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yadI yadI c0332 c0332 c0335 c0335 lacY lacY nagE nagE ptsG ptsG sotB sotB c1958 c1958 c1959 c1959 malX malX celB celB celA celA manX manX araG araG c2589 c2589 gatC gatC gatB gatB mglA mglA fruA fruA yeiO yeiO fryA fryA fryC fryC fryB fryB murP murP srlE srlE srlB srlB fucP fucP c3408 c3408 cmtA cmtA kpsE kpsE kpsD kpsD agaV agaV agaB agaB ptsN ptsN c4278 c4278 c4279 c4279 xylG xylG mtlA mtlA c4485 c4485 c4486 c4486 c4487 c4487 c4488 c4488 bglF bglF rbsA rbsA c4758 c4758 rhaT rhaT kdgT kdgT frwC frwC frwB frwB frwD frwD c4984 c4984 malE malE malK malK lamB lamB sgaB sgaB treB treB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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yadIPutative PTS system IIA component yadI; Escherichia coli K-12 ortholog: b0129; Escherichia coli O157:H7 ortholog: z0140. (146 aa)
c0332Putative L-fucose permease; Residues 1 to 438 of 438 are 96.11 pct identical to residues 1 to 438 of 438 from GenPept.129 : >gb|AAL22650.1| (AE008876) putative L-fucose permease [Salmonella typhimurium LT2]. (438 aa)
c0335Hypothetical protein; Residues 1 to 95 of 95 are 96.84 pct identical to residues 1 to 95 of 95 from GenPept.129 : >gb|AAK27336.1| (AF286670) unknown [Escherichia coli]. (95 aa)
lacYLactose-proton symport; Escherichia coli K-12 ortholog: b0343; Escherichia coli O157:H7 ortholog: z0439. (417 aa)
nagEPTS system, N-acetylglucosamine-specific IIABC component; EIIABC-NAG; Escherichia coli K-12 ortholog: b0679; Escherichia coli O157:H7 ortholog: z0826. (648 aa)
ptsGPTS system, glucose-specific IIBC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. Also functions as a chemoreceptor monitoring the environment for changes in sugar concentration. (477 aa)
sotBSugar efflux transporter; Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites; Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family. (396 aa)
c1958Putative conserved protein; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (453 aa)
c1959PTS system, cellobiose-specific IIB component; EIIB-Cel; Escherichia coli K-12 ortholog: b1738; Escherichia coli O157:H7 ortholog: z2768. (103 aa)
malXMaltose and glucose-permease IIABC component; Escherichia coli K-12 ortholog: b1621; Escherichia coli O157:H7 ortholog: z2626. (598 aa)
celBPTS system, cellobiose-specific IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (452 aa)
celAPTS system, cellobiose-specific IIB component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2). (106 aa)
manXPTS system, mannose-specific IIAB component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA. (323 aa)
araGL-arabinose transport ATP-binding protein araG; Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family. (519 aa)
c2589Putative conserved protein; Residues 1 to 211 of 214 are 99.52 pct identical to residues 1 to 211 of 379 from MG1655 : b2062. (214 aa)
gatCPTS system, galactitol-specific IIC component; EIIC-GAT; Escherichia coli K-12 ortholog: b2092; Escherichia coli O157:H7 ortholog: z3255. (451 aa)
gatBPTS system, galactitol-specific IIB component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II complex composed of GatA, GatB and GatC is involved in galactitol transport. (94 aa)
mglAGalactoside transport ATP-binding protein mglA; Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system. (506 aa)
fruAPTS system, fructose-specific IIBC component; EIIBC-Fru; Escherichia coli K-12 ortholog: b2167; Escherichia coli O157:H7 ortholog: z3425. (563 aa)
yeiOSugar efflux transporter B; Escherichia coli K-12 ortholog: b2170; Escherichia coli O157:H7 ortholog: z3428. (393 aa)
fryAPutative phosphoenolpyruvate-protein phosphotransferase ypdD; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport. (831 aa)
fryCPutative PTS system IIC component ypdG; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (415 aa)
fryBPutative PTS system IIB component ypdH; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport. (125 aa)
murPPutative PTS system IIBC component yfeV; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring. (474 aa)
srlEPTS system, glucitol/sorbitol-specific IIBC component; EIIBC-GUT; Escherichia coli K-12 ortholog: b2703; Escherichia coli O157:H7 ortholog: z4009. (319 aa)
srlBPTS system, glucitol/sorbitol-specific IIA component; EIIA-gut; Escherichia coli K-12 ortholog: b2704; Escherichia coli O157:H7 ortholog: z4011. (123 aa)
fucPL-fucose permease; Escherichia coli K-12 ortholog: b2801; Escherichia coli O157:H7 ortholog: z4118. (438 aa)
