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| | slt | Soluble lytic murein transglycosylase precursor; Escherichia coli K-12 ortholog: b4392; Escherichia coli O157:H7 ortholog: z5994. (645 aa) |
| | thrC | Threonine synthase; Escherichia coli K-12 ortholog: b0004; Escherichia coli O157:H7 ortholog: z0004. (428 aa) |
| | caiD | Carnitinyl-CoA dehydratase; Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA. (297 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa) |
| | acnB | Aconitate hydratase 2; Escherichia coli K-12 ortholog: b0118; Escherichia coli O157:H7 ortholog: z0128. (916 aa) |
| | speD | S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. (264 aa) |
| | yadF | Protein yadF; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (220 aa) |
| | panD | Aspartate 1-decarboxylase precursor; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | fabZ | (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity). (182 aa) |
| | ldcC | Lysine decarboxylase, constitutive; Escherichia coli K-12 ortholog: b0186; Escherichia coli O157:H7 ortholog: z0198. (713 aa) |
| | dniR | Membrane-bound lytic murein transglycosylase D precursor; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity); Belongs to the transglycosylase Slt family. (452 aa) |
| | c0319 | Putative oligogalacturonide lyase; Residues 1 to 386 of 390 are 65.02 pct identical to residues 1 to 386 of 388 from SwissProt.40 : >sp|Q59418|OGL_ERWCA OLIGOGALACTURONIDE LYASE. (390 aa) |
| | c0323 | Putative exopolygalacturonate lyase; Residues 21 to 729 of 768 are 40.62 pct identical to residues 8 to 686 of 732 from GenPept.129 : >gb|AAL51034.1|AF454849_1 (AF454849) pectate lyase [Klebsiella oxytoca]. (768 aa) |
| | prpB | Probable methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (296 aa) |
| | prpD | 2-methylcitrate dehydratase; Escherichia coli K-12 ortholog: b0334; Escherichia coli O157:H7 ortholog: z0429. (483 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase; Escherichia coli K-12 ortholog: b0369; Escherichia coli O157:H7 ortholog: z0468; Belongs to the ALAD family. (335 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. (320 aa) |
| | ybaK | Protein ybaK; Escherichia coli K-12 ortholog: b0481; Escherichia coli O157:H7 ortholog: z0600; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (159 aa) |
| | ybbT | Ureidoglycolate hydrolase; Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate. (160 aa) |
| | gcl | Glyoxylate carboligase; Escherichia coli K-12 ortholog: b0507; Escherichia coli O157:H7 ortholog: z0661; Belongs to the TPP enzyme family. (623 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (355 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (178 aa) |
| | rna | Ribonuclease I precursor; Escherichia coli K-12 ortholog: b0611; Escherichia coli O157:H7 ortholog: z0755; Belongs to the RNase T2 family. (274 aa) |
| | citF | Citrate lyase alpha chain; Escherichia coli K-12 ortholog: b0615; Escherichia coli O157:H7 ortholog: z0759. (510 aa) |
| | citE | Citrate lyase beta chain; Represents a citryl-ACP lyase; Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily. (307 aa) |
| | citC | [Citrate [pro-3S]-lyase] ligase; Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase. (335 aa) |
| | rlpA | Rare lipoprotein A precursor; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (362 aa) |
| | c0761 | Putative dihydrodipicolinate synthase; Residues 11 to 294 of 295 are 43.50 pct identical to residues 8 to 292 of 297 from GenPept.129 : >gb|AAL45759.1| (AE008931) dihydrodipicolinate synthase [Agrobacterium tumefaciens str. C58 (U. Washington)]; Belongs to the DapA family. (295 aa) |
| | speF | Ornithine decarboxylase, inducible; Escherichia coli K-12 ortholog: b0693; Escherichia coli O157:H7 ortholog: z0839. (735 aa) |
| | phrB | Deoxyribodipyrimidine photolyase; Escherichia coli K-12 ortholog: b0708; Escherichia coli O157:H7 ortholog: z0859; Belongs to the DNA photolyase family. (472 aa) |
| | nei | Endonuclease VIII; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (263 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (356 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (161 aa) |
| | c0909 | Putative pyruvate formate-lyase 3 activating enzyme; Escherichia coli K-12 ortholog: b0824; Escherichia coli O157:H7 ortholog: z1047. (308 aa) |
| | mipB | Fructose-6-phosphate aldolase 1; Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction; Belongs to the transaldolase family. Type 3A subfamily. (244 aa) |
