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csrA csrA xseA xseA yeiK yeiK yeiA yeiA cdd cdd yoeB yoeB TcpC TcpC rnb rnb rne rne rutA rutA ycdL ycdL ycdK ycdK ycdJ ycdJ rutE rutE rutF rutF arcC arcC deoD deoD deoB deoB deoC deoC c4898 c4898 c4896 c4896 c4895 c4895 udp udp rhlB rhlB gppA gppA tnaA tnaA yicP yicP rph rph dut dut pnp pnp deaD deaD yggV yggV ygfP ygfP ygeZ ygeZ pfs pfs dgt dgt rnhB rnhB rnhA rnhA xseB xseB ushA ushA ybbT ybbT ybbX ybbX ylbB ylbB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
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gene neighborhood
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textmining
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csrACarbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (61 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (458 aa)
yeiKHypothetical protein yeiK; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides; Belongs to the IUNH family. RihB subfamily. (313 aa)
yeiAHypothetical protein yeiA; Escherichia coli K-12 ortholog: b2147; Escherichia coli O157:H7 ortholog: z3402. (413 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa)
yoeBHypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. It has been proposed to be an mRNA interferase but also an inhibitor of translation initiation. Has an in vitro RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor (By similarity). (84 aa)
TcpCHypothetical protein; Virulence factor that suppresses host Toll-like receptor (TLR)-mediated cytokine production upon infection, thereby increasing bacterial burden in the urinary tract and promoting renal tissue damage. Acts as a NAD(+) hydrolase (NADase) by catalyzing cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. (307 aa)
rnbExoribonuclease II; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction. (644 aa)
rneRibonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1061 aa)
rutAPutative monooxygenase ycdM; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate; Belongs to the NtaA/SnaA/SoxA(DszA) monooxygenase family. RutA subfamily. (393 aa)
ycdLHypothetical isochorismatase family protein ycdL; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2. (244 aa)
ycdKHypothetical protein ycdK; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity). (128 aa)
ycdJHypothetical protein ycdJ; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. (275 aa)
rutEPutative NADH dehydrogenase/NAD(P)H nitroreductase ycdI; May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted; Belongs to the nitroreductase family. HadB/RutE subfamily. (196 aa)
rutFPutative flavin:NADH reductase ycdH; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway. (184 aa)
arcCCarbamate kinase; Escherichia coli K-12 ortholog: b0521; Escherichia coli O157:H7 ortholog: z0676; Belongs to the carbamate kinase family. (297 aa)
deoDPurine nucleoside phosphorylase; Escherichia coli K-12 ortholog: b4384; Escherichia coli O157:H7 ortholog: z5986. (258 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (267 aa)
c4898Hypothetical protein; Residues 3 to 519 of 519 are 91.87 pct identical to residues 1 to 517 of 518 from GenPept.129 : >gb|AAL22944.1| (AE008891) putative 5'-nucleotidase/2',3'-cyclic phosphodiesterase or related esterase [Salmonella typhimurium LT2]; Belongs to the 5'-nucleotidase family. (519 aa)
c4896Hypothetical protein; Residues 3 to 517 of 517 are 58.95 pct identical to residues 7 to 523 of 523 from GenPept.129 : >gb|AAL18997.1| (AE008694) putative 5'-nucleotidase [Salmonella typhimurium LT2]; Belongs to the 5'-nucleotidase family. (517 aa)
c4895Hypothetical protein; Residues 10 to 537 of 541 are 64.65 pct identical to residues 5 to 513 of 518 from GenPept.129 : >gb|AAL22944.1| (AE008891) putative 5'-nucleotidase/2',3'-cyclic phosphodiesterase or related esterase [Salmonella typhimurium LT2]; Belongs to the 5'-nucleotidase family. (541 aa)
udpUridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (217 aa)
rhlBPutative ATP-dependent RNA helicase rhlB; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (421 aa)
gppAGuanosine-5'-triphosphate,3'-diphosphate pyrophosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (497 aa)
tnaATryptophanase; Escherichia coli K-12 ortholog: b3708; Escherichia coli O157:H7 ortholog: z5203; Belongs to the beta-eliminating lyase family. (476 aa)
yicPProbable adenine deaminase; Escherichia coli K-12 ortholog: b3665; Escherichia coli O157:H7 ortholog: z5155. (588 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (246 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (152 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (740 aa)
deaDCold-shock DEAD-box protein A; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (651 aa)
yggVHAM1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa)
ygfPGuanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (479 aa)
ygeZHypothetical hydrolase ygeZ; Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'- position. Has no activity on dihydropyrimidines. The physiological function is unknown. (496 aa)
pfsMTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phosphorylas [...] (232 aa)
dgtDeoxyguanosinetriphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. (505 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (198 aa)
rnhARibonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (192 aa)
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (80 aa)
ushAProtein ushA precursor; Escherichia coli K-12 ortholog: b0480; Escherichia coli O157:H7 ortholog: z0599; bifunctional; UDP-sugar hydrolase; 5'-nucleotidase; Belongs to the 5'-nucleotidase family. (550 aa)
ybbTUreidoglycolate hydrolase; Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate. (160 aa)
ybbXAllantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. (453 aa)
ylbBAllantoate amidohydrolase; Escherichia coli K-12 ortholog: b0516; Escherichia coli O157:H7 ortholog: z0671. (417 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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