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| | gcd | Glucose dehydrogenase; Pyrroloquinoline-quinone; Escherichia coli K-12 ortholog: b0124; Escherichia coli O157:H7 ortholog: z0134. (802 aa) |
| | c0321 | Gluconate 5-dehydrogenase; Escherichia coli K-12 ortholog: b4266; Escherichia coli O157:H7 ortholog: z4085. (266 aa) |
| | yafH | Acyl-coenzyme A dehydrogenase; Escherichia coli K-12 ortholog: b0221; Escherichia coli O157:H7 ortholog: z0278. (840 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (417 aa) |
| | c0414 | 2,5-diketo-D-gluconic acid reductase A; Escherichia coli K-12 ortholog: b3012; Escherichia coli O157:H7 ortholog: z0374. (283 aa) |
| | c0417 | 2,5-diketo-D-gluconic acid reductase A; Escherichia coli K-12 ortholog: b3012; Escherichia coli O157:H7 ortholog: z0377. (294 aa) |
| | ykgC | Probable pyridine nucleotide-disulfide oxidoreductase ykgC; Escherichia coli K-12 ortholog: b0304; Escherichia coli O157:H7 ortholog: z0381. (450 aa) |
| | betA | Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. Belongs to the GMC oxidoreductase family. (571 aa) |
| | betB | Betaine aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. (491 aa) |
| | adhC | Alcohol dehydrogenase class III; Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa) |
| | tauD | Alpha-ketoglutarate-dependent taurine dioxygenase; Escherichia coli K-12 ortholog: b0368; Escherichia coli O157:H7 ortholog: z0467. (283 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (305 aa) |
| | ribD | Riboflavin biosynthesis protein ribD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (367 aa) |
| | yajO | Hypothetical oxidoreductase yajO; Escherichia coli K-12 ortholog: b0419; Escherichia coli O157:H7 ortholog: z0522. (324 aa) |
| | apbA | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (303 aa) |
| | cyoC | Cytochrome O ubiquinol oxidase subunit III; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity). (204 aa) |
| | cyoA | Ubiquinol oxidase polypeptide II precursor; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity). (315 aa) |
| | ybbO | Hypothetical oxidoreductase ybbO; Escherichia coli K-12 ortholog: b0493; Escherichia coli O157:H7 ortholog: z0646; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (269 aa) |
| | ybbQ | 2-hydroxy-3-oxopropionate reductase; Escherichia coli K-12 ortholog: b0509; Escherichia coli O157:H7 ortholog: z0663. (292 aa) |
| | c0631 | Ureidoglycolate dehydrogenase; Escherichia coli K-12 ortholog: b0517; Escherichia coli O157:H7 ortholog: z0672; Belongs to the LDH2/MDH2 oxidoreductase family. (349 aa) |
| | folD | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | nfnB | Oxygen-insensitive NAD(P)H nitroreductase; Escherichia coli K-12 ortholog: b0578; Escherichia coli O157:H7 ortholog: z0717. (217 aa) |
| | entA | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Escherichia coli K-12 ortholog: b0596; Escherichia coli O157:H7 ortholog: z0738. (248 aa) |
| | ybdH | Hypothetical oxidoreductase ybdH; Escherichia coli K-12 ortholog: b0599; Escherichia coli O157:H7 ortholog: z0742. (362 aa) |
| | ahpC | Alkyl hydroperoxide reductase C22 protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (187 aa) |
| | yleB | 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Escherichia coli K-12 ortholog: b0662; Escherichia coli O157:H7 ortholog: z0811. (398 aa) |
| | c0764 | Putative pyridoxine phosphate biosynthetic protein; Residues 5 to 326 of 328 are 76.08 pct identical to residues 6 to 327 of 327 from GenPept.129 : >gb|AAL19127.1| (AE008701) pyridoxine phosphate biosynthetic protein [Salmonella typhimurium LT2]; Belongs to the PdxA family. (328 aa) |
| | sdhA | Succinate dehydrogenase flavoprotein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (592 aa) |
| | sdhB | Succinate dehydrogenase iron-sulfur protein; Escherichia coli K-12 ortholog: b0724; Escherichia coli O157:H7 ortholog: z0878; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa) |
| | sucA | 2-oxoglutarate dehydrogenase E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (933 aa) |
| | ybiC | Hypothetical oxidoreductase ybiC; Escherichia coli K-12 ortholog: b0801; Escherichia coli O157:H7 ortholog: z1022; Belongs to the LDH2/MDH2 oxidoreductase family. (361 aa) |
| | ybiX | Hypothetical protein ybiX; Escherichia coli K-12 ortholog: b0804; Escherichia coli O157:H7 ortholog: z1025. (237 aa) |
| | dps | DNA protection during starvation protein; During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, ir [...] (167 aa) |
