STRINGSTRING
gpt gpt phoE phoE lacZ lacZ hemB hemB sbcD sbcD bolA bolA apt apt c0759 c0759 pgm pgm ybhL ybhL ybhM ybhM c0882 c0882 serS serS ompF ompF pncB pncB pepN pepN yccA yccA flgL flgL c1531 c1531 nmpC nmpC ompN ompN uidA uidA pdxY pdxY katE katE fliC fliC c2348 c2348 c2383 c2383 c2388 c2388 cdd cdd ompC ompC pdxK pdxK yphA yphA ebgA ebgA ygjK ygjK yqjF yqjF fkpA fkpA ibpB ibpB ibpA ibpA pgi pgi fklB fklB deoC deoC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gptXanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa)
phoEOuter membrane pore protein E precursor; Escherichia coli K-12 ortholog: b0241; Escherichia coli O157:H7 ortholog: z0302; Belongs to the Gram-negative porin family. (353 aa)
lacZBeta-galactosidase; Escherichia coli K-12 ortholog: b0344; Escherichia coli O157:H7 ortholog: z0440; Belongs to the glycosyl hydrolase 2 family. (1024 aa)
hemBDelta-aminolevulinic acid dehydratase; Escherichia coli K-12 ortholog: b0369; Escherichia coli O157:H7 ortholog: z0468; Belongs to the ALAD family. (335 aa)
sbcDNuclease sbcCD subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (400 aa)
bolABolA protein; Transcriptional regulator that plays an important role in general stress response. (116 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (201 aa)
c0759Hypthetical protein; Residues 3 to 385 of 389 are 46.78 pct identical to residues 6 to 391 of 396 from GenPept.129 : >gb|AAL45764.1| (AE008932) conserved hypothetical protein [Agrobacterium tumefaciens str. C58 (U. Washington)]. (389 aa)
pgmPhosphoglucomutase; Escherichia coli K-12 ortholog: b0688; Escherichia coli O157:H7 ortholog: z0837. (563 aa)
ybhLHypothetical protein ybhL; Escherichia coli K-12 ortholog: b0786; Escherichia coli O157:H7 ortholog: z1005. (261 aa)
ybhMHypothetical protein ybhM; Escherichia coli K-12 ortholog: b0787; Escherichia coli O157:H7 ortholog: z1006. (246 aa)
c0882Putative conserved protein; Residues 32 to 101 of 101 are 80.00 pct identical to residues 91 to 160 of 160 from MG1655 : b0798. (101 aa)
serSSeryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa)
ompFOuter membrane protein F precursor; Porin ompF; Escherichia coli K-12 ortholog: b0929; Escherichia coli O157:H7 ortholog: z1276; Belongs to the Gram-negative porin family. (362 aa)
pncBNicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (416 aa)
pepNAminopeptidase N; Escherichia coli K-12 ortholog: b0932; Escherichia coli O157:H7 ortholog: z1280. (870 aa)
yccAHypothetical protein yccA; Escherichia coli K-12 ortholog: b0970; Escherichia coli O157:H7 ortholog: z1322. (219 aa)
flgLFlagellar hook-associated protein 3; HAP3; Escherichia coli K-12 ortholog: b1083; Escherichia coli O157:H7 ortholog: z1721. (317 aa)
c1531Hypothetical protein; Residues 1 to 124 of 152 are 85.48 pct identical to residues 1 to 124 of 238 from GenPept.129 : >gb|AAK28855.1|AF335538_7 (AF335538) unknown [Bacteriophage HK620]. (152 aa)
nmpCOuter membrane porin protein nmpC precursor; Escherichia coli K-12 ortholog: b0553; Escherichia coli O157:H7 ortholog: z2239; Belongs to the Gram-negative porin family. (380 aa)
ompNOuter membrane protein N precursor; Porin ompN; Escherichia coli K-12 ortholog: b1377; Escherichia coli O157:H7 ortholog: z2334. (377 aa)
uidABeta-glucuronidase; Escherichia coli K-12 ortholog: b1617; Escherichia coli O157:H7 ortholog: z2621; Belongs to the glycosyl hydrolase 2 family. (603 aa)
pdxYPyridoxamine kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (287 aa)
katECatalase HPII; Serves to protect cells from the toxic effects of hydrogen peroxide. (753 aa)
fliCFlagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (595 aa)
c2348Outer membrane porin protein nmpC precursor; Escherichia coli K-12 ortholog: b0553; Escherichia coli O157:H7 ortholog: z2239; Belongs to the Gram-negative porin family. (342 aa)
c2383Outer membrane protein N precursor; Porin ompN; Escherichia coli K-12 ortholog: b1377; Escherichia coli O157:H7 ortholog: z0302. (375 aa)
c2388Transthyretin-like protein precursor; Escherichia coli K-12 ortholog: b1970; Escherichia coli O157:H7 ortholog: z3062; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (137 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa)
ompCOuter membrane protein C precursor; Forms pores that allow passive diffusion of small molecules across the outer membrane, including some antibiotics. Variation of the residues in the constriction zone modifies the transverse electric field in the zone, altering antibiotic resistance. Belongs to the Gram-negative porin family. (375 aa)
pdxKPyridoxine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. (283 aa)
yphAHypothetical protein yphA; Escherichia coli K-12 ortholog: b2543; Escherichia coli O157:H7 ortholog: z3815. (142 aa)
ebgAEvolved beta-galactosidase alpha-subunit; Escherichia coli K-12 ortholog: b3076; Escherichia coli O157:H7 ortholog: z4429. (1089 aa)
ygjKHypothetical protein ygjK precursor; Escherichia coli K-12 ortholog: b3080; Escherichia coli O157:H7 ortholog: z4433. (783 aa)
yqjFHypothetical protein yqjF; Escherichia coli K-12 ortholog: b3101; Escherichia coli O157:H7 ortholog: z4455. (134 aa)
fkpAFKBP-type peptidyl-prolyl cis-trans isomerase fkpA precursor; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (270 aa)
ibpB16 kDa heat shock protein B; Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent. (144 aa)
ibpA16 kDa heat shock protein A; Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent. (139 aa)
pgiGlucose-6-phosphate isomerase; Escherichia coli K-12 ortholog: b4025; Escherichia coli O157:H7 ortholog: z5623. (551 aa)
fklBFKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase; Escherichia coli K-12 ortholog: b4207; Escherichia coli O157:H7 ortholog: z5818. (259 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (267 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.