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yheJ yheJ yfgL yfgL nlpB nlpB fadL fadL c2589 c2589 fliR fliR fliQ fliQ fliP fliP fliJ fliJ fliI fliI flhB flhB flhA flhA ydgR ydgR sapC sapC sapD sapD sapF sapF tonB tonB oppB oppB hemM hemM c1565 c1565 lolE lolE lolD lolD lolC lolC mchE mchE c1192 c1192 msbA msbA lolA lolA tolB tolB tolR tolR ybgH ybgH ybeC ybeC ybbA ybbA tig tig secF secF secD secD yajC yajC fhiA fhiA c0362 c0362 yaeT yaeT hofC hofC secA secA imp imp ytfN ytfN lamB lamB secE secE yigU yigU tatB tatB tatA tatA yidC yidC secB secB upaG upaG dppB dppB yheK yheK pshM pshM hofQ hofQ ftsY ftsY yhiP yhiP dppC dppC yheI yheI yheH yheH hofH hofH hofG hofG hofF hofF yheG yheG yheF yheF yheE yheE prlA prlA yhbN yhbN yrbK yrbK yrbD yrbD secG secG exbB exbB exbD exbD c3702 c3702 yghD yghD kpsS kpsS kpsC kpsC kpsD kpsD kpsE kpsE hlyD hlyD hlyB hlyB ygeD ygeD bamE bamE ffh ffh yfiO yfiO
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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yheJProbable general secretion pathway protein K; Escherichia coli K-12 ortholog: b3332. (301 aa)
yfgLHypothetical protein yfgL; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (392 aa)
nlpBLipoprotein-34 precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (345 aa)
fadLLong-chain fatty acid transport protein precursor; Involved in translocation of long-chain fatty acids across the outer membrane. FadL may form a specific channel (By similarity). Belongs to the OmpP1/FadL family. (448 aa)
c2589Putative conserved protein; Residues 1 to 211 of 214 are 99.52 pct identical to residues 1 to 211 of 379 from MG1655 : b2062. (214 aa)
fliRFlagellar biosynthetic protein fliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (261 aa)
fliQFlagellar biosynthetic protein fliQ; Required for the assembly of the rivet at the earliest stage of flagellar biosynthesis; Belongs to the FliQ/MopD/SpaQ family. (89 aa)
fliPFlagellar biosynthetic protein fliP precursor; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (245 aa)
fliJFlagellar fliJ protein; Flagellar protein that affects chemotactic events. Belongs to the FliJ family. (147 aa)
fliIFlagellum-specific ATP synthase; Escherichia coli K-12 ortholog: b1941; Escherichia coli O157:H7 ortholog: z3031. (457 aa)
flhBFlagellar biosynthetic protein flhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (382 aa)
flhAFlagellar biosynthesis protein flhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (717 aa)
ydgRHypothetical transporter ydgR; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily. (500 aa)
sapCPeptide transport system permease protein sapC; Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (296 aa)
sapDPeptide transport system ATP-binding protein sapD; Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides; Belongs to the ABC transporter superfamily. (330 aa)
sapFPeptide transport system ATP-binding protein sapF; Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides; Belongs to the ABC transporter superfamily. (268 aa)
tonBTonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (255 aa)
oppBOligopeptide transport system permease protein oppB; Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (306 aa)
hemMOuter-membrane lipoprotein lolB precursor; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. (229 aa)
c1565Partial tonB-like membrane protein encoded within prophage; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (126 aa)
lolELipoprotein releasing system transmembrane protein lolE; Escherichia coli K-12 ortholog: b1118; Escherichia coli O157:H7 ortholog: z1759. (414 aa)
lolDLipoprotein releasing system ATP-binding protein lolD; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (233 aa)
lolCLipoprotein releasing system transmembrane protein lolC; Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity); Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily. (399 aa)
mchEMicrocin H47 secretion protein; Residues 1 to 424 of 424 are 98.82 pct identical to residues 1 to 424 of 424 from SwissProt.40 : >sp|Q9EXN6|MCHE_ECOLI Microcin H47 secretion protein mchE. (424 aa)
c1192Conserved hypothetical protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). (201 aa)
msbAProbable transport ATP-binding protein msbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (582 aa)
lolAOuter-membrane lipoproteins carrier protein precursor; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity). (204 aa)
tolBTolB protein precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. (431 aa)
tolRTolR protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (142 aa)
ybgHHypothetical transporter ybgH; Probable proton-dependent permease that transports dipeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpD subfamily. (493 aa)
ybeCSec-independent protein translocase protein tatE; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA; Belongs to the TatA/E family. TatE subfamily. (67 aa)
ybbAHypothetical ABC transporter ATP-binding protein ybbA; Escherichia coli K-12 ortholog: b0495; Escherichia coli O157:H7 ortholog: z0648. (228 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. (432 aa)
secFProtein-export membrane protein secF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (338 aa)
secDProtein-export membrane protein secD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (615 aa)
yajCHypothetical protein yajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (120 aa)
fhiAFhiA protein; Escherichia coli K-12 ortholog: b0229; Escherichia coli O157:H7 ortholog: z0290. (579 aa)
c0362Putative membrane spanning export protein; Escherichia coli O157:H7 ortholog: z0635. (420 aa)
yaeTUnknown protein from 2D-page spots M62/M63/O3/O9/T35 precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (810 aa)
hofCProtein transport protein hofC; Escherichia coli K-12 ortholog: b0106; Escherichia coli O157:H7 ortholog: z0116. (400 aa)