| | ybjU | Low-specificity L-threonine aldolase; Escherichia coli K-12 ortholog: b0870; Escherichia coli O157:H7 ortholog: z1104. (333 aa) |
| | fabA | 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length (By similarity). (208 aa) |
| | mgsA | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (155 aa) |
| | ycdB | Hypothetical protein ycdB precursor; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact (By similarity); Belongs to the DyP-type peroxidase family. EfeB subfamily. (423 aa) |
| | pabC | 4-amino-4-deoxychorismate lyase; Escherichia coli K-12 ortholog: b1096; Escherichia coli O157:H7 ortholog: z1735. (260 aa) |
| | yceG | Hypothetical protein yceG; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (269 aa) |
| | purB | Adenylosuccinate lyase; Escherichia coli K-12 ortholog: b1131; Escherichia coli O157:H7 ortholog: z1860. (456 aa) |
| | mltE | Membrane-bound lytic murein transglycosylase E; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain. (241 aa) |
| | chaC | Cation transport protein chaC; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (243 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa) |
| | trpD | Anthranilate synthase component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (531 aa) |
| | trpE | Anthranilate synthase component I; Escherichia coli K-12 ortholog: b1264; Escherichia coli O157:H7 ortholog: z2546. (520 aa) |
| | acnA | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (295 aa) |
| | sfcA | NAD-dependent malic enzyme; Escherichia coli K-12 ortholog: b1479; Escherichia coli O157:H7 ortholog: z2231; Belongs to the malic enzymes family. (574 aa) |
| | gadB | Glutamate decarboxylase beta; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). (489 aa) |
| | rspA | Starvation sensing protein rspA; Has low D-mannonate dehydratase activity (in vitro), suggesting that this is not a physiological substrate and that it has no significant role in D-mannonate degradation in vivo. Has no detectable activity with a panel of 70 other acid sugars (in vitro). Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily. (415 aa) |
| | fumC | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa) |
| | fumA | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80% of the fumarase activity when the bacteria grow aerobically. To a lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso-tartrate. Can also catalyze the isomerization of enol- to keto-oxaloacetate. (548 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa) |
| | gloA | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (135 aa) |
| | ydhZ | Hypothetical protein ydhZ; In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as substrate; Belongs to the FumD family. (69 aa) |
| | sufS | Selenocysteine lyase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (252 aa) |
| | ydjI | Hypothetical protein ydjI; Escherichia coli K-12 ortholog: b1773; Escherichia coli O157:H7 ortholog: z2811. (278 aa) |
| | pabB | Para-aminobenzoate synthase component I; Escherichia coli K-12 ortholog: b1812; Escherichia coli O157:H7 ortholog: z2855. (453 aa) |
| | sdaA | L-serine dehydratase 1; Escherichia coli K-12 ortholog: b1814; Escherichia coli O157:H7 ortholog: z2857; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa) |
| | eda | KHG/KDPG aldolase; Escherichia coli K-12 ortholog: b1850; Escherichia coli O157:H7 ortholog: z2902; bifunctional; 4-hydroxy-2-oxoglutarate aldolase; 2-dehydro-3-deoxyphosphogluconate aldolase. (213 aa) |
| | edd | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (625 aa) |
| | yedO | Putative 1-aminocyclopropane-1-carboxylate deaminase; Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine; Belongs to the ACC deaminase/D-cysteine desulfhydrase family. (328 aa) |
| | yedU | Protein yedU; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing th [...] (283 aa) |
| | c2419 | Putative anthranilate synthase; Similar to YbtS [Yersinia pestis] and Irp9 [Yersinia enterocolitica]; Residues 1 to 434 of 434 are 99.76 pct identical to residues 1 to 434 of 434 from GenPept.129 : >emb|CAC90732.1| (AJ414150) putative salicylate synthetase [Yersinia pestis]. (434 aa) |
| | hisB | Histidine biosynthesis bifunctional protein hisB; Escherichia coli K-12 ortholog: b2022; Escherichia coli O157:H7 ortholog: z3184; bifunctional; Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (356 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). (196 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa) |
| | gmd | GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. (373 aa) |