| | c0909 | Putative pyruvate formate-lyase 3 activating enzyme; Escherichia coli K-12 ortholog: b0824; Escherichia coli O157:H7 ortholog: z1047. (308 aa) |
| | mdaA | Oxygen-insensitive NADPH nitroreductase; Escherichia coli K-12 ortholog: b0851; Escherichia coli O157:H7 ortholog: z1078; Belongs to the flavin oxidoreductase frp family. (240 aa) |
| | c1005 | NADH oxidoreductase hcr; Escherichia coli K-12 ortholog: b0872; Escherichia coli O157:H7 ortholog: z1106. (324 aa) |
| | ybjW | Prismane protein homolog; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (552 aa) |
| | trxB | Thioredoxin reductase; Escherichia coli K-12 ortholog: b0888; Escherichia coli O157:H7 ortholog: z1232. (361 aa) |
| | dmsA | Anaerobic dimethyl sulfoxide reductase chain A precursor; Escherichia coli K-12 ortholog: b0894; Escherichia coli O157:H7 ortholog: z1240; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (814 aa) |
| | pflA | Pyruvate formate-lyase 1 activating enzyme; Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (255 aa) |
| | ycbN | Alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family. (381 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (345 aa) |
| | hyaA | Hydrogenase-1 small chain precursor; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth. (381 aa) |
| | hyaB | Hydrogenase-1 large chain; Escherichia coli K-12 ortholog: b0973; Escherichia coli O157:H7 ortholog: z1390; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (597 aa) |
| | appC | Cytochrome BD-II oxidase subunit I; Escherichia coli K-12 ortholog: b0978; Escherichia coli O157:H7 ortholog: z1395. (514 aa) |
| | appB | Cytochrome BD-II oxidase subunit II; Escherichia coli K-12 ortholog: b0979; Escherichia coli O157:H7 ortholog: z1396. (378 aa) |
| | torA | Trimethylamine-N-oxide reductase 1 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. (848 aa) |
| | wrbA | Flavoprotein wrbA; Trp repressor binding protein; Escherichia coli K-12 ortholog: b1004; Escherichia coli O157:H7 ortholog: z1423. (198 aa) |
| | rutF | Putative flavin:NADH reductase ycdH; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway. (184 aa) |
| | rutE | Putative NADH dehydrogenase/NAD(P)H nitroreductase ycdI; May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted; Belongs to the nitroreductase family. HadB/RutE subfamily. (196 aa) |
| | ycdK | Hypothetical protein ycdK; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity). (128 aa) |
| | rutA | Putative monooxygenase ycdM; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate; Belongs to the NtaA/SnaA/SoxA(DszA) monooxygenase family. RutA subfamily. (393 aa) |
| | putA | PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1342 aa) |
| | ycdB | Hypothetical protein ycdB precursor; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact (By similarity); Belongs to the DyP-type peroxidase family. EfeB subfamily. (423 aa) |
| | c1187 | 3-oxoacyl-[acyl-carrier protein] reductase; Escherichia coli K-12 ortholog: b1093; Escherichia coli O157:H7 ortholog: z4865. (243 aa) |
| | ycdW | Putative 2-hydroxyacid dehydrogenase ycdW; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. (312 aa) |
| | solA | N-methyl-L-tryptophan oxidase; Catalyzes the oxidative demethylation of N-methyl-L- tryptophan; Belongs to the MSOX/MTOX family. MTOX subfamily. (372 aa) |
| | ndh | NADH dehydrogenase; Escherichia coli K-12 ortholog: b1109; Escherichia coli O157:H7 ortholog: z1748. (443 aa) |
| | icdA | Isocitrate dehydrogenase (NADP); Escherichia coli K-12 ortholog: b1136; Escherichia coli O157:H7 ortholog: z1865. (416 aa) |
| | dsbB | Disulfide bond formation protein B; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the DsbA protein (By similarity); Belongs to the DsbB family. (178 aa) |
| | dadA | D-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids; Belongs to the DadA oxidoreductase family. (434 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (484 aa) |
| | narG | Respiratory nitrate reductase 1 alpha chain; Escherichia coli K-12 ortholog: b1224; Escherichia coli O157:H7 ortholog: z2001; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1247 aa) |
| | narH | Respiratory nitrate reductase 1 beta chain; Escherichia coli K-12 ortholog: b1225; Escherichia coli O157:H7 ortholog: z2002. (512 aa) |
| | narJ | Respiratory nitrate reductase 1 delta chain; Escherichia coli K-12 ortholog: b1226; Escherichia coli O157:H7 ortholog: z2003. (236 aa) |
| | narI | Respiratory nitrate reductase 1 gamma chain; Escherichia coli K-12 ortholog: b1227; Escherichia coli O157:H7 ortholog: z2004. (225 aa) |
