STRINGSTRING
higA higA cbtA cbtA yoeB yoeB yefM yefM higB higB tyrR tyrR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
higAHypothetical protein ygjM; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin. (138 aa)
cbtAHypothetical protein yeeV; Toxic component of a type IV toxin-antitoxin (TA) system. Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB. Toxic effects are neutralized by cognate antitoxin CbeA (A0A0H2V8S8), although there is no direct interaction detected between the 2 proteins. (124 aa)
yoeBHypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. It has been proposed to be an mRNA interferase but also an inhibitor of translation initiation. Has an in vitro RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor (By similarity). (84 aa)
yefMHypothetical protein yefM; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of the YoeB mRNA interferase. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor (By similarity). (92 aa)
higBHypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Probably counteracted by antitoxin HigA. (103 aa)
tyrRTranscriptional Regulatory protein tyrR; Escherichia coli K-12 ortholog: b1323; Escherichia coli O157:H7 ortholog: z2454. (522 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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