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| | thrA | Bifunctional; Escherichia coli K-12 ortholog: b0002; Escherichia coli O157:H7 ortholog: z0002; bifunctional; Homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. (841 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa) |
| | thrC | Threonine synthase; Escherichia coli K-12 ortholog: b0004; Escherichia coli O157:H7 ortholog: z0004. (428 aa) |
| | talB | Transaldolase B; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (338 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | araD | L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5- phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). (231 aa) |
| | aceE | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa) |
| | lpdA | Dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (495 aa) |
| | acnB | Aconitate hydratase 2; Escherichia coli K-12 ortholog: b0118; Escherichia coli O157:H7 ortholog: z0128. (916 aa) |
| | hemL | Glutamate-1-semialdehyde 2,1-aminomutase; Escherichia coli K-12 ortholog: b0154; Escherichia coli O157:H7 ortholog: z0165. (426 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Escherichia coli K-12 ortholog: b0166; Escherichia coli O157:H7 ortholog: z0176; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | ldcC | Lysine decarboxylase, constitutive; Escherichia coli K-12 ortholog: b0186; Escherichia coli O157:H7 ortholog: z0198. (713 aa) |
| | c0334 | Putative integral membrane protein; Residues 1 to 418 of 418 are 99.76 pct identical to residues 1 to 418 of 418 from GenPept.129 : >emb|CAC39291.1| (AJ278144) hypothetical protein [Escherichia coli]. (418 aa) |
| | c0335 | Hypothetical protein; Residues 1 to 95 of 95 are 96.84 pct identical to residues 1 to 95 of 95 from GenPept.129 : >gb|AAK27336.1| (AF286670) unknown [Escherichia coli]. (95 aa) |
| | c0336 | PTS system, mannitol (Cryptic)-specific IIA component; EIIA-(C)MTL; Escherichia coli K-12 ortholog: b2934; Escherichia coli O157:H7 ortholog: z4278. (147 aa) |
| | c0444 | Carbamate kinase-like protein yahI; Escherichia coli K-12 ortholog: b0323; Escherichia coli O157:H7 ortholog: z0412; Belongs to the carbamate kinase family. (316 aa) |
| | yahK | Hypothetical zinc-type alcohol dehydrogenase-like protein yahK; Escherichia coli K-12 ortholog: b0325; Escherichia coli O157:H7 ortholog: z0420. (349 aa) |
| | yaiM | Hypothetical protein yaiM; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (By similarity). (277 aa) |
| | adhC | Alcohol dehydrogenase class III; Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase; Escherichia coli K-12 ortholog: b0369; Escherichia coli O157:H7 ortholog: z0468; Belongs to the ALAD family. (335 aa) |
| | ybbX | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. (453 aa) |
| | ybbZ | Glycerate kinase 1; Escherichia coli K-12 ortholog: b0514; Escherichia coli O157:H7 ortholog: z0669; Belongs to the glycerate kinase type-1 family. (383 aa) |
| | ylbA | Hypothetical protein ylbA; Escherichia coli K-12 ortholog: b0515; Escherichia coli O157:H7 ortholog: z0670. (261 aa) |
| | ylbB | Allantoate amidohydrolase; Escherichia coli K-12 ortholog: b0516; Escherichia coli O157:H7 ortholog: z0671. (417 aa) |
| | c0631 | Ureidoglycolate dehydrogenase; Escherichia coli K-12 ortholog: b0517; Escherichia coli O157:H7 ortholog: z0672; Belongs to the LDH2/MDH2 oxidoreductase family. (349 aa) |
| | arcC | Carbamate kinase; Escherichia coli K-12 ortholog: b0521; Escherichia coli O157:H7 ortholog: z0676; Belongs to the carbamate kinase family. (297 aa) |
| | folD | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | nfnB | Oxygen-insensitive NAD(P)H nitroreductase; Escherichia coli K-12 ortholog: b0578; Escherichia coli O157:H7 ortholog: z0717. (217 aa) |
| | c0761 | Putative dihydrodipicolinate synthase; Residues 11 to 294 of 295 are 43.50 pct identical to residues 8 to 292 of 297 from GenPept.129 : >gb|AAL45759.1| (AE008931) dihydrodipicolinate synthase [Agrobacterium tumefaciens str. C58 (U. Washington)]; Belongs to the DapA family. (295 aa) |
| | pgm | Phosphoglucomutase; Escherichia coli K-12 ortholog: b0688; Escherichia coli O157:H7 ortholog: z0837. (563 aa) |
| | gltA | Citrate synthase; Escherichia coli K-12 ortholog: b0720; Escherichia coli O157:H7 ortholog: z0873; Belongs to the citrate synthase family. (427 aa) |
| | sdhC | Succinate dehydrogenase cytochrome b-556 subunit; Escherichia coli K-12 ortholog: b0721; Escherichia coli O157:H7 ortholog: z0875. (134 aa) |