| | adhE | Aldehyde-alcohol dehydrogenase; Escherichia coli K-12 ortholog: b1241; Escherichia coli O157:H7 ortholog: z2016; multifunctional; Alcohol dehydrogenase; Acetaldehyde dehydrogenase [acetylating]; Pyruvate-formate-lyase deactivase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (891 aa) |
| | yciK | Hypothetical oxidoreductase yciK; Escherichia coli K-12 ortholog: b1271; Escherichia coli O157:H7 ortholog: z2539. (252 aa) |
| | fabI | Enoyl-[acyl-carrier-protein] reductase (NADH); Escherichia coli K-12 ortholog: b1288; Escherichia coli O157:H7 ortholog: z2512. (262 aa) |
| | ycjS | Hypothetical oxidoreductase ycjS; Escherichia coli K-12 ortholog: b1315; Escherichia coli O157:H7 ortholog: z2468. (351 aa) |
| | tpx | Thiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (168 aa) |
| | ydbK | Probable pyruvate-flavodoxin oxidoreductase; Escherichia coli K-12 ortholog: b1378; Escherichia coli O157:H7 ortholog: z2332. (1174 aa) |
| | ldhA | D-lactate dehydrogenase; Escherichia coli K-12 ortholog: b1380; Escherichia coli O157:H7 ortholog: z2329; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa) |
| | ydbC | Hypothetical oxidoreductase ydbC; Escherichia coli K-12 ortholog: b1406; Escherichia coli O157:H7 ortholog: z2321. (286 aa) |
| | acpD | Acyl carrier protein phosphodiesterase; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity; Belongs to the azoreductase type 1 family. (201 aa) |
| | aldA | Aldehyde dehydrogenase A; Escherichia coli K-12 ortholog: b1415; Escherichia coli O157:H7 ortholog: z2306; Belongs to the aldehyde dehydrogenase family. (479 aa) |
| | c1843 | Glyceraldehyde 3-phosphate dehydrogenase A; Escherichia coli K-12 ortholog: b1779; Escherichia coli O157:H7 ortholog: z2304; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa) |
| | ydcW | Putative betaine aldehyde dehydrogenase; Catalyzes the oxidation 4-aminobutanal (gamma- aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4- aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (474 aa) |
| | narV | Respiratory nitrate reductase 2 gamma chain; Escherichia coli K-12 ortholog: b1465; Escherichia coli O157:H7 ortholog: z2247. (226 aa) |
| | narW | Respiratory nitrate reductase 2 delta chain; Escherichia coli K-12 ortholog: b1466; Escherichia coli O157:H7 ortholog: z2246. (231 aa) |
| | narY | Respiratory nitrate reductase 2 beta chain; Escherichia coli K-12 ortholog: b1467; Escherichia coli O157:H7 ortholog: z2245. (514 aa) |
| | narZ | Respiratory nitrate reductase 2 alpha chain; Escherichia coli K-12 ortholog: b1468; Escherichia coli O157:H7 ortholog: z2244; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1287 aa) |
| | adhP | Alcohol dehydrogenase, propanol-preferring; Escherichia coli K-12 ortholog: b1478; Escherichia coli O157:H7 ortholog: z2232. (346 aa) |
| | sfcA | NAD-dependent malic enzyme; Escherichia coli K-12 ortholog: b1479; Escherichia coli O157:H7 ortholog: z2231; Belongs to the malic enzymes family. (574 aa) |
| | ydeP | Hypothetical protein ydeP; Probably involved in acid resistance; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (759 aa) |
| | yneI | Aldehyde-dehydrogenase like protein yneI; Escherichia coli K-12 ortholog: b1525; Escherichia coli O157:H7 ortholog: z2178. (470 aa) |
| | ydfG | Probable oxidoreductase ydfG; NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP-dependent oxidation of L- allo-threonine to L-2-amino-3-keto-butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3-hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L-glycerate. Able to catalyze the reduction of the malonic semialdehyde to 3-hydroxypropionic acid. YdfG is apparently supplementing RutE, the presumed malonic semialdehyde reductase involved in pyrimidine degradatio [...] (253 aa) |
| | c1968 | Hypothetical oxidoreductase ydfI; Escherichia coli K-12 ortholog: b1542; Escherichia coli O157:H7 ortholog: z2155; Belongs to the mannitol dehydrogenase family. (486 aa) |
| | rspB | Starvation sensing protein rspB; Escherichia coli K-12 ortholog: b1580. (347 aa) |
| | ynfE | Putative dimethyl sulfoxide reductase chain ynfE precursor; Escherichia coli K-12 ortholog: b1587; Escherichia coli O157:H7 ortholog: z2575; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (808 aa) |
| | ynfF | Probable dimethyl sulfoxide reductase chain ynfF precursor; Escherichia coli K-12 ortholog: b1588; Escherichia coli O157:H7 ortholog: z2576; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (808 aa) |
| | pntA | NAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. (528 aa) |