c3408Maltose and glucose-permease IIABC component; Escherichia coli K-12 ortholog: b1621; Escherichia coli O157:H7 ortholog: z2626. (526 aa)
cmtAPTS system, mannitol (Cryptic)-specific IIBC component; EIIBC-(C)MTL; Escherichia coli K-12 ortholog: b2933; Escherichia coli O157:H7 ortholog: z4277. (462 aa)
kpsEKpsE protein; Involved in the translocation of the polysialic acid capsule. Belongs to the BexC/CtrB/KpsE family. (382 aa)
kpsDKpsD protein; Residues 2 to 559 of 559 are 99.46 pct identical to residues 1 to 558 of 558 from SwissProt.40 : >sp|P42213|KSD5_ECOLI POLYSIALIC ACID TRANSPORT PROTEIN KPSD PRECURSOR. (559 aa)
agaVPTS system, N-acetylgalactosamine-specific IIB component 2; EIIB-AGA'; Escherichia coli K-12 ortholog: b3133; Escherichia coli O157:H7 ortholog: z4485. (169 aa)
agaBPTS system, N-acetylgalactosamine-specific IIB component 1; EIIB-AGA; Escherichia coli K-12 ortholog: b3138; Escherichia coli O157:H7 ortholog: z4492. (158 aa)
ptsNNitrogen regulatory IIA protein; Escherichia coli K-12 ortholog: b3204; Escherichia coli O157:H7 ortholog: z4567. (171 aa)
c4278Putative phosphotransferase system enzyme subunit; Escherichia coli O157:H7 ortholog: z4876. (93 aa)
c4279PTS system, galactitol-specific IIC component; EIIC-GAT; Escherichia coli K-12 ortholog: b2092; Escherichia coli O157:H7 ortholog: z4877. (462 aa)
xylGD-xylose transport ATP-binding protein xylG; Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family. (525 aa)
mtlAPTS system, mannitol-specific IIABC component; EIIABC-MTL; Escherichia coli K-12 ortholog: b3599; Escherichia coli O157:H7 ortholog: z5023. (637 aa)
c4485Putative PTS enzyme-ii fructose; Residues 11 to 358 of 363 are 53.10 pct identical to residues 5 to 355 of 363 from GenPept.129 : >emb|CAC97469.1| (AL596171) similar to PTS system, fructose-specific enzyme IIC component [Listeria innocua]. (363 aa)
c4486PTS system, fructose-like-2 IIB component 1; Phosphotransferase enzyme II, B component; Escherichia coli K-12 ortholog: b3950; Escherichia coli O157:H7 ortholog: z5506. (104 aa)
c4487Putative phosphotransferase system (PTS), fructose-specific; Residues 1 to 149 of 156 are 48.32 pct identical to residues 6 to 154 of 157 from GenPept.129 : >emb|CAC97471.1| (AL596171) similar to PTS system, fructose-specific enzyme IIA component [Listeria innocua]. (156 aa)
c4488Putative transcriptional Antiterminator; Residues 18 to 515 of 532 are 28.32 pct identical to residues 2 to 483 of 485 from GenPept.129 : >emb|CAD00216.1| (AL591982) similar to transcription regulator [Listeria monocytogenes]. (532 aa)
bglFPTS system, beta-glucoside-specific IIABC component; EIIABC-Bgl; Escherichia coli K-12 ortholog: b3722. (649 aa)
rbsARibose transport ATP-binding protein rbsA; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. (501 aa)
c4758PTS system, glucose-specific IIBC component; EIIBC-Glc; Escherichia coli K-12 ortholog: b1101; Escherichia coli O157:H7 ortholog: z1740. (502 aa)
rhaTL-rhamnose-proton symport; Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Belongs to the L-rhamnose transporter (TC 2.A.7.6) family. (344 aa)
kdgT2-keto-3-deoxygluconate permease; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity); Belongs to the KdgT transporter family. (341 aa)
frwCPTS system, fructose-like-2 IIC component; Phosphotransferase enzyme II, C component; Escherichia coli K-12 ortholog: b3949; Escherichia coli O157:H7 ortholog: z5504. (359 aa)
frwBPTS system, fructose-like-2 IIB component 1; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport. (106 aa)
frwDPTS system, fructose-like-2 IIB component 2; Phosphotransferase enzyme II, B component; Escherichia coli K-12 ortholog: b3953; Escherichia coli O157:H7 ortholog: z5509. (113 aa)
c4984Putative sorbose PTS component; Escherichia coli O157:H7 ortholog: z5616. (164 aa)
malEMaltose-binding periplasmic protein precursor; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins. Belongs to the bacterial solute-binding protein 1 family. (396 aa)
malKMaltose/maltodextrin transport ATP-binding protein malK; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family. (401 aa)
lamBMaltoporin precursor; Involved in the transport of maltose and maltodextrins. Belongs to the porin LamB (TC 1.B.3) family. (446 aa)
sgaBUnknown pentitol phosphotransferase enzyme II, B component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (103 aa)
treBPTS system, trehalose-specific IIBC component; EIIBC-TRE; Escherichia coli K-12 ortholog: b4240; Escherichia coli O157:H7 ortholog: z5850. (473 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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