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| | mrdB | Rod shape-determining protein rodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (370 aa) |
| | kefC | Glutathione-regulated potassium-efflux system protein kefC; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (620 aa) |
| | ftsL | Cell division protein ftsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (121 aa) |
| | ftsI | Peptidoglycan synthetase ftsI precursor; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (588 aa) |
| | ftsW | Cell division protein ftsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (415 aa) |
| | ftsQ | Cell division protein ftsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (276 aa) |
| | yadQ | Voltage-gated ClC-type chloride channel eriC; Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response. (473 aa) |
| | ybdA | Hypothetical membrane protein P43; Component of an export pathway for enterobactin. Belongs to the major facilitator superfamily. EntS (TC 2.A.1.38) family. (416 aa) |
| | crcB | Protein crcB; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. (127 aa) |
| | ybeC | Sec-independent protein translocase protein tatE; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA; Belongs to the TatA/E family. TatE subfamily. (67 aa) |
| | kdpC | Potassium-transporting ATPase C chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (198 aa) |
| | kdpB | Potassium-transporting ATPase B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (682 aa) |
| | kdpA | Potassium-transporting ATPase A chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (557 aa) |
| | ybgH | Hypothetical transporter ybgH; Probable proton-dependent permease that transports dipeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpD subfamily. (493 aa) |
| | tolQ | TolQ protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (230 aa) |
| | tolR | TolR protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (142 aa) |
| | yceE | Hypothetical transport protein yceE; Confers resistance to fosfomycin and deoxycholate. Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. (408 aa) |
| | htrB | Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (327 aa) |
| | mviN | Virulence factor mviN homolog; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (511 aa) |
| | yceG | Hypothetical protein yceG; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (269 aa) |
| | sitD | SitD protein; Residues 1 to 272 of 285 are 53.30 pct identical to residues 4 to 275 of 297 from SwissProt.40 : >sp|Q56955|YFED_YERPE Chelated iron transport system membrane protein yfeD. (285 aa) |
| | sitC | SitC protein; Residues 1 to 276 of 285 are 65.94 pct identical to residues 2 to 277 of 294 from SwissProt.40 : >sp|Q56954|YFEC_YERPE Chelated iron transport system membrane protein yfeC. (285 aa) |
| | ycgO | Putative Na(+)/H(+) exchanger ycgO; K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily. (578 aa) |
| | chaA | Calcium/proton antiporter; Escherichia coli K-12 ortholog: b1216; Escherichia coli O157:H7 ortholog: z1991. (395 aa) |
| | ispZ | Probable intracellular septation protein; Involved in cell division; probably involved in intracellular septation; Belongs to the YciB family. (179 aa) |
| | yciS | Hypothetical protein yciS; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. (102 aa) |
| | c1820 | Hypothetical protein; Residues 4 to 90 of 122 are 72.41 pct identical to residues 18 to 104 of 282 from GenPept.129 : >gb|AAL21744.1| (AE008830) Salmonella iron transporter: fur regulated [Salmonella typhimurium LT2]. (122 aa) |
| | ydgE | Hypothetical protein ydgE; Catalyzes the excretion of spermidine. (109 aa) |
| | ydgF | Hypothetical protein ydgF; Catalyzes the excretion of spermidine. (121 aa) |
| | ydgR | Hypothetical transporter ydgR; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily. (500 aa) |
| | sppA | Protease IV; Escherichia coli K-12 ortholog: b1766; Escherichia coli O157:H7 ortholog: z2799. (618 aa) |
| | yeaL | Hypothetical protein yeaL; Escherichia coli K-12 ortholog: b1789; Escherichia coli O157:H7 ortholog: z2829. (148 aa) |
| | msbB | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (323 aa) |
| | yebI | High-affinity zinc uptake system membrane protein znuB; Escherichia coli K-12 ortholog: b1859; Escherichia coli O157:H7 ortholog: z2911. (261 aa) |
| | tyrP | Tyrosine-specific transport protein; Tyrosine permease; Escherichia coli K-12 ortholog: b1907; Escherichia coli O157:H7 ortholog: z2963. (403 aa) |
| | emrE | EmrE protein; Methyl viologen resistance protein C; Escherichia coli K-12 ortholog: b0543; Escherichia coli O157:H7 ortholog: z1870. (170 aa) |
| | yedZ | Hypothetical protein yedZ; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. MsrQ prov [...] (211 aa) |
| | yegB | Hypothetical transport protein yegB; Escherichia coli K-12 ortholog: b2077; Escherichia coli O157:H7 ortholog: z3246. (471 aa) |
| | yohM | Hypothetical protein yohM; Efflux system for nickel and cobalt. (274 aa) |
| | dld | D-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (582 aa) |
| | yeiU | Hypothetical protein yeiU; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (249 aa) |
| | yojN | Putative sensor-like histidine kinase yojN; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (890 aa) |
