STRINGSTRING
surA surA ftsY ftsY glpD glpD glnE glnE kpsM kpsM c3696 c3696 c3694 c3694 c3692 c3692 kpsC kpsC kpsD kpsD kpsE kpsE ffh ffh glpT glpT ompC ompC dld dld lpp lpp mdoH mdoH ompA ompA ompF ompF ompX ompX pal pal tolB tolB tolR tolR tolQ tolQ ompT ompT mdoB mdoB fimD fimD mopA mopA lamB lamB yidC yidC lldD lldD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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surASurvival protein surA precursor; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (428 aa)
ftsYCell division protein ftsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (498 aa)
glpDAerobic glycerol-3-phosphate dehydrogenase; Escherichia coli K-12 ortholog: b3426; Escherichia coli O157:H7 ortholog: z4786; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (506 aa)
glnEGlutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (983 aa)
kpsMKpsM protein; Residues 1 to 258 of 258 are 96.89 pct identical to residues 1 to 258 of 258 from SwissProt.40 : >sp|P24584|KPM2_ECOLI POLYSIALIC ACID TRANSPORT PROTEIN KPSM. (258 aa)
c3696Putative glycerol-3-phosphate cytidyltransferase; Residues 5 to 131 of 135 are 49.60 pct identical to residues 1 to 126 of 129 from SwissProt.40 : >sp|P27623|TAGD_BACSU Glycerol-3-phosphate cytidylyltransferase (GCT) (CDP-glycerol pyrophosphorylase) (Teichoic acid biosynthesis protein D). (135 aa)
c3694Hypothetical protein; Residues 495 to 1078 of 1266 are 33.16 pct identical to residues 10 to 602 of 807 from GenPept.129 : >gb|AAK05019.1|AE006326_10 (AE006326) teichoic acid biosynthesis protein [Lactococcus lactis subsp. lactis]. (1266 aa)
c3692Hypothetical protein. (331 aa)
kpsCKpsC protein; Residues 1 to 675 of 675 are 96.29 pct identical to residues 1 to 675 of 675 from SwissProt.40 : >sp|P42217|KSC5_ECOLI Capsule polysaccharide export protein KPSC. (675 aa)
kpsDKpsD protein; Residues 2 to 559 of 559 are 99.46 pct identical to residues 1 to 558 of 558 from SwissProt.40 : >sp|P42213|KSD5_ECOLI POLYSIALIC ACID TRANSPORT PROTEIN KPSD PRECURSOR. (559 aa)
kpsEKpsE protein; Involved in the translocation of the polysialic acid capsule. Belongs to the BexC/CtrB/KpsE family. (382 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] (453 aa)
glpTG-3-P transporter; Escherichia coli K-12 ortholog: b2240; Escherichia coli O157:H7 ortholog: z3498. (452 aa)
ompCOuter membrane protein C precursor; Forms pores that allow passive diffusion of small molecules across the outer membrane, including some antibiotics. Variation of the residues in the constriction zone modifies the transverse electric field in the zone, altering antibiotic resistance. Belongs to the Gram-negative porin family. (375 aa)
dldD-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (582 aa)
lppMajor outer membrane lipoprotein precursor; A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane. (78 aa)
mdoHPeriplasmic glucans biosynthesis protein mdoH; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (857 aa)
ompAOuter membrane protein II*; Escherichia coli K-12 ortholog: b0957; Escherichia coli O157:H7 ortholog: z1307; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. (379 aa)
ompFOuter membrane protein F precursor; Porin ompF; Escherichia coli K-12 ortholog: b0929; Escherichia coli O157:H7 ortholog: z1276; Belongs to the Gram-negative porin family. (362 aa)
ompXOuter membrane protein X precursor; Escherichia coli K-12 ortholog: b0814; Escherichia coli O157:H7 ortholog: z1036. (173 aa)
palPeptidoglycan-associated lipoprotein precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (181 aa)
tolBTolB protein precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. (431 aa)
tolRTolR protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (142 aa)
tolQTolQ protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction. (230 aa)
ompTProtease VII precursor; Escherichia coli K-12 ortholog: b0565; Escherichia coli O157:H7 ortholog: z1931. (317 aa)
mdoBPhosphoglycerol transferase I; Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones; Belongs to the OpgB family. (763 aa)
fimDOuter membrane usher protein fimD precursor; Escherichia coli K-12 ortholog: b4317; Escherichia coli O157:H7 ortholog: z5915. (878 aa)
mopA60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (548 aa)
lamBMaltoporin precursor; Involved in the transport of maltose and maltodextrins. Belongs to the porin LamB (TC 1.B.3) family. (446 aa)
yidC60 kDa inner-membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (548 aa)
lldDL-lactate dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (396 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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