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yafH yafH dapB dapB aidB aidB frdA frdA frdB frdB frdC frdC frdD frdD yjbN yjbN hemN hemN hemG hemG wecC wecC cysG cysG yhdG yhdG ygjL ygjL yggW yggW tyrA tyrA hemF hemF yeiA yeiA yohI yohI c2464 c2464 ydiO ydiO fabI fabI pyrD pyrD sdhB sdhB sdhA sdhA sdhD sdhD sdhC sdhC entA entA caiA caiA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
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textmining
co-expression
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yafHAcyl-coenzyme A dehydrogenase; Escherichia coli K-12 ortholog: b0221; Escherichia coli O157:H7 ortholog: z0278. (840 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
aidBAidB protein; Escherichia coli K-12 ortholog: b4187; Escherichia coli O157:H7 ortholog: z5794. (547 aa)
frdAFumarate reductase flavoprotein subunit; Escherichia coli K-12 ortholog: b4154; Escherichia coli O157:H7 ortholog: z5762. (602 aa)
frdBFumarate reductase iron-sulfur protein; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa)
frdCFumarate reductase 15 kDa hydrophobic protein; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa)
frdDFumarate reductase 13 kDa hydrophobic protein; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (129 aa)
yjbNHypothetical protein yjbN; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. (331 aa)
hemNOxygen-independent coproporphyrinogen III oxidase; Escherichia coli K-12 ortholog: b3867; Escherichia coli O157:H7 ortholog: z5403; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (459 aa)
hemGProtoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX using menaquinone as electron acceptor. (181 aa)
wecCUDP-N-acetyl-D-mannosamine dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
cysGSiroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (457 aa)
yhdGHypothetical protein yhdG; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. (321 aa)
ygjL2,4-dienoyl-CoA reductase (NADPH); Escherichia coli K-12 ortholog: b3081; Escherichia coli O157:H7 ortholog: z4434. (672 aa)
yggWHypothetical protein yggW; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (378 aa)
tyrAT-protein; Escherichia coli K-12 ortholog: b2600; Escherichia coli O157:H7 ortholog: z3892; bifunctional; Chorismate mutase; Prephenate dehydrogenase. (373 aa)
hemFCoproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (300 aa)
yeiAHypothetical protein yeiA; Escherichia coli K-12 ortholog: b2147; Escherichia coli O157:H7 ortholog: z3402. (413 aa)
yohIHypothetical protein yohI; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. (338 aa)
c2464Putative acyl-coa dehydrogenase; Residues 3 to 335 of 342 are 35.02 pct identical to residues 35 to 368 of 382 from GenPept.129 : >gb|AAD40109.1|AF155831_3 (AF155831) unknown [Bacillus cereus]. (342 aa)
ydiOHypothetical protein ydiO; Escherichia coli K-12 ortholog: b1695; Escherichia coli O157:H7 ortholog: z2723; Belongs to the acyl-CoA dehydrogenase family. (401 aa)
fabIEnoyl-[acyl-carrier-protein] reductase (NADH); Escherichia coli K-12 ortholog: b1288; Escherichia coli O157:H7 ortholog: z2512. (262 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (345 aa)
sdhBSuccinate dehydrogenase iron-sulfur protein; Escherichia coli K-12 ortholog: b0724; Escherichia coli O157:H7 ortholog: z0878; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
sdhASuccinate dehydrogenase flavoprotein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (592 aa)
sdhDSuccinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhCSuccinate dehydrogenase cytochrome b-556 subunit; Escherichia coli K-12 ortholog: b0721; Escherichia coli O157:H7 ortholog: z0875. (134 aa)
entA2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Escherichia coli K-12 ortholog: b0596; Escherichia coli O157:H7 ortholog: z0738. (248 aa)
caiACrotonobetainyl-CoA dehydrogenase; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA; Belongs to the acyl-CoA dehydrogenase family. (380 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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