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c3306 c3306 rpoE rpoE fliA fliA nusB nusB c0364 c0364 caiF caiF rpoC rpoC rpoB rpoB nusG nusG rho rho rpoZ rpoZ rpoH rpoH rplD rplD rpsD rpsD rpoA rpoA yhdM yhdM rpoN rpoN nusA nusA rpoD rpoD c3819 c3819 c3307 c3307
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
c3306Hypothetical protein; Residues 1 to 172 of 172 are 100.00 pct identical to residues 159 to 330 of 330 from GenPept.129 : >gb|AAL01414.1|AF410777_1 (AF410777) RpoS [Escherichia coli]. (172 aa)
rpoERNA polymerase sigma-E factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma-E controls the envelope stress response, responding to periplasmic protein stress, increased levels of periplasmic lipopolysaccharide (LPS) as well as heat shock and oxidative stress; it controls protein processing in the extracytoplasmic compartment (By similarity). (202 aa)
fliARNA polymerase sigma factor for flagellar operon; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (239 aa)
nusBN utilization substance protein B; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (139 aa)
c0364Hypothetical protein; Residues 1 to 156 of 160 are 33.12 pct identical to residues 1 to 157 of 157 from GenPept.129 : >gb|AAL31494.1|AF399847_3 (AF399847) ORF-156F [Escherichia coli]. (160 aa)
caiFTranscriptional activatory protein caiF; Escherichia coli K-12 ortholog: b0034; Escherichia coli O157:H7 ortholog: z0040. (166 aa)
rpoCDNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1407 aa)
rpoBDNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1353 aa)
nusGTranscription antitermination protein nusG; Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination [...] (181 aa)
rhoTranscription termination factor rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (443 aa)
rpoZDNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). (91 aa)
rpoHRNA polymerase sigma-32 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (284 aa)
rplD50S ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. Forms part of the polypeptide exit tunnel. Belongs to the universal ribosomal protein uL4 family. (201 aa)
rpsD30S ribosomal protein S4; One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. Protein S4 is also a translational repressor protein, it controls the translation of the alpha-operon (which codes for S13, S11, S4, RNA polymerase alpha subunit, and L17) by binding to its mRNA. (206 aa)
rpoADNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa)
yhdMZn(II)-responsive regulator of zntA; Escherichia coli K-12 ortholog: b3292; Escherichia coli O157:H7 ortholog: z4662. (141 aa)
rpoNRNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (477 aa)
nusAN utilization substance protein A; Participates in both transcription termination and antitermination. (495 aa)
rpoDRpoD protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (246 aa)
c3819Putative conserved protein; Residues 1 to 313 of 319 are 89.00 pct identical to residues 51 to 363 of 613 from MG1655 : b3067. (368 aa)
c3307Putative conserved protein; Residues 13 to 144 of 144 are 99.24 pct identical to residues 1 to 132 of 330 from MG1655 : b2741; Belongs to the sigma-70 factor family. (144 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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