| | sdhD | Succinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa) |
| | sdhA | Succinate dehydrogenase flavoprotein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (592 aa) |
| | sdhB | Succinate dehydrogenase iron-sulfur protein; Escherichia coli K-12 ortholog: b0724; Escherichia coli O157:H7 ortholog: z0878; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa) |
| | sucA | 2-oxoglutarate dehydrogenase E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (933 aa) |
| | sucB | Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (405 aa) |
| | sucC | Succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa) |
| | sucD | Succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa) |
| | gpmA | Phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (255 aa) |
| | galM | Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (346 aa) |
| | ybhE | Hypothetical protein ybhE; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. (331 aa) |
| | ybhJ | Hypothetical protein ybhJ; Escherichia coli K-12 ortholog: b0771; Escherichia coli O157:H7 ortholog: z0942. (761 aa) |
| | ybiW | Putative formate acetyltransferase 3; Escherichia coli K-12 ortholog: b0823; Escherichia coli O157:H7 ortholog: z1045. (810 aa) |
| | mdaA | Oxygen-insensitive NADPH nitroreductase; Escherichia coli K-12 ortholog: b0851; Escherichia coli O157:H7 ortholog: z1078; Belongs to the flavin oxidoreductase frp family. (240 aa) |
| | ybjU | Low-specificity L-threonine aldolase; Escherichia coli K-12 ortholog: b0870; Escherichia coli O157:H7 ortholog: z1104. (333 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | mgsA | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (155 aa) |
| | yccX | Putative acylphosphatase; Escherichia coli K-12 ortholog: b0968; Escherichia coli O157:H7 ortholog: z1320. (132 aa) |
| | hyaA | Hydrogenase-1 small chain precursor; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth. (381 aa) |
| | hyaB | Hydrogenase-1 large chain; Escherichia coli K-12 ortholog: b0973; Escherichia coli O157:H7 ortholog: z1390; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (597 aa) |
| | torC | Cytochrome c-type protein torC; Escherichia coli K-12 ortholog: b0996; Escherichia coli O157:H7 ortholog: z1414; Belongs to the TorC/TorY family. (406 aa) |
| | torA | Trimethylamine-N-oxide reductase 1 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. (848 aa) |
| | torD | Chaperone protein torD; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily. (210 aa) |
| | agp | Glucose-1-phosphatase precursor; Escherichia coli K-12 ortholog: b1002; Escherichia coli O157:H7 ortholog: z1421. (318 aa) |
| | ycdW | Putative 2-hydroxyacid dehydrogenase ycdW; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. (312 aa) |
| | icdA | Isocitrate dehydrogenase (NADP); Escherichia coli K-12 ortholog: b1136; Escherichia coli O157:H7 ortholog: z1865. (416 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (337 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (484 aa) |
| | narG | Respiratory nitrate reductase 1 alpha chain; Escherichia coli K-12 ortholog: b1224; Escherichia coli O157:H7 ortholog: z2001; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1247 aa) |
| | narH | Respiratory nitrate reductase 1 beta chain; Escherichia coli K-12 ortholog: b1225; Escherichia coli O157:H7 ortholog: z2002. (512 aa) |
| | narI | Respiratory nitrate reductase 1 gamma chain; Escherichia coli K-12 ortholog: b1227; Escherichia coli O157:H7 ortholog: z2004. (225 aa) |
| | adhE | Aldehyde-alcohol dehydrogenase; Escherichia coli K-12 ortholog: b1241; Escherichia coli O157:H7 ortholog: z2016; multifunctional; Alcohol dehydrogenase; Acetaldehyde dehydrogenase [acetylating]; Pyruvate-formate-lyase deactivase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (891 aa) |
| | acnA | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa) |
| | ydbK | Probable pyruvate-flavodoxin oxidoreductase; Escherichia coli K-12 ortholog: b1378; Escherichia coli O157:H7 ortholog: z2332. (1174 aa) |
| | ldhA | D-lactate dehydrogenase; Escherichia coli K-12 ortholog: b1380; Escherichia coli O157:H7 ortholog: z2329; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa) |
| | ydbC | Hypothetical oxidoreductase ydbC; Escherichia coli K-12 ortholog: b1406; Escherichia coli O157:H7 ortholog: z2321. (286 aa) |
