node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cybC | ybaJ | c5335 | c0579 | Soluble cytochrome b562 precursor; Electron-transport protein of unknown function. Belongs to the cytochrome b562 family. | Hypothetical protein ybaJ; Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA (By similarity). | 0.874 |
cybC | ybiJ | c5335 | c0886 | Soluble cytochrome b562 precursor; Electron-transport protein of unknown function. Belongs to the cytochrome b562 family. | Hypothetical protein ybiJ precursor; Escherichia coli K-12 ortholog: b0802; Escherichia coli O157:H7 ortholog: z1023. | 0.449 |
cybC | ycfR | c5335 | c1386 | Soluble cytochrome b562 precursor; Electron-transport protein of unknown function. Belongs to the cytochrome b562 family. | Hypothetical protein ycfR precursor; Reduces the permeability of the outer membrane to copper. May be involved in the regulation of biofilm formation (By similarity). Belongs to the BhsA/McbA family. | 0.832 |
cybC | ydgH | c5335 | c1996 | Soluble cytochrome b562 precursor; Electron-transport protein of unknown function. Belongs to the cytochrome b562 family. | Protein ydgH precursor; Escherichia coli K-12 ortholog: b1604; Escherichia coli O157:H7 ortholog: z2603. | 0.705 |
cybC | yhcN | c5335 | c3993 | Soluble cytochrome b562 precursor; Electron-transport protein of unknown function. Belongs to the cytochrome b562 family. | Hypothetical protein yhcN precursor; Escherichia coli K-12 ortholog: b3238; Escherichia coli O157:H7 ortholog: z4597. | 0.691 |
gadA | gadB | c4328 | c1922 | Glutamate decarboxylase alpha; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Glutamate decarboxylase beta; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 0.928 |
gadA | xasA | c4328 | c1921 | Glutamate decarboxylase alpha; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Amino acid antiporter; Involved in glutamate-dependent acid resistance. Imports glutamate inside the cell while simultaneously exporting to the periplasm the GABA produced by GadA and GadB. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 0.994 |
gadB | gadA | c1922 | c4328 | Glutamate decarboxylase beta; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Glutamate decarboxylase alpha; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 0.928 |
gadB | xasA | c1922 | c1921 | Glutamate decarboxylase beta; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Amino acid antiporter; Involved in glutamate-dependent acid resistance. Imports glutamate inside the cell while simultaneously exporting to the periplasm the GABA produced by GadA and GadB. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 0.995 |
gyrB | mdh | c4621 | c3991 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. | 0.883 |
mdh | gyrB | c3991 | c4621 | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.883 |
xasA | gadA | c1921 | c4328 | Amino acid antiporter; Involved in glutamate-dependent acid resistance. Imports glutamate inside the cell while simultaneously exporting to the periplasm the GABA produced by GadA and GadB. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Glutamate decarboxylase alpha; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 0.994 |
xasA | gadB | c1921 | c1922 | Amino acid antiporter; Involved in glutamate-dependent acid resistance. Imports glutamate inside the cell while simultaneously exporting to the periplasm the GABA produced by GadA and GadB. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Glutamate decarboxylase beta; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 0.995 |
ybaJ | cybC | c0579 | c5335 | Hypothetical protein ybaJ; Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA (By similarity). | Soluble cytochrome b562 precursor; Electron-transport protein of unknown function. Belongs to the cytochrome b562 family. | 0.874 |
ybaJ | ybiJ | c0579 | c0886 | Hypothetical protein ybaJ; Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA (By similarity). | Hypothetical protein ybiJ precursor; Escherichia coli K-12 ortholog: b0802; Escherichia coli O157:H7 ortholog: z1023. | 0.496 |
ybaJ | ycfR | c0579 | c1386 | Hypothetical protein ybaJ; Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA (By similarity). | Hypothetical protein ycfR precursor; Reduces the permeability of the outer membrane to copper. May be involved in the regulation of biofilm formation (By similarity). Belongs to the BhsA/McbA family. | 0.825 |
ybaJ | ydgH | c0579 | c1996 | Hypothetical protein ybaJ; Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA (By similarity). | Protein ydgH precursor; Escherichia coli K-12 ortholog: b1604; Escherichia coli O157:H7 ortholog: z2603. | 0.752 |
ybaJ | yhcN | c0579 | c3993 | Hypothetical protein ybaJ; Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA (By similarity). | Hypothetical protein yhcN precursor; Escherichia coli K-12 ortholog: b3238; Escherichia coli O157:H7 ortholog: z4597. | 0.786 |
ybiJ | cybC | c0886 | c5335 | Hypothetical protein ybiJ precursor; Escherichia coli K-12 ortholog: b0802; Escherichia coli O157:H7 ortholog: z1023. | Soluble cytochrome b562 precursor; Electron-transport protein of unknown function. Belongs to the cytochrome b562 family. | 0.449 |
ybiJ | ybaJ | c0886 | c0579 | Hypothetical protein ybiJ precursor; Escherichia coli K-12 ortholog: b0802; Escherichia coli O157:H7 ortholog: z1023. | Hypothetical protein ybaJ; Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA (By similarity). | 0.496 |