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| | speA | Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (662 aa) |
| | arcA-2 | Putative arginine deiminase; Residues 7 to 407 of 407 are 47.79 pct identical to residues 10 to 416 of 418 from SwissProt.40 : >sp|P13981|ARCA_PSEAE Arginine deiminase (ADI) (Arginine dihydrolase) (AD). (407 aa) |
| | deoD | Purine nucleoside phosphorylase; Escherichia coli K-12 ortholog: b4384; Escherichia coli O157:H7 ortholog: z5986. (258 aa) |
| | nanA2 | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. (305 aa) |
| | nanK2 | Hypothetical protein yhcI; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily. (291 aa) |
| | gcvP | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa) |
| | ygfP | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (479 aa) |
| | ygeZ | Hypothetical hydrolase ygeZ; Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'- position. Has no activity on dihydropyrimidines. The physiological function is unknown. (496 aa) |
| | amiC | N-acetylmuramoyl-L-alanine amidase amiC precursor; Cell-wall hydrolase involved in septum cleavage during cell division; Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. (447 aa) |
| | ygcY | Glucarate dehydratase related protein; Escherichia coli K-12 ortholog: b2788; Escherichia coli O157:H7 ortholog: z4103. (446 aa) |
| | gabD | Succinate-semialdehyde dehydrogenase (NADP+); Escherichia coli K-12 ortholog: b2661; Escherichia coli O157:H7 ortholog: z3959; Belongs to the aldehyde dehydrogenase family. (482 aa) |
| | ygaF | Hypothetical protein ygaF; Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665; Belongs to the L2HGDH family. (444 aa) |
| | ygaT | Hypothetical protein ygaT; Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (325 aa) |
| | c3180 | Probable lysozyme from lambdoid prophage Qin; Escherichia coli K-12 ortholog: b1554; Escherichia coli O157:H7 ortholog: z1796. (177 aa) |
| | eutS | Ethanolamine utilization protein eutS; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place; Belongs to the EutS/PduU family. (135 aa) |
| | eutT | Ethanolamine utilization cobalamin adenosyltransferase; Converts CNB12 to ADOB12. (267 aa) |
| | cchA | Ethanolamine utilization protein eutM precursor; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place; Belongs to the bacterial microcompartments protein family. (111 aa) |
| | cchB | Ethanolamine utilization protein eutN; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place; To cyanobacterial carbon dioxide concentrating mechanism protein CcmL. (95 aa) |
| | c2976 | Ethanolamine utilization protein eutA; Escherichia coli K-12 ortholog: b2451; Escherichia coli O157:H7 ortholog: z3707. (467 aa) |
| | eutC | Ethanolamine ammonia-lyase light chain; Escherichia coli K-12 ortholog: b2440; Escherichia coli O157:H7 ortholog: z3705; Belongs to the EutC family. (295 aa) |
| | c2973 | Ethanolamine utilization protein eutL; Escherichia coli K-12 ortholog: b2439; Escherichia coli O157:H7 ortholog: z3704. (219 aa) |
| | c2972 | Ethanolamine utilization protein eutK precursor; Escherichia coli K-12 ortholog: b2438; Escherichia coli O157:H7 ortholog: z3703. (168 aa) |
| | amiA | Probable N-acetylmuramoyl-L-alanine amidase amiA precursor; Escherichia coli K-12 ortholog: b2435; Escherichia coli O157:H7 ortholog: z3700. (289 aa) |
| | yfaW | Hypothetical protein yfaW; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). (405 aa) |
| | yeiK | Hypothetical protein yeiK; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides; Belongs to the IUNH family. RihB subfamily. (313 aa) |
| | yeiA | Hypothetical protein yeiA; Escherichia coli K-12 ortholog: b2147; Escherichia coli O157:H7 ortholog: z3402. (413 aa) |
| | cdd | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa) |
| | yegX | Hypothetical protein yegX; Escherichia coli K-12 ortholog: b2102; Escherichia coli O157:H7 ortholog: z3266; Belongs to the glycosyl hydrolase 25 family. (275 aa) |