| | aldA | Aldehyde dehydrogenase A; Escherichia coli K-12 ortholog: b1415; Escherichia coli O157:H7 ortholog: z2306; Belongs to the aldehyde dehydrogenase family. (479 aa) |
| | c1843 | Glyceraldehyde 3-phosphate dehydrogenase A; Escherichia coli K-12 ortholog: b1779; Escherichia coli O157:H7 ortholog: z2304; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa) |
| | ydcW | Putative betaine aldehyde dehydrogenase; Catalyzes the oxidation 4-aminobutanal (gamma- aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4- aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (474 aa) |
| | narV | Respiratory nitrate reductase 2 gamma chain; Escherichia coli K-12 ortholog: b1465; Escherichia coli O157:H7 ortholog: z2247. (226 aa) |
| | narY | Respiratory nitrate reductase 2 beta chain; Escherichia coli K-12 ortholog: b1467; Escherichia coli O157:H7 ortholog: z2245. (514 aa) |
| | narZ | Respiratory nitrate reductase 2 alpha chain; Escherichia coli K-12 ortholog: b1468; Escherichia coli O157:H7 ortholog: z2244; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1287 aa) |
| | adhP | Alcohol dehydrogenase, propanol-preferring; Escherichia coli K-12 ortholog: b1478; Escherichia coli O157:H7 ortholog: z2232. (346 aa) |
| | gadB | Glutamate decarboxylase beta; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). (489 aa) |
| | yneI | Aldehyde-dehydrogenase like protein yneI; Escherichia coli K-12 ortholog: b1525; Escherichia coli O157:H7 ortholog: z2178. (470 aa) |
| | fumC | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa) |
| | fumA | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80% of the fumarase activity when the bacteria grow aerobically. To a lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso-tartrate. Can also catalyze the isomerization of enol- to keto-oxaloacetate. (548 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (218 aa) |
| | nemA | N-ethylmaleimide reductase; Escherichia coli K-12 ortholog: b1650; Escherichia coli O157:H7 ortholog: z2668. (365 aa) |
| | ydhU | PhsC protein homolog; Escherichia coli K-12 ortholog: b1670; Escherichia coli O157:H7 ortholog: z2697. (261 aa) |
| | ydhZ | Hypothetical protein ydhZ; In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as substrate; Belongs to the FumD family. (69 aa) |
| | pykF | Pyruvate kinase I; Escherichia coli K-12 ortholog: b1676; Escherichia coli O157:H7 ortholog: z2704; Belongs to the pyruvate kinase family. (542 aa) |
| | ydiF | Hypothetical protein ydiF; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family. (531 aa) |
| | ppsA | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa) |
| | pfkB | 6-phosphofructokinase isozyme 2; Escherichia coli K-12 ortholog: b1723; Escherichia coli O157:H7 ortholog: z2752; Belongs to the carbohydrate kinase PfkB family. (310 aa) |
| | gdhA | NADP-specific glutamate dehydrogenase; Escherichia coli K-12 ortholog: b1761; Escherichia coli O157:H7 ortholog: z2793; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa) |
| | gapA | Glyceraldehyde 3-phosphate dehydrogenase A; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. (334 aa) |
| | yeaD | Unknown protein from 2D-page; Spots T26/PR37; Escherichia coli K-12 ortholog: b1780; Escherichia coli O157:H7 ortholog: z2820; Belongs to the glucose-6-phosphate 1-epimerase family. (301 aa) |
| | eda | KHG/KDPG aldolase; Escherichia coli K-12 ortholog: b1850; Escherichia coli O157:H7 ortholog: z2902; bifunctional; 4-hydroxy-2-oxoglutarate aldolase; 2-dehydro-3-deoxyphosphogluconate aldolase. (213 aa) |
| | edd | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (625 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa) |
| | pykA | Pyruvate kinase II; Escherichia coli K-12 ortholog: b1854; Escherichia coli O157:H7 ortholog: z2906; Belongs to the pyruvate kinase family. (527 aa) |
| | bisZ | Trimethylamine-N-oxide reductase 2 precursor; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N- oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency (By similarity); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (815 aa) |
| | yecK | Cytochrome c-type protein torY; Escherichia coli K-12 ortholog: b1873; Escherichia coli O157:H7 ortholog: z2926; Belongs to the TorC/TorY family. (366 aa) |
| | yedU | Protein yedU; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing th [...] (283 aa) |
| | c2388 | Transthyretin-like protein precursor; Escherichia coli K-12 ortholog: b1970; Escherichia coli O157:H7 ortholog: z3062; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (137 aa) |
