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nrdH nrdH dsbL dsbL dsbD dsbD trxB trxB grxA grxA dsbI dsbI gor gor grxC grxC trxA trxA grxB grxB dsbB dsbB ydhD ydhD trxC trxC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nrdHGlutaredoxin-like protein nrdH; Electron transport system for the ribonucleotide reductase system NrdEF. (81 aa)
dsbLPutative disulfide isomerase; Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT. (222 aa)
dsbDThiol:disulfide interchange protein dsbD precursor; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. (565 aa)
trxBThioredoxin reductase; Escherichia coli K-12 ortholog: b0888; Escherichia coli O157:H7 ortholog: z1232. (361 aa)
grxAGrx1; Escherichia coli K-12 ortholog: b0849; Escherichia coli O157:H7 ortholog: z1076. (90 aa)
dsbIPutative disulfide isomerase; Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT; Belongs to the DsbB family. DsbI subfamily. (223 aa)
gorGlutathione reductase; Escherichia coli K-12 ortholog: b3500; Escherichia coli O157:H7 ortholog: z4900. (450 aa)
grxCGlutaredoxin 3; The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase (By similarity); Belongs to the glutaredoxin family. (83 aa)
trxAThioredoxin 1; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions; Belongs to the thioredoxin family. (144 aa)
grxBGlutaredoxin 2; Involved in reducing some disulfides in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase (By similarity). (215 aa)
dsbBDisulfide bond formation protein B; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the DsbA protein (By similarity); Belongs to the DsbB family. (178 aa)
ydhDProtein ydhD; Monothiol glutaredoxin involved in the biogenesis of iron- sulfur clusters. (115 aa)
trxCThioredoxin 2; Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin (By similarity); Belongs to the thioredoxin family. (139 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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