STRINGSTRING
ydhV ydhV ydiQ ydiQ ydiR ydiR yecK yecK yedZ yedZ dld dld napA napA nuoN nuoN nuoM nuoM nuoL nuoL nuoK nuoK nuoJ nuoJ nuoG nuoG nuoF nuoF nuoC nuoC nuoB nuoB nuoA nuoA fdx fdx hycG hycG hycE hycE hycC hycC c3304 c3304 ygcQ ygcQ ygcR ygcR fldB fldB c3566 c3566 hybC hybC yhjA yhjA hemG hemG fdoI fdoI dsbD dsbD fdoG fdoG frdB frdB frdA frdA fdnG fdnG cybC cybC fixA fixA cyoD cyoD cyoC cyoC cyoB cyoB cyoA cyoA fldA fldA sdhC sdhC sdhA sdhA sdhB sdhB cydA cydA grxA grxA dmsC dmsC hyaB hyaB hyaC hyaC appC appC torC torC c1323 c1323 dsbB dsbB ydbK ydbK acpD acpD cybB cybB fdnI fdnI ynfH ynfH rsxA rsxA rsxB rsxB rsxC rsxC ydgO ydgO rsxG rsxG ydgQ ydgQ ydhU ydhU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ydhVHypothetical protein ydhV; Escherichia coli K-12 ortholog: b1673; Escherichia coli O157:H7 ortholog: z2701. (728 aa)
ydiQPutative electron transfer flavoprotein subunit ydiQ; Escherichia coli K-12 ortholog: b1697; Escherichia coli O157:H7 ortholog: z2726. (261 aa)
ydiRPutative electron transfer flavoprotein subunit ydiR; Escherichia coli K-12 ortholog: b1698; Escherichia coli O157:H7 ortholog: z2727. (312 aa)
yecKCytochrome c-type protein torY; Escherichia coli K-12 ortholog: b1873; Escherichia coli O157:H7 ortholog: z2926; Belongs to the TorC/TorY family. (366 aa)
yedZHypothetical protein yedZ; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. MsrQ prov [...] (211 aa)
dldD-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (582 aa)
napAPeriplasmic nitrate reductase precursor; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa)
nuoNNADH dehydrogenase I chain N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (485 aa)
nuoMNADH dehydrogenase I chain M; Escherichia coli K-12 ortholog: b2277; Escherichia coli O157:H7 ortholog: z3536. (509 aa)
nuoLNADH dehydrogenase I chain L; Escherichia coli K-12 ortholog: b2278; Escherichia coli O157:H7 ortholog: z3537. (613 aa)
nuoKNADH dehydrogenase I chain K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (100 aa)
nuoJNADH dehydrogenase I chain J; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity); Belongs to the complex I subunit 6 family. (184 aa)
nuoGNADH dehydrogenase I chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity). (910 aa)
nuoFNADH dehydrogenase I chain F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (445 aa)
nuoCNADH dehydrogenase I chain C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family. (600 aa)
nuoBNADH dehydrogenase I chain B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (220 aa)
nuoANADH dehydrogenase I chain A; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (147 aa)
fdxFerredoxin, 2Fe-2S; Escherichia coli K-12 ortholog: b2525; Escherichia coli O157:H7 ortholog: z3792. (111 aa)
hycGFHL subunit 7; Escherichia coli K-12 ortholog: b2719; Escherichia coli O157:H7 ortholog: z4027. (255 aa)
hycEFormate hydrogenlyase subunit 5 precursor; FHL subunit 5; Escherichia coli K-12 ortholog: b2721; Escherichia coli O157:H7 ortholog: z4029. (569 aa)
hycCFHL subunit 3; Escherichia coli K-12 ortholog: b2723; Escherichia coli O157:H7 ortholog: z4031. (608 aa)
c3304Hypothetical protein; Residues 1 to 183 of 183 are 100.00 pct identical to residues 1 to 183 of 183 from GenPept.129 : >gb|AAG27178.1|AF270497_3 (AF270497) unknown [Escherichia coli]. (183 aa)
ygcQPutative electron transfer flavoprotein subunit ygcQ; Escherichia coli K-12 ortholog: b2769; Escherichia coli O157:H7 ortholog: z4080. (297 aa)
ygcRPutative electron transfer flavoprotein subunit ygcR; Escherichia coli K-12 ortholog: b2770; Escherichia coli O157:H7 ortholog: z4081. (260 aa)
fldBFlavodoxin 2; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. (173 aa)
c3566Hypothetical protein; Residues 5 to 128 of 131 are 50.00 pct identical to residues 18 to 141 of 212 from GenPept.129 : >emb|CAD14149.1| (AL646060) PUTATIVE TRANSMEMBRANE HYDROGENASE CYTOCHROME B-TYPE SUBUNIT OXIDOREDUCTASE PROTEIN [Ralstonia solanacearum]. (131 aa)
hybCHydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa)
yhjAProbable cytochrome C peroxidase; Escherichia coli K-12 ortholog: b3518; Escherichia coli O157:H7 ortholog: z4931. (465 aa)
hemGProtoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX using menaquinone as electron acceptor. (181 aa)
fdoIFormate dehydrogenase; Allows to use formate as major electron donor during aerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the formate dehydrogenase (By similarity). (211 aa)
dsbDThiol:disulfide interchange protein dsbD precursor; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. (565 aa)
fdoGFormate dehydrogenase-O, major subunit; Escherichia coli K-12 ortholog: b3894; Escherichia coli O157:H7 ortholog: z5436. (1016 aa)