| | TcpC | Hypothetical protein; Virulence factor that suppresses host Toll-like receptor (TLR)-mediated cytokine production upon infection, thereby increasing bacterial burden in the urinary tract and promoting renal tissue damage. Acts as a NAD(+) hydrolase (NADase) by catalyzing cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. (307 aa) |
| | cstC | Succinylornithine transaminase; Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily. (406 aa) |
| | astA | Arginine N-succinyltransferase; Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. (315 aa) |
| | astD | Succinylglutamic semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. (492 aa) |
| | astB | Succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). (447 aa) |
| | ydjS | Succinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. (322 aa) |
| | ydjC | Hypothetical protein ydjC; Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6 [...] (252 aa) |
| | rspA | Starvation sensing protein rspA; Has low D-mannonate dehydratase activity (in vitro), suggesting that this is not a physiological substrate and that it has no significant role in D-mannonate degradation in vivo. Has no detectable activity with a panel of 70 other acid sugars (in vitro). Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily. (415 aa) |
| | ydcW | Putative betaine aldehyde dehydrogenase; Catalyzes the oxidation 4-aminobutanal (gamma- aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4- aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (474 aa) |
| | ycjG | Hypothetical protein ycjG; Escherichia coli K-12 ortholog: b1325; Escherichia coli O157:H7 ortholog: z2450. (335 aa) |
| | chaC | Cation transport protein chaC; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (243 aa) |
| | dadA | D-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids; Belongs to the DadA oxidoreductase family. (434 aa) |
| | ybcS | Probable lysozyme from lambdoid prophage DLP12; Escherichia coli K-12 ortholog: b0555; Escherichia coli O157:H7 ortholog: z0960. (165 aa) |
| | pepT | Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. (423 aa) |
| | c1436 | Probable lysozyme from lambdoid prophage Qin; Escherichia coli K-12 ortholog: b1554; Escherichia coli O157:H7 ortholog: z1796. (177 aa) |
| | putA | PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1342 aa) |
| | rutA | Putative monooxygenase ycdM; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate; Belongs to the NtaA/SnaA/SoxA(DszA) monooxygenase family. RutA subfamily. (393 aa) |
| | ycdL | Hypothetical isochorismatase family protein ycdL; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2. (244 aa) |
| | ycdK | Hypothetical protein ycdK; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity). (128 aa) |
| | ycdJ | Hypothetical protein ycdJ; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. (275 aa) |
| | rutE | Putative NADH dehydrogenase/NAD(P)H nitroreductase ycdI; May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted; Belongs to the nitroreductase family. HadB/RutE subfamily. (196 aa) |
| | rutF | Putative flavin:NADH reductase ycdH; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway. (184 aa) |
| | c1091 | Putative protease La homolog; Escherichia coli K-12 ortholog: b0955; Escherichia coli O157:H7 ortholog: z1305. (586 aa) |
| | aat | Leucyl/phenylalanyl-tRNA--protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. (234 aa) |
| | yljA | Protein yljA; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (106 aa) |
| | ybjR | Probable N-acetylmuramoyl-L-alanine amidase ybjR; Escherichia coli K-12 ortholog: b0867; Escherichia coli O157:H7 ortholog: z1100. (276 aa) |
| | c0957 | Fels-2 prophage: probable prophage lysozyme; Residues 1 to 168 of 170 are 91.66 pct identical to residues 1 to 168 of 169 from GenPept.129 : >gb|AAL21602.1| (AE008823) Fels-2 prophage: probable prophage lysozyme [Salmonella typhimurium LT2]. (170 aa) |
| | sucB | Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (405 aa) |
| | nagB | Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (266 aa) |
| | ylbB | Allantoate amidohydrolase; Escherichia coli K-12 ortholog: b0516; Escherichia coli O157:H7 ortholog: z0671. (417 aa) |
| | ybbX | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. (453 aa) |
