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| | c1810 | Hypothetical protein; Residues 10 to 258 of 271 are 35.34 pct identical to residues 18 to 260 of 268 from GenPept.129 : >emb|CAD16771.1| (AL646073) PROBABLE TRANSCRIPTION REGULATOR PROTEIN [Ralstonia solanacearum]. (271 aa) |
| | arcA | Aerobic respiration control protein arcA; Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter (By similarity). (238 aa) |
| | creB | Transcriptional Regulatory protein creB; Escherichia coli K-12 ortholog: b4398; Escherichia coli O157:H7 ortholog: z6001. (229 aa) |
| | trpR | Trp operon repressor; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. (108 aa) |
| | yjjM | Hypothetical protein yjjM; Escherichia coli K-12 ortholog: b4357; Escherichia coli O157:H7 ortholog: z5957. (301 aa) |
| | yjiE | Hypothetical transcriptional regulator yjiE; Escherichia coli K-12 ortholog: b4327; Escherichia coli O157:H7 ortholog: z5926; Belongs to the LysR transcriptional regulatory family. (329 aa) |
| | uxuR | Uxu operon transcriptional regulator; Escherichia coli K-12 ortholog: b4324; Escherichia coli O157:H7 ortholog: z5922. (257 aa) |
| | fimE | Type 1 fimbriae Regulatory protein fimE; FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off (By similarity). (198 aa) |
| | idnR | L-idonate Regulatory protein; Escherichia coli K-12 ortholog: b4264; Escherichia coli O157:H7 ortholog: z4806. (342 aa) |
| | argR-2 | Hypothetical protein; Regulates arginine biosynthesis genes. (184 aa) |
| | treR | Trehalose operon repressor; Escherichia coli K-12 ortholog: b4241; Escherichia coli O157:H7 ortholog: z5851. (315 aa) |
| | c5304 | Putative conserved protein; Residues 132 to 239 of 239 are 97.22 pct identical to residues 1 to 108 of 108 from MG1655 : b4205. (239 aa) |
| | yjfQ | Hypothetical transcriptional regulator yjfQ; Represses ulaG and the ulaABCDEF operon. (251 aa) |
| | yjeB | Hypothetical protein yjeB; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. (141 aa) |
| | yjdC | Protein yjdC; Escherichia coli K-12 ortholog: b4135; Escherichia coli O157:H7 ortholog: z5740. (199 aa) |
| | pgtA | Transport activator; Residues 4 to 417 of 418 are 79.95 pct identical to residues 1 to 414 of 415 from SwissProt.40 : >sp|P06184|PGTA_SALTY PHOSPHOGLYCERATE TRANSPORT SYSTEM TRANSCRIPTIONAL REGULATORY PROTEIN PGTA. (418 aa) |
| | cadC | Transcriptional activator cadC; Escherichia coli K-12 ortholog: b4133; Escherichia coli O157:H7 ortholog: z5736. (512 aa) |
| | yjdG | Transcriptional Regulatory protein dcuR; Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4- dicarboxylate transporter dctA (By similarity). (239 aa) |
| | melR | Melibiose operon Regulatory protein; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site (By similarity). (302 aa) |
| | adiY | Putative Regulatory protein adiY; Escherichia coli K-12 ortholog: b4116; Escherichia coli O157:H7 ortholog: z5718. (253 aa) |
| | basR | Transcriptional Regulatory protein basR/pmrA; Escherichia coli K-12 ortholog: b4113; Escherichia coli O157:H7 ortholog: z5715. (222 aa) |
| | phnF | Probable transcriptional regulator phnF; Escherichia coli K-12 ortholog: b4102; Escherichia coli O157:H7 ortholog: z5705. (244 aa) |
| | rpiR | Protein rpiR; Regulatory protein involved in rpiB gene repression. Also involved in als operon repression (By similarity). (307 aa) |
| | c5058 | Putative transcriptional regulator; Residues 1 to 291 of 294 are 89.04 pct identical to residues 1 to 292 of 295 from GenPept.129 : >emb|CAD09254.1| (AL627282) lysR family regulatory protein [Salmonella enterica subsp. enterica serovar Typhi]; Belongs to the LysR transcriptional regulatory family. (294 aa) |
| | soxS | Regulatory protein soxS; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters (By similarity). (107 aa) |
| | c5040 | Putative c4-dicarboxylate transport transcriptional Regulatory protein; Residues 10 to 441 of 452 are 51.61 pct identical to residues 7 to 439 of 448 from SwissProt.40 : >sp|P10046|DCTD_RHILE C4-DICARBOXYLATE TRANSPORT TRANSCRIPTIONAL REGULATORY PROTEIN DCTD. (452 aa) |
| | c5025 | Putative regulator; Residues 16 to 349 of 353 are 38.46 pct identical to residues 2 to 335 of 347 from GenPept.129 : >emb|CAC47885.1| (AL591793) PUTATIVE TRANSCRIPTION REGULATOR PROTEIN [Sinorhizobium meliloti]. (353 aa) |
| | lexA | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (202 aa) |
| | hydG | Transcriptional Regulatory protein zraR; Escherichia coli K-12 ortholog: b4004; Escherichia coli O157:H7 ortholog: z5580. (441 aa) |
| | yjaE | Regulator of sigma D; Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase. (158 aa) |
| | rpoC | DNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1407 aa) |
| | rpoB | DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1353 aa) |
| | nusG | Transcription antitermination protein nusG; Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination [...] (181 aa) |
| | birA | BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (321 aa) |
| | yijC | Hypothetical protein yijC; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. (234 aa) |
| | oxyR | Hydrogen peroxide-inducible genes activator; Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto- aggregation ab [...] (320 aa) |
| | yijO | Hypothetical transcriptional regulator yijO; Escherichia coli K-12 ortholog: b3954; Escherichia coli O157:H7 ortholog: z5512. (283 aa) |
| | metJ | Met repressor; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. (151 aa) |
