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| | nrfE | Cytochrome c-type biogenesis protein nrfE; Escherichia coli K-12 ortholog: b4074; Escherichia coli O157:H7 ortholog: z5673. (560 aa) |
| | papD_2 | PapD protein; Residues 3 to 244 of 244 are 40.74 pct identical to residues 9 to 246 of 250 from MG1655 : b2336. (244 aa) |
| | papC_2 | PapC protein; Residues 8 to 839 of 843 are 43.20 pct identical to residues 1 to 842 of 879 from EDL933 : z3600. (843 aa) |
| | dsbD | Thiol:disulfide interchange protein dsbD precursor; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. (565 aa) |
| | yjfG | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (457 aa) |
| | argR-2 | Hypothetical protein; Regulates arginine biosynthesis genes. (184 aa) |
| | c5378 | Hypothetical protein; Residues 1 to 1090 of 1092 are 60.92 pct identical to residues 1 to 1088 of 1089 from GenPept.129 : >gb|AAK02780.1| (AE006106) unknown [Pasteurella multocida]. (1092 aa) |
| | fimC | Chaperone protein fimC precursor; Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH (By similarity); Belongs to the periplasmic pilus chaperone family. (241 aa) |
| | fimD | Outer membrane usher protein fimD precursor; Escherichia coli K-12 ortholog: b4317; Escherichia coli O157:H7 ortholog: z5915. (878 aa) |
| | prfC | Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (529 aa) |
| | slt | Soluble lytic murein transglycosylase precursor; Escherichia coli K-12 ortholog: b4392; Escherichia coli O157:H7 ortholog: z5994. (645 aa) |
| | prfB | Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (365 aa) |
| | yehC | Hypothetical fimbrial chaperone yehC precursor; Escherichia coli K-12 ortholog: b2110; Escherichia coli O157:H7 ortholog: z3278. (224 aa) |
| | mrp | Mrp protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (379 aa) |
| | surA | Survival protein surA precursor; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (428 aa) |
| | imp | Organic solvent tolerance protein precursor; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Belongs to the LptD family. (784 aa) |
| | hepA | RNA polymerase associated protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. (968 aa) |
| | ftsI | Peptidoglycan synthetase ftsI precursor; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (588 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (495 aa) |
| | murF | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (452 aa) |
| | mraY | Phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (438 aa) |
| | ftsW | Cell division protein ftsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (415 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (355 aa) |
| | murC | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (491 aa) |
| | ddlB | D-alanine--D-alanine ligase B; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (306 aa) |
| | ftsQ | Cell division protein ftsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (276 aa) |
| | ftsZ | Cell division protein ftsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (383 aa) |
| | yacF | Hypothetical protein yacF; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. (247 aa) |
| | htrE | Outer membrane usher protein htrE precursor; EHeat shock protein; Escherichia coli K-12 ortholog: b0139; Escherichia coli O157:H7 ortholog: z0150. (862 aa) |
| | ecpD | Chaperone protein ecpD precursor; Escherichia coli K-12 ortholog: b0140; Escherichia coli O157:H7 ortholog: z0151. (246 aa) |
| | mrcB | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (844 aa) |
| | yadR | Hypothetical protein yadR; Required for insertion of 4Fe-4S clusters for at least IspG. (125 aa) |
| | frr | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa) |
| | yaeS | Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (253 aa) |
| | yaeT | Unknown protein from 2D-page spots M62/M63/O3/O9/T35 precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (810 aa) |
| | yaeJ | Hypothetical protein yaeJ; Escherichia coli K-12 ortholog: b0191; Escherichia coli O157:H7 ortholog: z0203. (140 aa) |
| | dniR | Membrane-bound lytic murein transglycosylase D precursor; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity); Belongs to the transglycosylase Slt family. (452 aa) |
| | prfH | Peptide chain release factor homolog; RF-H; Escherichia coli K-12 ortholog: b0236; Escherichia coli O157:H7 ortholog: z0297. (204 aa) |
| | ddlA | D-alanine--D-alanine ligase A; Cell wall formation. (364 aa) |
| | hupB | DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. (90 aa) |
