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| | lytB | IspH protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. (331 aa) |
| | fixX | Ferredoxin-like protein; Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster-containing protein (By similarity). (95 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa) |
| | acnB | Aconitate hydratase 2; Escherichia coli K-12 ortholog: b0118; Escherichia coli O157:H7 ortholog: z0128. (916 aa) |
| | yadR | Hypothetical protein yadR; Required for insertion of 4Fe-4S clusters for at least IspG. (125 aa) |
| | cyoB | Ubiquinol oxidase polypeptide I; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity). (663 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. (320 aa) |
| | fepB | Ferrienterobactin-binding periplasmic protein precursor; Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin. Belongs to the bacterial solute-binding protein 8 family. (318 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa) |
| | yleA | Hypothetical protein yleA; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (474 aa) |
| | fur | Ferric uptake regulation protein; Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon (By similarity). (148 aa) |
| | sdhC | Succinate dehydrogenase cytochrome b-556 subunit; Escherichia coli K-12 ortholog: b0721; Escherichia coli O157:H7 ortholog: z0875. (134 aa) |
| | sdhD | Succinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa) |
| | sdhB | Succinate dehydrogenase iron-sulfur protein; Escherichia coli K-12 ortholog: b0724; Escherichia coli O157:H7 ortholog: z0878; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa) |
| | cydA | Cytochrome D ubiquinol oxidase subunit I; A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton/electron. Belongs to the cytochrome ubiquinol oxidase subunit 1 family. (523 aa) |
| | cydB | Cytochrome D ubiquinol oxidase subunit II; A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton/electron. (379 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (347 aa) |
| | galT | Galactose-1-phosphate uridylyltransferase; Escherichia coli K-12 ortholog: b0758; Escherichia coli O157:H7 ortholog: z0928; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (348 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (346 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (356 aa) |
| | dinG | Probable ATP-dependent helicase dinG; DNA-dependent ATPase and 5'-3' DNA helicase. (716 aa) |
| | ybiX | Hypothetical protein ybiX; Escherichia coli K-12 ortholog: b0804; Escherichia coli O157:H7 ortholog: z1025. (237 aa) |
| | ybiL | Probable tonB-dependent receptor ybiL precursor; Involved in the active transport across the outer membrane of iron complexed with catecholate siderophores such as dihydroxybenzoylserine and dihydroxybenzoate. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB. Can also transport catechol-substituted cephalosporins. Receptor for microcins M, H47 and E492 (By similarity). (760 aa) |
| | dps | DNA protection during starvation protein; During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, ir [...] (167 aa) |
| | yliG | Hypothetical protein yliG; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (441 aa) |
| | ybjF | Hypothetical RNA methyltransferase ybjF; Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily. (375 aa) |
| | c1005 | NADH oxidoreductase hcr; Escherichia coli K-12 ortholog: b0872; Escherichia coli O157:H7 ortholog: z1106. (324 aa) |
| | ybjW | Prismane protein homolog; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (552 aa) |
| | dmsA | Anaerobic dimethyl sulfoxide reductase chain A precursor; Escherichia coli K-12 ortholog: b0894; Escherichia coli O157:H7 ortholog: z1240; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (814 aa) |
| | pflA | Pyruvate formate-lyase 1 activating enzyme; Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (255 aa) |
| | hyaA | Hydrogenase-1 small chain precursor; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth. (381 aa) |
| | appC | Cytochrome BD-II oxidase subunit I; Escherichia coli K-12 ortholog: b0978; Escherichia coli O157:H7 ortholog: z1395. (514 aa) |
| | torC | Cytochrome c-type protein torC; Escherichia coli K-12 ortholog: b0996; Escherichia coli O157:H7 ortholog: z1414; Belongs to the TorC/TorY family. (406 aa) |
| | efeU | Putative cytochrome; Uptake of Fe(2+) ions across the membrane. Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family. (255 aa) |