| | cytR | Transcriptional repressor cytR; This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors (By similarity). (341 aa) |
| | cpxR | Transcriptional Regulatory protein cpxR; Escherichia coli K-12 ortholog: b3912; Escherichia coli O157:H7 ortholog: z5457. (232 aa) |
| | rhaR | L-rhamnose operon transcriptional activator rhaR; Activates expression of the rhaSR operon in response to L- rhamnose. (319 aa) |
| | rhaS | L-rhamnose operon Regulatory protein rhaS; Activates expression of the rhaBAD and rhaT operons. (278 aa) |
| | yihW | Hypothetical transcriptional regulator yihW; Escherichia coli K-12 ortholog: b3884; Escherichia coli O157:H7 ortholog: z5422. (262 aa) |
| | yihL | Hypothetical transcriptional regulator yihL; Escherichia coli K-12 ortholog: b3872; Escherichia coli O157:H7 ortholog: z5408. (236 aa) |
| | glnG | Nitrogen regulation protein NR(I); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (489 aa) |
| | rfaH | Transcriptional activator rfaH; Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains (By similarity). Contributes to intestinal colonization via [...] (162 aa) |
| | c4761 | Putative conserved protein; Residues 4 to 297 of 301 are 34.35 pct identical to residues 3 to 296 of 310 from MG1655 : b1659; Belongs to the LysR transcriptional regulatory family. (301 aa) |
| | metR | Transcriptional activator protein metR; Escherichia coli K-12 ortholog: b3828; Escherichia coli O157:H7 ortholog: z5349; Belongs to the LysR transcriptional regulatory family. (317 aa) |
| | rho | Transcription termination factor rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (443 aa) |
| | ilvY | Transcriptional activator protein ilvY; Escherichia coli K-12 ortholog: b3773; Escherichia coli O157:H7 ortholog: z5284; Belongs to the LysR transcriptional regulatory family. (324 aa) |
| | yifA | Conserved hypothetical protein; Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon. (279 aa) |
| | yieP | Hypothetical transcriptional regulator yieP; Escherichia coli K-12 ortholog: b3755; Escherichia coli O157:H7 ortholog: z5258. (230 aa) |
| | rbsR | Ribose operon repressor; Transcriptional repressor for the ribose rbsDACBK operon. RbsR binds to a region of perfect dyad symmetry spanning the rbs operon transcriptional start site. The affinity for the rbs operator is reduced by addition of ribose, consistent with ribose being the inducer of the operon (By similarity). (330 aa) |
| | asnC | Regulatory protein asnC; Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post- transcriptional level. (152 aa) |
| | yidZ | Hypothetical transcriptional regulator yidZ; Involved in anaerobic NO protection. (322 aa) |
| | c4616 | Hypothetical protein; Fusion of Escherichia coli K-12 B3694 and B3695; Residues 1 to 229 of 229 are 99.12 pct identical to residues 1 to 229 of 229 from SwissProt.40 : >sp|P31460|DGOR_ECOLI GALACTONATE OPERON TRANSCRIPTIONAL REPRESSOR. (229 aa) |
| | yidL | Hypothetical transcriptional regulator yidL; Escherichia coli K-12 ortholog: b3680; Escherichia coli O157:H7 ortholog: z5175. (298 aa) |
| | uhpA | Transcriptional Regulatory protein uhpA; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. Activates the transcription of the uhpT gene. Acts by binding specifically to the uhpT promoter region. (196 aa) |
| | c4550 | Hypothetical protein; Residues 9 to 178 of 189 are 29.31 pct identical to residues 1 to 174 of 212 from GenPept.129 : >gb|AAG06962.1|AE004778_6 (AE004778) probable transcriptional regulator [Pseudomonas aeruginosa]. (189 aa) |
| | c4546 | Hypothetical protein; Residues 245 to 342 of 351 are 45.91 pct identical to residues 178 to 275 of 317 from GenPept.129 : >emb|CAD01088.1| (AJ297723) putative transcriptional regulator [Lactobacillus collinoides]. (351 aa) |
| | c4494 | Putative transcriptional regulator; Residues 9 to 364 of 364 are 54.03 pct identical to residues 1 to 359 of 360 from GenPept.129 : >emb|CAC89693.1| (AJ414145) LacI-family regulatory protein [Yersinia pestis]. (364 aa) |
| | rpoZ | DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). (91 aa) |
| | lldR | Putative L-lactate dehydrogenase operon Regulatory protein; Escherichia coli K-12 ortholog: b3604; Escherichia coli O157:H7 ortholog: z5031. (263 aa) |
| | mtlR | Mannitol operon repressor; Involved in the repression of the expression of the mannitol mtlADR operon. Does not bind the operator/promoter regulatory region of this operon. Therefore, seems to belong to a new class of transcription factors in bacteria that may regulate gene expression indirectly, perhaps as a part of a larger transcriptional complex. Belongs to the MtlR/FumE family. (195 aa) |
| | xylR | Xylose operon Regulatory protein; Regulatory protein for the xylBAFGHR operon. (392 aa) |
| | cspA | Cold shock protein cspA; Binds to and stimulates the transcription of the CCAAT- containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to the inverted repeat 5'-ATTGG-3' (By similarity). (70 aa) |
| | yiaG | Hypothetical protein yiaG; Escherichia coli K-12 ortholog: b3555; Escherichia coli O157:H7 ortholog: z4980. (96 aa) |
| | yhjC | Hypothetical transcriptional regulator yhjC; Escherichia coli K-12 ortholog: b3521; Escherichia coli O157:H7 ortholog: z4934; Belongs to the LysR transcriptional regulatory family. (323 aa) |