frdBFumarate reductase iron-sulfur protein; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa)
frdAFumarate reductase flavoprotein subunit; Escherichia coli K-12 ortholog: b4154; Escherichia coli O157:H7 ortholog: z5762. (602 aa)
fdnGFormate dehydrogenase, nitrate-inducible, major subunit; Escherichia coli K-12 ortholog: b1474; Escherichia coli O157:H7 ortholog: z2236. (1015 aa)
cybCSoluble cytochrome b562 precursor; Electron-transport protein of unknown function. Belongs to the cytochrome b562 family. (128 aa)
fixAFixA protein; Required for anaerobic carnitine reduction. May bring reductant to CaiA. (277 aa)
cyoDUbiquinol oxidase chain D; Escherichia coli K-12 ortholog: b0429; Escherichia coli O157:H7 ortholog: z0532. (109 aa)
cyoCCytochrome O ubiquinol oxidase subunit III; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity). (204 aa)
cyoBUbiquinol oxidase polypeptide I; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity). (663 aa)
cyoAUbiquinol oxidase polypeptide II precursor; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity). (315 aa)
fldAFlavodoxin 1; Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase (By similarity); Belongs to the flavodoxin family. (215 aa)
sdhCSuccinate dehydrogenase cytochrome b-556 subunit; Escherichia coli K-12 ortholog: b0721; Escherichia coli O157:H7 ortholog: z0875. (134 aa)
sdhASuccinate dehydrogenase flavoprotein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (592 aa)
sdhBSuccinate dehydrogenase iron-sulfur protein; Escherichia coli K-12 ortholog: b0724; Escherichia coli O157:H7 ortholog: z0878; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
cydACytochrome D ubiquinol oxidase subunit I; A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton/electron. Belongs to the cytochrome ubiquinol oxidase subunit 1 family. (523 aa)
grxAGrx1; Escherichia coli K-12 ortholog: b0849; Escherichia coli O157:H7 ortholog: z1076. (90 aa)
dmsCAnaerobic dimethyl sulfoxide reductase chain C; DMSO reductase anchor subunit; Escherichia coli K-12 ortholog: b0896; Escherichia coli O157:H7 ortholog: z1242. (287 aa)
hyaBHydrogenase-1 large chain; Escherichia coli K-12 ortholog: b0973; Escherichia coli O157:H7 ortholog: z1390; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (597 aa)
hyaCProbable Ni/Fe-hydrogenase 1 B-type cytochrome subunit; Escherichia coli K-12 ortholog: b0974; Escherichia coli O157:H7 ortholog: z1391. (235 aa)
appCCytochrome BD-II oxidase subunit I; Escherichia coli K-12 ortholog: b0978; Escherichia coli O157:H7 ortholog: z1395. (514 aa)
torCCytochrome c-type protein torC; Escherichia coli K-12 ortholog: b0996; Escherichia coli O157:H7 ortholog: z1414; Belongs to the TorC/TorY family. (406 aa)
c1323Cytochrome b561 homolog 2; Escherichia coli K-12 ortholog: b1057; Escherichia coli O157:H7 ortholog: z1693. (192 aa)
dsbBDisulfide bond formation protein B; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the DsbA protein (By similarity); Belongs to the DsbB family. (178 aa)
ydbKProbable pyruvate-flavodoxin oxidoreductase; Escherichia coli K-12 ortholog: b1378; Escherichia coli O157:H7 ortholog: z2332. (1174 aa)
acpDAcyl carrier protein phosphodiesterase; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity; Belongs to the azoreductase type 1 family. (201 aa)
cybBCytochrome b-561; Escherichia coli K-12 ortholog: b1418; Escherichia coli O157:H7 ortholog: z2303. (188 aa)
fdnIFormate dehydrogenase-N gamma subunit; Nitrate-inducible; Cytochrome b556 (FDN) subunit; Escherichia coli K-12 ortholog: b1476; Escherichia coli O157:H7 ortholog: z2234. (217 aa)
ynfHAnaerobic dimethyl sulfoxide reductase chain ynfH; DMSO reductase anchor subunit ynfH; Escherichia coli K-12 ortholog: b1590; Escherichia coli O157:H7 ortholog: z2579. (284 aa)
rsxAElectron transport complex protein rnfA; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR. (193 aa)
rsxBElectron transport complex protein rnfB; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR; Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (192 aa)
rsxCElectron transport complex protein rnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR; Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (742 aa)
ydgOElectron transport complex protein rnfD; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR; Belongs to the NqrB/RnfD family. (352 aa)
rsxGElectron transport complex protein rnfG; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR; Belongs to the RnfG family. (206 aa)
ydgQElectron transport complex protein rnfE; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR. (231 aa)
ydhUPhsC protein homolog; Escherichia coli K-12 ortholog: b1670; Escherichia coli O157:H7 ortholog: z2697. (261 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.