| | c2457 | Putative amidase; Residues 17 to 492 of 495 are 35.31 pct identical to residues 12 to 484 of 507 from GenPept.129 : >gb|AAG30199.1| (AF293442) enantiomer selective amidase [Streptomyces sp. R1128]. (495 aa) |
| | c2467 | Putative 3-hydroxyacyl-CoA dehydrogenase; Residues 2 to 282 of 289 are 45.55 pct identical to residues 1 to 278 of 278 from SwissProt.40 : >sp|Q9RVG1|HBD_DEIRA Probable 3-hydroxybutyryl-CoA dehydrogenase (Beta-hydroxybutyryl-CoA dehydrogenase) (BHBD). (289 aa) |
| | gnd | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa) |
| | fbaB | Fructose-bisphosphate aldolase class I; Escherichia coli K-12 ortholog: b2097; Escherichia coli O157:H7 ortholog: z3260. (374 aa) |
| | dld | D-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (582 aa) |
| | yeiG | Hypothetical protein yeiG; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (By similarity). (278 aa) |
| | fruA | PTS system, fructose-specific IIBC component; EIIBC-Fru; Escherichia coli K-12 ortholog: b2167; Escherichia coli O157:H7 ortholog: z3425. (563 aa) |
| | napB | Diheme cytochrome c napB precursor; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (156 aa) |
| | napA | Periplasmic nitrate reductase precursor; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (828 aa) |
| | yojH | Malate:quinone oxidoreductase; Escherichia coli K-12 ortholog: b2210; Escherichia coli O157:H7 ortholog: z3468. (548 aa) |
| | atoD | Acetate CoA-transferase alpha subunit; Escherichia coli K-12 ortholog: b2221. (220 aa) |
| | atoA | Acetate CoA-transferase beta subunit; Escherichia coli K-12 ortholog: b2222. (216 aa) |
| | atoB | Acetyl-CoA acetyltransferase; Escherichia coli K-12 ortholog: b2224; Escherichia coli O157:H7 ortholog: z4164; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | yfaU | Hypothetical protein yfaU; Catalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily. (267 aa) |
| | yfaW | Hypothetical protein yfaW; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). (405 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | pta | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa) |
| | ubiX | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (189 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (332 aa) |
| | fadJ | Putative fatty oxidation complex alpha subunit; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (714 aa) |
| | fadI | Probable 3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (436 aa) |
| | glk | Glucokinase; Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate. (321 aa) |
| | gltX | Glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (471 aa) |
| | cysK | Cysteine synthase A; Escherichia coli K-12 ortholog: b2414; Escherichia coli O157:H7 ortholog: z3680; Belongs to the cysteine synthase/cystathionine beta- synthase family. (327 aa) |
| | eutG | Ethanolamine utilization protein eutG; Escherichia coli K-12 ortholog: b2453; Escherichia coli O157:H7 ortholog: z3709. (404 aa) |
| | eutE | Ethanolamine utilization protein eutE; Escherichia coli K-12 ortholog: b2455; Escherichia coli O157:H7 ortholog: z3711. (467 aa) |
| | c2988 | NADP-dependent malic enzyme; Escherichia coli K-12 ortholog: b2463; Escherichia coli O157:H7 ortholog: z3719. (759 aa) |
| | talA | Transaldolase A; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (316 aa) |
| | tktB | Transketolase 2; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (688 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa) |
| | sseA | 3-mercaptopyruvate sulfurtransferase; Escherichia coli K-12 ortholog: b2521; Escherichia coli O157:H7 ortholog: z3788. (334 aa) |
| | yphB | Hypothetical protein yphB; Escherichia coli K-12 ortholog: b2544; Escherichia coli O157:H7 ortholog: z3816. (290 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa) |
| | ygaT | Hypothetical protein ygaT; Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (325 aa) |
| | ygaF | Hypothetical protein ygaF; Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665; Belongs to the L2HGDH family. (444 aa) |
| | gabD | Succinate-semialdehyde dehydrogenase (NADP+); Escherichia coli K-12 ortholog: b2661; Escherichia coli O157:H7 ortholog: z3959; Belongs to the aldehyde dehydrogenase family. (482 aa) |
| | gabT | 4-aminobutyrate aminotransferase; Escherichia coli K-12 ortholog: b2662; Escherichia coli O157:H7 ortholog: z3960; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (428 aa) |