| | yhiX | Transcriptional regulator gadX; Positively regulates the expression of about fifteen genes involved in acid resistance such as gadA, gadB and gadC. Depending on the conditions (growth phase and medium), can repress gadW (By similarity). (274 aa) |
| | yhiW | Hypothetical transcriptional regulator yhiW; Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via the repression of the expression of gadX. Activation occurs directly by the binding of GadW to the gadA and gadBC promoters (By similarity). (242 aa) |
| | yhiE | Hypothetical protein yhiE; Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci (By similarity). (201 aa) |
| | yhiF | Hypothetical transcriptional regulator yhiF; May act as a transcriptional regulator of dctA. (176 aa) |
| | c4276 | Putative regulator; Escherichia coli O157:H7 ortholog: z4874. (251 aa) |
| | yhhG | Nickel responsive regulator; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel (By similarity). (133 aa) |
| | rpoH | RNA polymerase sigma-32 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (284 aa) |
| | gntR | Gluconate utilization system GNT-I transcriptional repressor; Negative regulator for the gluconate utilization system GNT- I, the gntUKR operon. (331 aa) |
| | glpR | Glycerol-3-phosphate regulon repressor; Escherichia coli K-12 ortholog: b3423; Escherichia coli O157:H7 ortholog: z4781. (269 aa) |
| | rtcR | Transcriptional Regulatory protein rtcR; Escherichia coli K-12 ortholog: b3422; Escherichia coli O157:H7 ortholog: z4780. (532 aa) |
| | malT | MalT Regulatory protein; Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto- oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box. (901 aa) |
| | yhgG | Hypothetical protein yhgG; May function as a transcriptional regulator that controls feoABC expression. (81 aa) |
| | greB | Transcription elongation factor greB; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length. (170 aa) |
| | nhaR | Transcriptional activator protein nhaR; Na+/H+ antiporter regulatory protein; Escherichia coli K-12 ortholog: b0020; Escherichia coli O157:H7 ortholog: z0019; Belongs to the LysR transcriptional regulatory family. (307 aa) |
| | hepA | RNA polymerase associated protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. (968 aa) |
| | araC | Arabinose operon Regulatory protein; Escherichia coli K-12 ortholog: b0064; Escherichia coli O157:H7 ortholog: z0073. (281 aa) |
| | yabN | Hypothetical protein yabN; Activates the small RNA gene sgrS under glucose-phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain. (558 aa) |
| | leuO | Probable activator protein in leuABCD operon; Escherichia coli K-12 ortholog: b0076; Escherichia coli O157:H7 ortholog: z0086; Belongs to the LysR transcriptional regulatory family. (314 aa) |
| | fruR | Fructose repressor; Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism. (334 aa) |
| | yabB | Protein mraZ; Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster. (164 aa) |
| | pdhR | Pyruvate dehydrogenase complex repressor; Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd. (265 aa) |
| | pcnB | Poly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (472 aa) |
| | yafC | Hypothetical transcriptional regulator yafC; Escherichia coli K-12 ortholog: b0208; Escherichia coli O157:H7 ortholog: z0230; Belongs to the LysR transcriptional regulatory family. (304 aa) |
| | c0330 | Putative deoxyribose operon repressor; Residues 2 to 261 of 261 are 83.58 pct identical to residues 1 to 261 of 261 from GenPept.129 : >gb|AAL22652.1| (AE008876) putative regulatory protein, deoR family [Salmonella typhimurium LT2]. (261 aa) |
| | c0337 | Putative conserved protein; Residues 12 to 307 of 343 are 33.11 pct identical to residues 5 to 298 of 313 from MG1655 : b3438. (343 aa) |
| | crl | Curlin genes transcriptional activatory protein; Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32; Belongs to the Crl family. (133 aa) |
| | matA | Hypothetical protein ykgK; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Positively regulates the expression of the ecp operon (By similarity). (196 aa) |
| | c0411 | Putative LysR-like transcriptional regulator; Escherichia coli O157:H7 ortholog: z0371; Belongs to the LysR transcriptional regulatory family. (329 aa) |
| | c0412 | Hypothetical transcriptional regulator ycjZ; Escherichia coli K-12 ortholog: b1328; Escherichia coli O157:H7 ortholog: z2439; Belongs to the LysR transcriptional regulatory family. (322 aa) |
| | ykgD | Hypothetical transcriptional regulator ykgD; Escherichia coli K-12 ortholog: b0305; Escherichia coli O157:H7 ortholog: z0382. (301 aa) |
| | betI | Regulatory protein betI; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity). (201 aa) |
| | yahB | Hypothetical transcriptional regulator yahB; Escherichia coli K-12 ortholog: b0316; Escherichia coli O157:H7 ortholog: z0405; Belongs to the LysR transcriptional regulatory family. (310 aa) |
| | prpR | Propionate catabolism operon Regulatory protein; Escherichia coli K-12 ortholog: b0330; Escherichia coli O157:H7 ortholog: z0426. (528 aa) |
| | yaiN | Hypothetical protein yaiN; Repressor of the frmRAB operon; Belongs to the FrmR/RcnR family. (98 aa) |
| | phoB | Phosphate regulon transcriptional Regulatory protein phoB; Escherichia coli K-12 ortholog: b0399; Escherichia coli O157:H7 ortholog: z0497. (229 aa) |
| | ybaD | Hypothetical protein ybaD; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (149 aa) |
| | nusB | N utilization substance protein B; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (139 aa) |