| | gatY | Tagatose-bisphosphate aldolase gatY; Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires GatZ subunit for full activity and stability. Is involved in the catabolism of galactitol. (286 aa) |
| | fbaB | Fructose-bisphosphate aldolase class I; Escherichia coli K-12 ortholog: b2097; Escherichia coli O157:H7 ortholog: z3260. (374 aa) |
| | yfaU | Hypothetical protein yfaU; Catalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily. (267 aa) |
| | yfaW | Hypothetical protein yfaW; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). (405 aa) |
| | yfbG | Hypothetical protein yfbG; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (660 aa) |
| | menC | O-succinylbenzoate-CoA synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (320 aa) |
| | menB | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). (285 aa) |
| | yfbB | Hypothetical protein yfbB; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). (252 aa) |
| | folX | D-erythro-7,8-dihydroneopterin triphosphate epimerase; Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis. (120 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (189 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (362 aa) |
| | fadJ | Putative fatty oxidation complex alpha subunit; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (714 aa) |
| | dsdA | D-serine dehydratase; Escherichia coli K-12 ortholog: b2366; Escherichia coli O157:H7 ortholog: z3628. (442 aa) |
| | c2909 | Probable oxalyl-CoA decarboxylase; Escherichia coli K-12 ortholog: b2373; Escherichia coli O157:H7 ortholog: z3637; Belongs to the TPP enzyme family. (564 aa) |
| | cysK | Cysteine synthase A; Escherichia coli K-12 ortholog: b2414; Escherichia coli O157:H7 ortholog: z3680; Belongs to the cysteine synthase/cystathionine beta- synthase family. (327 aa) |
| | cysM | Cysteine synthase B; Escherichia coli K-12 ortholog: b2421; Escherichia coli O157:H7 ortholog: z3686; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa) |
| | yfeU | Protein yfeU; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (298 aa) |
| | eutC | Ethanolamine ammonia-lyase light chain; Escherichia coli K-12 ortholog: b2440; Escherichia coli O157:H7 ortholog: z3705; Belongs to the EutC family. (295 aa) |
| | eutB | Ethanolamine ammonia-lyase heavy chain; Escherichia coli K-12 ortholog: b2441; Escherichia coli O157:H7 ortholog: z3706. (453 aa) |
| | c2988 | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. (759 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa) |
| | yfhD | Hypothetical protein yfhD; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family. (518 aa) |
| | pheA | P-protein; Escherichia coli K-12 ortholog: b2599; Escherichia coli O157:H7 ortholog: z3891; bifunctional; Chorismate mutase; Prephenate dehydratase. (386 aa) |
| | ygaG | Autoinducer-2 production protein luxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa) |
| | hycH | Formate hydrogenlyase maturation protein hycH; Escherichia coli K-12 ortholog: b2718; Escherichia coli O157:H7 ortholog: z4026. (136 aa) |
| | hycG | FHL subunit 7; Escherichia coli K-12 ortholog: b2719; Escherichia coli O157:H7 ortholog: z4027. (255 aa) |
| | hycF | FHL subunit 6; Escherichia coli K-12 ortholog: b2720; Escherichia coli O157:H7 ortholog: z4028. (180 aa) |
| | hycE | Formate hydrogenlyase subunit 5 precursor; FHL subunit 5; Escherichia coli K-12 ortholog: b2721; Escherichia coli O157:H7 ortholog: z4029. (569 aa) |
| | hycD | FHL subunit 4; Escherichia coli K-12 ortholog: b2722; Escherichia coli O157:H7 ortholog: z4030. (307 aa) |
| | hycC | FHL subunit 3; Escherichia coli K-12 ortholog: b2723; Escherichia coli O157:H7 ortholog: z4031. (608 aa) |
| | hycA | Formate hydrogenlyase Regulatory protein hycA; Escherichia coli K-12 ortholog: b2725; Escherichia coli O157:H7 ortholog: z4033. (153 aa) |
| | fhlA | Formate hydrogenlyase transcriptional activator; Escherichia coli K-12 ortholog: b2731; Escherichia coli O157:H7 ortholog: z4040. (704 aa) |
| | ygbL | Hypothetical aldolase class II protein ygbL; Catalyzes the decarboxylation of 3-oxo-tetronate 4-phosphate to dihydroxyacetone phosphate (DHAP) and CO(2). Belongs to the aldolase class II family. AraD/FucA subfamily. (212 aa) |
| | ygbB | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (159 aa) |
| | ygcM | Putative 6-pyruvoyl tetrahydrobiopterin synthase; Escherichia coli K-12 ortholog: b2765; Escherichia coli O157:H7 ortholog: z4075. (149 aa) |
| | ygcF | Hypothetical protein ygcF; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa) |
