichia coli K-12 ortholog: b1873; Escherichia coli O157:H7 ortholog: z2926; Belongs to the TorC/TorY family.	Trimethylamine-N-oxide reductase 1 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.	0.987
yecK	torC	c2287	c1132	Cytochrome c-type protein torY; Escherichia coli K-12 ortholog: b1873; Escherichia coli O157:H7 ortholog: z2926; Belongs to the TorC/TorY family.	Cytochrome c-type protein torC; Escherichia coli K-12 ortholog: b0996; Escherichia coli O157:H7 ortholog: z1414; Belongs to the TorC/TorY family.	0.916
yecK	torD	c2287	c1134	Cytochrome c-type protein torY; Escherichia coli K-12 ortholog: b1873; Escherichia coli O157:H7 ortholog: z2926; Belongs to the TorC/TorY family.	Chaperone protein torD; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily.	0.968