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uvrA uvrA clpX clpX lon lon htpG htpG ybaR ybaR kdpB kdpB uvrB uvrB rhlE rhlE dinG dinG clpA clpA ycaJ ycaJ uup uup helD helD c1445 c1445 c1569 c1569 minD minD ychF ychF dbpA dbpA btuD btuD ruvB ruvB ruvA ruvA fliI fliI mrp mrp yehL yehL hscA hscA srmB srmB clpB clpB c3173 c3173 c3392 c3392 recB recB deaD deaD yhcM yhcM zntA zntA recG recG yieN yieN rep rep rhlB rhlB uvrD uvrD recQ recQ hslU hslU dnaB dnaB mutL mutL mgtA mgtA yjjK yjjK
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (940 aa)
clpXATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (424 aa)
lonATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, and UmuD. Its overproduction spec [...] (799 aa)
htpGChaperone protein htpG; Molecular chaperone. Has ATPase activity. (624 aa)
ybaRCopper-transporting P-type ATPase; Escherichia coli K-12 ortholog: b0484; Escherichia coli O157:H7 ortholog: z0604. (834 aa)
kdpBPotassium-transporting ATPase B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (682 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (673 aa)
rhlEPutative ATP-dependent RNA helicase rhlE; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. (453 aa)
dinGProbable ATP-dependent helicase dinG; DNA-dependent ATPase and 5'-3' DNA helicase. (716 aa)
clpAATP-dependent clp protease ATP-binding subunit clpA; ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific substrates. It has unfoldase activity. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins (By similarity). Belongs to the ClpA/ClpB family. (763 aa)
ycaJHypothetical protein ycaJ; DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. (447 aa)
uupABC transporter ATP-binding protein uup; Escherichia coli K-12 ortholog: b0949; Escherichia coli O157:H7 ortholog: z1299. (635 aa)
helDHelicase IV; Escherichia coli K-12 ortholog: b0962; Escherichia coli O157:H7 ortholog: z1313. (715 aa)
c1445Putative DNA packaging protein of prophage; Escherichia coli O157:H7 ortholog: z2364. (642 aa)
c1569Putative DNA packaging protein of prophage; Escherichia coli O157:H7 ortholog: z2364. (650 aa)
minDSeptum site-determining protein minD; ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings (By similarity). (270 aa)
ychFProbable GTP-binding protein ychF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (363 aa)
dbpAATP-independent RNA helicase dbpA; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes. (457 aa)
btuDVitamin B12 transport ATP-binding protein btuD; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system. (249 aa)
ruvBHolliday junction DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (336 aa)
ruvAHolliday junction DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa)
fliIFlagellum-specific ATP synthase; Escherichia coli K-12 ortholog: b1941; Escherichia coli O157:H7 ortholog: z3031. (457 aa)
mrpMrp protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (379 aa)
yehLHypothetical protein yehL; Escherichia coli K-12 ortholog: b2119; Escherichia coli O157:H7 ortholog: z3291. (384 aa)
hscAChaperone protein hscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. (634 aa)
srmBATP-dependent RNA helicase srmB; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity; Belongs to the DEAD box helicase family. SrmB subfamily. (444 aa)
clpBClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB family. (861 aa)
c3173Putative DNA packaging protein of prophage; Escherichia coli O157:H7 ortholog: z1883. (641 aa)
c3392Heat shock protein F84.1; Escherichia coli K-12 ortholog: b2592; Escherichia coli O157:H7 ortholog: z0254; Belongs to the ClpA/ClpB family. (878 aa)
recBExodeoxyribonuclease V beta chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repai [...] (1183 aa)
deaDCold-shock DEAD-box protein A; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (651 aa)
yhcMHypothetical protein yhcM; Reduces the stability of FtsZ polymers in the presence of ATP. (375 aa)
zntALead, cadmium, zinc and mercury transporting ATPase; Escherichia coli K-12 ortholog: b3469; Escherichia coli O157:H7 ortholog: z4843. (732 aa)
recGATP-dependent DNA helicase recG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (704 aa)
yieNHypothetical protein yieN; Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone; Belongs to the RavA family. (506 aa)
repATP-dependent DNA helicase rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (673 aa)
rhlBPutative ATP-dependent RNA helicase rhlB; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (421 aa)
uvrDDNA helicase II; Escherichia coli K-12 ortholog: b3813; Escherichia coli O157:H7 ortholog: z5330. (738 aa)
recQATP-dependent DNA helicase recQ; Escherichia coli K-12 ortholog: b3822; Escherichia coli O157:H7 ortholog: z5343. (611 aa)
hslUATP-dependent hsl protease ATP-binding subunit hslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (443 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. (483 aa)
mutLDNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (616 aa)
mgtAMg(2+) transport ATPase, P-type 1; Escherichia coli K-12 ortholog: b4242; Escherichia coli O157:H7 ortholog: z5853. (898 aa)
yjjKABC transporter ATP-binding protein yjjK; A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase. (555 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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