| | cusC | Probable outer membrane lipoprotein cusC precursor; Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver (By similarity); Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. (460 aa) |
| | yehU | Hypothetical protein yehU precursor; Member of the two-component regulatory system BtsS/BtsR. BtsS is a high-affinity receptor for extracellular pyruvate that activates BtsR by phosphorylation. (566 aa) |
| | dacA | Penicillin-binding protein 5 precursor; Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family. (403 aa) |
| | rlpA | Rare lipoprotein A precursor; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (362 aa) |
| | mrdB | Rod shape-determining protein rodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (370 aa) |
| | mrdA | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (633 aa) |
| | ybeB | Hypothetical protein ybeB; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (105 aa) |
| | rlpB | Rare lipoprotein B precursor; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (193 aa) |
| | ybgF | Hypothetical protein ybgF precursor; Escherichia coli K-12 ortholog: b0742; Escherichia coli O157:H7 ortholog: z0910. (221 aa) |
| | ybhC | Putative lipoprotein ybHC precursor; Escherichia coli K-12 ortholog: b0772; Escherichia coli O157:H7 ortholog: z0943. (427 aa) |
| | rhlE | Putative ATP-dependent RNA helicase rhlE; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. (453 aa) |
| | dinG | Probable ATP-dependent helicase dinG; DNA-dependent ATPase and 5'-3' DNA helicase. (716 aa) |
| | dps | DNA protection during starvation protein; During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, ir [...] (167 aa) |
| | ybiS | Protein ybiS precursor; Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp) to the peptidoglycan via a meso- diaminopimelyl-L-Lys- bond on the terminal residue of Lpp. (306 aa) |
| | dacC | Penicillin-binding protein 6 precursor; D-alanyl-D-alanine carboxypeptidase fraction C; Escherichia coli K-12 ortholog: b0839; Escherichia coli O157:H7 ortholog: z1066; Belongs to the peptidase S11 family. (407 aa) |
| | c0934 | Hypothetical protein; Residues 114 to 307 of 308 are 47.42 pct identical to residues 5 to 198 of 198 from SwissProt.40 : >sp|P21323|YR7I_ECOLI HYPOTHETICAL 21.9 KD PROTEIN (ORFI) (RETRON EC67). (308 aa) |
| | mukF | MukF protein; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity. (440 aa) |
| | mukE | MukE protein; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF. (243 aa) |
| | mukB | Cell division protein mukB; Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division; Belongs to the SMC family. MukB subfamily. (1486 aa) |
| | ycbW | Hypothetical protein ycbW; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ. (192 aa) |
| | sulA | Cell division inhibitor; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. (171 aa) |
| | helD | Helicase IV; Escherichia coli K-12 ortholog: b0962; Escherichia coli O157:H7 ortholog: z1313. (715 aa) |
| | torD | Chaperone protein torD; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily. (210 aa) |
| | focC | F1C periplasmic chaperone; Involved in the biogenesis of the F1C fimbriae. Belongs to the periplasmic pilus chaperone family. (231 aa) |
| | focD | F1C fimbrial usher; Escherichia coli K-12 ortholog: b4317; Escherichia coli O157:H7 ortholog: z5915. (892 aa) |
| | mviN | Virulence factor mviN homolog; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (511 aa) |
| | flgN | Flagella synthesis protein flgN; Escherichia coli K-12 ortholog: b1070; Escherichia coli O157:H7 ortholog: z1708. (138 aa) |
| | flgM | Negative regulator of flagellin synthesis; Anti-sigma-28 factor; Escherichia coli K-12 ortholog: b1071; Escherichia coli O157:H7 ortholog: z1709. (97 aa) |
| | flgA | Flagella basal body P-ring formation protein flgA precursor; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P- ring assembly; Belongs to the FlgA family. (219 aa) |
| | flgD | Basal-body rod modification protein flgD; Required for flagellar hook formation. May act as a scaffolding protein. (231 aa) |
| | flgJ | Peptidoglycan hydrolase flgJ; Escherichia coli K-12 ortholog: b1081; Escherichia coli O157:H7 ortholog: z1719. (323 aa) |
| | flgK | Flagellar hook-associated protein 1; HAP1; Escherichia coli K-12 ortholog: b1082; Escherichia coli O157:H7 ortholog: z1720. (547 aa) |
| | yceG | Hypothetical protein yceG; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (269 aa) |
| | nagZ | Beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. (341 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; Belongs to the UvrB family. In the N-terminal section; belongs to the UvrB family. (951 aa) |
