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leuD leuD leuC leuC leuB leuB leuA leuA ilvI ilvI ilvH ilvH acnB acnB gltA gltA ybhJ ybhJ aspC aspC icdA icdA acnA acnA alaA alaA argA argA argD argD asd asd ilvN ilvN ilvB ilvB ilvG ilvG ilvM ilvM ilvE ilvE ilvD ilvD ilvC ilvC argE argE argC argC argB argB lysC lysC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (364 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (537 aa)
ilvIAcetolactate synthase isozyme III large subunit; Escherichia coli K-12 ortholog: b0077; Escherichia coli O157:H7 ortholog: z0087. (604 aa)
ilvHAcetolactate synthase isozyme III small subunit; Escherichia coli K-12 ortholog: b0078; Escherichia coli O157:H7 ortholog: z0088. (173 aa)
acnBAconitate hydratase 2; Escherichia coli K-12 ortholog: b0118; Escherichia coli O157:H7 ortholog: z0128. (916 aa)
gltACitrate synthase; Escherichia coli K-12 ortholog: b0720; Escherichia coli O157:H7 ortholog: z0873; Belongs to the citrate synthase family. (427 aa)
ybhJHypothetical protein ybhJ; Escherichia coli K-12 ortholog: b0771; Escherichia coli O157:H7 ortholog: z0942. (761 aa)
aspCAspartate aminotransferase; Escherichia coli K-12 ortholog: b0928; Escherichia coli O157:H7 ortholog: z1275. (396 aa)
icdAIsocitrate dehydrogenase (NADP); Escherichia coli K-12 ortholog: b1136; Escherichia coli O157:H7 ortholog: z1865. (416 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa)
alaAProbable aminotransferase yfbQ; Involved in the biosynthesis of alanine. (405 aa)
argAAmino-acid acetyltransferase; Escherichia coli K-12 ortholog: b2818; Escherichia coli O157:H7 ortholog: z4135; Belongs to the acetyltransferase family. ArgA subfamily. (465 aa)
argDAcetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways. (406 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (387 aa)
ilvNAcetolactate synthase isozyme I small subunit; Escherichia coli K-12 ortholog: b3670; Escherichia coli O157:H7 ortholog: z5164; Belongs to the acetolactate synthase small subunit family. (96 aa)
ilvBAcetolactate synthase isozyme I large subunit; Escherichia coli K-12 ortholog: b3671; Escherichia coli O157:H7 ortholog: z5165. (562 aa)
ilvGAcetohydroxy acid synthase II; Escherichia coli O157:H7 ortholog: z5279. (548 aa)
ilvMAcetolactate synthase isozyme II small subunit; Escherichia coli K-12 ortholog: b3769; Escherichia coli O157:H7 ortholog: z5280. (87 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. (309 aa)
ilvDDihydroxy-acid dehydratase; Escherichia coli K-12 ortholog: b3771; Escherichia coli O157:H7 ortholog: z5282. (616 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (541 aa)
argEAcetylornithine deacetylase; Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde. (396 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (269 aa)
lysCLysine-sensitive aspartokinase III; Escherichia coli K-12 ortholog: b4024; Escherichia coli O157:H7 ortholog: z5622; Belongs to the aspartokinase family. (449 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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