| | ydgB | Hypothetical oxidoreductase ydgB; Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate. (240 aa) |
| | hdhA | 7-alpha-hydroxysteroid dehydrogenase; Escherichia coli K-12 ortholog: b1619; Escherichia coli O157:H7 ortholog: z2624. (255 aa) |
| | ydgJ | Hypothetical oxidoreductase ydgJ; Escherichia coli K-12 ortholog: b1624; Escherichia coli O157:H7 ortholog: z2629. (359 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (218 aa) |
| | sodC | Superoxide dismutase [Cu-Zn] precursor; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (190 aa) |
| | ydhF | Hypothetical oxidoreductase ydhF; Escherichia coli K-12 ortholog: b1647; Escherichia coli O157:H7 ortholog: z2664. (298 aa) |
| | nemA | N-ethylmaleimide reductase; Escherichia coli K-12 ortholog: b1650; Escherichia coli O157:H7 ortholog: z2668. (365 aa) |
| | sodB | Superoxide dismutase (Fe); Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (193 aa) |
| | ydiB | Hypothetical shikimate 5-dehydrogenase-like protein ydiB; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. (288 aa) |
| | ydiO | Hypothetical protein ydiO; Escherichia coli K-12 ortholog: b1695; Escherichia coli O157:H7 ortholog: z2723; Belongs to the acyl-CoA dehydrogenase family. (401 aa) |
| | ydiS | Probable electron transfer flavoprotein-quinone oxidoreductase ydiS; Part of an electron transfer system. Belongs to the ETF-QO/FixC family. (429 aa) |
| | btuE | Vitamin B12 transport periplasmic protein btuE; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent. (183 aa) |
| | katE | Catalase HPII; Serves to protect cells from the toxic effects of hydrogen peroxide. (753 aa) |
| | astD | Succinylglutamic semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. (492 aa) |
| | gdhA | NADP-specific glutamate dehydrogenase; Escherichia coli K-12 ortholog: b1761; Escherichia coli O157:H7 ortholog: z2793; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa) |
| | ydjG | Hypothetical oxidoreductase ydjG; Escherichia coli K-12 ortholog: b1771; Escherichia coli O157:H7 ortholog: z2809. (326 aa) |
| | yeaA | Peptide methionine sulfoxide reductase msrB; Escherichia coli K-12 ortholog: b1778; Escherichia coli O157:H7 ortholog: z2817; Belongs to the MsrB Met sulfoxide reductase family. (147 aa) |
| | gapA | Glyceraldehyde 3-phosphate dehydrogenase A; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. (334 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa) |
| | bisZ | Trimethylamine-N-oxide reductase 2 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N- oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency (By similarity); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (815 aa) |
| | ftn | Ferritin 1; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. (170 aa) |
| | yedY | Hypothetical protein yedY; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. The catal [...] (334 aa) |
| | c2464 | Putative acyl-coa dehydrogenase; Residues 3 to 335 of 342 are 35.02 pct identical to residues 35 to 368 of 382 from GenPept.129 : >gb|AAD40109.1|AF155831_3 (AF155831) unknown [Bacillus cereus]. (342 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (437 aa) |
| | ugd | UDP-glucose 6-dehydrogenase; Escherichia coli K-12 ortholog: b2028; Escherichia coli O157:H7 ortholog: z3190; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (388 aa) |
| | gnd | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa) |
| | wcaG | GDP-fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa) |
| | gatD | Galactitol-1-phosphate 5-dehydrogenase; Escherichia coli K-12 ortholog: b2091; Escherichia coli O157:H7 ortholog: z3254. (346 aa) |
| | dld | D-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (582 aa) |
| | yohI | Hypothetical protein yohI; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. (338 aa) |
| | yeiA | Hypothetical protein yeiA; Escherichia coli K-12 ortholog: b2147; Escherichia coli O157:H7 ortholog: z3402. (413 aa) |
| | yeiQ | Hypothetical oxidoreductase yeiQ; Escherichia coli K-12 ortholog: b2172; Escherichia coli O157:H7 ortholog: z3431; Belongs to the mannitol dehydrogenase family. (491 aa) |
| | napA | Periplasmic nitrate reductase precursor; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa) |
| | yojH | Malate:quinone oxidoreductase; Escherichia coli K-12 ortholog: b2210; Escherichia coli O157:H7 ortholog: z3468. (548 aa) |
| | nrdA | Ribonucleoside-diphosphate reductase 1 alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (761 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase 1 beta chain; Escherichia coli K-12 ortholog: b2235; Escherichia coli O157:H7 ortholog: z3491. (376 aa) |
