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carA carA carB carB yafV yafV ybaS ybaS asnB asnB ybiK ybiK aspC aspC putA putA purB purB gadB gadB yneH yneH yneI yneI gdhA gdhA ansA ansA alaA alaA purF purF nadB nadB gabD gabD gabT gabT ansB ansB argG argG gltB gltB gltD gltD gadA gadA glmS glmS asnA asnA glnA glnA argH argH aspA aspA purA purA pyrI pyrI pyrB pyrB
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
carACarbamoyl-phosphate synthase small chain; Escherichia coli K-12 ortholog: b0032; Escherichia coli O157:H7 ortholog: z0037; Belongs to the CarA family. (391 aa)
carBCarbamoyl-phosphate synthase large chain; Escherichia coli K-12 ortholog: b0033; Escherichia coli O157:H7 ortholog: z0038. (1073 aa)
yafVHypothetical protein yafV; Escherichia coli K-12 ortholog: b0219; Escherichia coli O157:H7 ortholog: z0276. (259 aa)
ybaSProbable glutaminase ybaS; Escherichia coli K-12 ortholog: b0485; Escherichia coli O157:H7 ortholog: z0606; Belongs to the glutaminase family. (310 aa)
asnBAsparagine synthetase B (glutamine-hydrolyzing); Escherichia coli K-12 ortholog: b0674; Escherichia coli O157:H7 ortholog: z0821. (632 aa)
ybiKPutative L-asparaginase precursor; Escherichia coli K-12 ortholog: b0828; Escherichia coli O157:H7 ortholog: z1052. (321 aa)
aspCAspartate aminotransferase; Escherichia coli K-12 ortholog: b0928; Escherichia coli O157:H7 ortholog: z1275. (396 aa)
putAPutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1342 aa)
purBAdenylosuccinate lyase; Escherichia coli K-12 ortholog: b1131; Escherichia coli O157:H7 ortholog: z1860. (456 aa)
gadBGlutamate decarboxylase beta; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). (489 aa)
yneHProbable glutaminase yneH; Escherichia coli K-12 ortholog: b1524; Escherichia coli O157:H7 ortholog: z2179; Belongs to the glutaminase family. (308 aa)
yneIAldehyde-dehydrogenase like protein yneI; Escherichia coli K-12 ortholog: b1525; Escherichia coli O157:H7 ortholog: z2178. (470 aa)
gdhANADP-specific glutamate dehydrogenase; Escherichia coli K-12 ortholog: b1761; Escherichia coli O157:H7 ortholog: z2793; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa)
ansAEscherichia coli K-12 ortholog: b1767; Escherichia coli O157:H7 ortholog: z2801. (338 aa)
alaAProbable aminotransferase yfbQ; Involved in the biosynthesis of alanine. (405 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa)
nadBL-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (540 aa)
gabDSuccinate-semialdehyde dehydrogenase (NADP+); Escherichia coli K-12 ortholog: b2661; Escherichia coli O157:H7 ortholog: z3959; Belongs to the aldehyde dehydrogenase family. (482 aa)
gabT4-aminobutyrate aminotransferase; Escherichia coli K-12 ortholog: b2662; Escherichia coli O157:H7 ortholog: z3960; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (428 aa)
ansBL-asparaginase II precursor; Escherichia coli K-12 ortholog: b2957; Escherichia coli O157:H7 ortholog: z4302; Belongs to the asparaginase 1 family. (348 aa)
argGArgininosuccinate synthase; Escherichia coli K-12 ortholog: b3172; Escherichia coli O157:H7 ortholog: z4534; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (447 aa)
gltBGlutamate synthase [NADPH] large chain precursor; Escherichia coli K-12 ortholog: b3212; Escherichia coli O157:H7 ortholog: z4576. (1522 aa)
gltDGlutamate synthase [NADPH] small chain; Escherichia coli K-12 ortholog: b3213; Escherichia coli O157:H7 ortholog: z4577. (472 aa)
gadAGlutamate decarboxylase alpha; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). (487 aa)
glmSGlucosamine--fructose-6-phosphate aminotransferase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa)
asnAAspartate--ammonia ligase; Escherichia coli K-12 ortholog: b3744; Escherichia coli O157:H7 ortholog: z5245; Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily. (330 aa)
glnAGlutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa)
argHArgininosuccinate lyase; Escherichia coli K-12 ortholog: b3960; Escherichia coli O157:H7 ortholog: z5518. (457 aa)
aspAAspartate ammonia-lyase; Escherichia coli K-12 ortholog: b4139; Escherichia coli O157:H7 ortholog: z5744; Belongs to the class-II fumarase/aspartase family. Aspartase subfamily. (493 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
pyrIAspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa)
pyrBAspartate carbamoyltransferase catalytic chain; Escherichia coli K-12 ortholog: b4245; Escherichia coli O157:H7 ortholog: z5856; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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