STRINGSTRING
tdcE tdcE yhbS yhbS yhhK yhhK yiaC yiaC yiaH yiaH cysE cysE kbl kbl c4525 c4525 c4537 c4537 glmU glmU dapD dapD lpxD lpxD fabZ fabZ lpxA lpxA yafP yafP yiiD yiiD pflD pflD yjaB yjaB metA metA plsB plsB c5034 c5034 phnO phnO yjdJ yjdJ c5355 c5355 rimI rimI lacA lacA ylaD ylaD tesA tesA crcA crcA lipB lipB lnt lnt sucB sucB bioF bioF ybiW ybiW c0970 c0970 fabA fabA c1186 c1186 c1187 c1187 c1189 c1189 ymdD ymdD htrB htrB rimJ rimJ plsX plsX fabH fabH fabD fabD fabF fabF ycfT ycfT cobB cobB fadA fadA c1689 c1689 fabI fabI rimL rimL yncA yncA nhoA nhoA speG speG astA astA msbB msbB c2427 c2427 c2470 c2470 wcaF wcaF wcaB wcaB atoB atoB elaA elaA pta pta fabB fabB fadI fadI wecD wecD ddg ddg ypeA ypeA eutI eutI ypfI ypfI yfiQ yfiQ argA argA aas aas yqeF yqeF plsC plsC ygiH ygiH ygjD ygjD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tdcEKeto-acid formate acetyltransferase; Escherichia coli K-12 ortholog: b3114; Escherichia coli O157:H7 ortholog: z4466. (764 aa)
yhbSHypothetical acetyltransferase yhbS; Escherichia coli K-12 ortholog: b3156; Escherichia coli O157:H7 ortholog: z4517; Belongs to the acetyltransferase family. (167 aa)
yhhKHypothetical protein yhhK; Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion; Belongs to the PanZ/PanM family. (127 aa)
yiaCHypothetical acetyltransferase yiaC; Escherichia coli K-12 ortholog: b3550; Escherichia coli O157:H7 ortholog: z4975. (146 aa)
yiaHHypothetical protein yiaH; Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units. (331 aa)
cysESerine acetyltransferase; Escherichia coli K-12 ortholog: b3607; Escherichia coli O157:H7 ortholog: z5034; Belongs to the transferase hexapeptide repeat family. (273 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (398 aa)
c4525Putative chormophorylate of CpcA; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (228 aa)
c4537Putative conserved protein; Residues 10 to 849 of 850 are 34.39 pct identical to residues 2 to 765 of 765 from MG1655 : b3951. (850 aa)
glmUGlmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (456 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Escherichia coli K-12 ortholog: b0166; Escherichia coli O157:H7 ortholog: z0176; Belongs to the transferase hexapeptide repeat family. (274 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (341 aa)
fabZ(3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity). (182 aa)
lpxAAcyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa)
yafPHypothetical acetyltransferase yafP; Escherichia coli K-12 ortholog: b0234; Escherichia coli O157:H7 ortholog: z0295. (150 aa)
yiiDHypothetical protein yiiD; Escherichia coli K-12 ortholog: b3888; Escherichia coli O157:H7 ortholog: z5427. (329 aa)
pflDFormate acetyltransferase 2; Escherichia coli K-12 ortholog: b3951; Escherichia coli O157:H7 ortholog: z5507. (765 aa)
yjaBHypothetical acetyltransferase yjaB; Escherichia coli K-12 ortholog: b4012; Escherichia coli O157:H7 ortholog: z5598. (147 aa)
metAHomoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (309 aa)
plsBGlycerol-3-phosphate acyltransferase; Escherichia coli K-12 ortholog: b4041; Escherichia coli O157:H7 ortholog: z5640; Belongs to the GPAT/DAPAT family. (827 aa)
c5034Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; Escherichia coli K-12 ortholog: b0727; Escherichia coli O157:H7 ortholog: z0881. (351 aa)
phnOPhnO protein; Escherichia coli K-12 ortholog: b4093; Escherichia coli O157:H7 ortholog: z5696. (144 aa)
yjdJHypothetical protein yjdJ; Escherichia coli K-12 ortholog: b4127; Escherichia coli O157:H7 ortholog: z5729. (90 aa)
c5355Hypothetical protein; Residues 7 to 173 of 173 are 91.61 pct identical to residues 1 to 167 of 167 from SwissProt.40 : >sp|P39337|YJGM_ECOLI HYPOTHETICAL 18.6 KDA PROTEIN IN ARGI-VALS INTERGENIC REGION. (173 aa)
rimIRibosomal-protein-alanine acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18. (148 aa)
