STRINGSTRING
yedZ yedZ fixA fixA fixC fixC fixX fixX cyoC cyoC cyoB cyoB cyoA cyoA fldA fldA sdhD sdhD sdhA sdhA cydA cydA cydB cydB appC appC torC torC grxB grxB dsbB dsbB ydbK ydbK fdnH fdnH ynfG ynfG rsxA rsxA rsxB rsxB rsxC rsxC ydgO ydgO rsxG rsxG ydgQ ydgQ ydiT ydiT yecK yecK napC napC napB napB napG napG napA napA yfaE yfaE trxC trxC ygaF ygaF nrdH nrdH hydN hydN hycB hycB cysJ cysJ ygcO ygcO fldB fldB dsbI dsbI yheA yheA grxC grxC trxA trxA fdoI fdoI fdoH fdoH nrfA nrfA nrfB nrfB dsbD dsbD frdB frdB frdA frdA cybC cybC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yedZHypothetical protein yedZ; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. MsrQ prov [...] (211 aa)
fixAFixA protein; Required for anaerobic carnitine reduction. May bring reductant to CaiA. (277 aa)
fixCFixC protein; Could be part of an electron transfer system required for anaerobic carnitine reduction; Belongs to the ETF-QO/FixC family. (428 aa)
fixXFerredoxin-like protein; Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster-containing protein (By similarity). (95 aa)
cyoCCytochrome O ubiquinol oxidase subunit III; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity). (204 aa)
cyoBUbiquinol oxidase polypeptide I; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity). (663 aa)
cyoAUbiquinol oxidase polypeptide II precursor; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity). (315 aa)
fldAFlavodoxin 1; Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase (By similarity); Belongs to the flavodoxin family. (215 aa)
sdhDSuccinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhASuccinate dehydrogenase flavoprotein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (592 aa)
cydACytochrome D ubiquinol oxidase subunit I; A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton/electron. Belongs to the cytochrome ubiquinol oxidase subunit 1 family. (523 aa)
cydBCytochrome D ubiquinol oxidase subunit II; A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton/electron. (379 aa)
appCCytochrome BD-II oxidase subunit I; Escherichia coli K-12 ortholog: b0978; Escherichia coli O157:H7 ortholog: z1395. (514 aa)
torCCytochrome c-type protein torC; Escherichia coli K-12 ortholog: b0996; Escherichia coli O157:H7 ortholog: z1414; Belongs to the TorC/TorY family. (406 aa)
grxBGlutaredoxin 2; Involved in reducing some disulfides in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase (By similarity). (215 aa)
dsbBDisulfide bond formation protein B; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the DsbA protein (By similarity); Belongs to the DsbB family. (178 aa)
ydbKProbable pyruvate-flavodoxin oxidoreductase; Escherichia coli K-12 ortholog: b1378; Escherichia coli O157:H7 ortholog: z2332. (1174 aa)
fdnHFormate dehydrogenase-N beta subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (294 aa)
ynfGProbable anaerobic dimethyl sulfoxide reductase chain ynfG; Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. (205 aa)
rsxAElectron transport complex protein rnfA; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR. (193 aa)
rsxBElectron transport complex protein rnfB; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR; Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (192 aa)
rsxCElectron transport complex protein rnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR; Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (742 aa)
ydgOElectron transport complex protein rnfD; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR; Belongs to the NqrB/RnfD family. (352 aa)
rsxGElectron transport complex protein rnfG; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR; Belongs to the RnfG family. (206 aa)
ydgQElectron transport complex protein rnfE; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR. (231 aa)
ydiTFerredoxin-like protein ydiT; Could be a 3Fe-4S cluster-containing protein. (97 aa)
yecKCytochrome c-type protein torY; Escherichia coli K-12 ortholog: b1873; Escherichia coli O157:H7 ortholog: z2926; Belongs to the TorC/TorY family. (366 aa)
napCCytochrome c-type protein napC; Mediates electron flow from quinones to the NapAB complex. (200 aa)
napBDiheme cytochrome c napB precursor; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (156 aa)
napGFerredoxin-type protein napG; Required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex. (231 aa)
napAPeriplasmic nitrate reductase precursor; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa)
yfaEHypothetical ferredoxin-like protein yfaE; Escherichia coli K-12 ortholog: b2236; Escherichia coli O157:H7 ortholog: z3492. (84 aa)
trxCThioredoxin 2; Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin (By similarity); Belongs to the thioredoxin family. (139 aa)
ygaFHypothetical protein ygaF; Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665; Belongs to the L2HGDH family. (444 aa)
nrdHGlutaredoxin-like protein nrdH; Electron transport system for the ribonucleotide reductase system NrdEF. (81 aa)
hydNElectron transport protein hydN; Electron transport from formate to hydrogen. (180 aa)
hycBFormate hydrogenlyase subunit 2; Probable electron transfer protein for hydrogenase 3. (203 aa)
cysJSulfite reductase [NADPH] flavoprotein alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (599 aa)
ygcOFerredoxin-like protein ygcO; Could be a 3Fe-4S cluster-containing protein. (98 aa)
fldBFlavodoxin 2; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. (173 aa)
dsbIPutative disulfide isomerase; Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT; Belongs to the DsbB family. DsbI subfamily. (223 aa)
yheABacterioferritin-associated ferredoxin; Seems to associate with BFR; could be a general redox and/or regulatory component participating in the iron storage mobilization functions of BFR. Could participate in the release or the delivery of iron from/to bacterioferritin (or other iron complexes) (By similarity). (64 aa)
grxCGlutaredoxin 3; The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase (By similarity); Belongs to the glutaredoxin family. (83 aa)
trxAThioredoxin 1; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions; Belongs to the thioredoxin family. (144 aa)
fdoIFormate dehydrogenase; Allows to use formate as major electron donor during aerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the formate dehydrogenase (By similarity). (211 aa)
fdoHFormate dehydrogenase-O beta subunit; Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit (By similarity). (300 aa)
nrfACytochrome c552 precursor; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (478 aa)
nrfBCytochrome c-type protein nrfB precursor; Plays a role in nitrite reduction. (190 aa)
dsbDThiol:disulfide interchange protein dsbD precursor; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. (565 aa)
frdBFumarate reductase iron-sulfur protein; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa)
frdAFumarate reductase flavoprotein subunit; Escherichia coli K-12 ortholog: b4154; Escherichia coli O157:H7 ortholog: z5762. (602 aa)
cybCSoluble cytochrome b562 precursor; Electron-transport protein of unknown function. Belongs to the cytochrome b562 family. (128 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.