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chuA chuA dppA dppA rfaG rfaG glnA glnA cpxR cpxR tpiA tpiA nrfA nrfA yjeB yjeB fimA fimA fimH fimH emrR emrR speB speB yqgA yqgA papX papX iutA iutA kpsM kpsM yqhG yqhG ygiD ygiD yhcN yhcN yhcR yhcR rpoE rpoE hmpA hmpA lrhA lrhA rcsB rcsB c2482 c2482 fliC fliC yeaR yeaR pspA pspA oppA oppA yceP yceP ybiJ ybiJ galK galK sdhB sdhB fepA fepA lacZ lacZ fhuA fhuA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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chuAOuter membrane heme/hemoglobin receptor; Escherichia coli O157:H7 ortholog: z4911. (648 aa)
dppAPeriplasmic dipeptide transport protein precursor; Dipeptide-binding protein; Escherichia coli K-12 ortholog: b3544; Escherichia coli O157:H7 ortholog: z4961. (535 aa)
rfaGLipopolysaccharide core biosynthesis protein rfaG; Glucosyltransferase I; Escherichia coli K-12 ortholog: b3631; Escherichia coli O157:H7 ortholog: z5055. (374 aa)
glnAGlutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa)
cpxRTranscriptional Regulatory protein cpxR; Escherichia coli K-12 ortholog: b3912; Escherichia coli O157:H7 ortholog: z5457. (232 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
nrfACytochrome c552 precursor; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (478 aa)
yjeBHypothetical protein yjeB; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. (141 aa)
fimAType-1 fimbrial protein, A chain precursor; Type-1A pilin; Escherichia coli K-12 ortholog: b4314; Escherichia coli O157:H7 ortholog: z5912. (201 aa)
fimHFimH protein precursor; Escherichia coli K-12 ortholog: b4320; Escherichia coli O157:H7 ortholog: z5918. (303 aa)
emrRTranscriptional repressor mprA; Negative regulator of the multidrug operon emrAB. (176 aa)
speBAgmatinase; Catalyzes the formation of putrescine from agmatine. Belongs to the arginase family. Agmatinase subfamily. (306 aa)
yqgAHypothetical protein yqgA; Escherichia coli K-12 ortholog: b2966; Escherichia coli O157:H7 ortholog: z4311. (235 aa)
papXPapX protein; Residues 18 to 183 of 183 are 96.38 pct identical to residues 1 to 166 of 166 from SwissProt.40 : >sp|P42192|PRSX_ECOLI PRSX PROTEIN. (183 aa)
iutAIutA protein; Residues 28 to 759 of 759 are 87.56 pct identical to residues 2 to 732 of 732 from SwissProt.40 : >sp|P14542|IUTA_ECOLI FERRIC AEROBACTIN RECEPTOR PRECURSOR (CLOACIN RECEPTOR). (759 aa)
kpsMKpsM protein; Residues 1 to 258 of 258 are 96.89 pct identical to residues 1 to 258 of 258 from SwissProt.40 : >sp|P24584|KPM2_ECOLI POLYSIALIC ACID TRANSPORT PROTEIN KPSM. (258 aa)
yqhGHypothetical protein yqhG precursor; Escherichia coli K-12 ortholog: b3013; Escherichia coli O157:H7 ortholog: z4368. (217 aa)
ygiDHypothetical protein ygiD; Escherichia coli K-12 ortholog: b3039; Escherichia coli O157:H7 ortholog: z4396. (271 aa)
yhcNHypothetical protein yhcN precursor; Escherichia coli K-12 ortholog: b3238; Escherichia coli O157:H7 ortholog: z4597. (104 aa)
yhcRHypothetical protein yhcR; Escherichia coli K-12 ortholog: b3242; Escherichia coli O157:H7 ortholog: z4601; Belongs to the AaeX family. (90 aa)
rpoERNA polymerase sigma-E factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma-E controls the envelope stress response, responding to periplasmic protein stress, increased levels of periplasmic lipopolysaccharide (LPS) as well as heat shock and oxidative stress; it controls protein processing in the extracytoplasmic compartment (By similarity). (202 aa)
hmpAFlavohemoprotein; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily. (396 aa)
lrhAProbable transcriptional regulator lrhA; Escherichia coli K-12 ortholog: b2289; Escherichia coli O157:H7 ortholog: z3549; Belongs to the LysR transcriptional regulatory family. (312 aa)
rcsBCapsular synthesis regulator component B; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. (231 aa)
c2482Putative outer membrane receptor for iron compound or colicin; Escherichia coli O157:H7 ortholog: z3159. (715 aa)
fliCFlagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (595 aa)
yeaRHypothetical protein yeaR; Escherichia coli K-12 ortholog: b1797; Escherichia coli O157:H7 ortholog: z2839. (119 aa)
pspAPhage shock protein A; Escherichia coli K-12 ortholog: b1304; Escherichia coli O157:H7 ortholog: z2482. (222 aa)
oppAPeriplasmic oligopeptide-binding protein precursor; Escherichia coli K-12 ortholog: b1243; Escherichia coli O157:H7 ortholog: z2019. (567 aa)
ycePHypothetical protein yceP; Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway (By similarity). (85 aa)
ybiJHypothetical protein ybiJ precursor; Escherichia coli K-12 ortholog: b0802; Escherichia coli O157:H7 ortholog: z1023. (86 aa)
galKGalactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (382 aa)
sdhBSuccinate dehydrogenase iron-sulfur protein; Escherichia coli K-12 ortholog: b0724; Escherichia coli O157:H7 ortholog: z0878; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
fepAFerrienterobactin receptor precursor; Enterobactin outer-membrane receptor; Escherichia coli K-12 ortholog: b0584; Escherichia coli O157:H7 ortholog: z0724. (746 aa)
lacZBeta-galactosidase; Escherichia coli K-12 ortholog: b0344; Escherichia coli O157:H7 ortholog: z0440; Belongs to the glycosyl hydrolase 2 family. (1024 aa)
fhuAFerrichrome-iron receptor precursor; Ferric hydroxamate uptake; Escherichia coli K-12 ortholog: b0150; Escherichia coli O157:H7 ortholog: z0161. (752 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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