| | cysC | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (201 aa) |
| | cysN | Sulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (475 aa) |
| | cysD | Sulfate adenylyltransferase subunit 2; Escherichia coli K-12 ortholog: b2752; Escherichia coli O157:H7 ortholog: z4060. (302 aa) |
| | cysH | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. (244 aa) |
| | cysI | Sulfite reductase [NADPH] hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa) |
| | cysJ | Sulfite reductase [NADPH] flavoprotein alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (599 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa) |
| | fucO | Lactaldehyde reductase; Escherichia coli K-12 ortholog: b2799; Escherichia coli O157:H7 ortholog: z4116. (383 aa) |
| | fucA | L-fuculose phosphate aldolase; Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. (215 aa) |
| | fucI | L-fucose isomerase; Converts the aldose L-fucose into the corresponding ketose L- fuculose. (591 aa) |
| | c3405 | 2-hydroxyacid dehydrogenase; Residues 5 to 318 of 318 are 37.77 pct identical to residues 3 to 317 of 317 from GenPept.129 : >gb|AAK90773.1| (AE007909) AGR_pAT_578p [Agrobacterium tumefaciens str. C58 (Cereon)]; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | yqeF | Probable acetyl-CoA acetyltransferase; Escherichia coli K-12 ortholog: b2844; Escherichia coli O157:H7 ortholog: z4164; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | c3444 | Xanthine dehydrogenase, molybdenum binding subunit; Escherichia coli K-12 ortholog: b2866; Escherichia coli O157:H7 ortholog: z4205. (765 aa) |
| | ygeT | Xanthine dehydrogenase, FAD binding subunit; Escherichia coli K-12 ortholog: b2867; Escherichia coli O157:H7 ortholog: z4206. (292 aa) |
| | c3446 | Xanthine dehydrogenase iron-sulfur binding subunit; Escherichia coli K-12 ortholog: b2868; Escherichia coli O157:H7 ortholog: z4207. (159 aa) |
| | yqeA | Carbamate kinase-like protein yqeA; Escherichia coli K-12 ortholog: b2874; Escherichia coli O157:H7 ortholog: z4213; Belongs to the carbamate kinase family. (310 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa) |
| | rpiA | Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (243 aa) |
| | c3498 | Putative conserved protein; Residues 1 to 309 of 351 are 86.88 pct identical to residues 1 to 343 of 714 from MG1655 : b2917. (351 aa) |
| | fba | Fructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (387 aa) |
| | pgk | Phosphoglycerate kinase; Escherichia coli K-12 ortholog: b2926; Escherichia coli O157:H7 ortholog: z4265; Belongs to the phosphoglycerate kinase family. (408 aa) |
| | yggD | Hypothetical protein yggD; Escherichia coli K-12 ortholog: b2929; Escherichia coli O157:H7 ortholog: z4274. (169 aa) |
| | tktA | Transketolase 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (673 aa) |
| | iucD | IucD protein; Residues 1 to 425 of 445 are 97.88 pct identical to residues 1 to 425 of 425 from SwissProt.40 : >sp|P11295|IUCD_ECOLI L-LYSINE 6-MONOOXYGENASE (LYSINE N6-HYDROXYLASE). (445 aa) |
| | iucC | IucC protein; Residues 1 to 580 of 580 are 96.89 pct identical to residues 1 to 580 of 580 from SwissProt.40 : >sp|Q47318|IUCC_ECOLI AEROBACTIN SIDEROPHORE BIOSYNTHESIS PROTEIN IUCC. (580 aa) |
| | iucB | IucB protein; Residues 1 to 315 of 315 are 94.92 pct identical to residues 1 to 315 of 315 from SwissProt.40 : >sp|Q47317|IUCB_ECOLI AEROBACTIN SIDEROPHORE BIOSYNTHESIS PROTEIN IUCB. (315 aa) |
| | iucA | IucA protein; Residues 22 to 595 of 595 are 93.04 pct identical to residues 1 to 575 of 575 from SwissProt.40 : >sp|Q47316|IUCA_ECOLI AEROBACTIN SIDEROPHORE BIOSYNTHESIS PROTEIN IUCA. (595 aa) |
| | glcB | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (723 aa) |
| | glcD | Glycolate oxidase subunit glcD; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is also able to oxidize D-lactate ((R)- lactate) with a similar rate. Does not link directly to O(2), and 2,6- dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (499 aa) |
| | hybC | Hydrogenase-2 large chain precursor; Escherichia coli K-12 ortholog: b2994; Escherichia coli O157:H7 ortholog: z4348; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (567 aa) |
| | hybO | Hydrogenase-2 small chain precursor; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake. (372 aa) |
| | c3736 | Putative enzyme; Escherichia coli O157:H7 ortholog: z4353. (308 aa) |