| | ygcX | Glucarate dehydratase; Escherichia coli K-12 ortholog: b2787; Escherichia coli O157:H7 ortholog: z4102; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (375 aa) |
| | ygcY | Glucarate dehydratase related protein; Escherichia coli K-12 ortholog: b2788; Escherichia coli O157:H7 ortholog: z4103. (446 aa) |
| | sdaB | L-serine dehydratase 2; Escherichia coli K-12 ortholog: b2797; Escherichia coli O157:H7 ortholog: z4114; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa) |
| | fucA | L-fuculose phosphate aldolase; Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. (215 aa) |
| | c3381 | Cysteine sulfinate desulfinase; Escherichia coli K-12 ortholog: b2810; Escherichia coli O157:H7 ortholog: z4127. (413 aa) |
| | mltA | Membrane-bound lytic murein transglycosylase A precursor; Escherichia coli K-12 ortholog: b2813; Escherichia coli O157:H7 ortholog: z4130. (477 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | ygeX | Putative diaminopropionate ammonia-lyase; Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate (DAP) to form pyruvate and ammonia. The D-isomer of serine is degraded to pyruvate, though very poorly; other amino acids (L-serine, D- and L-threonine, D- and L-beta-Cl-alanine) are not substrates. (398 aa) |
| | fba | Fructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (387 aa) |
| | speA | Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (662 aa) |
| | mltC | Membrane-bound lytic murein transglycosylase C precursor; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (360 aa) |
| | speC | Ornithine decarboxylase, constitutive; Escherichia coli K-12 ortholog: b2965; Escherichia coli O157:H7 ortholog: z4310. (711 aa) |
| | nanA2 | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. (305 aa) |
| | metC | Cystathionine beta-lyase; Escherichia coli K-12 ortholog: b3008; Escherichia coli O157:H7 ortholog: z4361. (440 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (217 aa) |
| | ygiG | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin at appreciable velocity. (123 aa) |
| | ttdA | L(+)-tartrate dehydratase alpha subunit; Escherichia coli K-12 ortholog: b3061; Escherichia coli O157:H7 ortholog: z4414; Belongs to the class-I fumarase family. (303 aa) |
| | ttdB | L(+)-tartrate dehydratase beta subunit; Escherichia coli K-12 ortholog: b3062; Escherichia coli O157:H7 ortholog: z4415. (201 aa) |
| | uxaA | Altronate hydrolase; Escherichia coli K-12 ortholog: b3091; Escherichia coli O157:H7 ortholog: z4444. (495 aa) |
| | c3870 | L-serine dehydratase 1; Escherichia coli K-12 ortholog: b1814; Escherichia coli O157:H7 ortholog: z4464; Belongs to the iron-sulfur dependent L-serine dehydratase family. (456 aa) |
| | tdcB | Threonine dehydratase catabolic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. TdcB also dehydrates serine to y [...] (329 aa) |
| | yhaF | 2-dehydro-3-deoxyglucarate aldolase; Catalyzes the reversible retro-aldol cleavage of both 5-keto- 4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde; Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily. (256 aa) |
| | yhaG | D-galactarate dehydratase; Catalyzes the dehydration of galactarate to form 5-dehydro-4- deoxy-D-glucarate. (523 aa) |
| | agaY | Tagatose-bisphosphate aldolase agaY; Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires KbaZ subunit for full activity and stability. (286 aa) |
| | yhbL | Enhancing lycopene biosynthesis protein 2; Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate; Belongs to the peptidase C56 family. (217 aa) |
| | nanA | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. (297 aa) |
| | c4018 | Tagatose-bisphosphate aldolase gatY; Escherichia coli K-12 ortholog: b2096; Escherichia coli O157:H7 ortholog: z3259. (284 aa) |
| | pabA | Para-aminobenzoate synthase glutamine amidotransferase component II; Escherichia coli K-12 ortholog: b3360; Escherichia coli O157:H7 ortholog: z4721. (187 aa) |
| | cysG | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (457 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (362 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (563 aa) |
| | c4284 | Putative aldolase; Escherichia coli O157:H7 ortholog: z4881. (283 aa) |
| | gadA | Glutamate decarboxylase alpha; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). (487 aa) |
| | sgbH | Probable hexulose-6-phosphate synthase; Escherichia coli K-12 ortholog: b3581; Escherichia coli O157:H7 ortholog: z5805. (220 aa) |
| | mutM | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (269 aa) |
| | dfp | DNA/pantothenate metabolism flavoprotein; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (430 aa) |