| | minD | Septum site-determining protein minD; ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings (By similarity). (270 aa) |
| | minC | Septum site-determining protein minC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (236 aa) |
| | ycgO | Putative Na(+)/H(+) exchanger ycgO; K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily. (578 aa) |
| | ldcA | Muramoyltetrapeptide carboxypeptidase; Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso-Dap-D-Ala. Can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc- tetrapeptide, and GlcNAc-anhMurNAc-tetrapeptide. Does not act on murein sacculi or cross-linked muropeptides. The tripeptides produced by the LcdA reaction can then be reused as peptidoglycan building blocks; LcdA is thereby involved in murein recycling (By similarity); Belongs to the [...] (304 aa) |
| | mltE | Membrane-bound lytic murein transglycosylase E; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain. (241 aa) |
| | prfA | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (360 aa) |
| | narJ | Respiratory nitrate reductase 1 delta chain; Escherichia coli K-12 ortholog: b1226; Escherichia coli O157:H7 ortholog: z2003. (236 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (879 aa) |
| | dbpA | ATP-independent RNA helicase dbpA; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes. (457 aa) |
| | narW | Respiratory nitrate reductase 2 delta chain; Escherichia coli K-12 ortholog: b1466; Escherichia coli O157:H7 ortholog: z2246. (231 aa) |
| | yddW | Hypothetical lipoprotein yddW precursor; Escherichia coli K-12 ortholog: b1491; Escherichia coli O157:H7 ortholog: z2217. (439 aa) |
| | c1934 | Outer membrane usher protein fimD precursor; Escherichia coli K-12 ortholog: b4317; Escherichia coli O157:H7 ortholog: z2203. (883 aa) |
| | c1935 | Chaperone protein fimC precursor; Escherichia coli K-12 ortholog: b4316; Escherichia coli O157:H7 ortholog: z2201. (236 aa) |
| | lpp | Major outer membrane lipoprotein precursor; A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane. (78 aa) |
| | ynhA | SufE protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family. (138 aa) |
| | ynhC | SufD protein; Escherichia coli K-12 ortholog: b1681; Escherichia coli O157:H7 ortholog: z2709. (423 aa) |
| | ynhE | SufB protein; Escherichia coli K-12 ortholog: b1683; Escherichia coli O157:H7 ortholog: z2711. (508 aa) |
| | ydiC | SufA protein; Escherichia coli K-12 ortholog: b1684; Escherichia coli O157:H7 ortholog: z2712; Belongs to the HesB/IscA family. (122 aa) |
| | rplT | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity). (118 aa) |
| | infC | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (144 aa) |
| | topB | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] (667 aa) |
| | yebA | Hypothetical protein yebA precursor; A murein DD-endopeptidase with specificity for D-Ala-meso- diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH (By similarity); Belongs to the peptidase M23B family. (440 aa) |
| | ruvB | Holliday junction DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (336 aa) |
| | ruvA | Holliday junction DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa) |
| | flhA | Flagellar biosynthesis protein flhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (717 aa) |
| | flhB | Flagellar biosynthetic protein flhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (382 aa) |
| | flhC | Flagellar transcriptional activator flhC; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. (192 aa) |
| | flhD | Flagellar transcriptional activator flhD; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (119 aa) |
| | fliS | Flagellar protein fliS; Escherichia coli K-12 ortholog: b1925; Escherichia coli O157:H7 ortholog: z3015. (136 aa) |
| | fliT | Flagellar protein fliT; Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus. (121 aa) |
| | fliH | Flagellar assembly protein fliH; Escherichia coli K-12 ortholog: b1940; Escherichia coli O157:H7 ortholog: z3030. (235 aa) |
| | fliI | Flagellum-specific ATP synthase; Escherichia coli K-12 ortholog: b1941; Escherichia coli O157:H7 ortholog: z3031. (457 aa) |
| | fliJ | Flagellar fliJ protein; Flagellar protein that affects chemotactic events. Belongs to the FliJ family. (147 aa) |
| | fliK | Flagellar hook-length control protein; Escherichia coli K-12 ortholog: b1943; Escherichia coli O157:H7 ortholog: z3033. (375 aa) |
| | fliO | Flagellar protein fliO; Escherichia coli K-12 ortholog: b1947; Escherichia coli O157:H7 ortholog: z3037. (122 aa) |
| | fliP | Flagellar biosynthetic protein fliP precursor; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (245 aa) |