| | bolA | BolA protein; Transcriptional regulator that plays an important role in general stress response. (116 aa) |
| | ybaO | Hypothetical transcriptional regulator ybaO; Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L- cysteine; activates transcription from the dlsT(yhaO)-yhaM operon. (188 aa) |
| | glnK | Nitrogen Regulatory protein P-II 2; P-II indirectly controls the transcription of the glutamine synthetase gene (GlnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity); Belongs to the P(II) protein family. (112 aa) |
| | hha | Haemolysin expression modulating protein; Down-regulates hemolysin expression, in complex with H-NS, and can also stimulate transposition events in vivo. Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex. Binds DNA and influences DNA topology in response to environmental stimuli. Decreases biofilm formation (By similarity). (76 aa) |
| | acrR | Potential acrAB operon repressor; Potential regulator protein for the acrAB genes. (215 aa) |
| | ybaQ | Hypothetical protein ybaQ; Escherichia coli K-12 ortholog: b0483; Escherichia coli O157:H7 ortholog: z0602; Belongs to the VapA/VapI family. (113 aa) |
| | ybbI | Transcriptional regulator cueR; Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations (By similarity). (135 aa) |
| | ybbS | Hypothetical transcriptional regulator ybbS; Positive regulator essential for the expression of allD operon. Binds to the allD promoter (By similarity). (308 aa) |
| | ybbU | Negative regulator of allantoin and glyoxylate utilization operons; Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS-allA intergenic region (By similarity). (271 aa) |
| | cusR | Transcriptional Regulatory protein cusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. (227 aa) |
| | ybdO | Hypothetical transcriptional regulator ybdO; Escherichia coli K-12 ortholog: b0603; Escherichia coli O157:H7 ortholog: z0747; Belongs to the LysR transcriptional regulatory family. (312 aa) |
| | citB | Transcriptional Regulatory protein dpiA; Member of the two-component regulatory system DpiA/DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. Could be involved in response to both the presence of citrate and external redox conditions (By similarity). (226 aa) |
| | cspE | Cold shock-like protein cspE; CSP-E; Escherichia coli K-12 ortholog: b0623; Escherichia coli O157:H7 ortholog: z0769. (97 aa) |
| | nagC | N-acetylglucosamine repressor; Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon. (406 aa) |
| | c0765 | Putative transcriptional regulator; LysR family; Residues 1 to 234 of 253 are 70.08 pct identical to residues 1 to 234 of 255 from GenPept.129 : >gb|AAL19128.1| (AE008701) putative transcriptional regulator (LysR family) [Salmonella typhimurium LT2]. (253 aa) |
| | fur | Ferric uptake regulation protein; Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon (By similarity). (148 aa) |
| | kdpE | KDP operon transcriptional Regulatory protein kdpE; Escherichia coli K-12 ortholog: b0694; Escherichia coli O157:H7 ortholog: z0841. (225 aa) |
| | ybhD | Hypothetical transcriptional regulator ybhD; Escherichia coli K-12 ortholog: b0768; Escherichia coli O157:H7 ortholog: z0939; Belongs to the LysR transcriptional regulatory family. (338 aa) |
| | ybiH | Hypothetical transcriptional regulator ybiH; Escherichia coli K-12 ortholog: b0796; Escherichia coli O157:H7 ortholog: z1016. (227 aa) |
| | mntR | Transcriptional regulator mntR; In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP (By similarity). Belongs to the DtxR/MntR family. (155 aa) |
| | deoR | Deoxyribose operon repressor; This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore-forming protein). The inducer is deoxyribose-5-phosphate (By similarity). (252 aa) |
| | ybjK | Hypothetical protein ybjK; Escherichia coli K-12 ortholog: b0846; Escherichia coli O157:H7 ortholog: z1073. (188 aa) |
| | lrp | Leucine-responsive Regulatory protein; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes (By similarity). (182 aa) |
| | himD | Integration host factor beta-subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (94 aa) |
| | cspH | Cold shock-like protein cspH; CSP-H; Escherichia coli K-12 ortholog: b0989; Escherichia coli O157:H7 ortholog: z1405. (70 aa) |
| | cspG | Cold shock-like protein cspG; CSP-G; Escherichia coli K-12 ortholog: b0990; Escherichia coli O157:H7 ortholog: z1406. (70 aa) |
| | torR | TorCAD operon transcriptional Regulatory protein torR; Escherichia coli K-12 ortholog: b0995; Escherichia coli O157:H7 ortholog: z1412. (230 aa) |
| | ycdC | Hypothetical transcriptional regulator ycdC; Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX) (By similarity). (221 aa) |
| | putA | PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1342 aa) |
| | focX | Putative Regulatory protein; Residues 18 to 183 of 183 are 100.00 pct identical to residues 1 to 166 of 166 from SwissProt.40 : >sp|P42192|PRSX_ECOLI PRSX PROTEIN. (183 aa) |
| | ycfQ | Hypothetical transcriptional regulator ycfQ; Escherichia coli K-12 ortholog: b1111; Escherichia coli O157:H7 ortholog: z1750. (236 aa) |
| | phoP | Transcriptional Regulatory protein phoP; Member of the two-component regulatory system PhoQ/PhoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. (223 aa) |
| | fadR | Fatty acid metabolism regulator protein; Multifunctional regulator of fatty acid metabolism. (239 aa) |
| | c1659 | Glycerol metabolism operon Regulatory protein; Escherichia coli K-12 ortholog: b1201. (642 aa) |