| | glpA | Anaerobic glycerol-3-phosphate dehydrogenase subunit A; Escherichia coli K-12 ortholog: b2241; Escherichia coli O157:H7 ortholog: z3499; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (542 aa) |
| | glpB | Anaerobic glycerol-3-phosphate dehydrogenase subunit B; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor; Belongs to the anaerobic G-3-P dehydrogenase subunit B family. (443 aa) |
| | yfbG | Hypothetical protein yfbG; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (660 aa) |
| | nuoM | NADH dehydrogenase I chain M; Escherichia coli K-12 ortholog: b2277; Escherichia coli O157:H7 ortholog: z3536. (509 aa) |
| | nuoL | NADH dehydrogenase I chain L; Escherichia coli K-12 ortholog: b2278; Escherichia coli O157:H7 ortholog: z3537. (613 aa) |
| | nuoF | NADH dehydrogenase I chain F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (445 aa) |
| | pdxB | Erythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (378 aa) |
| | yfcK | Hypothetical protein yfcK; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family. (688 aa) |
| | fadJ | Putative fatty oxidation complex alpha subunit; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (714 aa) |
| | ucpA | Oxidoreductase ucpA; Escherichia coli K-12 ortholog: b2426; Escherichia coli O157:H7 ortholog: z3691. (315 aa) |
| | hemF | Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (300 aa) |
| | c2988 | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. (759 aa) |
| | bcp | Bacterioferritin comigratory protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events; Belongs to the peroxiredoxin family. BCP/PrxQ subfamily. (156 aa) |
| | c3012 | Protein yfgD; Escherichia coli K-12 ortholog: b2495; Escherichia coli O157:H7 ortholog: z3758. (119 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (511 aa) |
| | gcpE | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (372 aa) |
| | hmpA | Flavohemoprotein; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. (396 aa) |
| | nadB | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (540 aa) |
| | trxC | Thioredoxin 2; Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin (By similarity); Belongs to the thioredoxin family. (139 aa) |
| | tyrA | T-protein; Escherichia coli K-12 ortholog: b2600; Escherichia coli O157:H7 ortholog: z3892; bifunctional; Chorismate mutase; Prephenate dehydrogenase. (373 aa) |
| | ygaT | Hypothetical protein ygaT; Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (325 aa) |
| | ygaF | Hypothetical protein ygaF; Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665; Belongs to the L2HGDH family. (444 aa) |
| | gabD | Succinate-semialdehyde dehydrogenase (NADP+); Escherichia coli K-12 ortholog: b2661; Escherichia coli O157:H7 ortholog: z3959; Belongs to the aldehyde dehydrogenase family. (482 aa) |
| | c3225 | Conserved hypothetical protein; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (161 aa) |
| | nrdE | Ribonucleoside-diphosphate reductase 2 alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (714 aa) |
| | nrdF | Ribonucleoside-diphosphate reductase 2 beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa) |
| | srlD | Sorbitol-6-phosphate 2-dehydrogenase; Escherichia coli K-12 ortholog: b2705; Escherichia coli O157:H7 ortholog: z4012; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (259 aa) |
| | ygbD | FlRd-NAD(+) reductase; One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase. (377 aa) |
| | ygbJ | Hypothetical oxidoreductase ygbJ; Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+). (302 aa) |
| | cysH | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. (244 aa) |
| | cysI | Sulfite reductase [NADPH] hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa) |
| | cysJ | Sulfite reductase [NADPH] flavoprotein alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (599 aa) |
| | ygcN | Probable electron transfer flavoprotein-quinone oxidoreductase ygcN; Part of an electron transfer system. Belongs to the ETF-QO/FixC family. (433 aa) |
| | c3331 | Putative conserved protein; Residues 221 to 484 of 484 are 98.10 pct identical to residues 1 to 264 of 264 from MG1655 : b2772. (484 aa) |
| | ygcW | Hypothetical oxidoreductase ygcW; Escherichia coli K-12 ortholog: b2774; Escherichia coli O157:H7 ortholog: z4085. (286 aa) |
| | yqcD | Hypothetical protein yqcD; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (282 aa) |
| | fucO | Lactaldehyde reductase; Escherichia coli K-12 ortholog: b2799; Escherichia coli O157:H7 ortholog: z4116. (383 aa) |
