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hypA hypA hycE hycE hyaB hyaB hypB hypB hybF hybF hybC hybC nikA nikA nikD nikD nikE nikE yhhG yhhG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
hypAHypA protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (120 aa)
hycEFormate hydrogenlyase subunit 5 precursor; FHL subunit 5; Escherichia coli K-12 ortholog: b2721; Escherichia coli O157:H7 ortholog: z4029. (569 aa)
hyaBHydrogenase-1 large chain; Escherichia coli K-12 ortholog: b0973; Escherichia coli O157:H7 ortholog: z1390; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (597 aa)
hypBHydrogenase isoenzymes nickel incorporation protein hypB; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. (290 aa)
hybFProbable hydrogenase nickel incorporation protein hybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)
hybCHydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa)
nikANickel-binding periplasmic protein precursor; Escherichia coli K-12 ortholog: b3476; Escherichia coli O157:H7 ortholog: z4868. (524 aa)
nikDNickel transport ATP-binding protein nikD; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (254 aa)
nikENickel transport ATP-binding protein nikE; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (268 aa)
yhhGNickel responsive regulator; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel (By similarity). (133 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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