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thrA thrA speD speD speE speE pfs pfs serC serC aspC aspC c1175 c1175 malY malY sdaA sdaA c2241 c2241 yedO yedO dcm dcm cysK cysK cysM cysM sseA sseA ygaG ygaG gshA gshA sdaB sdaB c3405 c3405 c3407 c3407 serA serA metK metK gshB gshB metC metC c3870 c3870 mdh mdh asd asd cysE cysE metK-2 metK-2 ilvE ilvE metE metE metB metB metL metL metA metA metH metH lysC lysC tyrB tyrB c5039 c5039
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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thrABifunctional; Escherichia coli K-12 ortholog: b0002; Escherichia coli O157:H7 ortholog: z0002; bifunctional; Homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. (841 aa)
speDS-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. (264 aa)
speESpermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (288 aa)
pfsMTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phosphorylas [...] (232 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
aspCAspartate aminotransferase; Escherichia coli K-12 ortholog: b0928; Escherichia coli O157:H7 ortholog: z1275. (396 aa)
c1175Putative aminotransferase; Residues 2 to 387 of 388 are 34.62 pct identical to residues 1 to 377 of 384 from GenPept.129 : >gb|AAK80912.1|AE007794_4 (AE007794) PLP-dependent aminotransferase, [Clostridium acetobutylicum]. (388 aa)
malYMalY protein; Escherichia coli K-12 ortholog: b1622; Escherichia coli O157:H7 ortholog: z2627; bifunctional; Cystathionine beta-lyase; Maltose regulon modulator. (390 aa)
sdaAL-serine dehydratase 1; Escherichia coli K-12 ortholog: b1814; Escherichia coli O157:H7 ortholog: z2857; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)
c2241Protein yebR; Escherichia coli K-12 ortholog: b1832; Escherichia coli O157:H7 ortholog: z2879. (148 aa)
yedOPutative 1-aminocyclopropane-1-carboxylate deaminase; Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine; Belongs to the ACC deaminase/D-cysteine desulfhydrase family. (328 aa)
dcmDNA-cytosine methyltransferase; Escherichia coli K-12 ortholog: b1961; Escherichia coli O157:H7 ortholog: z3054. (472 aa)
cysKCysteine synthase A; Escherichia coli K-12 ortholog: b2414; Escherichia coli O157:H7 ortholog: z3680; Belongs to the cysteine synthase/cystathionine beta- synthase family. (327 aa)
cysMCysteine synthase B; Escherichia coli K-12 ortholog: b2421; Escherichia coli O157:H7 ortholog: z3686; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa)
sseA3-mercaptopyruvate sulfurtransferase; Escherichia coli K-12 ortholog: b2521; Escherichia coli O157:H7 ortholog: z3788. (334 aa)
ygaGAutoinducer-2 production protein luxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
gshAGlutamate--cysteine ligase; Escherichia coli K-12 ortholog: b2688; Escherichia coli O157:H7 ortholog: z3989; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (518 aa)
sdaBL-serine dehydratase 2; Escherichia coli K-12 ortholog: b2797; Escherichia coli O157:H7 ortholog: z4114; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa)
c34052-hydroxyacid dehydrogenase; Residues 5 to 318 of 318 are 37.77 pct identical to residues 3 to 317 of 317 from GenPept.129 : >gb|AAK90773.1| (AE007909) AGR_pAT_578p [Agrobacterium tumefaciens str. C58 (Cereon)]; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa)
c3407Beta-cystathionase; Residues 1 to 336 of 391 are 99.70 pct identical to residues 1 to 336 of 336 from GenPept.129 : >gb|AAC61731.1| (AF081286) beta-cystathionase [Escherichia coli]. (391 aa)
serAD-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (388 aa)
gshBGlutathione synthetase; Escherichia coli K-12 ortholog: b2947; Escherichia coli O157:H7 ortholog: z4292. (316 aa)
metCCystathionine beta-lyase; Escherichia coli K-12 ortholog: b3008; Escherichia coli O157:H7 ortholog: z4361. (440 aa)
c3870L-serine dehydratase 1; Escherichia coli K-12 ortholog: b1814; Escherichia coli O157:H7 ortholog: z4464; Belongs to the iron-sulfur dependent L-serine dehydratase family. (456 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (334 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (387 aa)
cysESerine acetyltransferase; Escherichia coli K-12 ortholog: b3607; Escherichia coli O157:H7 ortholog: z5034; Belongs to the transferase hexapeptide repeat family. (273 aa)
metK-2S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (383 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. (309 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa)
metBCystathionine gamma-synthase; Escherichia coli K-12 ortholog: b3939; Escherichia coli O157:H7 ortholog: z5494. (424 aa)
metLAKII-HDII protein; Bifunctional; Escherichia coli K-12 ortholog: b3940; Escherichia coli O157:H7 ortholog: z5495; bifunctional; Aspartokinase II; Homoserine dehydrogenase II; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa)
metAHomoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (309 aa)
metH5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa)
lysCLysine-sensitive aspartokinase III; Escherichia coli K-12 ortholog: b4024; Escherichia coli O157:H7 ortholog: z5622; Belongs to the aspartokinase family. (449 aa)
tyrBAromatic-amino-acid aminotransferase; Escherichia coli K-12 ortholog: b4054; Escherichia coli O157:H7 ortholog: z5652. (411 aa)
c5039Putative lactate dehydrogenase; Residues 15 to 344 of 369 are 44.87 pct identical to residues 1 to 332 of 349 from SwissProt.40 : >sp|Q07251|LDH_ALCEU L-lactate dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family. (369 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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