| | chaB | Cation transport regulator chaB; Might be a regulator of the sodium-potassium/proton antiporter ChaA; Belongs to the ChaB family. (76 aa) |
| | narL | Nitrate/nitrite response regulator protein narL; This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal transmitted by either the NarX or NarQ proteins. (238 aa) |
| | hns | DNA-binding protein H-NS; A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity). (137 aa) |
| | cysB | Cys regulon transcriptional activator; This protein is a positive regulator of gene expression for the cysteine regulon. The inducer for CysB is N-acetylserine (By similarity). (324 aa) |
| | yciT | Hypothetical transcriptional regulator yciT; Escherichia coli K-12 ortholog: b1284; Escherichia coli O157:H7 ortholog: z2521. (249 aa) |
| | c1760 | Putative transcriptional repressor; Escherichia coli O157:H7 ortholog: z2510. (221 aa) |
| | pspF | Psp operon transcriptional activator; Escherichia coli K-12 ortholog: b1303; Escherichia coli O157:H7 ortholog: z2484. (330 aa) |
| | pspC | Phage shock protein C; The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspC is involved in transcription regulation (By similarity); Belongs to the phageshock PspC family. (119 aa) |
| | ycjW | Hypothetical transcriptional regulator ycjW; Escherichia coli K-12 ortholog: b1320; Escherichia coli O157:H7 ortholog: z2461. (332 aa) |
| | tyrR | Transcriptional Regulatory protein tyrR; Escherichia coli K-12 ortholog: b1323; Escherichia coli O157:H7 ortholog: z2454. (522 aa) |
| | c1802 | Hypothetical transcriptional regulator ycjZ; Escherichia coli K-12 ortholog: b1328; Escherichia coli O157:H7 ortholog: z2439; Belongs to the LysR transcriptional regulatory family. (299 aa) |
| | fnr | Fumarate and nitrate reduction Regulatory protein; Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O(2), is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration (By similarity). (269 aa) |
| | ompR | Transcriptional Regulatory protein ompR; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes. Plays a central role in both acid and osmotic stress responses. Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription. (239 aa) |
| | crp | Catabolite gene activator; A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity). (210 aa) |
| | rplD | 50S ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. Forms part of the polypeptide exit tunnel. Belongs to the universal ribosomal protein uL4 family. (201 aa) |
| | rpsD | 30S ribosomal protein S4; One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. Protein S4 is also a translational repressor protein, it controls the translation of the alpha-operon (which codes for S13, S11, S4, RNA polymerase alpha subunit, and L17) by binding to its mRNA. (206 aa) |
| | rpoA | DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa) |
| | envR | Potential acrEF/envCD operon repressor; Escherichia coli K-12 ortholog: b3264; Escherichia coli O157:H7 ortholog: z4624. (220 aa) |
| | fis | DNA-binding protein fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. (98 aa) |
| | c4020 | Hypothetical protein; Residues 8 to 270 of 276 are 42.00 pct identical to residues 3 to 270 of 277 from GenPept.129 : >gb|AAL22124.1| (AE008850) aga operon transcriptional repressor (DeoR family) [Salmonella typhimurium LT2]. (276 aa) |
| | yhcS | Hypothetical transcriptional regulator yhcS; Activates transcription of the aaeXAB operon. (309 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes; Belongs to the ArgR family. (156 aa) |
| | yhcK | Hypothetical transcriptional regulator yhcK; Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids. (263 aa) |
| | arcB | Aerobic respiration control sensor protein arcB; Escherichia coli K-12 ortholog: b3210; Escherichia coli O157:H7 ortholog: z4574. (778 aa) |
| | rpoN | RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (477 aa) |
| | nlp | Sugar fermentation stimulation protein B; This protein is involved in positive regulation of the metabolism of sugars. (92 aa) |
| | greA | Transcription elongation factor greA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity). (158 aa) |
| | nusA | N utilization substance protein A; Participates in both transcription termination and antitermination. (495 aa) |
| | agaR | Putative aga operon transcriptional repressor; Probable repressor for the aga operon for N-acetyl galactosamine transport and metabolism. (269 aa) |
| | yhaV | Hypothetical protein yhaV; Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity in vitro. Acts as a transcription factor. The YhaV/PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression (By similarity). (154 aa) |
| | sohA | HtrA suppressor protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the YhaV toxin and neutralizes its ribonuclease activity. Also acts as a transcription factor. The YhaV/PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression (By similarity). (111 aa) |
| | tdcA | Tdc operon transcriptional activator; Escherichia coli K-12 ortholog: b3118; Escherichia coli O157:H7 ortholog: z4470; Belongs to the LysR transcriptional regulatory family. (312 aa) |
| | yhaJ | Hypothetical transcriptional regulator yhaJ; Escherichia coli K-12 ortholog: b3105; Escherichia coli O157:H7 ortholog: z4459; Belongs to the LysR transcriptional regulatory family. (298 aa) |
