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yacK yacK acrB acrB acrA acrA ybbI ybbI cusS cusS cusR cusR cusC cusC cusX cusX cusB cusB cusA cusA pheP pheP ybhT ybhT cmr cmr macA macA c1016 c1016 yceE yceE yceL yceL ycfS ycfS c1761 c1761 c1764 c1764 c1765 c1765 c1919 c1919 ydhE ydhE c2059 c2059 ydhS ydhS spy spy yebE yebE yegM yegM yegN yegN yegO yegO yegB yegB baeS baeS baeR baeR acrD acrD emrR emrR emrA emrA emrB emrB tolC tolC acrE acrE acrF acrF yhdV yhdV yhiU yhiU yhiV yhiV yibF yibF yibH yibH yibI yibI c4551 c4551 emrD emrD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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yacKBlue copper oxidase cueO precursor; Copper efflux oxidase; Escherichia coli K-12 ortholog: b0123; Escherichia coli O157:H7 ortholog: z0133. (529 aa)
acrBAcriflavine resistance protein B; Escherichia coli K-12 ortholog: b0462; Escherichia coli O157:H7 ortholog: z0576. (1049 aa)
acrAAcriflavine resistance protein A precursor; Escherichia coli K-12 ortholog: b0463; Escherichia coli O157:H7 ortholog: z0578; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (409 aa)
ybbITranscriptional regulator cueR; Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations (By similarity). (135 aa)
cusSSensor kinase cusS; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. (480 aa)
cusRTranscriptional Regulatory protein cusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. (227 aa)
cusCProbable outer membrane lipoprotein cusC precursor; Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver (By similarity); Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. (460 aa)
cusXHypothetical protein cusX precursor; Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide (By similarity). (110 aa)
cusBPutative copper efflux system protein cusB precursor; Part of a cation efflux system that mediates resistance to copper and silver. (407 aa)
cusAPutative cation efflux system protein cusA; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1047 aa)
phePPhenylalanine-specific permease; Escherichia coli K-12 ortholog: b0576; Escherichia coli O157:H7 ortholog: z0715. (472 aa)
ybhTHypothetical protein ybhT precursor; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. (51 aa)
cmrMultidrug translocase mdfA; Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs (By similarity). (420 aa)
macAMacrolide-specific efflux protein macA precursor; Escherichia coli K-12 ortholog: b0878; Escherichia coli O157:H7 ortholog: z1115; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (380 aa)
c1016Hypothetical protein; Residues 1 to 114 of 114 are 99.12 pct identical to residues 535 to 648 of 648 from GenPept.129 : >gb|AAG55261.1|AE005269_5 (AE005269) putative ATP-binding component of a transport system [Escherichia coli O157:H7 EDL933]. (114 aa)
yceEHypothetical transport protein yceE; Confers resistance to fosfomycin and deoxycholate. Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. (408 aa)
yceLHypothetical transport protein yceL; Confers resistance to norfloxacin and enoxacin. Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily. (412 aa)
ycfSHypothetical protein ycfS precursor; Escherichia coli K-12 ortholog: b1113; Escherichia coli O157:H7 ortholog: z1752. (377 aa)
c1761Acriflavine resistance protein A precursor; Escherichia coli K-12 ortholog: b0463; Escherichia coli O157:H7 ortholog: z2509; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (384 aa)
c1764Acriflavine resistance protein B; Escherichia coli K-12 ortholog: b0462; Escherichia coli O157:H7 ortholog: z2508. (1005 aa)
c1765Partial Putative outer membrane channel protein; Escherichia coli O157:H7 ortholog: z2506. (457 aa)
c1919Putative conserved protein; Residues 19 to 72 of 72 are 98.14 pct identical to residues 407 to 460 of 460 from MG1655 : b1490. (72 aa)