| | c3405 | 2-hydroxyacid dehydrogenase; Residues 5 to 318 of 318 are 37.77 pct identical to residues 3 to 317 of 317 from GenPept.129 : >gb|AAK90773.1| (AE007909) AGR_pAT_578p [Agrobacterium tumefaciens str. C58 (Cereon)]; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa) |
| | kduD | 2-deoxy-D-gluconate 3-dehydrogenase; Escherichia coli K-12 ortholog: b2842; Escherichia coli O157:H7 ortholog: z4162. (253 aa) |
| | c3444 | Xanthine dehydrogenase, molybdenum binding subunit; Escherichia coli K-12 ortholog: b2866; Escherichia coli O157:H7 ortholog: z4205. (765 aa) |
| | ygeT | Xanthine dehydrogenase, FAD binding subunit; Escherichia coli K-12 ortholog: b2867; Escherichia coli O157:H7 ortholog: z4206. (292 aa) |
| | c3459 | Possible hypoxanthine oxidase xdhD; Escherichia coli K-12 ortholog: b2881; Escherichia coli O157:H7 ortholog: z4220. (956 aa) |
| | gcvP | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa) |
| | visC | Protein visC; Escherichia coli K-12 ortholog: b2906; Escherichia coli O157:H7 ortholog: z4243. (400 aa) |
| | ubiH | 2-octaprenyl-6-methoxyphenol hydroxylase; Escherichia coli K-12 ortholog: b2907; Escherichia coli O157:H7 ortholog: z4244. (392 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa) |
| | epd | D-erythrose 4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. (367 aa) |
| | glcD | Glycolate oxidase subunit glcD; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is also able to oxidize D-lactate ((R)- lactate) with a similar rate. Does not link directly to O(2), and 2,6- dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (499 aa) |
| | hybC | Hydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa) |
| | hybO | Hydrogenase-2 small chain precursor; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake. (372 aa) |
| | yghA | Hypothetical oxidoreductase yghA; Escherichia coli K-12 ortholog: b3003; Escherichia coli O157:H7 ortholog: z4356. (295 aa) |
| | yqhD | Hypothetical oxidoreductase yqhD; Escherichia coli K-12 ortholog: b3011; Escherichia coli O157:H7 ortholog: z4364. (387 aa) |
| | c3746 | 2,5-diketo-D-gluconic acid reductase A; Escherichia coli K-12 ortholog: b3012; Escherichia coli O157:H7 ortholog: z4365. (275 aa) |
| | c3751 | Hypothetical oxidoreductase ydfI; Escherichia coli K-12 ortholog: b1542; Escherichia coli O157:H7 ortholog: z2155; Belongs to the mannitol dehydrogenase family. (502 aa) |
| | c3753 | Ureidoglycolate dehydrogenase; Escherichia coli K-12 ortholog: b0517; Escherichia coli O157:H7 ortholog: z0672; Belongs to the LDH2/MDH2 oxidoreductase family. (336 aa) |
| | mdaB | Modulator of drug activity B; NADPH-specific quinone reductase. (193 aa) |
| | dsbI | Putative disulfide isomerase; Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT; Belongs to the DsbB family. DsbI subfamily. (223 aa) |
| | ygjL | 2,4-dienoyl-CoA reductase (NADPH); Escherichia coli K-12 ortholog: b3081; Escherichia coli O157:H7 ortholog: z4434. (672 aa) |
| | ygjR | Hypothetical oxidoreductase ygjR; Escherichia coli K-12 ortholog: b3087; Escherichia coli O157:H7 ortholog: z4440. (334 aa) |
| | yhaE | 2-hydroxy-3-oxopropionate reductase; Catalyzes the reduction of tatronate semialdehyde to D- glycerate; Belongs to the HIBADH-related family. 2-hydroxy-3- oxopropionate reductase subfamily. (299 aa) |
| | yhbW | Hypothetical protein yhbW; Escherichia coli K-12 ortholog: b3160; Escherichia coli O157:H7 ortholog: z4521; To bacterial alkanal monooxygenase alpha and beta chains. (335 aa) |
| | gltB | Glutamate synthase [NADPH] large chain precursor; Escherichia coli K-12 ortholog: b3212; Escherichia coli O157:H7 ortholog: z4576. (1522 aa) |
| | gltD | Glutamate synthase [NADPH] small chain; Escherichia coli K-12 ortholog: b3213; Escherichia coli O157:H7 ortholog: z4577. (472 aa) |
| | yhcB | Hypothetical protein yhcB; Escherichia coli K-12 ortholog: b3233; Escherichia coli O157:H7 ortholog: z4592; To H.influenzae HI_1628. (134 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (334 aa) |
| | yhdG | Hypothetical protein yhdG; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. (321 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | bfr | Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex. (158 aa) |
| | yheR | Putative NAD(P)H oxidoreductase yheR; Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB. (184 aa) |
| | nirB | Nitrite reductase [NAD(P)H] large subunit; Escherichia coli K-12 ortholog: b3365; Escherichia coli O157:H7 ortholog: z4726; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (847 aa) |