| | ygjG | Probable ornithine aminotransferase; Catalyzes the aminotransferase reaction from putrescine to 2- oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4- aminobutanal. Also functions as a cadaverine transaminase in a a L- lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (496 aa) |
| | tdcE | Keto-acid formate acetyltransferase; Escherichia coli K-12 ortholog: b3114; Escherichia coli O157:H7 ortholog: z4466. (764 aa) |
| | yhaD | Glycerate kinase 2; Escherichia coli K-12 ortholog: b3124; Escherichia coli O157:H7 ortholog: z4476; Belongs to the glycerate kinase type-1 family. (408 aa) |
| | gltB | Glutamate synthase [NADPH] large chain precursor; Escherichia coli K-12 ortholog: b3212; Escherichia coli O157:H7 ortholog: z4576. (1522 aa) |
| | gltD | Glutamate synthase [NADPH] small chain; Escherichia coli K-12 ortholog: b3213; Escherichia coli O157:H7 ortholog: z4577. (472 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (334 aa) |
| | accB | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (156 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (462 aa) |
| | prkB | Probable phosphoribulokinase; Escherichia coli K-12 ortholog: b3355; Escherichia coli O157:H7 ortholog: z4716. (289 aa) |
| | argD | Acetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways. (406 aa) |
| | nirB | Nitrite reductase [NAD(P)H] large subunit; Escherichia coli K-12 ortholog: b3365; Escherichia coli O157:H7 ortholog: z4726; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (847 aa) |
| | nirD | Nitrite reductase [NAD(P)H] small subunit; Escherichia coli K-12 ortholog: b3366; Escherichia coli O157:H7 ortholog: z4727. (108 aa) |
| | cysG | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (457 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (563 aa) |
| | glpE | Thiosulfate sulfurtransferase glpE; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. (116 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (387 aa) |
| | gntK | Thermoresistant gluconokinase; Escherichia coli K-12 ortholog: b3437; Escherichia coli O157:H7 ortholog: z4805. (163 aa) |
| | gadA | Glutamate decarboxylase alpha; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). (487 aa) |
| | kdgK | 2-dehydro-3-deoxygluconokinase; Escherichia coli K-12 ortholog: b3526; Escherichia coli O157:H7 ortholog: z4940. (425 aa) |
| | yiaE | 2-ketogluconate reductase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. (328 aa) |
| | sgbH | Probable hexulose-6-phosphate synthase; Escherichia coli K-12 ortholog: b3581; Escherichia coli O157:H7 ortholog: z5805. (220 aa) |
| | sgbU | Putative hexulose-6-phosphate isomerase; Escherichia coli K-12 ortholog: b3582; Escherichia coli O157:H7 ortholog: z5806. (297 aa) |
| | sgbE | Probable sugar isomerase sgbE; Escherichia coli K-12 ortholog: b3583; Escherichia coli O157:H7 ortholog: z0069. (231 aa) |
| | aldB | Aldehyde dehydrogenase B; Escherichia coli K-12 ortholog: b3588; Escherichia coli O157:H7 ortholog: z5008; Belongs to the aldehyde dehydrogenase family. (542 aa) |
| | yiaY | Probable alcohol dehydrogenase; Escherichia coli K-12 ortholog: b3589; Escherichia coli O157:H7 ortholog: z5010. (383 aa) |
| | cysE | Serine acetyltransferase; Escherichia coli K-12 ortholog: b3607; Escherichia coli O157:H7 ortholog: z5034; Belongs to the transferase hexapeptide repeat family. (273 aa) |
| | yibO | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (523 aa) |
| | c4483 | Putative aldolase; Escherichia coli O157:H7 ortholog: z5687. (286 aa) |
| | c4484 | Putative aldolase; Residues 1 to 283 of 283 are 39.78 pct identical to residues 1 to 283 of 284 from GenPept.129 : >emb|CAD00212.1| (AL591982) similar to fructose-1,6-biphosphate aldolase type II [Listeria monocytogenes]. (283 aa) |
| | c4485 | Putative PTS enzyme-ii fructose; Residues 11 to 358 of 363 are 53.10 pct identical to residues 5 to 355 of 363 from GenPept.129 : >emb|CAC97469.1| (AL596171) similar to PTS system, fructose-specific enzyme IIC component [Listeria innocua]. (363 aa) |
| | c4486 | PTS system, fructose-like-2 IIB component 1; Phosphotransferase enzyme II, B component; Escherichia coli K-12 ortholog: b3950; Escherichia coli O157:H7 ortholog: z5506. (104 aa) |
| | c4487 | Putative phosphotransferase system (PTS), fructose-specific; Residues 1 to 149 of 156 are 48.32 pct identical to residues 6 to 154 of 157 from GenPept.129 : >emb|CAC97471.1| (AL596171) similar to PTS system, fructose-specific enzyme IIA component [Listeria innocua]. (156 aa) |
