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| | fryA | Putative phosphoenolpyruvate-protein phosphotransferase ypdD; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport. (831 aa) |
| | thrA | Bifunctional; Escherichia coli K-12 ortholog: b0002; Escherichia coli O157:H7 ortholog: z0002; bifunctional; Homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. (841 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa) |
| | ribF | Riboflavin biosynthesis protein ribF; Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD. (313 aa) |
| | araB | L-ribulokinase; Escherichia coli K-12 ortholog: b0063; Escherichia coli O157:H7 ortholog: z0072. (566 aa) |
| | yacE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa) |
| | yadI | Putative PTS system IIA component yadI; Escherichia coli K-12 ortholog: b0129; Escherichia coli O157:H7 ortholog: z0140. (146 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Escherichia coli K-12 ortholog: b0142; Escherichia coli O157:H7 ortholog: z0153. (159 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) |
| | rbsK-2 | Putative ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (306 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (380 aa) |
| | c0444 | Carbamate kinase-like protein yahI; Escherichia coli K-12 ortholog: b0323; Escherichia coli O157:H7 ortholog: z0412; Belongs to the carbamate kinase family. (316 aa) |
| | aroL | Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (174 aa) |
| | phoR | Phosphate regulon sensor protein phoR; Escherichia coli K-12 ortholog: b0400; Escherichia coli O157:H7 ortholog: z0498. (431 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (234 aa) |
| | gsk | Inosine-guanosine kinase; Escherichia coli K-12 ortholog: b0477; Escherichia coli O157:H7 ortholog: z0596; Belongs to the carbohydrate kinase PfkB family. (434 aa) |
| | ybbZ | Glycerate kinase 1; Escherichia coli K-12 ortholog: b0514; Escherichia coli O157:H7 ortholog: z0669; Belongs to the glycerate kinase type-1 family. (383 aa) |
| | arcC | Carbamate kinase; Escherichia coli K-12 ortholog: b0521; Escherichia coli O157:H7 ortholog: z0676; Belongs to the carbamate kinase family. (297 aa) |
| | cusS | Sensor kinase cusS; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. (480 aa) |
| | citA | Sensor kinase dpiB; Escherichia coli K-12 ortholog: b0619; Escherichia coli O157:H7 ortholog: z0764. (572 aa) |
| | nagE | PTS system, N-acetylglucosamine-specific IIABC component; EIIABC-NAG; Escherichia coli K-12 ortholog: b0679; Escherichia coli O157:H7 ortholog: z0826. (648 aa) |
| | c0763 | Putative inner membrane protein; Residues 11 to 372 of 376 are 40.21 pct identical to residues 41 to 418 of 423 from GenPept.129 : >gb|AAL19126.1| (AE008701) putative inner membrane protein [Salmonella typhimurium LT2]. (376 aa) |
| | kdpD | Sensor protein kdpD; Escherichia coli K-12 ortholog: b0695; Escherichia coli O157:H7 ortholog: z0842. (895 aa) |
| | galK | Galactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (382 aa) |
| | cmk | Cytidylate kinase; Escherichia coli K-12 ortholog: b0910; Escherichia coli O157:H7 ortholog: z1256. (227 aa) |
| | torS | Sensor protein torS; Escherichia coli K-12 ortholog: b0993; Escherichia coli O157:H7 ortholog: z1410. (576 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa) |
| | ptsG | PTS system, glucose-specific IIBC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. Also functions as a chemoreceptor monitoring the environment for changes in sugar concentration. (477 aa) |
| | ycfN | Hypothetical protein ycfN; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (274 aa) |
| | ycfX | Hypothetical protein ycfX; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. (303 aa) |
| | phoQ | Sensor protein phoQ; Member of the two-component regulatory system PhoP/PhoQ involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, which results in the repression of PG and may l [...] (486 aa) |
| | ycgC | Hypothetical protein ycgC; Escherichia coli K-12 ortholog: b1198; Escherichia coli O157:H7 ortholog: z1969; Belongs to the PEP-utilizing enzyme family. (474 aa) |
