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yfbG yfbG fadJ fadJ eutG eutG c2988 c2988 guaB guaB yphC yphC ygaF ygaF srlD srlD ygbJ ygbJ fucO fucO c3405 c3405 kduD kduD serA serA glcD glcD yqhD yqhD c3746 c3746 c3751 c3751 c3753 c3753 yhaE yhaE mdh mdh aroE aroE glpD glpD yiaE yiaE yiaK yiaK yiaY yiaY mtlD mtlD lldD lldD gpsA gpsA tdh tdh c4524 c4524 ilvC ilvC wecC wecC fadB fadB yihU yihU thrA thrA pdxA pdxA leuB leuB gcd gcd c0321 c0321 betA betA yahK yahK adhC adhC ribD ribD apbA apbA ybbQ ybbQ c0631 c0631 ybdH ybdH rutE rutE c1187 c1187 ycdW ycdW c5437 c5437 uxuB uxuB yjgB yjgB idnD idnD idnO idnO melA melA murB murB gldA gldA metL metL icdA icdA adhE adhE ldhA ldhA adhP adhP sfcA sfcA ydfG ydfG c1968 c1968 hdhA hdhA ydiB ydiB celF celF ydjJ ydjJ zwf zwf c2467 c2467 hisD hisD ugd ugd gnd gnd wcaG wcaG gatD gatD dld dld yeiQ yeiQ yojH yojH glpA glpA glpB glpB pdxB pdxB
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yfbGHypothetical protein yfbG; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (660 aa)
fadJPutative fatty oxidation complex alpha subunit; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (714 aa)
eutGEthanolamine utilization protein eutG; Escherichia coli K-12 ortholog: b2453; Escherichia coli O157:H7 ortholog: z3709. (404 aa)
c2988NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. (759 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (511 aa)
yphCHypothetical zinc-type alcohol dehydrogenase-like protein yphC; Escherichia coli K-12 ortholog: b2545; Escherichia coli O157:H7 ortholog: z3817. (364 aa)
ygaFHypothetical protein ygaF; Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665; Belongs to the L2HGDH family. (444 aa)
srlDSorbitol-6-phosphate 2-dehydrogenase; Escherichia coli K-12 ortholog: b2705; Escherichia coli O157:H7 ortholog: z4012; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (259 aa)
ygbJHypothetical oxidoreductase ygbJ; Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+). (302 aa)
fucOLactaldehyde reductase; Escherichia coli K-12 ortholog: b2799; Escherichia coli O157:H7 ortholog: z4116. (383 aa)
c34052-hydroxyacid dehydrogenase; Residues 5 to 318 of 318 are 37.77 pct identical to residues 3 to 317 of 317 from GenPept.129 : >gb|AAK90773.1| (AE007909) AGR_pAT_578p [Agrobacterium tumefaciens str. C58 (Cereon)]; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa)
kduD2-deoxy-D-gluconate 3-dehydrogenase; Escherichia coli K-12 ortholog: b2842; Escherichia coli O157:H7 ortholog: z4162. (253 aa)
serAD-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa)
glcDGlycolate oxidase subunit glcD; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is also able to oxidize D-lactate ((R)- lactate) with a similar rate. Does not link directly to O(2), and 2,6- dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (499 aa)
yqhDHypothetical oxidoreductase yqhD; Escherichia coli K-12 ortholog: b3011; Escherichia coli O157:H7 ortholog: z4364. (387 aa)
c37462,5-diketo-D-gluconic acid reductase A; Escherichia coli K-12 ortholog: b3012; Escherichia coli O157:H7 ortholog: z4365. (275 aa)
c3751Hypothetical oxidoreductase ydfI; Escherichia coli K-12 ortholog: b1542; Escherichia coli O157:H7 ortholog: z2155; Belongs to the mannitol dehydrogenase family. (502 aa)
c3753Ureidoglycolate dehydrogenase; Escherichia coli K-12 ortholog: b0517; Escherichia coli O157:H7 ortholog: z0672; Belongs to the LDH2/MDH2 oxidoreductase family. (336 aa)
yhaE2-hydroxy-3-oxopropionate reductase; Catalyzes the reduction of tatronate semialdehyde to D- glycerate; Belongs to the HIBADH-related family. 2-hydroxy-3- oxopropionate reductase subfamily. (299 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (334 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa)
glpDAerobic glycerol-3-phosphate dehydrogenase; Escherichia coli K-12 ortholog: b3426; Escherichia coli O157:H7 ortholog: z4786; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (506 aa)
yiaE2-ketogluconate reductase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. (328 aa)
yiaKHypothetical oxidoreductase yiaK; Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate. (332 aa)
yiaYProbable alcohol dehydrogenase; Escherichia coli K-12 ortholog: b3589; Escherichia coli O157:H7 ortholog: z5010. (383 aa)
