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rfaD rfaD folA folA ftsI ftsI pic pic c0393 c0393 ribH ribH acrA acrA mrdA mrdA c0941 c0941 grxA grxA cydD cydD lrp lrp sfaC sfaC sfaB sfaB focG focG iroE iroE iroB iroB csgG csgG csgE csgE csgD csgD csgB csgB csgA csgA phoQ phoQ phoP phoP sitA sitA c1990 c1990 ydgB ydgB yobG yobG fliC fliC gyrA gyrA glpT glpT purL purL gshA gshA relA relA hlyA hlyA sat sat iutA iutA parC parC parE parE tolC tolC hldE hldE folP folP murA murA rpsL rpsL dam dam chuA chuA rfaC rfaC rfaP rfaP uhpT uhpT rho rho ampC ampC fimB fimB fimE fimE fimA fimA fimI fimI fimC fimC fimH fimH
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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rfaDADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. (310 aa)
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). (204 aa)
ftsIPeptidoglycan synthetase ftsI precursor; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (588 aa)
picPic serine protease precursor; Involved in virulence of uropathogenic E.coli although it is not known how it contributes to it. Has no mucinase activity. (1371 aa)
c0393Haemoglobin protease; Residues 1 to 1376 of 1376 are 79.04 pct identical to residues 1 to 1377 of 1377 from GenPept.129 : >emb|CAA11507.1| (AJ223631) haemoglobin protease [Escherichia coli]. (1376 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (188 aa)
acrAAcriflavine resistance protein A precursor; Escherichia coli K-12 ortholog: b0463; Escherichia coli O157:H7 ortholog: z0578; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (409 aa)
mrdAPenicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (633 aa)
c0941DNA adenine methylase; Escherichia coli K-12 ortholog: b3387; Escherichia coli O157:H7 ortholog: z4740. (285 aa)
grxAGrx1; Escherichia coli K-12 ortholog: b0849; Escherichia coli O157:H7 ortholog: z1076. (90 aa)
cydDTransport ATP-binding protein cydD; Escherichia coli K-12 ortholog: b0887; Escherichia coli O157:H7 ortholog: z1231. (588 aa)
lrpLeucine-responsive Regulatory protein; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes (By similarity). (182 aa)
sfaCPutative F1C and S fimbrial switch Regulatory protein; Residues 22 to 94 of 94 are 93.15 pct identical to residues 5 to 77 of 77 from SwissProt.40 : >sp|P04743|PAPI_ECOLI Major pilus subunit operon regulatory protein. (94 aa)
sfaBPutative F1C and S fimbrial switch Regulatory protein; Residues 1 to 102 of 109 are 82.35 pct identical to residues 1 to 102 of 104 from SwissProt.40 : >sp|P04744|PAPB_ECOLI MAJOR PILU SUBUNIT OPERON REGULATORY PROTEIN PAPB. (109 aa)
focGF1C minor fimbrial subunit protein G presursor; Escherichia coli K-12 ortholog: b4319; Escherichia coli O157:H7 ortholog: z5917. (167 aa)
iroEIroE protein; Residues 1 to 318 of 318 are 99.37 pct identical to residues 1 to 318 of 318 from GenPept.129 : >emb|CAC43425.1| (X16664) IroE protein [Escherichia coli]. (318 aa)
iroBPutative glucosyltransferase; Escherichia coli O157:H7 ortholog: z1190. (387 aa)
csgGCurli production assembly/transport component csgG precursor; May be involved in the biogenesis of curli organelles. Belongs to the CsgG family. (277 aa)
csgECurli production assembly/transport component csgE precursor; May be involved in the biogenesis of curli organelles. (129 aa)
csgDProbable csgAB operon transcriptional Regulatory protein; Escherichia coli K-12 ortholog: b1040; Escherichia coli O157:H7 ortholog: z1673. (216 aa)
csgBMinor curlin subunit precursor; Escherichia coli K-12 ortholog: b1041; Escherichia coli O157:H7 ortholog: z1675. (160 aa)
csgAMajor curlin subunit precursor; Escherichia coli K-12 ortholog: b1042; Escherichia coli O157:H7 ortholog: z1676. (152 aa)
phoQSensor protein phoQ; Member of the two-component regulatory system PhoP/PhoQ involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, which results in the repression of PG and may l [...] (486 aa)
phoPTranscriptional Regulatory protein phoP; Member of the two-component regulatory system PhoQ/PhoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. (223 aa)