| | fliQ | Flagellar biosynthetic protein fliQ; Required for the assembly of the rivet at the earliest stage of flagellar biosynthesis; Belongs to the FliQ/MopD/SpaQ family. (89 aa) |
| | fliR | Flagellar biosynthetic protein fliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (261 aa) |
| | dacD | Penicillin-binding protein 6B precursor; D-alanyl-D-alanine carboxypeptidase; Escherichia coli K-12 ortholog: b2010; Escherichia coli O157:H7 ortholog: z3171; Belongs to the peptidase S11 family. (390 aa) |
| | yehB | Hypothetical outer membrane usher protein yehB precursor; Escherichia coli K-12 ortholog: b2109; Escherichia coli O157:H7 ortholog: z3277. (831 aa) |
| | pbpG | Penicillin-binding protein 7 precursor; PBP-7; Escherichia coli K-12 ortholog: b2134; Escherichia coli O157:H7 ortholog: z3383; Belongs to the peptidase S11 family. (313 aa) |
| | yeiU | Hypothetical protein yeiU; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (249 aa) |
| | spr | Lipoprotein spr precursor; A murein DD-endopeptidase with specificity for D-Ala-meso- diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH. Also has weak LD-carboxypeptidase activity on L-mDAP-D-Ala peptide bonds (By similarity). (188 aa) |
| | dsbE | Thiol:disulfide interchange protein dsbE; Cytochrome c biogenesis protein ccmG; Escherichia coli K-12 ortholog: b2195; Escherichia coli O157:H7 ortholog: z3452. (185 aa) |
| | ccmF | Cytochrome c-type biogenesis protein ccmF; Escherichia coli K-12 ortholog: b2196; Escherichia coli O157:H7 ortholog: z3453. (647 aa) |
| | ccmE | Cytochrome c-type biogenesis protein ccmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (159 aa) |
| | ccmD | Heme exporter protein D; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. (69 aa) |
| | ccmC | Heme exporter protein C; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (253 aa) |
| | ccmB | Heme exporter protein B; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. (220 aa) |
| | ccmA | Heme exporter protein A; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (207 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (875 aa) |
| | yfcS | Hypothetical fimbrial chaperone yfcS precursor; Escherichia coli K-12 ortholog: b2336; Escherichia coli O157:H7 ortholog: z3599. (250 aa) |
| | yfcU | Putative outer membrane protein; Escherichia coli K-12 ortholog: b2338; Escherichia coli O157:H7 ortholog: z3600. (884 aa) |
| | ypdA | Hypothetical protein ypdA; Escherichia coli K-12 ortholog: b2380; Escherichia coli O157:H7 ortholog: z3645. (565 aa) |
| | zipA | Cell division protein zipA; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. (349 aa) |
| | nlpB | Lipoprotein-34 precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (345 aa) |
| | yfgL | Hypothetical protein yfgL; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (392 aa) |
| | yfhJ | Hypothetical protein yfhJ; May function as iron donor in the assembly of iron-sulfur clusters; Belongs to the IscX family. (66 aa) |
| | hscA | Chaperone protein hscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. (634 aa) |
| | yfhE | Chaperone protein hscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity); Belongs to the HscB family. (171 aa) |
| | yfhF | Protein yfhF; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB (By similarity). (109 aa) |
| | iscU | NifU-like protein; A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity). Belongs to the NifU family. (128 aa) |
| | yfhO | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate; Belongs to the class-V pyridoxal-phosphate-dependent aminotransfer [...] (412 aa) |
| | yfhD | Hypothetical protein yfhD; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family. (518 aa) |
| | srmB | ATP-dependent RNA helicase srmB; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity; Belongs to the DEAD box helicase family. SrmB subfamily. (444 aa) |
| | yfiO | Hypothetical lipoprotein yfiO precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (245 aa) |
| | ypjD | Hypothetical protein ypjD; Escherichia coli K-12 ortholog: b2611; Escherichia coli O157:H7 ortholog: z3905. (288 aa) |
| | bamE | Small protein A; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (113 aa) |
| | c3381 | Cysteine sulfinate desulfinase; Escherichia coli K-12 ortholog: b2810; Escherichia coli O157:H7 ortholog: z4127. (413 aa) |
| | mltA | Membrane-bound lytic murein transglycosylase A precursor; Escherichia coli K-12 ortholog: b2813; Escherichia coli O157:H7 ortholog: z4130. (477 aa) |