| | c4483 | Putative aldolase; Escherichia coli O157:H7 ortholog: z5687. (286 aa) |
| | c4484 | Putative aldolase; Residues 1 to 283 of 283 are 39.78 pct identical to residues 1 to 283 of 284 from GenPept.129 : >emb|CAD00212.1| (AL591982) similar to fructose-1,6-biphosphate aldolase type II [Listeria monocytogenes]. (283 aa) |
| | c4501 | Putative conserved protein; Residues 7 to 750 of 789 are 38.82 pct identical to residues 4 to 744 of 756 from MG1655 : b4117. (789 aa) |
| | c4538 | Putative pyruvate formate-lyase 3 activating enzyme; Escherichia coli K-12 ortholog: b0824; Escherichia coli O157:H7 ortholog: z1047. (305 aa) |
| | tnaA | Tryptophanase; Escherichia coli K-12 ortholog: b3708; Escherichia coli O157:H7 ortholog: z5203; Belongs to the beta-eliminating lyase family. (476 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Escherichia coli K-12 ortholog: b3771; Escherichia coli O157:H7 ortholog: z5282. (616 aa) |
| | ilvA | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (515 aa) |
| | rffG | dTDP-glucose 4,6-dehydratase; Escherichia coli K-12 ortholog: b3788; Escherichia coli O157:H7 ortholog: z5299; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (355 aa) |
| | hemD | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (246 aa) |
| | cyaA | Adenylate cyclase; Escherichia coli K-12 ortholog: b3806; Escherichia coli O157:H7 ortholog: z5322; Belongs to the adenylyl cyclase class-1 family. (848 aa) |
| | c4777 | Putative conserved protein; Residues 9 to 203 of 209 are 41.08 pct identical to residues 6 to 200 of 587 from MG1655 : b3692. (209 aa) |
| | yigC | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (497 aa) |
| | fadB | Fatty oxidation complex alpha subunit; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (771 aa) |
| | yihT | Hypothetical protein yihT; Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA). Belongs to the aldolase LacD family. (295 aa) |
| | rhaD | Rhamnulose-1-phosphate aldolase; Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. Belongs to the aldolase class II family. RhaD subfamily. (305 aa) |
| | talC | Fructose-6-phosphate aldolase 2; Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction; Belongs to the transaldolase family. Type 3A subfamily. (220 aa) |
| | pflC | Pyruvate formate-lyase 2 activating enzyme; Escherichia coli K-12 ortholog: b3952; Escherichia coli O157:H7 ortholog: z5508. (292 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (883 aa) |
| | argH | Argininosuccinate lyase; Escherichia coli K-12 ortholog: b3960; Escherichia coli O157:H7 ortholog: z5518. (457 aa) |
| | thiC | Thiamine biosynthesis protein thiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (635 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa) |
| | aceA | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. (439 aa) |
| | ubiC | Chorismate--pyruvate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway. (165 aa) |
| | c5023 | Putative crotonase; Residues 14 to 256 of 259 are 43.20 pct identical to residues 13 to 254 of 256 from GenPept.129 : >gb|AAK65427.1| (AE007264) Putative dehydratase [Sinorhizobium meliloti]. (259 aa) |
| | phnJ | PhnJ protein; Catalyzes the breakage of the C-P bond in alpha-D-ribose 1- methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose. Belongs to the PhnJ family. (309 aa) |
| | adiA | Biodegradative arginine decarboxylase; Escherichia coli K-12 ortholog: b4117; Escherichia coli O157:H7 ortholog: z5719. (756 aa) |
| | fumB | Fumarate hydratase class I, anaerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (548 aa) |
| | cadA | Lysine decarboxylase, inducible; Escherichia coli K-12 ortholog: b4131; Escherichia coli O157:H7 ortholog: z5734. (717 aa) |
| | aspA | Aspartate ammonia-lyase; Escherichia coli K-12 ortholog: b4139; Escherichia coli O157:H7 ortholog: z5744; Belongs to the class-II fumarase/aspartase family. Aspartase subfamily. (493 aa) |
| | psd | Phosphatidylserine decarboxylase proenzyme; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (322 aa) |
| | yjeF | Hypothetical protein yjeF; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of bot [...] (522 aa) |
| | sgaH | Probable hexulose-6-phosphate synthase; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization. Belongs to the HPS/KGPDC family. KGPDC subfamily. (229 aa) |
| | uxuA | Mannonate dehydratase; Catalyzes the dehydration of D-mannonate; Belongs to the mannonate dehydratase family. (394 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (267 aa) |