ydhEMultidrug resistance protein norM; Multidrug efflux pump that functions probably as a Na(+)/drug antiporter; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. (457 aa)
c2059Protein ydhR precursor; Escherichia coli K-12 ortholog: b1667; Escherichia coli O157:H7 ortholog: z2694. (101 aa)
ydhSHypothetical protein ydhS; Escherichia coli K-12 ortholog: b1668; Escherichia coli O157:H7 ortholog: z2695. (536 aa)
spySpheroplast protein Y precursor; Escherichia coli K-12 ortholog: b1743; Escherichia coli O157:H7 ortholog: z2775. (161 aa)
yebEHypothetical protein yebE; Escherichia coli K-12 ortholog: b1846; Escherichia coli O157:H7 ortholog: z2897. (219 aa)
yegMHypothetical protein yegM precursor; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (464 aa)
yegNHypothetical protein yegN; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily. (1040 aa)
yegOHypothetical protein yegO; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily. (1025 aa)
yegBHypothetical transport protein yegB; Escherichia coli K-12 ortholog: b2077; Escherichia coli O157:H7 ortholog: z3246. (471 aa)
baeSSensor protein baeS; Escherichia coli K-12 ortholog: b2078; Escherichia coli O157:H7 ortholog: z3247. (467 aa)
baeRTranscriptional Regulatory protein baeR; Member of the two-component regulatory system BaeS/BaeR. Activates the mdtABCD operon (By similarity). (240 aa)
acrDProbable aminoglycoside efflux pump; Acriflavine resistance protein D; Escherichia coli K-12 ortholog: b2470; Escherichia coli O157:H7 ortholog: z3727. (1037 aa)
emrRTranscriptional repressor mprA; Negative regulator of the multidrug operon emrAB. (176 aa)
emrAMultidrug resistance protein A; Escherichia coli K-12 ortholog: b2685; Escherichia coli O157:H7 ortholog: z3986. (394 aa)
emrBMultidrug resistance protein B; Escherichia coli K-12 ortholog: b2686; Escherichia coli O157:H7 ortholog: z3987; Belongs to the major facilitator superfamily. (515 aa)
tolCOuter membrane protein tolC precursor; Escherichia coli K-12 ortholog: b3035; Escherichia coli O157:H7 ortholog: z4392. (506 aa)
acrEAcriflavine resistance protein E precursor; Protein envC; Escherichia coli K-12 ortholog: b3265; Escherichia coli O157:H7 ortholog: z4625; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (385 aa)
acrFAcriflavine resistance protein F; Protein envD; Escherichia coli K-12 ortholog: b3266; Escherichia coli O157:H7 ortholog: z0576. (1034 aa)
yhdVHypothetical protein yhdV; Escherichia coli K-12 ortholog: b3267; Escherichia coli O157:H7 ortholog: z4628. (73 aa)
yhiUHypothetical lipoprotein yhiU precursor; Part of the tripartite efflux system MdtEF-TolC, which confers resistance to various compounds. (385 aa)
yhiVHypothetical protein yhiV; Part of the tripartite efflux system MdtEF-TolC, which confers resistance to various compounds. (1037 aa)
yibFHypothetical GST-like protein yibF; Escherichia coli K-12 ortholog: b3592; Escherichia coli O157:H7 ortholog: z5013; Belongs to the GST superfamily. HSP26 family. (202 aa)
yibHHypothetical protein yibH; Escherichia coli K-12 ortholog: b3597; Escherichia coli O157:H7 ortholog: z5021. (378 aa)
yibIHypothetical protein yibI; Escherichia coli K-12 ortholog: b3598; Escherichia coli O157:H7 ortholog: z5022. (120 aa)
c4551Hypothetical protein; Residues 33 to 328 of 354 are 21.82 pct identical to residues 185 to 490 of 1046 from GenPept.129 : >gb|AAG03815.1|AE004479_10 (AE004479) RND multidrug efflux transporter MexB [Pseudomonas aeruginosa]; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (354 aa)
emrDMultidrug resistance protein D; Escherichia coli K-12 ortholog: b3673; Escherichia coli O157:H7 ortholog: z5168. (396 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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