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metG metG recO recO cspI cspI cspB cspB cspF cspF ygcA ygcA lysS lysS ygjH ygjH pnp pnp nusA nusA cafA cafA rpsQ rpsQ rplB rplB rpsL rpsL yhgF yhgF ugpC ugpC cspA cspA yicF yicF lig lig ccmE ccmE recG recG rho rho malK malK ssb ssb lysU lysU efp efp yjeQ yjeQ vacB vacB yeiP yeiP aspS aspS ruvA ruvA cspC cspC ycjV ycjV rnb rnb c1497 c1497 rne rne cspG cspG cspH cspH asnS asnS rpsA rpsA infA infA cspD cspD yliG yliG cspE cspE ybbJ ybbJ dnaE dnaE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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metGMethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (680 aa)
recODNA repair protein recO; Involved in DNA repair and RecF pathway recombination. Belongs to the RecO family. (242 aa)
cspICold shock-like protein cspI; CSP-I; Escherichia coli K-12 ortholog: b1552; Escherichia coli O157:H7 ortholog: z1406. (71 aa)
cspBCold shock-like protein cspB; CSP-B; Escherichia coli K-12 ortholog: b1557; Escherichia coli O157:H7 ortholog: z4981. (71 aa)
cspFCold shock-like protein cspF; CSP-F; Escherichia coli K-12 ortholog: b1558; Escherichia coli O157:H7 ortholog: z1405. (70 aa)
ygcA23S rRNA (Uracil-5-)-methyltransferase rumA; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (433 aa)
lysSLysyl-tRNA synthetase; Escherichia coli K-12 ortholog: b2890; Escherichia coli O157:H7 ortholog: z4228; Belongs to the class-II aminoacyl-tRNA synthetase family. (505 aa)
ygjHHypothetical protein ygjH; Escherichia coli K-12 ortholog: b3074; Escherichia coli O157:H7 ortholog: z4427. (110 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (740 aa)
nusAN utilization substance protein A; Participates in both transcription termination and antitermination. (495 aa)
cafARibonuclease G; Involved in the processing of the 5'-end of 16S rRNA. Could be involved in chromosome segregation and cell division. It may be one of the components of the cytoplasmic axial filaments bundles or merely regulate the formation of this structure (By similarity). (495 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (84 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (273 aa)
rpsL30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (144 aa)
yhgFProtein yhgF; Escherichia coli K-12 ortholog: b3407; Escherichia coli O157:H7 ortholog: z4762. (773 aa)
ugpCSN-glycerol-3-phosphate transport ATP-binding protein ugpC; Part of the ABC transporter complex UgpABCE involved in sn- glycerol-3-phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. sn-glycerol-3- phosphate importer (TC 3.A.1.1.3) family. (369 aa)
cspACold shock protein cspA; Binds to and stimulates the transcription of the CCAAT- containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to the inverted repeat 5'-ATTGG-3' (By similarity). (70 aa)
yicFHypothetical DNA ligase-like protein yicF; Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. Belongs to the NAD-dependent DNA ligase family. LigB subfamily. (562 aa)
ligDNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (671 aa)
ccmECytochrome c-type biogenesis protein ccmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (159 aa)
recGATP-dependent DNA helicase recG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (704 aa)
rhoTranscription termination factor rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (443 aa)
malKMaltose/maltodextrin transport ATP-binding protein malK; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family. (401 aa)
ssbSingle-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (178 aa)
lysULysyl-tRNA synthetase, heat inducible; Escherichia coli K-12 ortholog: b4129; Escherichia coli O157:H7 ortholog: z5732; Belongs to the class-II aminoacyl-tRNA synthetase family. (514 aa)
efpElongation factor P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation; Belongs to the elongation factor P family. (188 aa)
yjeQHypothetical protein yjeQ; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (361 aa)
vacBRibonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. Belongs to the RNR ribonuclease family. RNase R subfamily. (827 aa)
yeiPProtein yeiP; Escherichia coli K-12 ortholog: b2171; Escherichia coli O157:H7 ortholog: z3430; Belongs to the elongation factor P family. (275 aa)
aspSAspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (590 aa)
ruvAHolliday junction DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa)
cspCCold shock-like protein cspC; CSP-C; Escherichia coli K-12 ortholog: b1823; Escherichia coli O157:H7 ortholog: z2868. (69 aa)
ycjVHypothetical ABC transporter ATP-binding protein ycjV; Escherichia coli K-12 ortholog: b1318; Escherichia coli O157:H7 ortholog: z2463; Belongs to the ABC transporter superfamily. (360 aa)
rnbExoribonuclease II; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction. (644 aa)
c1497Putative single stranded DNA-binding protein of prophage; Escherichia coli O157:H7 ortholog: z1845. (136 aa)
rneRibonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1061 aa)
cspGCold shock-like protein cspG; CSP-G; Escherichia coli K-12 ortholog: b0990; Escherichia coli O157:H7 ortholog: z1406. (70 aa)
cspHCold shock-like protein cspH; CSP-H; Escherichia coli K-12 ortholog: b0989; Escherichia coli O157:H7 ortholog: z1405. (70 aa)
asnSAsparaginyl-tRNA synthetase; Escherichia coli K-12 ortholog: b0930; Escherichia coli O157:H7 ortholog: z1278. (466 aa)
rpsA30S ribosomal protein S1; Required for translation of most natural mRNAs except for leaderless mRNA. Binds mRNA upstream of the Shine-Dalgarno (SD) sequence and helps it bind to the 30S ribosomal subunit; acts as an RNA chaperone to unfold structured mRNA on the ribosome but is not essential for mRNAs with strong SDs and little 5'-UTR structure, thus it may help fine-tune which mRNAs that are translated. Unwinds dsRNA by binding to transiently formed ssRNA regions; binds about 10 nucleotides. Has a preference for polypyrimidine tracts. Negatively autoregulates its own translation. (557 aa)
infATranslation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa)
cspDCold shock-like protein cspD; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells (By similarity). (84 aa)
yliGHypothetical protein yliG; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (441 aa)
cspECold shock-like protein cspE; CSP-E; Escherichia coli K-12 ortholog: b0623; Escherichia coli O157:H7 ortholog: z0769. (97 aa)
ybbJHypothetical protein ybbJ; Escherichia coli K-12 ortholog: b0488; Escherichia coli O157:H7 ortholog: z0641. (152 aa)
dnaEDNA polymerase III alpha subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity). (1160 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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