STRINGSTRING
glpB glpB glpD glpD glpA glpA yhiN yhiN gor gor yidS yidS gidA gidA udhA udhA c5021 c5021 c5035 c5035 frdA frdA c5299 c5299 fixC fixC yojH yojH yeiT yeiT ydiS ydiS ydhS ydhS dadA dadA ndh ndh solA solA trxB trxB sdhA sdhA yleB yleB ahpF ahpF betA betA ykgC ykgC lpdA lpdA nirB nirB gltD gltD ygjL ygjL iucD iucD ubiH ubiH visC visC ygfT ygfT ygfK ygfK ygcN ygcN ygbD ygbD ygaF ygaF nadB nadB yffG yffG yfcK yfcK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
glpBAnaerobic glycerol-3-phosphate dehydrogenase subunit B; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor; Belongs to the anaerobic G-3-P dehydrogenase subunit B family. (443 aa)
glpDAerobic glycerol-3-phosphate dehydrogenase; Escherichia coli K-12 ortholog: b3426; Escherichia coli O157:H7 ortholog: z4786; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (506 aa)
glpAAnaerobic glycerol-3-phosphate dehydrogenase subunit A; Escherichia coli K-12 ortholog: b2241; Escherichia coli O157:H7 ortholog: z3499; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (542 aa)
yhiNHypothetical protein yhiN; Escherichia coli K-12 ortholog: b3492; Escherichia coli O157:H7 ortholog: z4891. (397 aa)
gorGlutathione reductase; Escherichia coli K-12 ortholog: b3500; Escherichia coli O157:H7 ortholog: z4900. (450 aa)
yidSHypothetical protein yidS precursor; Escherichia coli K-12 ortholog: b3690; Escherichia coli O157:H7 ortholog: z5186; Belongs to the CbrA family. (373 aa)
gidAGlucose inhibited division protein A; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (629 aa)
udhASoluble pyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation. (466 aa)
c5021Putative oxidoreductase; Residues 70 to 648 of 721 are 36.66 pct identical to residues 6 to 596 of 664 from GenPept.129 : >gb|AAD35512.1|AE001721_11 (AE001721) oxidoreductase, putative [Thermotoga maritima]. (721 aa)
c5035Putative 2-oxoglutarate dehydrogenase; Residues 1 to 468 of 472 are 49.04 pct identical to residues 1 to 470 of 474 from SwissProt.40 : >sp|P52992|DLDH_ALCEU DIHYDROLIPOAMIDE DEHYDROGENASE (E3 COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX). (472 aa)
frdAFumarate reductase flavoprotein subunit; Escherichia coli K-12 ortholog: b4154; Escherichia coli O157:H7 ortholog: z5762. (602 aa)
c5299Putative oxidoreductase; Residues 29 to 688 of 690 are 35.69 pct identical to residues 5 to 663 of 664 from GenPept.129 : >gb|AAD35512.1|AE001721_11 (AE001721) oxidoreductase, putative [Thermotoga maritima]. (690 aa)
fixCFixC protein; Could be part of an electron transfer system required for anaerobic carnitine reduction; Belongs to the ETF-QO/FixC family. (428 aa)
yojHMalate:quinone oxidoreductase; Escherichia coli K-12 ortholog: b2210; Escherichia coli O157:H7 ortholog: z3468. (548 aa)
yeiTHypothetical oxidoreductase yeiT; Escherichia coli K-12 ortholog: b2146; Escherichia coli O157:H7 ortholog: z3401. (412 aa)
ydiSProbable electron transfer flavoprotein-quinone oxidoreductase ydiS; Part of an electron transfer system. Belongs to the ETF-QO/FixC family. (429 aa)
ydhSHypothetical protein ydhS; Escherichia coli K-12 ortholog: b1668; Escherichia coli O157:H7 ortholog: z2695. (536 aa)
dadAD-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids; Belongs to the DadA oxidoreductase family. (434 aa)
ndhNADH dehydrogenase; Escherichia coli K-12 ortholog: b1109; Escherichia coli O157:H7 ortholog: z1748. (443 aa)
solAN-methyl-L-tryptophan oxidase; Catalyzes the oxidative demethylation of N-methyl-L- tryptophan; Belongs to the MSOX/MTOX family. MTOX subfamily. (372 aa)
trxBThioredoxin reductase; Escherichia coli K-12 ortholog: b0888; Escherichia coli O157:H7 ortholog: z1232. (361 aa)
sdhASuccinate dehydrogenase flavoprotein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (592 aa)
yleB2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Escherichia coli K-12 ortholog: b0662; Escherichia coli O157:H7 ortholog: z0811. (398 aa)
ahpFAlkyl hydroperoxide reductase subunit F; Escherichia coli K-12 ortholog: b0606; Escherichia coli O157:H7 ortholog: z0750. (531 aa)
betACholine dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. Belongs to the GMC oxidoreductase family. (571 aa)
ykgCProbable pyridine nucleotide-disulfide oxidoreductase ykgC; Escherichia coli K-12 ortholog: b0304; Escherichia coli O157:H7 ortholog: z0381. (450 aa)
lpdADihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (495 aa)
nirBNitrite reductase [NAD(P)H] large subunit; Escherichia coli K-12 ortholog: b3365; Escherichia coli O157:H7 ortholog: z4726; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (847 aa)
gltDGlutamate synthase [NADPH] small chain; Escherichia coli K-12 ortholog: b3213; Escherichia coli O157:H7 ortholog: z4577. (472 aa)
ygjL2,4-dienoyl-CoA reductase (NADPH); Escherichia coli K-12 ortholog: b3081; Escherichia coli O157:H7 ortholog: z4434. (672 aa)
iucDIucD protein; Residues 1 to 425 of 445 are 97.88 pct identical to residues 1 to 425 of 425 from SwissProt.40 : >sp|P11295|IUCD_ECOLI L-LYSINE 6-MONOOXYGENASE (LYSINE N6-HYDROXYLASE). (445 aa)
ubiH2-octaprenyl-6-methoxyphenol hydroxylase; Escherichia coli K-12 ortholog: b2907; Escherichia coli O157:H7 ortholog: z4244. (392 aa)
visCProtein visC; Escherichia coli K-12 ortholog: b2906; Escherichia coli O157:H7 ortholog: z4243. (400 aa)
ygfTHypothetical protein ygfT; Escherichia coli K-12 ortholog: b2887; Escherichia coli O157:H7 ortholog: z4225. (644 aa)
ygfKHypothetical protein ygfK; Escherichia coli K-12 ortholog: b2878; Escherichia coli O157:H7 ortholog: z4217. (1032 aa)
ygcNProbable electron transfer flavoprotein-quinone oxidoreductase ygcN; Part of an electron transfer system. Belongs to the ETF-QO/FixC family. (433 aa)
ygbDFlRd-NAD(+) reductase; One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase. (377 aa)
ygaFHypothetical protein ygaF; Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665; Belongs to the L2HGDH family. (444 aa)
nadBL-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (540 aa)
yffGAegA protein; Escherichia coli K-12 ortholog: b2468; Escherichia coli O157:H7 ortholog: z3724. (659 aa)
yfcKHypothetical protein yfcK; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family. (688 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.