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yebU yebU yebH yebH cfa cfa tam tam tehB tehB ogt ogt purU purU c1555 c1555 ymdD ymdD c1271 c1271 c1203 c1203 yccW yccW ycbY ycbY smtA smtA ybjF ybjF c0941 c0941 ybiN ybiN bioC bioC ybeA ybeA c0651 c0651 yafS yafS yafE yafE accA accA panB panB yabC yabC ksgA ksgA hemK hemK lasT lasT yjjT yjjT c5424 c5424 c5373 c5373 argI argI arcB-2 arcB-2 pyrB pyrB yjfH yjfH metH metH purH purH trmA trmA ubiE ubiE metE metE hemX hemX gidB gidB spoU spoU yibK yibK yhiR yhiR yhiQ yhiQ yhhF yhhF dam dam cysG cysG sun sun fmt fmt yhdJ yhdJ prmA prmA ftsJ ftsJ yraL yraL ygjO ygjO yggH yggH yggJ yggJ gcvT gcvT ygeW ygeW thyA thyA ygdE ygdE ygcA ygcA pcm pcm hypF hypF trmD trmD yfiF yfiF yfiC yfiC glyA glyA yfhQ yfhQ yfgB yfgB purN purN yfcB yfcB yfcK yfcK accD accD yfbG yfbG ubiG ubiG ada ada dcm dcm cheR cheR yecO yecO
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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textmining
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yebUHypothetical protein yebU; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. (481 aa)
yebHRibosomal RNA large subunit methyltransferase A; Escherichia coli K-12 ortholog: b1822; Escherichia coli O157:H7 ortholog: z2866. (269 aa)
cfaCyclopropane-fatty-acyl-phospholipid synthase; Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; Belongs to the CFA/CMAS family. (382 aa)
tamTrans-aconitate 2-methyltransferase; Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate. (252 aa)
tehBTellurite resistance protein tehB; Escherichia coli K-12 ortholog: b1430; Escherichia coli O157:H7 ortholog: z2288. (197 aa)
ogtMethylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (171 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (280 aa)
c1555Putative DNA N-6-adenine-methyltransferase of bacteriophage; Escherichia coli O157:H7 ortholog: z1454. (185 aa)
ymdDGlucans biosynthesis protein mdoC; Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane. (385 aa)
c1271Hypothetical protein; Residues 1 to 80 of 98 are 48.75 pct identical to residues 19 to 92 of 520 from GenPept.129 : >emb|CAA31541.1| (X13145) hsdM protein (AA 1-520) [Escherichia coli]. (98 aa)
c1203Putative O-methyltransferase; Escherichia coli O157:H7 ortholog: z4850. (352 aa)
yccWHypothetical protein yccW; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. (396 aa)
ycbYHypothetical protein ycbY; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. (702 aa)
smtAProtein smtA; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family. (265 aa)
ybjFHypothetical RNA methyltransferase ybjF; Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily. (375 aa)
c0941DNA adenine methylase; Escherichia coli K-12 ortholog: b3387; Escherichia coli O157:H7 ortholog: z4740. (285 aa)
ybiNHypothetical protein ybiN; Specifically methylates the adenine in position 1618 of 23S rRNA. (338 aa)
bioCBiotin synthesis protein bioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (264 aa)
ybeAHypothetical protein ybeA; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (155 aa)
c0651Hypothetical protein ybcY precursor; Escherichia coli K-12 ortholog: b0562; Escherichia coli O157:H7 ortholog: z1925. (221 aa)
yafSHypothetical protein yafS; Escherichia coli K-12 ortholog: b0213; Escherichia coli O157:H7 ortholog: z0237. (246 aa)
yafEHypothetical protein yafE; Escherichia coli K-12 ortholog: b0210; Escherichia coli O157:H7 ortholog: z0233. (256 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (264 aa)
yabCS-adenosyl-methyltransferase mraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (313 aa)
ksgADimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (273 aa)
hemKProtein methyltransferase hemK; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (277 aa)
lasTHypothetical tRNA/rRNA methyltransferase lasT; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (235 aa)
yjjTRibosomal RNA small subunit methyltransferase C; Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle; Belongs to the methyltransferase superfamily. RsmC family. (343 aa)
c5424Putative restriction modification enzyme M subunit; Methylase; Escherichia coli O157:H7 ortholog: z5947. (507 aa)
c5373Hypothetical protein; Residues 2 to 668 of 670 are 43.91 pct identical to residues 3 to 634 of 636 from GenPept.129 : >gb|AAK02782.1| (AE006106) unknown [Pasteurella multocida]. (670 aa)
argIOrnithine carbamoyltransferase chain I; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (334 aa)
arcB-2Ornithine carbamoyltransferase chain I; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (343 aa)
pyrBAspartate carbamoyltransferase catalytic chain; Escherichia coli K-12 ortholog: b4245; Escherichia coli O157:H7 ortholog: z5856; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa)
yjfHHypothetical tRNA/rRNA methyltransferase yjfH; Specifically methylates the ribose of guanosine 2251 in 23S rRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily. (243 aa)