| | nirD | Nitrite reductase [NAD(P)H] small subunit; Escherichia coli K-12 ortholog: b3366; Escherichia coli O157:H7 ortholog: z4727. (108 aa) |
| | cysG | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (457 aa) |
| | glpD | Aerobic glycerol-3-phosphate dehydrogenase; Escherichia coli K-12 ortholog: b3426; Escherichia coli O157:H7 ortholog: z4786; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (506 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (387 aa) |
| | yhhX | Putative oxidoreductase yhhX; Escherichia coli K-12 ortholog: b3440; Escherichia coli O157:H7 ortholog: z4808. (345 aa) |
| | gor | Glutathione reductase; Escherichia coli K-12 ortholog: b3500; Escherichia coli O157:H7 ortholog: z4900. (450 aa) |
| | arsC | Arsenate reductase; Escherichia coli K-12 ortholog: b3503; Escherichia coli O157:H7 ortholog: z4905. (141 aa) |
| | yhjA | Probable cytochrome C peroxidase; Escherichia coli K-12 ortholog: b3518; Escherichia coli O157:H7 ortholog: z4931. (465 aa) |
| | bisC | Biotin sulfoxide reductase; Escherichia coli K-12 ortholog: b3551; Escherichia coli O157:H7 ortholog: z4976; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (777 aa) |
| | yiaE | 2-ketogluconate reductase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. (328 aa) |
| | yiaK | Hypothetical oxidoreductase yiaK; Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate. (332 aa) |
| | aldB | Aldehyde dehydrogenase B; Escherichia coli K-12 ortholog: b3588; Escherichia coli O157:H7 ortholog: z5008; Belongs to the aldehyde dehydrogenase family. (542 aa) |
| | yiaY | Probable alcohol dehydrogenase; Escherichia coli K-12 ortholog: b3589; Escherichia coli O157:H7 ortholog: z5010. (383 aa) |
| | mtlD | Mannitol-1-phosphate 5-dehydrogenase; Escherichia coli K-12 ortholog: b3600; Escherichia coli O157:H7 ortholog: z5024. (442 aa) |
| | lldD | L-lactate dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (396 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase (NAD(P)+); Escherichia coli K-12 ortholog: b3608; Escherichia coli O157:H7 ortholog: z5035; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa) |
| | tdh | Threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa) |
| | c4538 | Putative pyruvate formate-lyase 3 activating enzyme; Escherichia coli K-12 ortholog: b0824; Escherichia coli O157:H7 ortholog: z1047. (305 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (541 aa) |
| | wecC | UDP-N-acetyl-D-mannosamine dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa) |
| | ubiB | NAD(P)H-flavin reductase; Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides; Belongs to the Fre/LuxG FAD/NAD(P) flavoprotein oxidoreductase family. (244 aa) |
| | fadB | Fatty oxidation complex alpha subunit; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (771 aa) |
| | hemG | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX using menaquinone as electron acceptor. (181 aa) |
| | hemN | Oxygen-independent coproporphyrinogen III oxidase; Escherichia coli K-12 ortholog: b3867; Escherichia coli O157:H7 ortholog: z5403; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (459 aa) |
| | yihU | Hypothetical oxidoreductase yihU; Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1- sulfonate (DHPS); Belongs to the HIBADH-related family. 3-sulfolactaldehyde reductase subfamily. (359 aa) |
| | sodA | Superoxide dismutase (Mn); Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (208 aa) |
| | fpr | Ferredoxin--NADP reductase; Escherichia coli K-12 ortholog: b3924; Escherichia coli O157:H7 ortholog: z5469. (248 aa) |
| | metL | AKII-HDII protein; Bifunctional; Escherichia coli K-12 ortholog: b3940; Escherichia coli O157:H7 ortholog: z5495; bifunctional; Aspartokinase II; Homoserine dehydrogenase II; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Escherichia coli K-12 ortholog: b3941; Escherichia coli O157:H7 ortholog: z5496; Belongs to the methylenetetrahydrofolate reductase family. (296 aa) |
| | katG | Peroxidase/catalase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (739 aa) |
| | gldA | Glycerol dehydrogenase; Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions (By similarity). Belongs to the iron-containing alcohol dehydrogenase family. (380 aa) |
| | pflC | Pyruvate formate-lyase 2 activating enzyme; Escherichia coli K-12 ortholog: b3952; Escherichia coli O157:H7 ortholog: z5508. (292 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa) |
| | udhA | Soluble pyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation. (466 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (342 aa) |