| | c1657 | Protein ycgS; Escherichia coli K-12 ortholog: b1199; Escherichia coli O157:H7 ortholog: z1970. (236 aa) |
| | ycgT | Hypothetical protein ycgT; Escherichia coli K-12 ortholog: b1200; Escherichia coli O157:H7 ortholog: z1971. (366 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (337 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily. (283 aa) |
| | narX | Nitrate/nitrite sensor protein narX; Escherichia coli K-12 ortholog: b1222; Escherichia coli O157:H7 ortholog: z1998. (598 aa) |
| | tdk | Thymidine kinase; Phosphorylates both thymidine and deoxyuridine. (205 aa) |
| | c1918 | Putative sensor kinase; Escherichia coli O157:H7 ortholog: z2220. (446 aa) |
| | hipA | Protein hipA; Toxic component of a type II toxin-antitoxin (TA) system. Phosphorylates Glu-tRNA-ligase (GltX, on 'Ser-239') in vivo. Phosphorylation of GltX prevents it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA/SpoT and increased ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to multidrug resistance and persistence. Low level expression of HipA induces dormancy and depending on the protein level, can be toxic enough t [...] (472 aa) |
| | c1959 | PTS system, cellobiose-specific IIB component; EIIB-Cel; Escherichia coli K-12 ortholog: b1738; Escherichia coli O157:H7 ortholog: z2768. (103 aa) |
| | rstB | Sensor protein rstB; Escherichia coli K-12 ortholog: b1609; Escherichia coli O157:H7 ortholog: z2610. (433 aa) |
| | malX | Maltose and glucose-permease IIABC component; Escherichia coli K-12 ortholog: b1621; Escherichia coli O157:H7 ortholog: z2626. (598 aa) |
| | pdxY | Pyridoxamine kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (287 aa) |
| | ydhH | Hypothetical protein ydhH; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (369 aa) |
| | pykF | Pyruvate kinase I; Escherichia coli K-12 ortholog: b1676; Escherichia coli O157:H7 ortholog: z2704; Belongs to the pyruvate kinase family. (542 aa) |
| | ppsA | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa) |
| | ydiA | Hypothetical protein ydiA; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (277 aa) |
| | pfkB | 6-phosphofructokinase isozyme 2; Escherichia coli K-12 ortholog: b1723; Escherichia coli O157:H7 ortholog: z2752; Belongs to the carbohydrate kinase PfkB family. (310 aa) |
| | yniA | Hypothetical protein yniA; Escherichia coli K-12 ortholog: b1725; Escherichia coli O157:H7 ortholog: z2754; Belongs to the fructosamine kinase family. (286 aa) |
| | celA | PTS system, cellobiose-specific IIB component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2). (106 aa) |
| | selD | Selenide,water dikinase; Synthesizes selenophosphate from selenide and ATP. (349 aa) |
| | ydjH | Hypothetical sugar kinase ydjH; Escherichia coli K-12 ortholog: b1772; Escherichia coli O157:H7 ortholog: z2810; Belongs to the carbohydrate kinase PfkB family. (322 aa) |
| | yeaG | Hypothetical protein yeaG; Escherichia coli K-12 ortholog: b1783; Escherichia coli O157:H7 ortholog: z2823; Belongs to the PrkA family. (644 aa) |
| | manX | PTS system, mannose-specific IIAB component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA. (323 aa) |
| | pykA | Pyruvate kinase II; Escherichia coli K-12 ortholog: b1854; Escherichia coli O157:H7 ortholog: z2906; Belongs to the pyruvate kinase family. (527 aa) |
| | cheA | Chemotaxis protein cheA; Escherichia coli K-12 ortholog: b1888; Escherichia coli O157:H7 ortholog: z2942. (672 aa) |
| | yedV | Putative sensor-like histidine kinase yedV; Member of a two-component regulatory system. (452 aa) |
| | cobU | Cobalamin biosynthesis protein cobU; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (181 aa) |
| | rbsK-3 | Putative carbohydrate kinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (404 aa) |
| | c2586 | Tyrosine-protein kinase wzc; Escherichia coli K-12 ortholog: b2060; Escherichia coli O157:H7 ortholog: z3224. (732 aa) |
| | udk | Uridine kinase; Escherichia coli K-12 ortholog: b2066; Escherichia coli O157:H7 ortholog: z3234; Belongs to the uridine kinase family. (234 aa) |