metH5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa)
purHPurine biosynthesis protein PurH; Bifunctional; Escherichia coli K-12 ortholog: b4006; Escherichia coli O157:H7 ortholog: z5583; bifunctional; Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase. (529 aa)
trmAtRNA (Uracil-5-)-methyltransferase; Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA). (366 aa)
ubiEUbiquinone/menaquinone biosynthesis methyltransferase ubiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (251 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa)
hemXPutative uroporphyrin-III C-methyltransferase; Escherichia coli K-12 ortholog: b3803; Escherichia coli O157:H7 ortholog: z5317. (405 aa)
gidBMethyltransferase gidB; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (207 aa)
spoUtRNA (Guanosine-2'-O-)-methyltransferase; Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (229 aa)
yibKHypothetical tRNA/rRNA methyltransferase yibK; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. (157 aa)
yhiRHypothetical protein yhiR; Specifically methylates the adenine in position 2030 of 23S rRNA. (297 aa)
yhiQHypothetical protein yhiQ; Specifically methylates the guanosine in position 1516 of 16S rRNA. (271 aa)
yhhFPutative methylase yhhF; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle; Belongs to the methyltransferase superfamily. RsmD family. (198 aa)
damDNA adenine methylase; Escherichia coli K-12 ortholog: b3387; Escherichia coli O157:H7 ortholog: z4740. (278 aa)
cysGSiroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (457 aa)
sunSUN protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (429 aa)
fmtMethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus. (315 aa)
yhdJHypothetical adenine-specific methylase yhdJ; Escherichia coli K-12 ortholog: b3262; Escherichia coli O157:H7 ortholog: z4622; Belongs to the N(4)/N(6)-methyltransferase family. (296 aa)
prmARibosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (293 aa)
ftsJRibosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (209 aa)
yraLHypothetical protein yraL; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (287 aa)
ygjOPutative ribosomal RNA small subunit methyltransferase D; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. (378 aa)
yggHHypothetical methyltransferase yggH; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. (239 aa)
yggJHypothetical protein yggJ; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity); Belongs to the RNA methyltransferase RsmE family. (252 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
ygeWHypothetical protein ygeW; Escherichia coli K-12 ortholog: b2870; Escherichia coli O157:H7 ortholog: z4209. (396 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily. (264 aa)
ygdEHypothetical protein ygdE; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily. (366 aa)
ygcA23S rRNA (Uracil-5-)-methyltransferase rumA; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (433 aa)
pcmProtein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (208 aa)
hypFHydrogenase maturation protein hypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (774 aa)
trmDtRNA (Guanine-N(1)-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (255 aa)
yfiFHypothetical tRNA/rRNA methyltransferase yfiF; Escherichia coli K-12 ortholog: b2581; Escherichia coli O157:H7 ortholog: z3865; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (370 aa)
yfiCHypothetical protein yfiC; Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC). (285 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa)
yfhQHypothetical tRNA/rRNA methyltransferase yfhQ; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (246 aa)
yfgBHypothetical protein yfgB; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (384 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa)
yfcBHypothetical adenine-specific methylase yfcB; Specifically methylates the 50S ribosomal protein L3 on 'Gln- 150'; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. (421 aa)
yfcKHypothetical protein yfcK; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family. (688 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (332 aa)
yfbGHypothetical protein yfbG; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (660 aa)
ubiG3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (240 aa)
adaRegulatory protein of adaptative response; Escherichia coli K-12 ortholog: b2213; Escherichia coli O157:H7 ortholog: z3471; bifunctional; Methylated-DNA--protein-cysteine methyltransferase. (354 aa)
dcmDNA-cytosine methyltransferase; Escherichia coli K-12 ortholog: b1961; Escherichia coli O157:H7 ortholog: z3054. (472 aa)
cheRChemotaxis protein methyltransferase; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (286 aa)
yecOProtein yecO; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM). (247 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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