| | c4537 | Putative conserved protein; Residues 10 to 849 of 850 are 34.39 pct identical to residues 2 to 765 of 765 from MG1655 : b3951. (850 aa) |
| | hemX | Putative uroporphyrin-III C-methyltransferase; Escherichia coli K-12 ortholog: b3803; Escherichia coli O157:H7 ortholog: z5317. (405 aa) |
| | hemD | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (246 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (320 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (275 aa) |
| | c4757 | Hypothetical protein; Residues 5 to 189 of 189 are 38.37 pct identical to residues 1 to 184 of 184 from GenPept.129 : >emb|CAD22377.1| (AX343668) unnamed protein product [Brevibacillus brevis]. (189 aa) |
| | c4759 | Transketolase 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (665 aa) |
| | c4764 | Carbamate kinase-like protein yahI; Escherichia coli K-12 ortholog: b0323; Escherichia coli O157:H7 ortholog: z0412; Belongs to the carbamate kinase family. (318 aa) |
| | c4769 | Hypothetical protein; Residues 1 to 197 of 199 are 56.78 pct identical to residues 34 to 232 of 233 from GenPept.129 : >dbj|BAB53241.1| (AP003010) hypothetical protein [Mesorhizobium loti]. (199 aa) |
| | c4771 | Putative carboxymethylenebutenolidase; Escherichia coli O157:H7 ortholog: z5352. (291 aa) |
| | fadA | 3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids (By similarity). (387 aa) |
| | fadB | Fatty oxidation complex alpha subunit; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (771 aa) |
| | glnA | Glutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa) |
| | c4831 | Hypothetical protein; Residues 46 to 310 of 314 are 43.39 pct identical to residues 4 to 259 of 262 from GenPept.129 : >emb|CAB42038.1| (AL049754) hypothetical protein [Streptomyces coelicolor A3(2)]. (314 aa) |
| | yihX | Hypothetical protein yihX; Escherichia coli K-12 ortholog: b3885; Escherichia coli O157:H7 ortholog: z5424. (206 aa) |
| | fdoI | Formate dehydrogenase; Allows to use formate as major electron donor during aerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the formate dehydrogenase (By similarity). (211 aa) |
| | fdoH | Formate dehydrogenase-O beta subunit; Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit (By similarity). (300 aa) |
| | rhaD | Rhamnulose-1-phosphate aldolase; Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. Belongs to the aldolase class II family. RhaD subfamily. (305 aa) |
| | rhaA | L-rhamnose isomerase; Escherichia coli K-12 ortholog: b3903; Escherichia coli O157:H7 ortholog: z5447. (421 aa) |
| | rhaB | Rhamnulokinase; Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1- hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate. (489 aa) |
| | pfkA | 6-phosphofructokinase isozyme I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (352 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | glpX | Protein glpX; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate; Belongs to the FBPase class 2 family. (336 aa) |
| | metL | AKII-HDII protein; Bifunctional; Escherichia coli K-12 ortholog: b3940; Escherichia coli O157:H7 ortholog: z5495; bifunctional; Aspartokinase II; Homoserine dehydrogenase II; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Escherichia coli K-12 ortholog: b3941; Escherichia coli O157:H7 ortholog: z5496; Belongs to the methylenetetrahydrofolate reductase family. (296 aa) |
| | pflD | Formate acetyltransferase 2; Escherichia coli K-12 ortholog: b3951; Escherichia coli O157:H7 ortholog: z5507. (765 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (883 aa) |
| | aceB | Malate synthase A; Escherichia coli K-12 ortholog: b4014; Escherichia coli O157:H7 ortholog: z5600; Belongs to the malate synthase family. (539 aa) |
| | aceA | Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. (439 aa) |
| | lysC | Lysine-sensitive aspartokinase III; Escherichia coli K-12 ortholog: b4024; Escherichia coli O157:H7 ortholog: z5622; Belongs to the aspartokinase family. (449 aa) |
| | pgi | Glucose-6-phosphate isomerase; Escherichia coli K-12 ortholog: b4025; Escherichia coli O157:H7 ortholog: z5623. (551 aa) |
| | c5032 | 2-oxoglutarate dehydrogenase E1 component; Escherichia coli K-12 ortholog: b0726; Escherichia coli O157:H7 ortholog: z0880. (939 aa) |
