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speA speA surA surA yacA yacA yadT yadT hlpA hlpA pic pic tesA tesA cusX cusX fepB fepB dsbG dsbG tolB tolB ybhG ybhG ybiJ ybiJ glnH glnH ybiS ybiS gsiB gsiB lolA lolA torA torA ycdO ycdO ycdB ycdB focC focC csgC csgC mdoG mdoG yceI yceI flgA flgA flgI flgI potD potD treA treA ydcG ydcG asr asr yobA yobA bisZ bisZ fliY fliY yedY yedY yohN yohN mglB mglB napB napB napG napG napA napA eco eco ais ais hisJ hisJ mepA mepA yfgC yfgC amiC amiC ptr ptr dsbC dsbC sat sat nanM1 nanM1 hybO hybO sufI sufI asst asst dsbL dsbL yraP yraP yhbN yhbN yhcN yhcN fkpA fkpA ppiA ppiA ugpB ugpB livJ livJ hdeB hdeB hdeA hdeA dsbA dsbA cpxP cpxP yjaI yjaI malE malE aphA aphA nrfA nrfA nrfB nrfB yjfN yjfN yjfY yjfY cybC cybC nanM2 nanM2 fimC fimC osmY osmY
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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speABiosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (662 aa)
surASurvival protein surA precursor; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (428 aa)
yacASecretion monitor precursor; Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation. Belongs to the SecM family. (221 aa)
yadTVitamin B12 transport protein btuF precursor; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. (266 aa)
hlpAHistone-like protein HLP-1 precursor; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. (161 aa)
picPic serine protease precursor; Involved in virulence of uropathogenic E.coli although it is not known how it contributes to it. Has no mucinase activity. (1371 aa)
tesAAcyl-CoA thioesterase I precursor; TesA is a multifunctional esterase that can act as a thioesterase, arylesterase, lysophospholipase and protease. (218 aa)
cusXHypothetical protein cusX precursor; Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide (By similarity). (110 aa)
fepBFerrienterobactin-binding periplasmic protein precursor; Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin. Belongs to the bacterial solute-binding protein 8 family. (318 aa)
dsbGThiol:disulfide interchange protein dsbG precursor; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily. (268 aa)
tolBTolB protein precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. (431 aa)
ybhGHypothetical membrane protein ybhG; Escherichia coli K-12 ortholog: b0795; Escherichia coli O157:H7 ortholog: z1015. (332 aa)
ybiJHypothetical protein ybiJ precursor; Escherichia coli K-12 ortholog: b0802; Escherichia coli O157:H7 ortholog: z1023. (86 aa)
glnHGlutamine-binding periplasmic protein precursor; Involved in a glutamine-transport system GlnHPQ. (248 aa)
ybiSProtein ybiS precursor; Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp) to the peptidoglycan via a meso- diaminopimelyl-L-Lys- bond on the terminal residue of Lpp. (306 aa)
gsiBPutative binding protein yliB precursor; Part of the ABC transporter complex GsiABCD involved in glutathione import. Binds glutathione. (564 aa)
lolAOuter-membrane lipoproteins carrier protein precursor; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity). (204 aa)
torATrimethylamine-N-oxide reductase 1 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. (848 aa)
ycdOProtein ycdO; Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component (By similarity); Belongs to the EfeM/EfeO family. (375 aa)
ycdBHypothetical protein ycdB precursor; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact (By similarity); Belongs to the DyP-type peroxidase family. EfeB subfamily. (423 aa)
focCF1C periplasmic chaperone; Involved in the biogenesis of the F1C fimbriae. Belongs to the periplasmic pilus chaperone family. (231 aa)
csgCPutative curli production protein csgC precursor; Escherichia coli K-12 ortholog: b1043; Escherichia coli O157:H7 ortholog: z1677. (110 aa)
mdoGPeriplasmic glucans biosynthesis protein mdoG precursor; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (517 aa)
yceIProtein yceI precursor; Escherichia coli K-12 ortholog: b1056; Escherichia coli O157:H7 ortholog: z1692. (191 aa)
flgAFlagella basal body P-ring formation protein flgA precursor; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P- ring assembly; Belongs to the FlgA family. (219 aa)
flgIFlagellar P-ring protein precursor; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (366 aa)
potDSpermidine/putrescine-binding periplasmic protein precursor; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the bacterial solute-binding protein PotD/PotF family. (348 aa)
treAPeriplasmic trehalase precursor; Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system; Belongs to the glycosyl hydrolase 37 family. (565 aa)
ydcGProtein ydcG precursor; Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs); Belongs to the OpgD/OpgG family. (551 aa)
asrAcid shock protein precursor; Required for growth and/or survival at acidic conditions. (111 aa)
yobAProtein yobA precursor; Escherichia coli K-12 ortholog: b1841; Escherichia coli O157:H7 ortholog: z2889. (124 aa)
bisZTrimethylamine-N-oxide reductase 2 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N- oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency (By similarity); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (815 aa)
fliYCystine-binding periplasmic protein precursor; Part of the ABC transporter complex FliY-YecC-YecS involved in L-cystine transport. Binds cystine. (285 aa)
yedYHypothetical protein yedY; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. The catal [...] (334 aa)
yohNHypothetical protein yohN precursor; Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux (By similarity); Belongs to the RcnB family. (172 aa)
mglBD-galactose-binding periplasmic protein precursor; This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor (By similarity). (332 aa)
