STRINGSTRING
arnC arnC kpsF kpsF yeiU yeiU c2586 c2586 wcaI wcaI wcaL wcaL msbB msbB wzzB wzzB ugd ugd galF galF htrB htrB kdsA kdsA yfbE yfbE gutQ gutQ ddg ddg yfbJ yfbJ arnE arnE yfbI yfbI yfbH yfbH yfbG yfbG yaeD yaeD gmhA gmhA fepE fepE kdsB kdsB wzzE wzzE rfe rfe kdtA kdtA rfaG rfaG rfaP rfaP rfaI rfaI rfaJ rfaJ waaW waaW rfaC rfaC rfaF rfaF rfaD rfaD yrbI yrbI kdsD kdsD hldE hldE kdsB-2 kdsB-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
arnCPutative glycosyl transferase yfbF; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (322 aa)
kpsFHypothetical protein yrbH; Involved in the biosynthesis of K-antigen capsules. Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). Belongs to the SIS family. GutQ/KpsF subfamily. (339 aa)
yeiUHypothetical protein yeiU; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (249 aa)
c2586Tyrosine-protein kinase wzc; Escherichia coli K-12 ortholog: b2060; Escherichia coli O157:H7 ortholog: z3224. (732 aa)
wcaIPutative colanic acid biosynthesis glycosyl transferase wcaI; Escherichia coli K-12 ortholog: b2050; Escherichia coli O157:H7 ortholog: z3214. (407 aa)
wcaLPutative colanic acid biosynthesis glycosyl transferase wcaL; Escherichia coli K-12 ortholog: b2044; Escherichia coli O157:H7 ortholog: z3208. (406 aa)
msbBLipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (323 aa)
wzzBChain length determinant protein; Polysaccharide antigen chain regulator; Escherichia coli K-12 ortholog: b2027; Escherichia coli O157:H7 ortholog: z3189. (337 aa)
ugdUDP-glucose 6-dehydrogenase; Escherichia coli K-12 ortholog: b2028; Escherichia coli O157:H7 ortholog: z3190; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (388 aa)
galFUTP--glucose-1-phosphate uridylyltransferase; Escherichia coli K-12 ortholog: b2042; Escherichia coli O157:H7 ortholog: z3205. (301 aa)
htrBLipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (327 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; Escherichia coli K-12 ortholog: b1215; Escherichia coli O157:H7 ortholog: z1986; Belongs to the KdsA family. (284 aa)
yfbEHypothetical protein yfbE; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (390 aa)
gutQGutQ protein; Catalyzes the reversible aldol-ketol isomerization between D- ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). It is also able of sustaining the biosynthetic pathway of 3-deoxy-D-manno- octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs) (By similarity). (321 aa)
ddgDDG protein; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (328 aa)
yfbJHypothetical protein yfbJ; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. (222 aa)
arnEConserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. (111 aa)
yfbIHypothetical protein yfbI; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. (550 aa)
yfbHHypothetical protein yfbH; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (296 aa)
yfbGHypothetical protein yfbG; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (660 aa)
yaeDHypothetical protein yaeD; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position; Belongs to the GmhB family. (190 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (246 aa)
fepEFerric enterobactin transport protein fepE; Escherichia coli K-12 ortholog: b0587; Escherichia coli O157:H7 ortholog: z0728. (377 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (248 aa)
wzzELipopolysaccharide biosynthesis protein wzzE; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. (349 aa)
rfeUndecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (367 aa)
kdtA3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. (425 aa)
rfaGLipopolysaccharide core biosynthesis protein rfaG; Glucosyltransferase I; Escherichia coli K-12 ortholog: b3631; Escherichia coli O157:H7 ortholog: z5055. (374 aa)
rfaPLipopolysaccharide core biosynthesis protein rfaP; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family. (268 aa)
rfaILipopolysaccharide 1,3-galactosyltransferase; Escherichia coli K-12 ortholog: b3627; Escherichia coli O157:H7 ortholog: z5053. (338 aa)
rfaJLipopolysaccharide 1,2-glucosyltransferase; Escherichia coli K-12 ortholog: b3626; Escherichia coli O157:H7 ortholog: z5051. (331 aa)
waaWUDP-galactose:(galactosyl) LPS alpha1,2-galactosyltransferase; Residues 1 to 341 of 342 are 98.24 pct identical to residues 1 to 341 of 341 from GenPept.129 : >gb|AAC69673.1| (AF019746) UDP-galactose:(galactosyl) LPS alpha1,2-galactosyltransferase WaaW [Escherichia coli]. (342 aa)
rfaCLipopolysaccharide heptosyltransferase-1; Escherichia coli K-12 ortholog: b3621; Escherichia coli O157:H7 ortholog: z5048. (326 aa)
rfaFADP-heptose--LPS heptosyltransferase II; Escherichia coli K-12 ortholog: b3620; Escherichia coli O157:H7 ortholog: z5047. (348 aa)
rfaDADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. (310 aa)
yrbIHypothetical protein yrbI; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (188 aa)
kdsDHypothetical protein yrbH; Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P) (By similarity). (335 aa)
hldEADP-heptose synthase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (477 aa)
kdsB-23-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (246 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
Server load: medium (56%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.