STRINGSTRING
c1112 c1112 hyaA hyaA hyaB hyaB hyaC hyaC hyaD hyaD hyaE hyaE hyaF hyaF appC appC appB appB appA appA hypF hypF hydN hydN c3276 c3276 hycI hycI hycH hycH hycG hycG hycF hycF hycE hycE hycD hycD hycC hycC hycB hycB hycA hycA hypA hypA hypB hypB hypC hypC hypD hypD hypE hypE fhlA fhlA c3292 c3292 hybG hybG hybF hybF hybE hybE hybD hybD hybC hybC hybB hybB hybA hybA hybO hybO fdhF fdhF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
c1112Hypothetical protein. (46 aa)
hyaAHydrogenase-1 small chain precursor; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth. (381 aa)
hyaBHydrogenase-1 large chain; Escherichia coli K-12 ortholog: b0973; Escherichia coli O157:H7 ortholog: z1390; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (597 aa)
hyaCProbable Ni/Fe-hydrogenase 1 B-type cytochrome subunit; Escherichia coli K-12 ortholog: b0974; Escherichia coli O157:H7 ortholog: z1391. (235 aa)
hyaDHydrogenase 1 maturation protease; Escherichia coli K-12 ortholog: b0975; Escherichia coli O157:H7 ortholog: z1392. (195 aa)
hyaEHydrogenase-1 operon protein hyaE; Escherichia coli K-12 ortholog: b0976; Escherichia coli O157:H7 ortholog: z1393. (132 aa)
hyaFHydrogenase-1 operon protein hyaF; Escherichia coli K-12 ortholog: b0977; Escherichia coli O157:H7 ortholog: z1394. (285 aa)
appCCytochrome BD-II oxidase subunit I; Escherichia coli K-12 ortholog: b0978; Escherichia coli O157:H7 ortholog: z1395. (514 aa)
appBCytochrome BD-II oxidase subunit II; Escherichia coli K-12 ortholog: b0979; Escherichia coli O157:H7 ortholog: z1396. (378 aa)
appAPeriplasmic appA protein precursor; Escherichia coli K-12 ortholog: b0980; Escherichia coli O157:H7 ortholog: z1397; bifunctional; Phosphoanhydride phosphohydrolase; 6-phytase. (446 aa)
hypFHydrogenase maturation protein hypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (774 aa)
hydNElectron transport protein hydN; Electron transport from formate to hydrogen. (180 aa)
c3276Hypothetical protein; Residues 12 to 257 of 257 are 72.17 pct identical to residues 22 to 269 of 269 from GenPept.129 : >gb|AAL21724.1| (AE008830) putative periplasmic or exported protein [Salmonella typhimurium LT2]. (257 aa)
hycIHydrogenase 3 maturation protease; Escherichia coli K-12 ortholog: b2717; Escherichia coli O157:H7 ortholog: z4025. (156 aa)
hycHFormate hydrogenlyase maturation protein hycH; Escherichia coli K-12 ortholog: b2718; Escherichia coli O157:H7 ortholog: z4026. (136 aa)
hycGFHL subunit 7; Escherichia coli K-12 ortholog: b2719; Escherichia coli O157:H7 ortholog: z4027. (255 aa)
hycFFHL subunit 6; Escherichia coli K-12 ortholog: b2720; Escherichia coli O157:H7 ortholog: z4028. (180 aa)
hycEFormate hydrogenlyase subunit 5 precursor; FHL subunit 5; Escherichia coli K-12 ortholog: b2721; Escherichia coli O157:H7 ortholog: z4029. (569 aa)
hycDFHL subunit 4; Escherichia coli K-12 ortholog: b2722; Escherichia coli O157:H7 ortholog: z4030. (307 aa)
hycCFHL subunit 3; Escherichia coli K-12 ortholog: b2723; Escherichia coli O157:H7 ortholog: z4031. (608 aa)
hycBFormate hydrogenlyase subunit 2; Probable electron transfer protein for hydrogenase 3. (203 aa)
hycAFormate hydrogenlyase Regulatory protein hycA; Escherichia coli K-12 ortholog: b2725; Escherichia coli O157:H7 ortholog: z4033. (153 aa)
hypAHypA protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (120 aa)
hypBHydrogenase isoenzymes nickel incorporation protein hypB; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. (290 aa)
hypCHydrogenase isoenzymes formation protein hypC; Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor. HypC delivers iron- bound CO(2) to HypD where reduction to CO probably occurs. In complex with HypD, accepts the cyanide ligand generated by HypF and HypE, and also coordinates the carbon monoxide ligand. Belongs to the HupF/HypC family. (90 aa)
hypDHydrogenase isoenzymes formation protein hypD; Escherichia coli K-12 ortholog: b2729; Escherichia coli O157:H7 ortholog: z4038; Belongs to the HypD family. (373 aa)
hypEHydrogenase isoenzymes formation protein hypE; Escherichia coli K-12 ortholog: b2730; Escherichia coli O157:H7 ortholog: z4039. (336 aa)
fhlAFormate hydrogenlyase transcriptional activator; Escherichia coli K-12 ortholog: b2731; Escherichia coli O157:H7 ortholog: z4040. (704 aa)
c3292Potential molybdenum-pterin-binding-protein; Residues 14 to 155 of 155 are 48.59 pct identical to residues 1 to 142 of 142 from GenPept.129 : >emb|CAA90038.1| (Z49882) potential molybdenum-pterin-binding-protein [Azotobacter vinelandii]. (155 aa)
hybGHydrogenase-2 operon protein hybG; Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor. HybG delivers iron- bound CO(2) to HypD where reduction to CO probably occurs. In complex with HypD, accepts the cyanide ligand generated by HypF and HypE, and also coordinates the carbon monoxide ligand. Belongs to the HupF/HypC family. (82 aa)
hybFProbable hydrogenase nickel incorporation protein hybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)
hybEHydrogenase-2 operon protein hybE; Escherichia coli K-12 ortholog: b2992; Escherichia coli O157:H7 ortholog: z4346; Belongs to the HupJ family. (162 aa)
hybDHydrogenase 2 maturation protease; Escherichia coli K-12 ortholog: b2993; Escherichia coli O157:H7 ortholog: z4347. (164 aa)
hybCHydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa)
hybBProbable Ni/Fe-hydrogenase 2 B-type cytochrome subunit; Escherichia coli K-12 ortholog: b2995; Escherichia coli O157:H7 ortholog: z4349. (392 aa)
hybAHydrogenase-2 operon protein hybA precursor; Escherichia coli K-12 ortholog: b2996; Escherichia coli O157:H7 ortholog: z4350. (328 aa)
hybOHydrogenase-2 small chain precursor; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake. (372 aa)
fdhFFormate dehydrogenase H; Escherichia coli K-12 ortholog: b4079; Escherichia coli O157:H7 ortholog: z5678; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (715 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.