| | yegI | Hypothetical protein yegI; Escherichia coli K-12 ortholog: b2070; Escherichia coli O157:H7 ortholog: z3239. (649 aa) |
| | baeS | Sensor protein baeS; Escherichia coli K-12 ortholog: b2078; Escherichia coli O157:H7 ortholog: z3247. (467 aa) |
| | yegS | Hypothetical protein yegS; Probably phosphorylates lipids; the in vivo substrate is unknown. (299 aa) |
| | gatA | PTS system, galactitol-specific IIA component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of GatA, GatB and GatC is involved in galactitol transport. (150 aa) |
| | yegV | Hypothetical sugar kinase yegV; Escherichia coli K-12 ortholog: b2100; Escherichia coli O157:H7 ortholog: z3263; Belongs to the carbohydrate kinase PfkB family. (321 aa) |
| | thiD | Phosphomethylpyrimidine kinase; Escherichia coli K-12 ortholog: b2103; Escherichia coli O157:H7 ortholog: z3267. (266 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (262 aa) |
| | yehU | Hypothetical protein yehU precursor; Member of the two-component regulatory system BtsS/BtsR. BtsS is a high-affinity receptor for extracellular pyruvate that activates BtsR by phosphorylation. (566 aa) |
| | yeiI | Hypothetical sugar kinase yeiI; Escherichia coli K-12 ortholog: b2160; Escherichia coli O157:H7 ortholog: z3417. (362 aa) |
| | yeiC | Hypothetical sugar kinase yeiC; Escherichia coli K-12 ortholog: b2166; Escherichia coli O157:H7 ortholog: z3423. (351 aa) |
| | fruK | 1-phosphofructokinase; Escherichia coli K-12 ortholog: b2168; Escherichia coli O157:H7 ortholog: z3426; Belongs to the carbohydrate kinase PfkB family. (312 aa) |
| | yojN | Putative sensor-like histidine kinase yojN; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (890 aa) |
| | rcsC | Sensor protein rcsC; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (949 aa) |
| | atoS | Sensor protein atoS; Escherichia coli K-12 ortholog: b2219. (612 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | evgS | Sensor protein evgS precursor; Escherichia coli K-12 ortholog: b2370; Escherichia coli O157:H7 ortholog: z3632. (1197 aa) |
| | ypdA | Hypothetical protein ypdA; Escherichia coli K-12 ortholog: b2380; Escherichia coli O157:H7 ortholog: z3645. (565 aa) |
| | fryB | Putative PTS system IIB component ypdH; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport. (125 aa) |
| | glk | Glucokinase; Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate. (321 aa) |
| | crr | PTS system, glucose-specific IIA component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. (169 aa) |
| | pdxK | Pyridoxine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. (283 aa) |
| | murP | Putative PTS system IIBC component yfeV; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring. (474 aa) |
| | narQ | Nitrate/nitrite sensor protein narQ; Escherichia coli K-12 ortholog: b2469; Escherichia coli O157:H7 ortholog: z3726. (571 aa) |
| | ppk | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. (690 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa) |
| | yfhK | Putative sensor-like histidine kinase yfhK; Escherichia coli K-12 ortholog: b2556; Escherichia coli O157:H7 ortholog: z3833. (496 aa) |
| | yfjB | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa) |
| | ygbK | Hypothetical protein ygbK; Escherichia coli K-12 ortholog: b2737. (420 aa) |
| | cysC | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (201 aa) |
| | ygcE | Hypothetical sugar kinase ygcE; Escherichia coli K-12 ortholog: b2776; Escherichia coli O157:H7 ortholog: z4087. (492 aa) |
| | relA | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). (744 aa) |
| | barA | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). (918 aa) |
| | c3408 | Maltose and glucose-permease IIABC component; Escherichia coli K-12 ortholog: b1621; Escherichia coli O157:H7 ortholog: z2626. (526 aa) |
| | yqeA | Carbamate kinase-like protein yqeA; Escherichia coli K-12 ortholog: b2874; Escherichia coli O157:H7 ortholog: z4213; Belongs to the carbamate kinase family. (310 aa) |
| | pgk | Phosphoglycerate kinase; Escherichia coli K-12 ortholog: b2926; Escherichia coli O157:H7 ortholog: z4265; Belongs to the phosphoglycerate kinase family. (408 aa) |
