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gyrB gyrB ilvG ilvG fhiA fhiA yagV yagV yagW yagW tonB tonB fumC fumC uvrY uvrY yfcN yfcN dsdX dsdX recA recA yggC yggC exuT exuT exuR exuR agaV agaV mdh mdh rpsJ rpsJ
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (805 aa)
ilvGAcetohydroxy acid synthase II; Escherichia coli O157:H7 ortholog: z5279. (548 aa)
fhiAFhiA protein; Escherichia coli K-12 ortholog: b0229; Escherichia coli O157:H7 ortholog: z0290. (579 aa)
yagVHypothetical protein yagV precursor; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity); Belongs to the EcpB/EcpE family. (251 aa)
yagWHypothetical protein yagW; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Tip pilus adhesin, which is required for assembly of EcpA into fibers (By similarity); Belongs to the EcpD/MatE family. (547 aa)
tonBTonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family. (255 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
uvrYUvrY protein; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the effects of CsrA on csrB RNA by BarA-dependent and BarA-independent mechanisms (By similarity). (218 aa)
yfcNHypothetical protein yfcN; Escherichia coli K-12 ortholog: b2331; Escherichia coli O157:H7 ortholog: z3594; Belongs to the UPF0115 family. (183 aa)
dsdXDsdX permease; Protein that allows transport of D-serine across the inner membrane, does not transport D-alanine nor probably glycine. Is probably a H(+) symporter, as CCCP inhibits transport. Transports D- serine more efficiently than CycA; Belongs to the GntP permease family. (445 aa)
recARecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (353 aa)
yggCHypothetical protein yggC; Escherichia coli K-12 ortholog: b2928; Escherichia coli O157:H7 ortholog: z4273. (237 aa)
exuTHexuronate transporter; Escherichia coli K-12 ortholog: b3093; Escherichia coli O157:H7 ortholog: z4446. (472 aa)
exuRExu regulon transcriptional regulator; Escherichia coli K-12 ortholog: b3094; Escherichia coli O157:H7 ortholog: z4448. (263 aa)
agaVPTS system, N-acetylgalactosamine-specific IIB component 2; EIIB-AGA'; Escherichia coli K-12 ortholog: b3133; Escherichia coli O157:H7 ortholog: z4485. (169 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (334 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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