lacAGalactoside O-acetyltransferase; Escherichia coli K-12 ortholog: b0342; Escherichia coli O157:H7 ortholog: z0438. (220 aa)
ylaDMaltose O-acetyltransferase; Escherichia coli K-12 ortholog: b0459; Escherichia coli O157:H7 ortholog: z0571. (183 aa)
tesAAcyl-CoA thioesterase I precursor; TesA is a multifunctional esterase that can act as a thioesterase, arylesterase, lysophospholipase and protease. (218 aa)
crcACrcA protein; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. (186 aa)
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (213 aa)
lntApolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Utilizes a two-step reaction via a ping-pong mechanism. Lnt undergoes covalent modification in the presence of phospholipids, resulting in a thioester acyl-enzyme intermediate. It then transfers the acyl chain to the amine group of the N-terminal diacylglyceryl- modified cysteine of apolipoprotein, leading to the formation of mature triacylated lipoprotein; Belongs to the CN hydrolase family. Apolipoprotein N- acyltra [...] (512 aa)
sucBDihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (405 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (384 aa)
ybiWPutative formate acetyltransferase 3; Escherichia coli K-12 ortholog: b0823; Escherichia coli O157:H7 ortholog: z1045. (810 aa)
c0970Hypothetical protein; Residues 2 to 297 of 343 are 26.87 pct identical to residues 5 to 301 of 401 from GenPept.129 : >emb|CAC07472.1| (AX009415) product = eps11 [Lactobacillus helveticus]. (343 aa)
fabA3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length (By similarity). (208 aa)
c1186Putative beta-ketoacyl-ACP synthase; Escherichia coli O157:H7 ortholog: z4866; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (409 aa)
c11873-oxoacyl-[acyl-carrier protein] reductase; Escherichia coli K-12 ortholog: b1093; Escherichia coli O157:H7 ortholog: z4865. (243 aa)
c1189Putative 3-oxoacyl-[ACP] synthase; Escherichia coli O157:H7 ortholog: z4863; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (392 aa)
ymdDGlucans biosynthesis protein mdoC; Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane. (385 aa)
htrBLipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (327 aa)
rimJRibosomal-protein-alanine acetyltransferase; Escherichia coli K-12 ortholog: b1066; Escherichia coli O157:H7 ortholog: z1703; Acetylating enzyme for N-terminal of ribosomal protein S5. (194 aa)
plsXFatty acid/phospholipid synthesis protein plsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (356 aa)
fabH3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids. (317 aa)
fabDMalonyl CoA-acyl carrier protein transacylase; Escherichia coli K-12 ortholog: b1092; Escherichia coli O157:H7 ortholog: z1731; Belongs to the FabD family. (309 aa)
fabF3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis (By similarity); Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (413 aa)
ycfTHypothetical protein ycfT; Escherichia coli K-12 ortholog: b1115; Escherichia coli O157:H7 ortholog: z1756. (357 aa)
cobBCobB protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. (273 aa)
fadA3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids (By similarity). (387 aa)
c1689Hypothetical protein; Residues 176 to 347 of 347 are 80.81 pct identical to residues 4 to 175 of 175 from GenPept.129 : >emb|CAA21325.1| (AL031866) ORF3, len: 175 aa,similar to C-terminal end of XCU70053_2 Xanthomonas campestris gumO (435 aa), possible frameshift, this ORF is the prolongation of ORF 4 also similar to XCU70053_2. Fasta score: opt: 367, E(): 1.8e-17 39.5%identity in 172 aa overlap [Yersinia pestis]. (347 aa)
fabIEnoyl-[acyl-carrier-protein] reductase (NADH); Escherichia coli K-12 ortholog: b1288; Escherichia coli O157:H7 ortholog: z2512. (262 aa)
rimLRibosomal-protein-serine acetyltransferase; Escherichia coli K-12 ortholog: b1427. (184 aa)