| | c3564 | Hypothetical protein; Residues 169 to 490 of 490 are 26.31 pct identical to residues 162 to 473 of 475 from GenPept.129 : >gb|AAK81155.1|AE007818_1 (AE007818) Membrane associated histidine kinase with HAMP domain [Clostridium acetobutylicum]. (490 aa) |
| | nanK2 | Hypothetical protein yhcI; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily. (291 aa) |
| | ygiY | Sensor protein qseC; Escherichia coli K-12 ortholog: b3026; Escherichia coli O157:H7 ortholog: z4378. (449 aa) |
| | hldE | ADP-heptose synthase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (477 aa) |
| | tdcD-2 | Putative conserved protein; Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. (50 aa) |
| | yhaD | Glycerate kinase 2; Escherichia coli K-12 ortholog: b3124; Escherichia coli O157:H7 ortholog: z4476; Belongs to the glycerate kinase type-1 family. (408 aa) |
| | agaV | PTS system, N-acetylgalactosamine-specific IIB component 2; EIIB-AGA'; Escherichia coli K-12 ortholog: b3133; Escherichia coli O157:H7 ortholog: z4485. (169 aa) |
| | c3891 | Putative phosphotransferase system enzyme subunit; Escherichia coli O157:H7 ortholog: z4488. (144 aa) |
| | agaB | PTS system, N-acetylgalactosamine-specific IIB component 1; EIIB-AGA; Escherichia coli K-12 ortholog: b3138; Escherichia coli O157:H7 ortholog: z4492. (158 aa) |
| | arcB | Aerobic respiration control sensor protein arcB; Escherichia coli K-12 ortholog: b3210; Escherichia coli O157:H7 ortholog: z4574. (778 aa) |
| | nanK1 | Hypothetical protein yhcI; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily. (302 aa) |
| | prkB | Probable phosphoribulokinase; Escherichia coli K-12 ortholog: b3355; Escherichia coli O157:H7 ortholog: z4716. (289 aa) |
| | aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (240 aa) |
| | envZ | Osmolarity sensor protein envZ; Escherichia coli K-12 ortholog: b3404; Escherichia coli O157:H7 ortholog: z4759. (450 aa) |
| | gntK | Thermoresistant gluconokinase; Escherichia coli K-12 ortholog: b3437; Escherichia coli O157:H7 ortholog: z4805. (163 aa) |
| | c4280 | Putative xylulose kinase; Escherichia coli O157:H7 ortholog: z4878. (482 aa) |
| | kdgK | 2-dehydro-3-deoxygluconokinase; Escherichia coli K-12 ortholog: b3526; Escherichia coli O157:H7 ortholog: z4940. (425 aa) |
| | xylB | Xylulose kinase; Escherichia coli K-12 ortholog: b3564; Escherichia coli O157:H7 ortholog: z4989. (484 aa) |
| | lyxK | Cryptic L-xylulose kinase; Escherichia coli K-12 ortholog: b3580; Belongs to the FGGY kinase family. (498 aa) |
| | rfaP | Lipopolysaccharide core biosynthesis protein rfaP; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family. (268 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (226 aa) |
| | tdcD | Propionate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (406 aa) |
| | c4545 | Hypothetical protein; Residues 12 to 416 of 420 are 34.38 pct identical to residues 1 to 407 of 410 from GenPept.129 : >dbj|BAB80633.1| (AP003188) two-component sensor histidine kinase [Clostridium perfringens]. (420 aa) |
| | uhpB | Sensor protein uhpB; Escherichia coli K-12 ortholog: b3668; Escherichia coli O157:H7 ortholog: z5158. (502 aa) |
| | dgoK | 2-dehydro-3-deoxygalactonokinase; Escherichia coli K-12 ortholog: b3693. (292 aa) |
| | bglF | PTS system, beta-glucoside-specific IIABC component; EIIABC-Bgl; Escherichia coli K-12 ortholog: b3722. (649 aa) |
| | rbsK | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (318 aa) |
| | c4758 | PTS system, glucose-specific IIBC component; EIIBC-Glc; Escherichia coli K-12 ortholog: b1101; Escherichia coli O157:H7 ortholog: z1740. (502 aa) |
| | c4764 | Carbamate kinase-like protein yahI; Escherichia coli K-12 ortholog: b0323; Escherichia coli O157:H7 ortholog: z0412; Belongs to the carbamate kinase family. (318 aa) |
| | c4778 | Putative conserved protein; Residues 7 to 319 of 334 are 34.38 pct identical to residues 5 to 289 of 292 from MG1655 : b3693. (334 aa) |
| | yigR | Probable ubiquinone biosynthesis protein ubiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (546 aa) |