| | exuR | Exu regulon transcriptional regulator; Escherichia coli K-12 ortholog: b3094; Escherichia coli O157:H7 ortholog: z4448. (263 aa) |
| | higA | Hypothetical protein ygjM; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin. (138 aa) |
| | ebgR | Ebg operon repressor; Escherichia coli K-12 ortholog: b3075; Escherichia coli O157:H7 ortholog: z4428. (327 aa) |
| | rpoD | RpoD protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (246 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (581 aa) |
| | ygiP | Hypothetical transcriptional regulator ygiP; Positive regulator required for L-tartrate-dependent anaerobic growth on glycerol. Induces expression of the ttdA-ttdB-ygjE operon (By similarity). (326 aa) |
| | ygiX | Transcriptional Regulatory protein qseB; Escherichia coli K-12 ortholog: b3025; Escherichia coli O157:H7 ortholog: z4377. (219 aa) |
| | c3750 | Putative regulator; Residues 1 to 248 of 249 are 78.62 pct identical to residues 18 to 265 of 266 from GenPept.129 : >gb|AAL21959.1| (AE008842) putative regulatory protein, gntR family [Salmonella typhimurium LT2]. (249 aa) |
| | yqhC | Hypothetical transcriptional regulator yqhC; Escherichia coli K-12 ortholog: b3010; Escherichia coli O157:H7 ortholog: z4363. (375 aa) |
| | glcC | Glc operon transcriptional activator; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity. Also negatively regulates the transcription of its own gene. Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector. (274 aa) |
| | c3600 | Hypothetical protein; Residues 3 to 165 of 186 are 27.54 pct identical to residues 7 to 173 of 201 from GenPept.129 : >dbj|BAB76266.1| (AP003596) transcriptional regulator [Nostoc sp. PCC 7120]. (186 aa) |
| | papI | PapI protein; Residues 1 to 77 of 77 are 98.70 pct identical to residues 1 to 77 of 77 from SwissProt.40 : >sp|P25395|KS7A_ECOLI P FIMBRIAL REGULATORY PROTEIN KS71A. (77 aa) |
| | papX | PapX protein; Residues 18 to 183 of 183 are 96.38 pct identical to residues 1 to 166 of 166 from SwissProt.40 : >sp|P42192|PRSX_ECOLI PRSX PROTEIN. (183 aa) |
| | c3565 | Putative response regulator; Residues 6 to 232 of 240 are 47.16 pct identical to residues 12 to 240 of 247 from GenPept.129 : >gb|AAD36722.1|AE001807_13 (AE001807) response regulator DrrA [Thermotoga maritima]. (240 aa) |
| | ygfI | Hypothetical transcriptional regulator ygfI; Escherichia coli K-12 ortholog: b2921; Escherichia coli O157:H7 ortholog: z4258; Belongs to the LysR transcriptional regulatory family. (298 aa) |
| | iciA | Chromosome initiation inhibitor; Controls the transcription of genes involved in arginine and lysine metabolism; Belongs to the LysR transcriptional regulatory family. (319 aa) |
| | ygeV | Hypothetical sigma-54-dependent transcriptional regulator ygeV; Escherichia coli K-12 ortholog: b2869; Escherichia coli O157:H7 ortholog: z4208. (592 aa) |
| | lysR | Transcriptional activator protein lysR; Escherichia coli K-12 ortholog: b2839; Escherichia coli O157:H7 ortholog: z4157; Belongs to the LysR transcriptional regulatory family. (311 aa) |
| | galR | Galactose operon repressor; Escherichia coli K-12 ortholog: b2837; Escherichia coli O157:H7 ortholog: z4155. (343 aa) |
| | gcvA | Glycine cleavage system transcriptional activator; Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter (By similarity); Belongs to the LysR transcriptional regulatory family. (305 aa) |
| | fucR | L-fucose operon activator; Escherichia coli K-12 ortholog: b2805; Escherichia coli O157:H7 ortholog: z4122. (246 aa) |
| | barA | Sensor protein barA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity). (918 aa) |
| | c3307 | Putative conserved protein; Residues 13 to 144 of 144 are 99.24 pct identical to residues 1 to 132 of 330 from MG1655 : b2741; Belongs to the sigma-70 factor family. (144 aa) |
| | ygbI | Hypothetical transcriptional regulator ygbI; Escherichia coli K-12 ortholog: b2735. (265 aa) |
| | fhlA | Formate hydrogenlyase transcriptional activator; Escherichia coli K-12 ortholog: b2731; Escherichia coli O157:H7 ortholog: z4040. (704 aa) |
| | ygaA | Hypothetical sigma-54-dependent transcriptional regulator ygaA; Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54. (529 aa) |
| | srlR | Glucitol operon repressor; Escherichia coli K-12 ortholog: b2707; Escherichia coli O157:H7 ortholog: z4014. (257 aa) |
| | emrR | Transcriptional repressor mprA; Negative regulator of the multidrug operon emrAB. (176 aa) |
| | c3224 | Conserved hypothetical protein; Escherichia coli O157:H7 ortholog: z3973. (444 aa) |
| | ygaE | Hypothetical transcriptional regulator ygaE; Escherichia coli K-12 ortholog: b2664; Escherichia coli O157:H7 ortholog: z3963. (226 aa) |
| | cspF | Cold shock-like protein cspF; CSP-F; Escherichia coli K-12 ortholog: b1558; Escherichia coli O157:H7 ortholog: z1405. (70 aa) |
| | cspI | Cold shock-like protein cspI; CSP-I; Escherichia coli K-12 ortholog: b1552; Escherichia coli O157:H7 ortholog: z1406. (71 aa) |
| | yfiE | Hypothetical transcriptional regulator yfiE; Escherichia coli K-12 ortholog: b2577; Escherichia coli O157:H7 ortholog: z3860; Belongs to the LysR transcriptional regulatory family. (308 aa) |
| | rpoE | RNA polymerase sigma-E factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma-E controls the envelope stress response, responding to periplasmic protein stress, increased levels of periplasmic lipopolysaccharide (LPS) as well as heat shock and oxidative stress; it controls protein processing in the extracytoplasmic compartment (By similarity). (202 aa) |