| | ycdB | Hypothetical protein ycdB precursor; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact (By similarity); Belongs to the DyP-type peroxidase family. EfeB subfamily. (423 aa) |
| | narG | Respiratory nitrate reductase 1 alpha chain; Escherichia coli K-12 ortholog: b1224; Escherichia coli O157:H7 ortholog: z2001; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1247 aa) |
| | yciE | Protein yciE; Escherichia coli K-12 ortholog: b1257; Escherichia coli O157:H7 ortholog: z2555. (168 aa) |
| | acnA | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa) |
| | yciM | Hypothetical protein yciM precursor; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. (389 aa) |
| | fnr | Fumarate and nitrate reduction Regulatory protein; Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O(2), is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration (By similarity). (269 aa) |
| | ydaO | Hypothetical protein ydaO; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (311 aa) |
| | ydbK | Probable pyruvate-flavodoxin oxidoreductase; Escherichia coli K-12 ortholog: b1378; Escherichia coli O157:H7 ortholog: z2332. (1174 aa) |
| | narZ | Respiratory nitrate reductase 2 alpha chain; Escherichia coli K-12 ortholog: b1468; Escherichia coli O157:H7 ortholog: z2244; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1287 aa) |
| | fdnH | Formate dehydrogenase-N beta subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (294 aa) |
| | ydeM | Hypothetical protein ydeM; Escherichia coli K-12 ortholog: b1497; Escherichia coli O157:H7 ortholog: z2211. (390 aa) |
| | ydeP | Hypothetical protein ydeP; Probably involved in acid resistance; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (759 aa) |
| | ynfE | Putative dimethyl sulfoxide reductase chain ynfE precursor; Escherichia coli K-12 ortholog: b1587; Escherichia coli O157:H7 ortholog: z2575; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (808 aa) |
| | ynfF | Probable dimethyl sulfoxide reductase chain ynfF precursor; Escherichia coli K-12 ortholog: b1588; Escherichia coli O157:H7 ortholog: z2576; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (808 aa) |
| | ynfG | Probable anaerobic dimethyl sulfoxide reductase chain ynfG; Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. (205 aa) |
| | fumA | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80% of the fumarase activity when the bacteria grow aerobically. To a lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso-tartrate. Can also catalyze the isomerization of enol- to keto-oxaloacetate. (548 aa) |
| | rsxB | Electron transport complex protein rnfB; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR; Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (192 aa) |
| | rsxC | Electron transport complex protein rnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR; Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (742 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa) |
| | ydhD | Protein ydhD; Monothiol glutaredoxin involved in the biogenesis of iron- sulfur clusters. (115 aa) |
| | sodB | Superoxide dismutase (Fe); Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (193 aa) |
| | ydiT | Ferredoxin-like protein ydiT; Could be a 3Fe-4S cluster-containing protein. (97 aa) |
| | katE | Catalase HPII; Serves to protect cells from the toxic effects of hydrogen peroxide. (753 aa) |
| | sdaA | L-serine dehydratase 1; Escherichia coli K-12 ortholog: b1814; Escherichia coli O157:H7 ortholog: z2857; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa) |
| | edd | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (625 aa) |
| | yecK | Cytochrome c-type protein torY; Escherichia coli K-12 ortholog: b1873; Escherichia coli O157:H7 ortholog: z2926; Belongs to the TorC/TorY family. (366 aa) |
| | ftn | Ferritin 1; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. (170 aa) |
| | yedZ | Hypothetical protein yedZ; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. MsrQ prov [...] (211 aa) |
| | mrp | Mrp protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (379 aa) |
| | ccmH | Cytochrome c-type biogenesis protein ccmH precursor; Possible subunit of a heme lyase. (350 aa) |
| | ccmE | Cytochrome c-type biogenesis protein ccmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (159 aa) |
| | napC | Cytochrome c-type protein napC; Mediates electron flow from quinones to the NapAB complex. (200 aa) |
| | napB | Diheme cytochrome c napB precursor; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (156 aa) |