mtlDMannitol-1-phosphate 5-dehydrogenase; Escherichia coli K-12 ortholog: b3600; Escherichia coli O157:H7 ortholog: z5024. (442 aa)
lldDL-lactate dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (396 aa)
gpsAGlycerol-3-phosphate dehydrogenase (NAD(P)+); Escherichia coli K-12 ortholog: b3608; Escherichia coli O157:H7 ortholog: z5035; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa)
tdhThreonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa)
c4524Putative propanol dehydrogenase; Residues 10 to 370 of 372 are 44.41 pct identical to residues 9 to 375 of 376 from GenPept.129 : >dbj|BAB80598.1| (AP003188) NADPH-dependent butanol dehydrogenase [Clostridium perfringens]. (372 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (541 aa)
wecCUDP-N-acetyl-D-mannosamine dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
fadBFatty oxidation complex alpha subunit; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (771 aa)
yihUHypothetical oxidoreductase yihU; Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1- sulfonate (DHPS); Belongs to the HIBADH-related family. 3-sulfolactaldehyde reductase subfamily. (359 aa)
thrABifunctional; Escherichia coli K-12 ortholog: b0002; Escherichia coli O157:H7 ortholog: z0002; bifunctional; Homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. (841 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (329 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (364 aa)
gcdGlucose dehydrogenase; Pyrroloquinoline-quinone; Escherichia coli K-12 ortholog: b0124; Escherichia coli O157:H7 ortholog: z0134. (802 aa)
c0321Gluconate 5-dehydrogenase; Escherichia coli K-12 ortholog: b4266; Escherichia coli O157:H7 ortholog: z4085. (266 aa)
betACholine dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. Belongs to the GMC oxidoreductase family. (571 aa)
yahKHypothetical zinc-type alcohol dehydrogenase-like protein yahK; Escherichia coli K-12 ortholog: b0325; Escherichia coli O157:H7 ortholog: z0420. (349 aa)
adhCAlcohol dehydrogenase class III; Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa)
ribDRiboflavin biosynthesis protein ribD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (367 aa)
apbA2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (303 aa)
ybbQ2-hydroxy-3-oxopropionate reductase; Escherichia coli K-12 ortholog: b0509; Escherichia coli O157:H7 ortholog: z0663. (292 aa)
c0631Ureidoglycolate dehydrogenase; Escherichia coli K-12 ortholog: b0517; Escherichia coli O157:H7 ortholog: z0672; Belongs to the LDH2/MDH2 oxidoreductase family. (349 aa)
ybdHHypothetical oxidoreductase ybdH; Escherichia coli K-12 ortholog: b0599; Escherichia coli O157:H7 ortholog: z0742. (362 aa)
rutEPutative NADH dehydrogenase/NAD(P)H nitroreductase ycdI; May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted; Belongs to the nitroreductase family. HadB/RutE subfamily. (196 aa)
c11873-oxoacyl-[acyl-carrier protein] reductase; Escherichia coli K-12 ortholog: b1093; Escherichia coli O157:H7 ortholog: z4865. (243 aa)
ycdWPutative 2-hydroxyacid dehydrogenase ycdW; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. (312 aa)
c5437Hypothetical zinc-type alcohol dehydrogenase-like protein yjjN; Escherichia coli K-12 ortholog: b4358; Escherichia coli O157:H7 ortholog: z5958. (340 aa)
uxuBD-mannonate oxidoreductase; Escherichia coli K-12 ortholog: b4323; Escherichia coli O157:H7 ortholog: z5921; Belongs to the mannitol dehydrogenase family. (486 aa)
yjgBHypothetical zinc-type alcohol dehydrogenase-like protein yjgB; Escherichia coli K-12 ortholog: b4269; Escherichia coli O157:H7 ortholog: z5876. (353 aa)
idnDL-idonate 5-dehydrogenase; Escherichia coli K-12 ortholog: b4267. (343 aa)
idnOGluconate 5-dehydrogenase; Catalyzes the reduction of 5-keto-D-gluconate to D-gluconate, using either NADH or NADPH. Is likely involved in an L-idonate degradation pathway that allows E.coli to utilize L-idonate as the sole carbon and energy source. Is also able to catalyze the reverse reaction in vitro, but the D-gluconate oxidation by the enzyme can only proceed with NAD; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (254 aa)
melAAlpha-galactosidase; Escherichia coli K-12 ortholog: b4119; Escherichia coli O157:H7 ortholog: z5721. (451 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (342 aa)