| | rcsC | Sensor protein rcsC; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (949 aa) |
| | arnE | Conserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. (111 aa) |
| | yfbJ | Hypothetical protein yfbJ; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. (222 aa) |
| | dedD | DedD protein; Non-essential cell division protein that could be required for efficient cell constriction. (226 aa) |
| | ddg | DDG protein; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (328 aa) |
| | zipA | Cell division protein zipA; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. (349 aa) |
| | cysZ | CysZ protein; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (253 aa) |
| | ygaW | Hypothetical protein ygaW; Exports L-alanine; Belongs to the AlaE exporter family. (149 aa) |
| | ygbQ | Hypothetical protein ygbQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (103 aa) |
| | lgt | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (291 aa) |
| | nupG | Nucleoside permease nupG; Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force; Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family. (434 aa) |
| | nanT2 | Putative sialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. (502 aa) |
| | yghK | Glycolate permease glcA; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family. (560 aa) |
| | dsbI | Putative disulfide isomerase; Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT; Belongs to the DsbB family. DsbI subfamily. (223 aa) |
| | yqjB | Hypothetical protein yqjB; Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. (127 aa) |
| | mtr | Tryptophan-specific transport protein; Tryptophan permease; Escherichia coli K-12 ortholog: b3161; Escherichia coli O157:H7 ortholog: z4522. (414 aa) |
| | yrbG | Hypothetical protein yrbG; Escherichia coli K-12 ortholog: b3196; Escherichia coli O157:H7 ortholog: z4559. (325 aa) |
| | yrbK | Hypothetical protein yrbK; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. (191 aa) |
| | nanT | Putative sialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. (506 aa) |
| | mscL | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (137 aa) |
| | kefB | Glutathione-regulated potassium-efflux system protein kefB; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (601 aa) |
| | damX | DamX protein; Non-essential cell division protein. (428 aa) |
| | ugpE | SN-glycerol-3-phosphate transport system permease protein ugpE; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane. (281 aa) |
| | yhhQ | Hypothetical protein yhhQ; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (221 aa) |
| | yhhS | Hypothetical protein yhhS; Escherichia coli K-12 ortholog: b3473; Escherichia coli O157:H7 ortholog: z4847. (419 aa) |
| | yhiP | Hypothetical transporter yhiP; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily. (489 aa) |
| | yiaH | Hypothetical protein yiaH; Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units. (331 aa) |
| | lldP | L-lactate permease; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force (By similarity). (558 aa) |
| | tnaB | Low affinity tryptophan permease; Escherichia coli K-12 ortholog: b3709; Escherichia coli O157:H7 ortholog: z5204. (415 aa) |
| | pstA | Phosphate transport system permease protein pstA; Escherichia coli K-12 ortholog: b3726; Escherichia coli O157:H7 ortholog: z5217. (296 aa) |
| | rfe | Undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (367 aa) |
| | wzzE | Lipopolysaccharide biosynthesis protein wzzE; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. (349 aa) |
| | wzxE | WzxE protein; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. (416 aa) |
| | wecF | Putative ECA polymerase; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units; Belongs to the WzyE family. (450 aa) |
| | rarD | Protein rarD; Escherichia coli K-12 ortholog: b3819; Escherichia coli O157:H7 ortholog: z5340. (296 aa) |
| | tatA | Sec-independent protein translocase protein tatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (103 aa) |
| | tatB | Sec-independent protein translocase protein tatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (171 aa) |
| | yigU | Sec-independent protein translocase protein tatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (258 aa) |
| | rbn | Ribonuclease BN; Escherichia coli K-12 ortholog: b3886; Escherichia coli O157:H7 ortholog: z5425. (290 aa) |
| | menA | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. (312 aa) |
| | ftsN | Cell division protein ftsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. (319 aa) |
| | yjcG | Putative symporter yjcG; Transports acetate; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (549 aa) |
| | phnE | Membrane channel protein component of Pn transporter; Escherichia coli O157:H7 ortholog: z5706. (280 aa) |
| | sugE | SugE protein; Guanidinium ion exporter. Couples guanidinium export to the proton motive force, exchanging one guanidinium ion for two protons. Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Gdx/SugE subfamily. (155 aa) |
| | ytfN | Hypothetical protein ytfN; Escherichia coli K-12 ortholog: b4221; Escherichia coli O157:H7 ortholog: z5832. (1259 aa) |
| | mrdA | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (633 aa) |
| | potE | Putrescine-ornithine antiporter; Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. (439 aa) |