| | amiC | N-acetylmuramoyl-L-alanine amidase amiC precursor; Cell-wall hydrolase involved in septum cleavage during cell division; Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. (447 aa) |
| | recD | Exodeoxyribonuclease V alpha chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repa [...] (608 aa) |
| | recB | Exodeoxyribonuclease V beta chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repai [...] (1183 aa) |
| | recC | Exodeoxyribonuclease V gamma chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repa [...] (1122 aa) |
| | ygfE | Hypothetical protein ygfE; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (109 aa) |
| | mltC | Membrane-bound lytic murein transglycosylase C precursor; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (360 aa) |
| | papD | PapD protein; Residues 1 to 201 of 201 are 41.58 pct identical to residues 46 to 246 of 250 from MG1655 : b2336. (201 aa) |
| | papC | PapC protein; Residues 5 to 836 of 840 are 43.20 pct identical to residues 1 to 842 of 879 from EDL933 : z3600. (840 aa) |
| | parC | Topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (752 aa) |
| | parE | Topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (630 aa) |
| | yqiG | Hypothetical outer membrane usher protein yqiG precursor; Escherichia coli K-12 ortholog: b3046; Escherichia coli O157:H7 ortholog: z0871. (840 aa) |
| | yqiH | Hypothetical fimbrial chaperone yqiH precursor; Escherichia coli K-12 ortholog: b3047; Escherichia coli O157:H7 ortholog: z0869. (249 aa) |
| | bacA | Putative undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (274 aa) |
| | deaD | Cold-shock DEAD-box protein A; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (651 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa) |
| | yrbK | Hypothetical protein yrbK; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. (191 aa) |
| | yhbN | Protein yhbN precursor; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (192 aa) |
| | mtgA | Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (242 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes; Belongs to the ArgR family. (156 aa) |
| | yrdD | Hypothetical protein yrdD; Escherichia coli K-12 ortholog: b3283; Escherichia coli O157:H7 ortholog: z4654. (180 aa) |
| | yhgI | Protein yhgI; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (191 aa) |
| | c4208 | Putative fimbrial chaperone precursor; Residues 27 to 251 of 265 are 37.61 pct identical to residues 15 to 230 of 234 from GenPept.129 : >emb|CAD01181.1| (AL627265) fimbrial chaperone [Salmonella enterica subsp. enterica serovar Typhi]. (265 aa) |
| | ycbS | Hypothetical outer membrane usher protein ycbS precursor; Escherichia coli K-12 ortholog: b0940; Escherichia coli O157:H7 ortholog: z5915. (864 aa) |
| | c4213 | Chaperone protein fimC precursor; Escherichia coli K-12 ortholog: b4316; Escherichia coli O157:H7 ortholog: z2201. (259 aa) |
| | secB | Protein-export protein secB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (175 aa) |
| | recG | ATP-dependent DNA helicase recG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (704 aa) |
| | gyrB | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (805 aa) |
| | glmU | GlmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (456 aa) |
| | rep | ATP-dependent DNA helicase rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (673 aa) |
| | rfe | Undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (367 aa) |
| | cyaY | CyaY protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (106 aa) |
| | uvrD | DNA helicase II; Escherichia coli K-12 ortholog: b3813; Escherichia coli O157:H7 ortholog: z5330. (738 aa) |
| | recQ | ATP-dependent DNA helicase recQ; Escherichia coli K-12 ortholog: b3822; Escherichia coli O157:H7 ortholog: z5343. (611 aa) |
| | yihA | Probable GTP-binding protein engB; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (199 aa) |
| | yihK | GTP-binding protein typA/BipA; A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA. (607 aa) |
| | yiiU | Hypothetical protein yiiU; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. (87 aa) |
| | ftsN | Cell division protein ftsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. (319 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (756 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (285 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (342 aa) |
| | hupA | DNA-binding protein HU-alpha; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. (90 aa) |
| | dnaB | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. (483 aa) |
| | alr | Alanine racemase, biosynthetic; Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis (By similarity). (359 aa) |
