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yheB yheB c3655 c3655 sat sat papK papK papG papG hlyA hlyA eno eno yfhM yfhM c2895 c2895 TcpC TcpC fliD fliD fliC fliC yebF yebF lpp lpp flgL flgL flgK flgK c1273 c1273 mchB mchB c0393 c0393 pic pic
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yheBProbable bifunctional chitinase/lysozyme precursor; Escherichia coli K-12 ortholog: b3338bifunctional; Chitinase; Lysozyme. (900 aa)
c3655Antigen 43 precursor; AG43; Sap; Escherichia coli K-12 ortholog: b2000; Escherichia coli O157:H7 ortholog: z1651. (1042 aa)
satSecreted auto transpoter toxin; Shows serine protease activity and displays cytophatic activity, including elongation, rounding, and detachment of a proportion of the cells from monolayer in culture. Triggers vacuolation within the cytoplasm of the human bladder and kidney cells. (1299 aa)
papKPapK protein; Adapter that links the pilus rod to the base of the tip fibrillum. Regulates the length of the tip fibrillum and joins it to the pilus rod. Pili are polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, and enable bacteria to colonize the epithelium of specific host organs (By similarity). (179 aa)
papGPapG protein; Residues 1 to 336 of 336 are 57.01 pct identical to residues 1 to 335 of 335 from SwissProt.40 : >sp|P42188|PRSG_ECOLI FIMBRIAL PROTEIN PRSG PRECURSOR (ADHESIN). (336 aa)
hlyAHemolysin A; Residues 1 to 1024 of 1024 are 98.63 pct identical to residues 1 to 1023 of 1023 from SwissProt.40 : >sp|P09983|HLY1_ECOLI HEMOLYSIN, CHROMOSOMAL. (1024 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa)
yfhMHypothetical lipoprotein yfhM precursor; Protects the bacterial cell from host peptidases. (1653 aa)
c2895yapH homolog; Residues 45 to 1255 of 2387 are 21.57 pct identical to residues 2499 to 3684 of 3705 from GenPept.129 : >emb|CAC89847.1| (AJ414146) putative autotransporter protein [Yersinia pestis]. (2387 aa)
TcpCHypothetical protein; Virulence factor that suppresses host Toll-like receptor (TLR)-mediated cytokine production upon infection, thereby increasing bacterial burden in the urinary tract and promoting renal tissue damage. Acts as a NAD(+) hydrolase (NADase) by catalyzing cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. (307 aa)
fliDFlagellar hook-associated protein 2; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. (468 aa)
fliCFlagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (595 aa)
yebFHypothetical lipoprotein yebF precursor; Escherichia coli K-12 ortholog: b1847; Escherichia coli O157:H7 ortholog: z2899. (122 aa)
lppMajor outer membrane lipoprotein precursor; A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane. (78 aa)
flgLFlagellar hook-associated protein 3; HAP3; Escherichia coli K-12 ortholog: b1083; Escherichia coli O157:H7 ortholog: z1721. (317 aa)
flgKFlagellar hook-associated protein 1; HAP1; Escherichia coli K-12 ortholog: b1082; Escherichia coli O157:H7 ortholog: z1720. (547 aa)
c1273Antigen 43 precursor; AG43; Sap; Escherichia coli K-12 ortholog: b2000; Escherichia coli O157:H7 ortholog: z1651. (1091 aa)
mchBMchB protein; Bactericidal antibiotic. Active on bacteria phylogenetically related to the producing strain (By similarity). (97 aa)
c0393Haemoglobin protease; Residues 1 to 1376 of 1376 are 79.04 pct identical to residues 1 to 1377 of 1377 from GenPept.129 : >emb|CAA11507.1| (AJ223631) haemoglobin protease [Escherichia coli]. (1376 aa)
picPic serine protease precursor; Involved in virulence of uropathogenic E.coli although it is not known how it contributes to it. Has no mucinase activity. (1371 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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