| | yfhA | Hypothetical protein yfHa; ORF-2; Escherichia coli K-12 ortholog: b2554; Escherichia coli O157:H7 ortholog: z3830. (457 aa) |
| | glnB | Nitrogen Regulatory protein P-II 1; P-II indirectly controls the transcription of the glutamine synthetase gene (GlnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity). (112 aa) |
| | yfhP | Hypothetical protein yfhP; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. (162 aa) |
| | yfeG | Ethanolamine operon Regulatory protein; Escherichia coli K-12 ortholog: b2437; Escherichia coli O157:H7 ortholog: z3702. (350 aa) |
| | yfeR | Hypothetical transcriptional regulator yfeR; Escherichia coli K-12 ortholog: b2409; Belongs to the LysR transcriptional regulatory family. (308 aa) |
| | xapR | Xanthosine operon Regulatory protein; Escherichia coli K-12 ortholog: b2405; Belongs to the LysR transcriptional regulatory family. (299 aa) |
| | ypdC | Hypothetical transcriptional regulator ypdC; Escherichia coli K-12 ortholog: b2382; Escherichia coli O157:H7 ortholog: z3647. (285 aa) |
| | ypdB | Hypothetical protein ypdB; Member of the two-component regulatory system YpdA/YpdB. YpdB regulates expression of yhjX by binding to its promoter region. (251 aa) |
| | evgA | Positive transcription regulator evgA; Member of the two-component regulatory system EvgS/EvgA. Regulates the expression of emrKY operon and yfdX. Seems also to control expression of at least one other multidrug efflux operon (By similarity). (204 aa) |
| | dsdC | D-serine deaminase activator; Escherichia coli K-12 ortholog: b2364; Belongs to the LysR transcriptional regulatory family. (317 aa) |
| | lrhA | Probable transcriptional regulator lrhA; Escherichia coli K-12 ortholog: b2289; Escherichia coli O157:H7 ortholog: z3549; Belongs to the LysR transcriptional regulatory family. (312 aa) |
| | atoC | Acetoacetate metabolism Regulatory protein atoC; Ornithine/arginine decarboxylase inhibitor; Escherichia coli K-12 ortholog: b2220; Escherichia coli O157:H7 ortholog: z5580. (461 aa) |
| | rcsB | Capsular synthesis regulator component B; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. (231 aa) |
| | ada | Regulatory protein of adaptative response; Escherichia coli K-12 ortholog: b2213; Escherichia coli O157:H7 ortholog: z3471; bifunctional; Methylated-DNA--protein-cysteine methyltransferase. (354 aa) |
| | narP | Nitrate/nitrite response regulator protein narP; Escherichia coli K-12 ortholog: b2193; Escherichia coli O157:H7 ortholog: z3450. (225 aa) |
| | yeiL | Regulatory protein nsr; Escherichia coli K-12 ortholog: b2163; Escherichia coli O157:H7 ortholog: z3420. (232 aa) |
| | yeiE | Hypothetical transcriptional regulator yeiE; Escherichia coli K-12 ortholog: b2157; Escherichia coli O157:H7 ortholog: z3414; Belongs to the LysR transcriptional regulatory family. (293 aa) |
| | galS | Mgl repressor and galactose ultrainduction factor; Escherichia coli K-12 ortholog: b2151; Escherichia coli O157:H7 ortholog: z3407. (348 aa) |
| | yehT | Hypothetical protein yehT; Member of the two-component regulatory system BtsS/BtsR. BtsR regulates expression of btsT by binding to its promoter region. (244 aa) |
| | yohL | Hypothetical protein yohL; Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter (By similarity); Belongs to the FrmR/RcnR family. (90 aa) |
| | yegW | Hypothetical transcriptional regulator yegW; Escherichia coli K-12 ortholog: b2101; Escherichia coli O157:H7 ortholog: z3264. (248 aa) |
| | c2615 | Hypothetical protein; Possible Fusion of Escherichia coli K-12 B2087 and B2091; Residues 1 to 259 of 259 are 99.61 pct identical to residues 1 to 259 of 259 from SwissProt.40 : >sp|P36930|GATR_ECOLI GALACTITOL UTILIZATION OPERON REPRESSOR. (259 aa) |
| | baeR | Transcriptional Regulatory protein baeR; Member of the two-component regulatory system BaeS/BaeR. Activates the mdtABCD operon (By similarity). (240 aa) |
| | yefM | Hypothetical protein yefM; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of the YoeB mRNA interferase. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor (By similarity). (92 aa) |
| | yoeB | Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. It has been proposed to be an mRNA interferase but also an inhibitor of translation initiation. Has an in vitro RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor (By similarity). (84 aa) |
| | yeeY | Hypothetical transcriptional regulator yeeY; Escherichia coli K-12 ortholog: b2015; Escherichia coli O157:H7 ortholog: z3177; Belongs to the LysR transcriptional regulatory family. (316 aa) |
| | rbsK-3 | Putative carbohydrate kinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (404 aa) |
| | cbl | Transcriptional regulator cbl; Escherichia coli K-12 ortholog: b1987; Escherichia coli O157:H7 ortholog: z3146; Belongs to the LysR transcriptional regulatory family. (316 aa) |
| | nac | Nitrogen assimilation control protein; Escherichia coli K-12 ortholog: b1988; Escherichia coli O157:H7 ortholog: z3147; Belongs to the LysR transcriptional regulatory family. (315 aa) |
| | yeeN | Hypothetical protein yeeN; Escherichia coli K-12 ortholog: b1983; Escherichia coli O157:H7 ortholog: z3140. (238 aa) |
| | c2423 | Similar to YbtA, AraC type regulator [Yersinia pestis]; Residues 1 to 319 of 319 are 99.37 pct identical to residues 1 to 319 of 319 from GenPept.129 : >emb|CAC90728.1| (AJ414150) transcriptional regulator YbtA [Yersinia pestis]. (319 aa) |