sitASitA protein; Residues 2 to 263 of 285 are 62.97 pct identical to residues 3 to 257 of 293 from SwissProt.40 : >sp|Q57449|Y362_HAEIN PUTATIVE PERIPLASMIC IRON-BINDING PROTEIN HI0362 PRECURSOR; Belongs to the bacterial solute-binding protein 9 family. (285 aa)
c1990Putative protease ydgD precursor; Escherichia coli K-12 ortholog: b1598; Escherichia coli O157:H7 ortholog: z2592; Belongs to the peptidase S1B family. (273 aa)
ydgBHypothetical oxidoreductase ydgB; Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate. (240 aa)
yobGHypothetical protein yobG; PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing. MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP. (47 aa)
fliCFlagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (595 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (875 aa)
glpTG-3-P transporter; Escherichia coli K-12 ortholog: b2240; Escherichia coli O157:H7 ortholog: z3498. (452 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa)
gshAGlutamate--cysteine ligase; Escherichia coli K-12 ortholog: b2688; Escherichia coli O157:H7 ortholog: z3989; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (518 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). (744 aa)
hlyAHemolysin A; Residues 1 to 1024 of 1024 are 98.63 pct identical to residues 1 to 1023 of 1023 from SwissProt.40 : >sp|P09983|HLY1_ECOLI HEMOLYSIN, CHROMOSOMAL. (1024 aa)
satSecreted auto transpoter toxin; Shows serine protease activity and displays cytophatic activity, including elongation, rounding, and detachment of a proportion of the cells from monolayer in culture. Triggers vacuolation within the cytoplasm of the human bladder and kidney cells. (1299 aa)
iutAIutA protein; Residues 28 to 759 of 759 are 87.56 pct identical to residues 2 to 732 of 732 from SwissProt.40 : >sp|P14542|IUTA_ECOLI FERRIC AEROBACTIN RECEPTOR PRECURSOR (CLOACIN RECEPTOR). (759 aa)
parCTopoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (752 aa)
parETopoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (630 aa)
tolCOuter membrane protein tolC precursor; Escherichia coli K-12 ortholog: b3035; Escherichia coli O157:H7 ortholog: z4392. (506 aa)
hldEADP-heptose synthase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (477 aa)
folPDihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (304 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa)
rpsL30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (144 aa)
damDNA adenine methylase; Escherichia coli K-12 ortholog: b3387; Escherichia coli O157:H7 ortholog: z4740. (278 aa)
chuAOuter membrane heme/hemoglobin receptor; Escherichia coli O157:H7 ortholog: z4911. (648 aa)
rfaCLipopolysaccharide heptosyltransferase-1; Escherichia coli K-12 ortholog: b3621; Escherichia coli O157:H7 ortholog: z5048. (326 aa)
rfaPLipopolysaccharide core biosynthesis protein rfaP; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family. (268 aa)
uhpTHexose phosphate transport protein; Escherichia coli K-12 ortholog: b3666; Escherichia coli O157:H7 ortholog: z5156. (463 aa)
rhoTranscription termination factor rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (443 aa)
ampCBeta-lactamase precursor; Escherichia coli K-12 ortholog: b4150; Escherichia coli O157:H7 ortholog: z5757. (388 aa)
fimBType 1 fimbriae Regulatory protein fimB; Escherichia coli K-12 ortholog: b4312; Escherichia coli O157:H7 ortholog: z5910. (200 aa)
fimEType 1 fimbriae Regulatory protein fimE; FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off (By similarity). (198 aa)
fimAType-1 fimbrial protein, A chain precursor; Type-1A pilin; Escherichia coli K-12 ortholog: b4314; Escherichia coli O157:H7 ortholog: z5912. (201 aa)
fimIFimbrin-like protein fimI precursor; Escherichia coli K-12 ortholog: b4315; Escherichia coli O157:H7 ortholog: z5913. (179 aa)
fimCChaperone protein fimC precursor; Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH (By similarity); Belongs to the periplasmic pilus chaperone family. (241 aa)
fimHFimH protein precursor; Escherichia coli K-12 ortholog: b4320; Escherichia coli O157:H7 ortholog: z5918. (303 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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