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c4494 c4494 lacZ lacZ kdpD kdpD phoQ phoQ nohA nohA hns hns c2397 c2397 TcpC TcpC c2411 c2411 stpA stpA c3243 c3243 ygaG ygaG kup kup pepA pepA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
c4494Putative transcriptional regulator; Residues 9 to 364 of 364 are 54.03 pct identical to residues 1 to 359 of 360 from GenPept.129 : >emb|CAC89693.1| (AJ414145) LacI-family regulatory protein [Yersinia pestis]. (364 aa)
lacZBeta-galactosidase; Escherichia coli K-12 ortholog: b0344; Escherichia coli O157:H7 ortholog: z0440; Belongs to the glycosyl hydrolase 2 family. (1024 aa)
kdpDSensor protein kdpD; Escherichia coli K-12 ortholog: b0695; Escherichia coli O157:H7 ortholog: z0842. (895 aa)
phoQSensor protein phoQ; Member of the two-component regulatory system PhoP/PhoQ involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, which results in the repression of PG and may l [...] (486 aa)
nohAProphage Qin DNA packaging protein NU1 homolog; Involved in the initiation of the phage DNA packaging into the prohead. Processes replicating concatemeric DNA into pieces of unit length with cohesive ends (By similarity); Belongs to the terminase small subunit family. (182 aa)
hnsDNA-binding protein H-NS; A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. A subset of genes are repressed by H-NS in association with other proteins (By similarity). (137 aa)
c2397Hypothetical protein; Residues 1 to 201 of 500 are 45.77 pct identical to residues 1 to 200 of 714 from GenPept.129 : >gb|AAK13432.1| (AF322908) repB/MobA-like protein [Xylella fastidiosa]. (500 aa)
TcpCHypothetical protein; Virulence factor that suppresses host Toll-like receptor (TLR)-mediated cytokine production upon infection, thereby increasing bacterial burden in the urinary tract and promoting renal tissue damage. Acts as a NAD(+) hydrolase (NADase) by catalyzing cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. (307 aa)
c2411DNA-binding protein H-NS; Histone-like protein HLP-II; Escherichia coli K-12 ortholog: b1237; Escherichia coli O157:H7 ortholog: z2013; Belongs to the histone-like protein H-NS family. (134 aa)
stpADNA-binding protein stpA; H-NS homolog stpA; Escherichia coli K-12 ortholog: b2669; Escherichia coli O157:H7 ortholog: z3968; Belongs to the histone-like protein H-NS family. (134 aa)
c3243Hypothetical protein; Residues 16 to 359 of 370 are 37.50 pct identical to residues 19 to 360 of 363 from GenPept.129 : >gb|AAK78729.1|AE007591_2 (AE007591) PolyA polymerase related protein (HD hydrolase) and P-loop ATP-ase domain [Clostridium acetobutylicum]. (370 aa)
ygaGAutoinducer-2 production protein luxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
kupKup system potassium uptake protein; Responsible for the low-affinity transport of potassium into the cell, with the probable concomitant uptake of protons (symport system); Belongs to the HAK/KUP transporter (TC 2.A.72) family. (622 aa)
pepACytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. Required for plasmid ColE1 site-specific recombination but not in its aminopeptidase activity. Could act as a structural component of the putative nucleoprotein complex in which the Xer recombination reaction takes place (By similarity); Belongs to the peptidase M17 family. (503 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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