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pyrD pyrD pyrL pyrL deoA deoA pyrB pyrB pyrI pyrI sgaH sgaH purD purD yicP yicP sgbH sgbH ygfP ygfP ygeZ ygeZ upp upp carA carA codB codB apt apt ybbT ybbT ybbX ybbX ybeK ybeK rutF rutF rutE rutE ycdJ ycdJ ycdK ycdK ycdL ycdL rutA rutA pyrC pyrC pyrF pyrF c2388 c2388 yeiA yeiA yeiK yeiK purF purF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (345 aa)
pyrLPyrBI operon leader peptide; Attenuator; Escherichia coli K-12 ortholog: b4246. (44 aa)
deoAThymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (463 aa)
pyrBAspartate carbamoyltransferase catalytic chain; Escherichia coli K-12 ortholog: b4245; Escherichia coli O157:H7 ortholog: z5856; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa)
pyrIAspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa)
sgaHProbable hexulose-6-phosphate synthase; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization. Belongs to the HPS/KGPDC family. KGPDC subfamily. (229 aa)
purDPhosphoribosylamine--glycine ligase; Escherichia coli K-12 ortholog: b4005; Escherichia coli O157:H7 ortholog: z5582; Belongs to the GARS family. (429 aa)
yicPProbable adenine deaminase; Escherichia coli K-12 ortholog: b3665; Escherichia coli O157:H7 ortholog: z5155. (588 aa)
sgbHProbable hexulose-6-phosphate synthase; Escherichia coli K-12 ortholog: b3581; Escherichia coli O157:H7 ortholog: z5805. (220 aa)
ygfPGuanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (479 aa)
ygeZHypothetical hydrolase ygeZ; Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'- position. Has no activity on dihydropyrimidines. The physiological function is unknown. (496 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (217 aa)
carACarbamoyl-phosphate synthase small chain; Escherichia coli K-12 ortholog: b0032; Escherichia coli O157:H7 ortholog: z0037; Belongs to the CarA family. (391 aa)
codBCytosine permease; Required for cytosine transport into the cell; Belongs to the purine-cytosine permease (2.A.39) family. (419 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (201 aa)
ybbTUreidoglycolate hydrolase; Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate. (160 aa)
ybbXAllantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. (453 aa)
ybeKHypothetical protein ybeK; Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively. (322 aa)
rutFPutative flavin:NADH reductase ycdH; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway. (184 aa)
rutEPutative NADH dehydrogenase/NAD(P)H nitroreductase ycdI; May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted; Belongs to the nitroreductase family. HadB/RutE subfamily. (196 aa)
ycdJHypothetical protein ycdJ; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. (275 aa)
ycdKHypothetical protein ycdK; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity). (128 aa)
ycdLHypothetical isochorismatase family protein ycdL; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2. (244 aa)
rutAPutative monooxygenase ycdM; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate; Belongs to the NtaA/SnaA/SoxA(DszA) monooxygenase family. RutA subfamily. (393 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (295 aa)
c2388Transthyretin-like protein precursor; Escherichia coli K-12 ortholog: b1970; Escherichia coli O157:H7 ortholog: z3062; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (137 aa)
yeiAHypothetical protein yeiA; Escherichia coli K-12 ortholog: b2147; Escherichia coli O157:H7 ortholog: z3402. (413 aa)
yeiKHypothetical protein yeiK; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides; Belongs to the IUNH family. RihB subfamily. (313 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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