| | napG | Ferredoxin-type protein napG; Required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex. (231 aa) |
| | napA | Periplasmic nitrate reductase precursor; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa) |
| | napF | Ferredoxin-type protein napF; Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm; Belongs to the NapF family. (164 aa) |
| | yfaE | Hypothetical ferredoxin-like protein yfaE; Escherichia coli K-12 ortholog: b2236; Escherichia coli O157:H7 ortholog: z3492. (84 aa) |
| | nuoI | NADH dehydrogenase I chain I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (180 aa) |
| | nuoG | NADH dehydrogenase I chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity). (910 aa) |
| | nuoF | NADH dehydrogenase I chain F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (445 aa) |
| | nuoE | NADH dehydrogenase I chain E; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity); Belongs to the complex I 24 kDa subunit family. (166 aa) |
| | nuoB | NADH dehydrogenase I chain B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (220 aa) |
| | gcpE | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (372 aa) |
| | yfgB | Hypothetical protein yfgB; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (384 aa) |
| | yfhF | Protein yfhF; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB (By similarity). (109 aa) |
| | yfhO | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate; Belongs to the class-V pyridoxal-phosphate-dependent aminotransfer [...] (412 aa) |
| | yfhP | Hypothetical protein yfhP; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. (162 aa) |
| | hmpA | Flavohemoprotein; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. (396 aa) |
| | ygaT | Hypothetical protein ygaT; Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (325 aa) |
| | nrdF | Ribonucleoside-diphosphate reductase 2 beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa) |
| | ygaG | Autoinducer-2 production protein luxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa) |
| | hydN | Electron transport protein hydN; Electron transport from formate to hydrogen. (180 aa) |
| | hycB | Formate hydrogenlyase subunit 2; Probable electron transfer protein for hydrogenase 3. (203 aa) |
| | cysI | Sulfite reductase [NADPH] hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa) |
| | ygcO | Ferredoxin-like protein ygcO; Could be a 3Fe-4S cluster-containing protein. (98 aa) |
| | ygcF | Hypothetical protein ygcF; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa) |
| | ygcA | 23S rRNA (Uracil-5-)-methyltransferase rumA; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (433 aa) |
| | sdaB | L-serine dehydratase 2; Escherichia coli K-12 ortholog: b2797; Escherichia coli O157:H7 ortholog: z4114; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa) |
| | yggW | Hypothetical protein yggW; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (378 aa) |
| | mutY | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (360 aa) |
| | yggX | Protein yggX; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. (91 aa) |
| | hybO | Hydrogenase-2 small chain precursor; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake. (372 aa) |
| | ygiQ | Conserved hypothetical protein; Escherichia coli O157:H7 ortholog: z4370. (739 aa) |
| | ttdA | L(+)-tartrate dehydratase alpha subunit; Escherichia coli K-12 ortholog: b3061; Escherichia coli O157:H7 ortholog: z4414; Belongs to the class-I fumarase family. (303 aa) |
| | ygjD | Probable O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (337 aa) |
| | c3870 | L-serine dehydratase 1; Escherichia coli K-12 ortholog: b1814; Escherichia coli O157:H7 ortholog: z4464; Belongs to the iron-sulfur dependent L-serine dehydratase family. (456 aa) |
| | def | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity); Belongs to the polypeptide deformylase family. (169 aa) |
| | bfr | Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex. (158 aa) |
| | yheA | Bacterioferritin-associated ferredoxin; Seems to associate with BFR; could be a general redox and/or regulatory component participating in the iron storage mobilization functions of BFR. Could participate in the release or the delivery of iron from/to bacterioferritin (or other iron complexes) (By similarity). (64 aa) |
| | nirB | Nitrite reductase [NAD(P)H] large subunit; Escherichia coli K-12 ortholog: b3365; Escherichia coli O157:H7 ortholog: z4726; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (847 aa) |
