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crp crp yacA yacA yaeS yaeS lacZ lacZ hupB hupB flgB flgB chaC chaC flhA flhA flhB flhB cheY cheY flhC flhC flhD flhD ftn ftn fliA fliA fliC fliC fliE fliE fliL fliL yegH yegH pmrD pmrD icc icc aer aer argR argR mreB mreB lexA lexA mopB mopB argR-2 argR-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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crpCatabolite gene activator; A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity). (210 aa)
yacASecretion monitor precursor; Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation. Belongs to the SecM family. (221 aa)
yaeSUndecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (253 aa)
lacZBeta-galactosidase; Escherichia coli K-12 ortholog: b0344; Escherichia coli O157:H7 ortholog: z0440; Belongs to the glycosyl hydrolase 2 family. (1024 aa)
hupBDNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. (90 aa)
flgBFlagellar basal-body rod protein flgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity). (138 aa)
chaCCation transport protein chaC; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (243 aa)
flhAFlagellar biosynthesis protein flhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (717 aa)
flhBFlagellar biosynthetic protein flhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (382 aa)
cheYChemotaxis protein cheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation (By similarity). (129 aa)
flhCFlagellar transcriptional activator flhC; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. (192 aa)
flhDFlagellar transcriptional activator flhD; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (119 aa)
ftnFerritin 1; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. (170 aa)
fliARNA polymerase sigma factor for flagellar operon; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (239 aa)
fliCFlagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (595 aa)
fliEFlagellar hook-basal body complex protein fliE; Escherichia coli K-12 ortholog: b1937; Escherichia coli O157:H7 ortholog: z3027. (114 aa)
fliLFlagellar fliL protein; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family. (154 aa)
yegHHypothetical protein yegH; Escherichia coli K-12 ortholog: b2063; Escherichia coli O157:H7 ortholog: z3229. (549 aa)
pmrDPolymyxin B resistance protein pmrD; Escherichia coli K-12 ortholog: b2259; Escherichia coli O157:H7 ortholog: z3519. (98 aa)
iccIcc protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (275 aa)
aerAerotaxis receptor; Escherichia coli K-12 ortholog: b3072; Escherichia coli O157:H7 ortholog: z4425. (506 aa)
argRArginine repressor; Regulates arginine biosynthesis genes; Belongs to the ArgR family. (156 aa)
mreBRod shape-determining protein mreB; Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature. (372 aa)
lexALexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (202 aa)
mopB10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (97 aa)
argR-2Hypothetical protein; Regulates arginine biosynthesis genes. (184 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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