gldAGlycerol dehydrogenase; Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions (By similarity). Belongs to the iron-containing alcohol dehydrogenase family. (380 aa)
metLAKII-HDII protein; Bifunctional; Escherichia coli K-12 ortholog: b3940; Escherichia coli O157:H7 ortholog: z5495; bifunctional; Aspartokinase II; Homoserine dehydrogenase II; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa)
icdAIsocitrate dehydrogenase (NADP); Escherichia coli K-12 ortholog: b1136; Escherichia coli O157:H7 ortholog: z1865. (416 aa)
adhEAldehyde-alcohol dehydrogenase; Escherichia coli K-12 ortholog: b1241; Escherichia coli O157:H7 ortholog: z2016; multifunctional; Alcohol dehydrogenase; Acetaldehyde dehydrogenase [acetylating]; Pyruvate-formate-lyase deactivase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (891 aa)
ldhAD-lactate dehydrogenase; Escherichia coli K-12 ortholog: b1380; Escherichia coli O157:H7 ortholog: z2329; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa)
adhPAlcohol dehydrogenase, propanol-preferring; Escherichia coli K-12 ortholog: b1478; Escherichia coli O157:H7 ortholog: z2232. (346 aa)
sfcANAD-dependent malic enzyme; Escherichia coli K-12 ortholog: b1479; Escherichia coli O157:H7 ortholog: z2231; Belongs to the malic enzymes family. (574 aa)
ydfGProbable oxidoreductase ydfG; NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP-dependent oxidation of L- allo-threonine to L-2-amino-3-keto-butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3-hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L-glycerate. Able to catalyze the reduction of the malonic semialdehyde to 3-hydroxypropionic acid. YdfG is apparently supplementing RutE, the presumed malonic semialdehyde reductase involved in pyrimidine degradatio [...] (253 aa)
c1968Hypothetical oxidoreductase ydfI; Escherichia coli K-12 ortholog: b1542; Escherichia coli O157:H7 ortholog: z2155; Belongs to the mannitol dehydrogenase family. (486 aa)
hdhA7-alpha-hydroxysteroid dehydrogenase; Escherichia coli K-12 ortholog: b1619; Escherichia coli O157:H7 ortholog: z2624. (255 aa)
ydiBHypothetical shikimate 5-dehydrogenase-like protein ydiB; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. (288 aa)
celF6-phospho-beta-glucosidase; Escherichia coli K-12 ortholog: b1734; Escherichia coli O157:H7 ortholog: z2764. (468 aa)
ydjJHypothetical zinc-type alcohol dehydrogenase-like protein ydjJ; Escherichia coli K-12 ortholog: b1774; Escherichia coli O157:H7 ortholog: z2812. (347 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
c2467Putative 3-hydroxyacyl-CoA dehydrogenase; Residues 2 to 282 of 289 are 45.55 pct identical to residues 1 to 278 of 278 from SwissProt.40 : >sp|Q9RVG1|HBD_DEIRA Probable 3-hydroxybutyryl-CoA dehydrogenase (Beta-hydroxybutyryl-CoA dehydrogenase) (BHBD). (289 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (437 aa)
ugdUDP-glucose 6-dehydrogenase; Escherichia coli K-12 ortholog: b2028; Escherichia coli O157:H7 ortholog: z3190; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (388 aa)
gnd6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
wcaGGDP-fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa)
gatDGalactitol-1-phosphate 5-dehydrogenase; Escherichia coli K-12 ortholog: b2091; Escherichia coli O157:H7 ortholog: z3254. (346 aa)
dldD-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (582 aa)
yeiQHypothetical oxidoreductase yeiQ; Escherichia coli K-12 ortholog: b2172; Escherichia coli O157:H7 ortholog: z3431; Belongs to the mannitol dehydrogenase family. (491 aa)
yojHMalate:quinone oxidoreductase; Escherichia coli K-12 ortholog: b2210; Escherichia coli O157:H7 ortholog: z3468. (548 aa)
glpAAnaerobic glycerol-3-phosphate dehydrogenase subunit A; Escherichia coli K-12 ortholog: b2241; Escherichia coli O157:H7 ortholog: z3499; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (542 aa)
glpBAnaerobic glycerol-3-phosphate dehydrogenase subunit B; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor; Belongs to the anaerobic G-3-P dehydrogenase subunit B family. (443 aa)
pdxBErythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (378 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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