yncAHypothetical acetyltransferase yncA; Escherichia coli K-12 ortholog: b1448; Escherichia coli O157:H7 ortholog: z2271. (193 aa)
nhoAN-hydroxyarylamine O-acetyltransferase; Escherichia coli K-12 ortholog: b1463; Escherichia coli O157:H7 ortholog: z2250; Belongs to the arylamine N-acetyltransferase family. (281 aa)
speGSpermidine N(1)-acetyltransferase; Escherichia coli K-12 ortholog: b1584; Escherichia coli O157:H7 ortholog: z2571. (186 aa)
astAArginine N-succinyltransferase; Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. (315 aa)
msbBLipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (323 aa)
c2427Putative peptide/polyketide synthetase protein; Similar to the N-terminus of the synthetase for the yersiniabactin siderophore [Yersinia enterocolitica]; Residues 5 to 721 of 731 are 99.72 pct identical to residues 1 to 717 of 3163 from GenPept.129 : >emb|CAC90726.1| (AJ414150) yersiniabactin biosynthetic protein [Yersinia pestis]. (731 aa)
c2470Putative peptide/polyketide synthase; Residues 527 to 1874 of 1875 are 32.28 pct identical to residues 47 to 1483 of 2632 from GenPept.129 : >dbj|BAB12213.1| (AB032549) peptide synthetase and polyketide synthase [Microcystis aeruginosa]. (1875 aa)
wcaFPutative colanic acid biosynthesis acetyltransferase wcaF; Escherichia coli K-12 ortholog: b2054; Escherichia coli O157:H7 ortholog: z3218. (182 aa)
wcaBPutative colanic acid biosynthesis acetyltransferase wcaB; Escherichia coli K-12 ortholog: b2058; Escherichia coli O157:H7 ortholog: z3222; Belongs to the transferase hexapeptide repeat family. (162 aa)
atoBAcetyl-CoA acetyltransferase; Escherichia coli K-12 ortholog: b2224; Escherichia coli O157:H7 ortholog: z4164; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
elaAProtein elaA; Escherichia coli K-12 ortholog: b2267; Escherichia coli O157:H7 ortholog: z3527. (153 aa)
ptaPhosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa)
fabB3-oxoacyl-[acyl-carrier-protein] synthase I; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids (By similarity). (406 aa)
fadIProbable 3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (436 aa)
wecDLipopolysaccharide biosynthesis protein rffC; Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino- 4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA). Belongs to the WecD family. (224 aa)
ddgDDG protein; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (328 aa)
ypeAHypothetical protein ypeA; Escherichia coli K-12 ortholog: b2434; Escherichia coli O157:H7 ortholog: z3699; Belongs to the acetyltransferase family. YpeA subfamily. (178 aa)
eutIEthanolamine utilization protein eutD; Escherichia coli K-12 ortholog: b2458; Escherichia coli O157:H7 ortholog: z3714. (338 aa)
ypfIHypothetical protein ypfI; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (671 aa)
yfiQHypothetical protein yfiQ; Escherichia coli K-12 ortholog: b2584; Escherichia coli O157:H7 ortholog: z3869. (886 aa)
argAAmino-acid acetyltransferase; Escherichia coli K-12 ortholog: b2818; Escherichia coli O157:H7 ortholog: z4135; Belongs to the acetyltransferase family. ArgA subfamily. (465 aa)
aasAAS bifunctional protein; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1. (719 aa)
yqeFProbable acetyl-CoA acetyltransferase; Escherichia coli K-12 ortholog: b2844; Escherichia coli O157:H7 ortholog: z4164; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
plsC1-acyl-sn-glycerol-3-phosphate acyltransferase; Escherichia coli K-12 ortholog: b3018; Escherichia coli O157:H7 ortholog: z4372; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (245 aa)
ygiHHypothetical protein ygiH; Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl- PO(4); Belongs to the PlsY family. (205 aa)
ygjDProbable O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (337 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.