| | feoA | Ferrous iron transport protein A; Involved in Fe(2+) ion uptake (By similarity). (75 aa) |
| | feoB | Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. (777 aa) |
| | yhgG | Hypothetical protein yhgG; May function as a transcriptional regulator that controls feoABC expression. (81 aa) |
| | yhgI | Protein yhgI; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (191 aa) |
| | yhjA | Probable cytochrome C peroxidase; Escherichia coli K-12 ortholog: b3518; Escherichia coli O157:H7 ortholog: z4931. (465 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Escherichia coli K-12 ortholog: b3771; Escherichia coli O157:H7 ortholog: z5282. (616 aa) |
| | aslB | Putative arylsulfatase Regulatory protein; Escherichia coli K-12 ortholog: b3800; Escherichia coli O157:H7 ortholog: z5313. (411 aa) |
| | cyaY | CyaY protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (106 aa) |
| | ubiB | NAD(P)H-flavin reductase; Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides; Belongs to the Fre/LuxG FAD/NAD(P) flavoprotein oxidoreductase family. (244 aa) |
| | hemN | Oxygen-independent coproporphyrinogen III oxidase; Escherichia coli K-12 ortholog: b3867; Escherichia coli O157:H7 ortholog: z5403; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (459 aa) |
| | fdoI | Formate dehydrogenase; Allows to use formate as major electron donor during aerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the formate dehydrogenase (By similarity). (211 aa) |
| | fdoH | Formate dehydrogenase-O beta subunit; Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit (By similarity). (300 aa) |
| | yiiP | Hypothetical protein yiiP; Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner (By similarity). (314 aa) |
| | c4898 | Hypothetical protein; Residues 3 to 519 of 519 are 91.87 pct identical to residues 1 to 517 of 518 from GenPept.129 : >gb|AAL22944.1| (AE008891) putative 5'-nucleotidase/2',3'-cyclic phosphodiesterase or related esterase [Salmonella typhimurium LT2]; Belongs to the 5'-nucleotidase family. (519 aa) |
| | katG | Peroxidase/catalase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (739 aa) |
| | thiH | Thiazole biosynthesis protein thiH; Escherichia coli K-12 ortholog: b3990; Escherichia coli O157:H7 ortholog: z5564. (377 aa) |
| | thiC | Thiamine biosynthesis protein thiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (635 aa) |
| | nrfA | Cytochrome c552 precursor; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (478 aa) |
| | nrfB | Cytochrome c-type protein nrfB precursor; Plays a role in nitrite reduction. (190 aa) |
| | nrfF | Formate-dependent nitrite reductase complex nrfF subunit precursor; Possible subunit of a heme lyase. (127 aa) |
| | phnJ | PhnJ protein; Catalyzes the breakage of the C-P bond in alpha-D-ribose 1- methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose. Belongs to the PhnJ family. (309 aa) |
| | fumB | Fumarate hydratase class I, anaerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (548 aa) |
| | yjeK | Hypothetical protein yjeK; Escherichia coli K-12 ortholog: b4146; Escherichia coli O157:H7 ortholog: z5751. (342 aa) |
| | frdB | Fumarate reductase iron-sulfur protein; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa) |
| | yjeS | Putative electron transport protein yjeS; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (394 aa) |
| | yjeB | Hypothetical protein yjeB; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. (141 aa) |
| | ytfE | Hypothetical protein ytfE; Di-iron-containing protein involved in the repair of iron- sulfur clusters damaged by oxidative and nitrosative stress conditions. (220 aa) |
| | cybC | Soluble cytochrome b562 precursor; Electron-transport protein of unknown function. Belongs to the cytochrome b562 family. (128 aa) |
| | uxuA | Mannonate dehydratase; Catalyzes the dehydration of D-mannonate; Belongs to the mannonate dehydratase family. (394 aa) |
| | fdnG | Formate dehydrogenase, nitrate-inducible, major subunit; Escherichia coli K-12 ortholog: b1474; Escherichia coli O157:H7 ortholog: z2236. (1015 aa) |
| | fdoG | Formate dehydrogenase-O, major subunit; Escherichia coli K-12 ortholog: b3894; Escherichia coli O157:H7 ortholog: z5436. (1016 aa) |
| | fdhF | Formate dehydrogenase H; Escherichia coli K-12 ortholog: b4079; Escherichia coli O157:H7 ortholog: z5678; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (715 aa) |