| | ybbT | Ureidoglycolate hydrolase; Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate. (160 aa) |
| | lon | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, and UmuD. Its overproduction spec [...] (799 aa) |
| | dgt | Deoxyguanosinetriphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. (505 aa) |
| | pfs | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phosphorylas [...] (232 aa) |
| | ampD | AmpD protein; Escherichia coli K-12 ortholog: b0110; Escherichia coli O157:H7 ortholog: z0120. (183 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (364 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (130 aa) |
| | c4535 | Hypothetical protein. (99 aa) |
| | c4533 | Putative pduB protein; Residues 33 to 261 of 261 are 63.31 pct identical to residues 6 to 233 of 233 from SwissProt.40 : >sp|P37449|PDUB_SALTY PROPANEDIOL UTILIZATION PROTEIN PDUB. (261 aa) |
| | c4532 | Hypothetical protein; Residues 18 to 67 of 83 are 89.99 pct identical to residues 1 to 50 of 94 from GenPept.129 : >gb|AAL20942.1| (AE008790) Propanediol utilization: polyhedral bodies [Salmonella typhimurium LT2]. (83 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (152 aa) |
| | dfp | DNA/pantothenate metabolism flavoprotein; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (430 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (398 aa) |
| | tdh | Threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa) |
| | ggt | Gamma-glutamyltranspeptidase precursor; Escherichia coli K-12 ortholog: b3447; Escherichia coli O157:H7 ortholog: z4813. (577 aa) |
| | nanA | N-acetylneuraminate lyase subunit; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. (297 aa) |
| | yhcJ | Hypothetical protein yhcJ; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (243 aa) |
| | nanK1 | Hypothetical protein yhcI; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily. (302 aa) |
| | tdcB | Threonine dehydratase catabolic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. TdcB also dehydrates serine to y [...] (329 aa) |
| | tdcD-2 | Putative conserved protein; Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. (50 aa) |
| | yhaR | TdcF protein; May be a post-translational regulator that controls the metabolic fate of L-threonine or the potentially toxic intermediate 2- ketobutyrate. (150 aa) |
| | ygjG | Probable ornithine aminotransferase; Catalyzes the aminotransferase reaction from putrescine to 2- oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4- aminobutanal. Also functions as a cadaverine transaminase in a a L- lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (496 aa) |
| | c4548 | Hypothetical protein; Residues 37 to 121 of 213 are 55.29 pct identical to residues 6 to 89 of 94 from GenPept.129 : >gb|AAL94296.1| (AE010523) Ethanolamine utilization protein eutM precursor [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]. (213 aa) |
| | yicP | Probable adenine deaminase; Escherichia coli K-12 ortholog: b3665; Escherichia coli O157:H7 ortholog: z5155. (588 aa) |
| | tnaA | Tryptophanase; Escherichia coli K-12 ortholog: b3708; Escherichia coli O157:H7 ortholog: z5203; Belongs to the beta-eliminating lyase family. (476 aa) |
| | gppA | Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (497 aa) |
| | udp | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (217 aa) |
| | yihZ | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (145 aa) |
| | hslV | ATP-dependent protease hslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. Belongs to the peptidase T1B family. HslV subfamily. (176 aa) |
| | c4920 | Starvation sensing protein rspA; Escherichia coli K-12 ortholog: b1581. (404 aa) |
| | c5034 | Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; Escherichia coli K-12 ortholog: b0727; Escherichia coli O157:H7 ortholog: z0881. (351 aa) |
| | amiB | N-acetylmuramoyl-L-alanine amidase amiB precursor; Escherichia coli K-12 ortholog: b4169; Escherichia coli O157:H7 ortholog: z5776. (448 aa) |
| | arcB-2 | Ornithine carbamoyltransferase chain I; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (343 aa) |