| | yihE | Hypothetical protein yihE; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (328 aa) |
| | glnL | Nitrogen regulation protein NR(II); Escherichia coli K-12 ortholog: b3869; Escherichia coli O157:H7 ortholog: z5405. (349 aa) |
| | yihV | Hypothetical sugar kinase yihV; Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6-deoxy-6- sulfo-D-fructose 1-phosphate (SFP); Belongs to the carbohydrate kinase PfkB family. (315 aa) |
| | rhaB | Rhamnulokinase; Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1- hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate. (489 aa) |
| | cpxA | Sensor protein cpxA; This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synthesis, translocation, or stability of cell envelope proteins. Activates CpxR by phosphorylation (By similarity). (457 aa) |
| | pfkA | 6-phosphofructokinase isozyme I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (352 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (537 aa) |
| | metL | AKII-HDII protein; Bifunctional; Escherichia coli K-12 ortholog: b3940; Escherichia coli O157:H7 ortholog: z5495; bifunctional; Aspartokinase II; Homoserine dehydrogenase II; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa) |
| | frwB | PTS system, fructose-like-2 IIB component 1; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport. (106 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (269 aa) |
| | coaA | Pantothenate kinase; Escherichia coli K-12 ortholog: b3974; Escherichia coli O157:H7 ortholog: z5545. (323 aa) |
| | hydH | Sensor protein zraS; Escherichia coli K-12 ortholog: b4003; Escherichia coli O157:H7 ortholog: z5579. (458 aa) |
| | aceK | Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (574 aa) |
| | c4984 | Putative sorbose PTS component; Escherichia coli O157:H7 ortholog: z5616. (164 aa) |
| | c4985 | Putative sorbose PTS component; Escherichia coli O157:H7 ortholog: z5617. (135 aa) |
| | lysC | Lysine-sensitive aspartokinase III; Escherichia coli K-12 ortholog: b4024; Escherichia coli O157:H7 ortholog: z5622; Belongs to the aspartokinase family. (449 aa) |
| | dgkA | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (122 aa) |
| | c5041 | Putative transport sensor protein; Residues 20 to 591 of 606 are 31.81 pct identical to residues 28 to 612 of 633 from GenPept.129 : >gb|AAG04725.1|AE004563_2 (AE004563) probable two-component sensor [Pseudomonas aeruginosa]. (606 aa) |
| | yjcT | D-allose kinase; Catalyzes the phosphorylation of D-allose to D-allose 6- phosphate. (309 aa) |
| | basS | Sensor protein basS/pmrB; Escherichia coli K-12 ortholog: b4112; Escherichia coli O157:H7 ortholog: z5714. (366 aa) |
| | yjdH | Sensor protein dcuS; Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4- dicarboxylate transporter dctA. Activates DcuR by phosphorylation (By similarity). (543 aa) |
| | pgtB | Regulatory protein; Residues 139 to 669 of 669 are 79.28 pct identical to residues 63 to 593 of 593 from SwissProt.40 : >sp|P37433|PGTB_SALTY PHOSPHOGLYCERATE TRANSPORT SYSTEM SENSOR PROTEIN PGTB. (669 aa) |
| | sgaB | Unknown pentitol phosphotransferase enzyme II, B component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (103 aa) |
| | ptxA | Unknown pentitol phosphotransferase enzyme II, A component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (154 aa) |
| | treB | PTS system, trehalose-specific IIBC component; EIIBC-TRE; Escherichia coli K-12 ortholog: b4240; Escherichia coli O157:H7 ortholog: z5850. (473 aa) |
| | c5349 | Carbamate kinase; Escherichia coli K-12 ortholog: b0521; Escherichia coli O157:H7 ortholog: z0676; Belongs to the carbamate kinase family. (310 aa) |
| | idnK | Thermosensitive gluconokinase; Escherichia coli K-12 ortholog: b4268; Escherichia coli O157:H7 ortholog: z4805. (187 aa) |
| | nadR | Transcriptional regulator nadR; Escherichia coli K-12 ortholog: b4390; Escherichia coli O157:H7 ortholog: z5991. (417 aa) |
| | creC | Sensor protein creC; Escherichia coli K-12 ortholog: b4399; Escherichia coli O157:H7 ortholog: z6002. (474 aa) |
