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yhcN yhcN gadA gadA gyrB gyrB yjfN yjfN yjfY yjfY cybC cybC ykgI ykgI ybaJ ybaJ ybbW ybbW ybiJ ybiJ ycfR ycfR xasA xasA gadB gadB ydgH ydgH mdh mdh
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yhcNHypothetical protein yhcN precursor; Escherichia coli K-12 ortholog: b3238; Escherichia coli O157:H7 ortholog: z4597. (104 aa)
gadAGlutamate decarboxylase alpha; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). (487 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (805 aa)
yjfNHypothetical protein yjfN; Escherichia coli K-12 ortholog: b4188; Escherichia coli O157:H7 ortholog: z5795. (100 aa)
yjfYHypothetical protein yjfY precursor; Escherichia coli K-12 ortholog: b4199; Escherichia coli O157:H7 ortholog: z5808. (91 aa)
cybCSoluble cytochrome b562 precursor; Electron-transport protein of unknown function. Belongs to the cytochrome b562 family. (128 aa)
ykgIHypothetical protein ykgI precursor; Escherichia coli K-12 ortholog: b0303; Escherichia coli O157:H7 ortholog: z0380. (83 aa)
ybaJHypothetical protein ybaJ; Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA (By similarity). (124 aa)
ybbWPutative allantoin permease; Allantoin transport protein; Escherichia coli K-12 ortholog: b0511; Escherichia coli O157:H7 ortholog: z0665. (484 aa)
ybiJHypothetical protein ybiJ precursor; Escherichia coli K-12 ortholog: b0802; Escherichia coli O157:H7 ortholog: z1023. (86 aa)
ycfRHypothetical protein ycfR precursor; Reduces the permeability of the outer membrane to copper. May be involved in the regulation of biofilm formation (By similarity). Belongs to the BhsA/McbA family. (85 aa)
xasAAmino acid antiporter; Involved in glutamate-dependent acid resistance. Imports glutamate inside the cell while simultaneously exporting to the periplasm the GABA produced by GadA and GadB. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). (511 aa)
gadBGlutamate decarboxylase beta; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). (489 aa)
ydgHProtein ydgH precursor; Escherichia coli K-12 ortholog: b1604; Escherichia coli O157:H7 ortholog: z2603. (314 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (334 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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