| | rcsA | Colanic acid capsular biosynthesis activation protein A; Component of the Rcs signaling system, which controls transcription of numerous genes. Binds, with RcsB, to the RcsAB box to regulate expression of genes. (207 aa) |
| | ybcM | Hypothetical transcriptional regulator ybcM; Escherichia coli K-12 ortholog: b0546. (265 aa) |
| | fliT | Flagellar protein fliT; Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus. (121 aa) |
| | fliA | RNA polymerase sigma factor for flagellar operon; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (239 aa) |
| | uvrY | UvrY protein; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the effects of CsrA on csrB RNA by BarA-dependent and BarA-independent mechanisms (By similarity). (218 aa) |
| | flhD | Flagellar transcriptional activator flhD; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (119 aa) |
| | flhC | Flagellar transcriptional activator flhC; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. (192 aa) |
| | yebC | Protein yebC; Escherichia coli K-12 ortholog: b1864; Escherichia coli O157:H7 ortholog: z2916. (246 aa) |
| | cspC | Cold shock-like protein cspC; CSP-C; Escherichia coli K-12 ortholog: b1823; Escherichia coli O157:H7 ortholog: z2868. (69 aa) |
| | yeaM | Hypothetical transcriptional regulator yeaM; Escherichia coli K-12 ortholog: b1790; Escherichia coli O157:H7 ortholog: z2831. (273 aa) |
| | ydjF | Hypothetical transcriptional regulator ydjF; Escherichia coli K-12 ortholog: b1770; Escherichia coli O157:H7 ortholog: z2808. (252 aa) |
| | celD | Cel operon repressor; Escherichia coli K-12 ortholog: b1735; Escherichia coli O157:H7 ortholog: z2765. (280 aa) |
| | himA | Integration host factor alpha-subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (99 aa) |
| | ydiP | Hypothetical transcriptional regulator ydiP; Escherichia coli K-12 ortholog: b1696; Escherichia coli O157:H7 ortholog: z2724. (303 aa) |
| | ydhB | Hypothetical transcriptional regulator ydhB; Escherichia coli K-12 ortholog: b1659; Escherichia coli O157:H7 ortholog: z2682; Belongs to the LysR transcriptional regulatory family. (310 aa) |
| | purR | Purine nucleotide synthesis repressor; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. (341 aa) |
| | ydhM | Hypothetical transcriptional regulator ydhM; Involved in response to both electrophiles and reactive chlorine species (RCS). Represses the transcription of the nemRA-gloA operon by binding to the NemR box. (199 aa) |
| | slyA | Transcriptional regulator slyA; Transcription regulator that can specifically activate or repress expression of target genes; Belongs to the SlyA family. (146 aa) |
| | ydgT | Hypothetical protein ydgT; Modifies the set of genes regulated by H-NS; Hha and cnu (YdgT) increase the number of genes bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex on DNA. The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC; Belongs to the Hha/YmoA/Cnu family. (71 aa) |
| | malI | Maltose regulon Regulatory protein malI; Escherichia coli K-12 ortholog: b1620; Escherichia coli O157:H7 ortholog: z2625. (342 aa) |
| | uidR | Uid operon repressor; Repressor for the uidRABC (gusRABC) operon. (196 aa) |
| | rstA | Transcriptional Regulatory protein rstA; Escherichia coli K-12 ortholog: b1608; Escherichia coli O157:H7 ortholog: z2609. (259 aa) |
| | ynfL | Hypothetical transcriptional regulator ynfL; Escherichia coli K-12 ortholog: b1595; Escherichia coli O157:H7 ortholog: z2589; Belongs to the LysR transcriptional regulatory family. (297 aa) |
| | ydfH | Hypothetical transcriptional regulator ydfH; Escherichia coli K-12 ortholog: b1540; Escherichia coli O157:H7 ortholog: z2157. (228 aa) |
| | c1960 | Putative conserved protein; Residues 1 to 232 of 232 are 35.77 pct identical to residues 1 to 232 of 238 from MG1655 : b3684. (232 aa) |
| | marA | Multiple antibiotic resistance protein marA; Escherichia coli K-12 ortholog: b1531; Escherichia coli O157:H7 ortholog: z2170. (129 aa) |
| | marR | Multiple antibiotic resistance protein marR; Escherichia coli K-12 ortholog: b1530; Escherichia coli O157:H7 ortholog: z2171. (144 aa) |
| | yneJ | Hypothetical transcriptional regulator yneJ; Escherichia coli K-12 ortholog: b1526; Escherichia coli O157:H7 ortholog: z2177; Belongs to the LysR transcriptional regulatory family. (293 aa) |
| | hipB | Protein hipB; Antitoxin component of a type II type II toxin-antitoxin (TA) system. Neutralizes the toxic effect of cognate toxin HipA. Represses the hipBA operon promoter (By similarity). (94 aa) |
| | oprR | Hypothetical transcriptional regulator ycjZ; Escherichia coli K-12 ortholog: b1328; Escherichia coli O157:H7 ortholog: z2439; Belongs to the LysR transcriptional regulatory family. (315 aa) |
| | ydeO | Hypothetical transcriptional regulator ydeO; Induces the expression of gadE and mdtEF. Could also regulate the expression of other genes involved in acid resistance (By similarity). (253 aa) |
| | yddM | Hypothetical protein yddM; Escherichia coli K-12 ortholog: b1477; Escherichia coli O157:H7 ortholog: z2233; Belongs to the VapA/VapI family. (94 aa) |
| | ydcR | Hypothetical protein ydcR; Escherichia coli K-12 ortholog: b1439; Escherichia coli O157:H7 ortholog: z2280. (468 aa) |
| | ycdI | Hypothetical transcriptional regulator ydcI; Escherichia coli K-12 ortholog: b1422; Escherichia coli O157:H7 ortholog: z2299; Belongs to the LysR transcriptional regulatory family. (354 aa) |