napBDiheme cytochrome c napB precursor; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (156 aa)
napGFerredoxin-type protein napG; Required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex. (231 aa)
napAPeriplasmic nitrate reductase precursor; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa)
ecoEcotin precursor; General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. (169 aa)
aisAis protein; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. (209 aa)
hisJHistidine-binding periplasmic protein precursor; Part of the histidine permease ABC transporter. Binds histidine. Interacts with HisQMP and stimulates ATPase activity of HisP, which results in histidine translocation (By similarity). (260 aa)
mepAPenicillin-insensitive murein endopeptidase precursor; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus. Belongs to the peptidase M74 family. (274 aa)
yfgCHypothetical protein yfgC precursor; Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state. (487 aa)
amiCN-acetylmuramoyl-L-alanine amidase amiC precursor; Cell-wall hydrolase involved in septum cleavage during cell division; Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. (447 aa)
ptrProtease III precursor; Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin. (962 aa)
dsbCThiol:disulfide interchange protein dsbC precursor; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily. (236 aa)
satSecreted auto transpoter toxin; Shows serine protease activity and displays cytophatic activity, including elongation, rounding, and detachment of a proportion of the cells from monolayer in culture. Triggers vacuolation within the cytoplasm of the human bladder and kidney cells. (1299 aa)
nanM1Hypothetical protein yjhT precursor; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. (372 aa)
hybOHydrogenase-2 small chain precursor; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake. (372 aa)
sufIProtein sufI precursor; Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress; Belongs to the FtsP family. (470 aa)
asstArylsulfate sulfotransferase; Catalyzes the transfer of sulfuryl groups between phenolic compounds. (598 aa)
dsbLPutative disulfide isomerase; Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT. (222 aa)
yraPHypothetical protein yraP precursor; Escherichia coli K-12 ortholog: b3150; Escherichia coli O157:H7 ortholog: z4509. (191 aa)
yhbNProtein yhbN precursor; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (192 aa)
yhcNHypothetical protein yhcN precursor; Escherichia coli K-12 ortholog: b3238; Escherichia coli O157:H7 ortholog: z4597. (104 aa)
fkpAFKBP-type peptidyl-prolyl cis-trans isomerase fkpA precursor; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (270 aa)
ppiAPeptidyl-prolyl cis-trans isomerase A precursor; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). (190 aa)
ugpBGlycerol-3-phosphate-binding periplasmic protein precursor; sn-glycerol-3-phosphate and glycerophosphoryl diester-binding protein interacts with the binding protein-dependent transport system UgpACE. (438 aa)
livJLeu/Ile/Val-binding protein precursor; This protein is a component of the leucine, isoleucine, valine, (threonine) transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high- affinity transport of the branched-chain amino acids; Belongs to the leucine-binding protein family. (386 aa)
hdeBProtein hdeB precursor; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins. Belongs to the HdeB family. (112 aa)
hdeAProtein hdeA precursor; Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Belongs to the HdeA family. (110 aa)
dsbAThiol:disulfide interchange protein dsbA precursor; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis (By similarity). Belongs to the thioredoxin family. DsbA subfamily. (208 aa)
cpxPConserved hypothetical protein; Acts as an accessory protein in the Cpx two-component envelope stress response system. Binds the periplasmic domain of sensor histidine kinase CpxA, inhibiting induction of the envelope stress response in the absence of inducer. Aids in combating extracytoplasmic protein-mediated toxicity. (167 aa)
yjaIZinc resistance-associated protein precursor; Binds zinc. Could be an important component of the zinc- balancing mechanism (By similarity); Belongs to the ZraP family. (186 aa)
malEMaltose-binding periplasmic protein precursor; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins. Belongs to the bacterial solute-binding protein 1 family. (396 aa)
aphAClass B acid phosphatase precursor; Escherichia coli K-12 ortholog: b4055; Escherichia coli O157:H7 ortholog: z5654; Belongs to the class B bacterial acid phosphatase family. (237 aa)
nrfACytochrome c552 precursor; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (478 aa)
nrfBCytochrome c-type protein nrfB precursor; Plays a role in nitrite reduction. (190 aa)
yjfNHypothetical protein yjfN; Escherichia coli K-12 ortholog: b4188; Escherichia coli O157:H7 ortholog: z5795. (100 aa)
yjfYHypothetical protein yjfY precursor; Escherichia coli K-12 ortholog: b4199; Escherichia coli O157:H7 ortholog: z5808. (91 aa)
cybCSoluble cytochrome b562 precursor; Electron-transport protein of unknown function. Belongs to the cytochrome b562 family. (128 aa)
nanM2Hypothetical protein yjhT precursor; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. (404 aa)
fimCChaperone protein fimC precursor; Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH (By similarity); Belongs to the periplasmic pilus chaperone family. (241 aa)
osmYOsmotically inducible protein Y precursor; Escherichia coli K-12 ortholog: b4376; Escherichia coli O157:H7 ortholog: z5977. (227 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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