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fimA fimA frdA frdA papA_2 papA_2 fumB fumB oxyR oxyR fliC fliC fliA fliA gapA gapA fumA fumA fumC fumC c1843 c1843 ndh ndh sdhB sdhB sdhA sdhA sdhD sdhD sdhC sdhC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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fimAType-1 fimbrial protein, A chain precursor; Type-1A pilin; Escherichia coli K-12 ortholog: b4314; Escherichia coli O157:H7 ortholog: z5912. (201 aa)
frdAFumarate reductase flavoprotein subunit; Escherichia coli K-12 ortholog: b4154; Escherichia coli O157:H7 ortholog: z5762. (602 aa)
papA_2PapA protein; Residues 12 to 198 of 198 are 99.46 pct identical to residues 1 to 187 of 187 from SwissProt.40 : >sp|P04740|FMK1_ECOLI KS71A FIMBRILLIN PRECURSOR (P-FIMBRIAL ANTIGEN). (198 aa)
fumBFumarate hydratase class I, anaerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (548 aa)
oxyRHydrogen peroxide-inducible genes activator; Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto- aggregation ab [...] (320 aa)
fliCFlagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (595 aa)
fliARNA polymerase sigma factor for flagellar operon; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (239 aa)
gapAGlyceraldehyde 3-phosphate dehydrogenase A; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. (334 aa)
fumAFumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80% of the fumarase activity when the bacteria grow aerobically. To a lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso-tartrate. Can also catalyze the isomerization of enol- to keto-oxaloacetate. (548 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
c1843Glyceraldehyde 3-phosphate dehydrogenase A; Escherichia coli K-12 ortholog: b1779; Escherichia coli O157:H7 ortholog: z2304; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
ndhNADH dehydrogenase; Escherichia coli K-12 ortholog: b1109; Escherichia coli O157:H7 ortholog: z1748. (443 aa)
sdhBSuccinate dehydrogenase iron-sulfur protein; Escherichia coli K-12 ortholog: b0724; Escherichia coli O157:H7 ortholog: z0878; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
sdhASuccinate dehydrogenase flavoprotein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (592 aa)
sdhDSuccinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhCSuccinate dehydrogenase cytochrome b-556 subunit; Escherichia coli K-12 ortholog: b0721; Escherichia coli O157:H7 ortholog: z0875. (134 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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