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yacA yacA secA secA yajC yajC secD secD secF secF ybeC ybeC c1883 c1883 c1888 c1888 ffh ffh c3388 c3388 c3391 c3391 c3392 c3392 c3393 c3393 c3398 c3398 c3401 c3401 hlyB hlyB hlyD hlyD yghD yghD c3702 c3702 tolC tolC secG secG prlA prlA yheE yheE yheF yheF yheG yheG hofF hofF hofG hofG hofH hofH yheH yheH yheI yheI yheJ yheJ yheK yheK pshM pshM hofD hofD ftsY ftsY secB secB yidC yidC tatA tatA tatB tatB yigU yigU secE secE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yacASecretion monitor precursor; Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation. Belongs to the SecM family. (221 aa)
secAPreprotein translocase secA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (901 aa)
yajCHypothetical protein yajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (120 aa)
secDProtein-export membrane protein secD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (615 aa)
secFProtein-export membrane protein secF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (338 aa)
ybeCSec-independent protein translocase protein tatE; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA; Belongs to the TatA/E family. TatE subfamily. (67 aa)
c1883Conserved hypothetical protein; Escherichia coli O157:H7 ortholog: z0707. (652 aa)
c1888Conserved hypothetical protein; Escherichia coli O157:H7 ortholog: z0267. (801 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] (453 aa)
c3388Hypothetical protein; Residues 8 to 218 of 221 are 51.38 pct identical to residues 13 to 226 of 228 from GenPept.129 : >emb|CAC90293.1| (AJ414148) putative membrane protein [Yersinia pestis]. (221 aa)
c3391Secreted protein Hcp; Residues 1 to 163 of 163 are 83.43 pct identical to residues 1 to 163 of 163 from GenPept.129 : >emb|CAC90295.1| (AJ414148) conserved hypothetical protein [Yersinia pestis]. (163 aa)
c3392Heat shock protein F84.1; Escherichia coli K-12 ortholog: b2592; Escherichia coli O157:H7 ortholog: z0254; Belongs to the ClpA/ClpB family. (878 aa)
c3393Hypothetical protein; Residues 10 to 743 of 824 are 62.75 pct identical to residues 10 to 749 of 782 from GenPept.129 : >emb|CAC89815.1| (AJ414145) conserved hypothetical protein [Yersinia pestis]. (824 aa)
c3398Hypothetical protein; Residues 78 to 1111 of 1112 are 50.43 pct identical to residues 97 to 1136 of 1140 from GenPept.129 : >emb|CAC90304.1| (AJ414148) putative membrane protein [Yersinia pestis]. (1112 aa)
c3401Hypothetical protein; Residues 19 to 172 of 178 are 47.77 pct identical to residues 1 to 157 of 162 from GenPept.129 : >emb|CAC90310.1| (AJ414148) conserved hypothetical protein [Yersinia pestis]. (178 aa)
hlyBHemolysin B; Part of the ABC transporter complex HlyBD involved in hemolysin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). (707 aa)
hlyDResidues 1 to 478 of 478 are 98.95 pct identical to residues 1 to 478 of 478 from SwissProt.40 : >sp|P09986|HLY4_ECOLI Hemolysin secretion protein D, chromosomal. (478 aa)
yghDPutative general secretion pathway protein M-type yghD; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (178 aa)
c3702Hypothetical protein; Residues 1 to 137 of 137 are 98.54 pct identical to residues 189 to 325 of 325 from GenPept.129 : >gb|AAL60191.1|AF426313_11 (AF426313) hypothetical type II secretion protein GspK [Escherichia coli]. (137 aa)
tolCOuter membrane protein tolC precursor; Escherichia coli K-12 ortholog: b3035; Escherichia coli O157:H7 ortholog: z4392. (506 aa)
secGProtein-export membrane protein secG; Involved in protein export. Participates in an early event of protein translocation (By similarity). (126 aa)
prlAPreprotein translocase secY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (443 aa)
yheEProbable general secretion pathway protein C; Escherichia coli K-12 ortholog: b3324. (271 aa)
yheFProbable general secretion pathway protein D precursor; Escherichia coli K-12 ortholog: b3325. (654 aa)
yheGProbable general secretion pathway protein E; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (493 aa)
hofFPutative general secretion pathway protein F; Protein transport protein hofF; Escherichia coli K-12 ortholog: b3327. (398 aa)
hofGPutative general secretion pathway protein G precursor; Protein transport protein hofG; Escherichia coli K-12 ortholog: b3328. (145 aa)
hofHPutative general secretion pathway protein H precursor; Protein transport protein hofH; Escherichia coli K-12 ortholog: b3329. (169 aa)
yheHProbable general secretion pathway protein I precursor; Escherichia coli K-12 ortholog: b3330; Escherichia coli O157:H7 ortholog: z5741. (138 aa)
yheIProbable general secretion pathway protein J precursor; Escherichia coli K-12 ortholog: b3331. (195 aa)
yheJProbable general secretion pathway protein K; Escherichia coli K-12 ortholog: b3332. (301 aa)
yheKProbable general secretion pathway protein L; Escherichia coli K-12 ortholog: b3333; Escherichia coli O157:H7 ortholog: z2633. (388 aa)
pshMPutative general secretion pathway protein M; Transport protein pshM; Escherichia coli K-12 ortholog: b3334. (161 aa)
hofDType 4 prepilin-like proteins leader peptide processing enzyme; Escherichia coli K-12 ortholog: b3335; Escherichia coli O157:H7 ortholog: z4693; bifunctional; Leader peptidase; N-methyltransferase; Belongs to the peptidase A24 family. (225 aa)
ftsYCell division protein ftsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (498 aa)
secBProtein-export protein secB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (175 aa)
yidC60 kDa inner-membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (548 aa)
tatASec-independent protein translocase protein tatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (103 aa)
tatBSec-independent protein translocase protein tatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (171 aa)
yigUSec-independent protein translocase protein tatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (258 aa)
secEPreprotein translocase secE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (127 aa)
Your Current Organism:
Escherichia coli CFT073
NCBI taxonomy Id: 199310
Other names: E. coli CFT073, Escherichia coli str. CFT073, Escherichia coli strain CFT073
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