| | c5034 | Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; Escherichia coli K-12 ortholog: b0727; Escherichia coli O157:H7 ortholog: z0881. (351 aa) |
| | c5035 | Putative 2-oxoglutarate dehydrogenase; Residues 1 to 468 of 472 are 49.04 pct identical to residues 1 to 470 of 474 from SwissProt.40 : >sp|P52992|DLDH_ALCEU DIHYDROLIPOAMIDE DEHYDROGENASE (E3 COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX). (472 aa) |
| | sucC-2 | Succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa) |
| | sucD-2 | Succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa) |
| | c5039 | Putative lactate dehydrogenase; Residues 15 to 344 of 369 are 44.87 pct identical to residues 1 to 332 of 349 from SwissProt.40 : >sp|Q07251|LDH_ALCEU L-lactate dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family. (369 aa) |
| | acs | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (652 aa) |
| | nrfA | Cytochrome c552 precursor; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. (478 aa) |
| | yjcT | D-allose kinase; Catalyzes the phosphorylation of D-allose to D-allose 6- phosphate. (309 aa) |
| | yjcU | D-allulose-6-phosphate 3-epimerase; Escherichia coli K-12 ortholog: b4085. (233 aa) |
| | rpiB | Ribose 5-phosphate isomerase B; Escherichia coli K-12 ortholog: b4090. (149 aa) |
| | fumB | Fumarate hydratase class I, anaerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (548 aa) |
| | cadA | Lysine decarboxylase, inducible; Escherichia coli K-12 ortholog: b4131; Escherichia coli O157:H7 ortholog: z5734. (717 aa) |
| | frdD | Fumarate reductase 13 kDa hydrophobic protein; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (129 aa) |
| | frdC | Fumarate reductase 15 kDa hydrophobic protein; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa) |
| | frdB | Fumarate reductase iron-sulfur protein; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa) |
| | frdA | Fumarate reductase flavoprotein subunit; Escherichia coli K-12 ortholog: b4154; Escherichia coli O157:H7 ortholog: z5762. (602 aa) |
| | yjfR | Hypothetical protein yjfR; Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3- keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions; Belongs to the UlaG family. (356 aa) |
| | sgaT | Putative transport protein sgaT; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (465 aa) |
| | sgaB | Unknown pentitol phosphotransferase enzyme II, B component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (103 aa) |
| | ptxA | Unknown pentitol phosphotransferase enzyme II, A component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. (154 aa) |
| | sgaH | Probable hexulose-6-phosphate synthase; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization. Belongs to the HPS/KGPDC family. KGPDC subfamily. (229 aa) |
| | sgaU | Putative hexulose-6-phosphate isomerase; Catalyzes the isomerization of L-xylulose-5-phosphate to L- ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization; Belongs to the L-ribulose-5-phosphate 3-epimerase family. (284 aa) |
| | sgaE | Probable sugar isomerase sgaE; Catalyzes the isomerization of L-ribulose 5-phosphate to D- xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization. (244 aa) |
| | c5300 | Putative acetyl-CoA:acetoacetyl-CoA transferase; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family. (513 aa) |
| | cysQ | CysQ protein; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (246 aa) |
| | fbp | Fructose-1,6-bisphosphatase; Escherichia coli K-12 ortholog: b4232; Escherichia coli O157:H7 ortholog: z5842. (353 aa) |
| | c5349 | Carbamate kinase; Escherichia coli K-12 ortholog: b0521; Escherichia coli O157:H7 ortholog: z0676; Belongs to the carbamate kinase family. (310 aa) |
| | idnK | Thermosensitive gluconokinase; Escherichia coli K-12 ortholog: b4268; Escherichia coli O157:H7 ortholog: z4805. (187 aa) |
| | yjgB | Hypothetical zinc-type alcohol dehydrogenase-like protein yjgB; Escherichia coli K-12 ortholog: b4269; Escherichia coli O157:H7 ortholog: z5876. (353 aa) |
| | serB | Phosphoserine phosphatase; Escherichia coli K-12 ortholog: b4388; Escherichia coli O157:H7 ortholog: z5989. (368 aa) |
| | gpmB | Probable phosphoglycerate mutase 2; Escherichia coli K-12 ortholog: b4395; Escherichia coli O157:H7 ortholog: z5997; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa) |
| | fdoG | Formate dehydrogenase-O, major subunit; Escherichia coli K-12 ortholog: b3894; Escherichia coli O157:H7 ortholog: z5436. (1016 aa) |