| | yjbN | Hypothetical protein yjbN; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. (331 aa) |
| | qor | Quinone oxidoreductase; Escherichia coli K-12 ortholog: b4051; Escherichia coli O157:H7 ortholog: z5649. (327 aa) |
| | c5032 | 2-oxoglutarate dehydrogenase E1 component; Escherichia coli K-12 ortholog: b0726; Escherichia coli O157:H7 ortholog: z0880. (939 aa) |
| | c5035 | Putative 2-oxoglutarate dehydrogenase; Residues 1 to 468 of 472 are 49.04 pct identical to residues 1 to 470 of 474 from SwissProt.40 : >sp|P52992|DLDH_ALCEU DIHYDROLIPOAMIDE DEHYDROGENASE (E3 COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX). (472 aa) |
| | c5039 | Putative lactate dehydrogenase; Residues 15 to 344 of 369 are 44.87 pct identical to residues 1 to 332 of 349 from SwissProt.40 : >sp|Q07251|LDH_ALCEU L-lactate dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family. (369 aa) |
| | nrfA | Cytochrome c552 precursor; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (478 aa) |
| | dsbD | Thiol:disulfide interchange protein dsbD precursor; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. (565 aa) |
| | frdB | Fumarate reductase iron-sulfur protein; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa) |
| | frdA | Fumarate reductase flavoprotein subunit; Escherichia coli K-12 ortholog: b4154; Escherichia coli O157:H7 ortholog: z5762. (602 aa) |
| | yjeS | Putative electron transport protein yjeS; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (394 aa) |
| | aidB | AidB protein; Escherichia coli K-12 ortholog: b4187; Escherichia coli O157:H7 ortholog: z5794. (547 aa) |
| | msrA | Peptide methionine sulfoxide reductase msrA; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity). (234 aa) |
| | nrdG | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (154 aa) |
| | nrdD | Anaerobic ribonucleoside-triphosphate reductase; Escherichia coli K-12 ortholog: b4238; Escherichia coli O157:H7 ortholog: z5848. (712 aa) |
| | idnO | Gluconate 5-dehydrogenase; Catalyzes the reduction of 5-keto-D-gluconate to D-gluconate, using either NADH or NADPH. Is likely involved in an L-idonate degradation pathway that allows E.coli to utilize L-idonate as the sole carbon and energy source. Is also able to catalyze the reverse reaction in vitro, but the D-gluconate oxidation by the enzyme can only proceed with NAD; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (254 aa) |
| | idnD | L-idonate 5-dehydrogenase; Escherichia coli K-12 ortholog: b4267. (343 aa) |
| | uxuB | D-mannonate oxidoreductase; Escherichia coli K-12 ortholog: b4323; Escherichia coli O157:H7 ortholog: z5921; Belongs to the mannitol dehydrogenase family. (486 aa) |
| | fdnG | Formate dehydrogenase, nitrate-inducible, major subunit; Escherichia coli K-12 ortholog: b1474; Escherichia coli O157:H7 ortholog: z2236. (1015 aa) |
| | fdoG | Formate dehydrogenase-O, major subunit; Escherichia coli K-12 ortholog: b3894; Escherichia coli O157:H7 ortholog: z5436. (1016 aa) |
| | fdhF | Formate dehydrogenase H; Escherichia coli K-12 ortholog: b4079; Escherichia coli O157:H7 ortholog: z5678; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (715 aa) |
| | thrA | Bifunctional; Escherichia coli K-12 ortholog: b0002; Escherichia coli O157:H7 ortholog: z0002; bifunctional; Homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. (841 aa) |
| | lytB | IspH protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. (331 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | caiA | Crotonobetainyl-CoA dehydrogenase; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA; Belongs to the acyl-CoA dehydrogenase family. (380 aa) |
| | fixC | FixC protein; Could be part of an electron transfer system required for anaerobic carnitine reduction; Belongs to the ETF-QO/FixC family. (428 aa) |
| | yabF | Putative NAD(P)H oxidoreductase yabF; Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC; Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily. (176 aa) |
| | folA | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). (204 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (329 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (364 aa) |
| | guaC | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity). (347 aa) |
| | aceE | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa) |
| | lpdA | Dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (495 aa) |
| | yafB | 2,5-diketo-D-gluconic acid reductase B; Escherichia coli K-12 ortholog: b0207; Escherichia coli O157:H7 ortholog: z0229. (267 aa) |