secAPreprotein translocase secA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (901 aa)
impOrganic solvent tolerance protein precursor; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Belongs to the LptD family. (784 aa)
ytfNHypothetical protein ytfN; Escherichia coli K-12 ortholog: b4221; Escherichia coli O157:H7 ortholog: z5832. (1259 aa)
lamBMaltoporin precursor; Involved in the transport of maltose and maltodextrins. Belongs to the porin LamB (TC 1.B.3) family. (446 aa)
secEPreprotein translocase secE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (127 aa)
yigUSec-independent protein translocase protein tatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (258 aa)
tatBSec-independent protein translocase protein tatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (171 aa)
tatASec-independent protein translocase protein tatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (103 aa)
yidC60 kDa inner-membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (548 aa)
secBProtein-export protein secB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (175 aa)
upaGPutative adhesin; Mediates aggregation, biofilm formation and adhesion to a range of extracellular matrix (ECM) proteins, such as fibronectin, fibrinogen, laminin and collagen types I, II, III, and V. Mediates adhesion to human T24 bladder epithelial cells. (1778 aa)
dppBDipeptide transport system permease protein dppB; Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (339 aa)
yheKProbable general secretion pathway protein L; Escherichia coli K-12 ortholog: b3333; Escherichia coli O157:H7 ortholog: z2633. (388 aa)
pshMPutative general secretion pathway protein M; Transport protein pshM; Escherichia coli K-12 ortholog: b3334. (161 aa)
hofQProtein transport protein hofQ precursor; Escherichia coli K-12 ortholog: b3391; Escherichia coli O157:H7 ortholog: z4744. (412 aa)
ftsYCell division protein ftsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (498 aa)
yhiPHypothetical transporter yhiP; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily. (489 aa)
dppCDipeptide transport system permease protein dppC; Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (300 aa)
yheIProbable general secretion pathway protein J precursor; Escherichia coli K-12 ortholog: b3331. (195 aa)
yheHProbable general secretion pathway protein I precursor; Escherichia coli K-12 ortholog: b3330; Escherichia coli O157:H7 ortholog: z5741. (138 aa)
hofHPutative general secretion pathway protein H precursor; Protein transport protein hofH; Escherichia coli K-12 ortholog: b3329. (169 aa)
hofGPutative general secretion pathway protein G precursor; Protein transport protein hofG; Escherichia coli K-12 ortholog: b3328. (145 aa)
hofFPutative general secretion pathway protein F; Protein transport protein hofF; Escherichia coli K-12 ortholog: b3327. (398 aa)
yheGProbable general secretion pathway protein E; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (493 aa)
yheFProbable general secretion pathway protein D precursor; Escherichia coli K-12 ortholog: b3325. (654 aa)
yheEProbable general secretion pathway protein C; Escherichia coli K-12 ortholog: b3324. (271 aa)
prlAPreprotein translocase secY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (443 aa)
yhbNProtein yhbN precursor; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (192 aa)
yrbKHypothetical protein yrbK; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. (191 aa)
yrbDHypothetical protein yrbD precursor; Escherichia coli K-12 ortholog: b3193; Escherichia coli O157:H7 ortholog: z4556. (188 aa)
secGProtein-export membrane protein secG; Involved in protein export. Participates in an early event of protein translocation (By similarity). (126 aa)
exbBBiopolymer transport exbB protein; Escherichia coli K-12 ortholog: b3006; Escherichia coli O157:H7 ortholog: z4359. (244 aa)
exbDBiopolymer transport exbD protein; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. (141 aa)
c3702Hypothetical protein; Residues 1 to 137 of 137 are 98.54 pct identical to residues 189 to 325 of 325 from GenPept.129 : >gb|AAL60191.1|AF426313_11 (AF426313) hypothetical type II secretion protein GspK [Escherichia coli]. (137 aa)
yghDPutative general secretion pathway protein M-type yghD; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (178 aa)
kpsSKpsS protein; Residues 1 to 389 of 412 are 97.17 pct identical to residues 1 to 389 of 389 from SwissProt.40 : >sp|P42218|KSS5_ECOLI CAPSULE POLYSACCHARIDE EXPORT PROTEIN KPSS. (412 aa)
kpsCKpsC protein; Residues 1 to 675 of 675 are 96.29 pct identical to residues 1 to 675 of 675 from SwissProt.40 : >sp|P42217|KSC5_ECOLI Capsule polysaccharide export protein KPSC. (675 aa)
kpsDKpsD protein; Residues 2 to 559 of 559 are 99.46 pct identical to residues 1 to 558 of 558 from SwissProt.40 : >sp|P42213|KSD5_ECOLI POLYSIALIC ACID TRANSPORT PROTEIN KPSD PRECURSOR. (559 aa)
kpsEKpsE protein; Involved in the translocation of the polysialic acid capsule. Belongs to the BexC/CtrB/KpsE family. (382 aa)
hlyDResidues 1 to 478 of 478 are 98.95 pct identical to residues 1 to 478 of 478 from SwissProt.40 : >sp|P09986|HLY4_ECOLI Hemolysin secretion protein D, chromosomal. (478 aa)
hlyBHemolysin B; Part of the ABC transporter complex HlyBD involved in hemolysin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). (707 aa)
ygeDHypothetical protein ygeD; Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell; Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family. (397 aa)
bamESmall protein A; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (113 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] (453 aa)
yfiOHypothetical lipoprotein yfiO precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (245 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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